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Author Giuseppe Biondi Zoccai

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Dual pathway inhibition in atherothrombosis prevention: yes, now we can!

Francesco Summaria, Giuseppe Biondi-Zoccai, Enrico Romagnoli, Mamas A Mamas, Francesco Franchi, Paolo Severino, Carlo Lavalle, Francesco Versaci, Achille Gaspardone, Deepak L Bhatt,

Despite ongoing developments, prevention and treatment of atherothrombotic cardiovascular disease remains a common challenge. Antithrombotic options for cardiocerebrovascular disease prevention involves a choice between dual antiplatelet therapy (DAPT) and dual pathway inhibition (DPI), which includes an antiplatelet agent and a reduced dose anticoagulant agent. In selected patients at high risk ... Read more >>

Minerva Cardiol Angiol (Minerva cardiology and angiology)
[2021, :]

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Effect of exercise on epicardial adipose tissue in adults: a systematic review and meta-analyses.

Tamy Colonetti, Antonio Jose Grande, Marcos Cruz Amaral, Laura Colonetti, Maria Laura Uggioni, Maria Inês da Rosa, Adrian V Hernandez, Gary Tse, Tong Liu, Nitesh Nerlekar, Giuseppe Biondi-Zoccai, Mansueto Gomes Neto, André Rodrigues Durães, Octávio Pontes-Neto, Elmiro Santos Resende, Leonardo Roever,

According to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) levels. We included randomized controlled trials ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, 26(6):1399-1411]

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Prognostic value of 12-leads admission electrocardiogram in low-risk patients hospitalized for Covid-19.

Martino Pepe, Gianluigi Napoli, Gaetano Brindicci, Eugenio Carulli, Palma L Nestola, Carmen R Santoro, Giuseppe Biondi-Zoccai, Arturo Giordano, Fabrizio D'Ascenzo, Plinio Cirillo, Annalisa Saracino, Stefano Favale,

<h4>Background</h4>Cardiac involvement significantly contributes to coronavirus disease 2019 (COVID-19)mortality.12-lead electrocardiogram (ECG) represents a fast, cheap, and easy to perform exam with the adjunctive advantage of the remote reporting possibility. In this study, we sought to investigate if electrocardiographic parameters are able to identify patients, deemed at low-risk at admission,who will ... Read more >>

Minerva Med (Minerva medica)
[2021, :]

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Paclitexel versus sirolimus-coated balloon in the treatment of coronary instent restenosis.

Carlo Briguori, Gabriella Visconti, Marco Golino, Amelia Focaccio, Mario Scarpelli, Silvia Nuzzo, Giuseppe Biondi-Zoccai,

<h4>Background</h4>Few studies compared paclitaxel-coated balloon (PCB) versus sirolimus-coated balloon (SCB) in the treatment of drug-eluting stent (DES) instent restenosis (ISR).<h4>Methods</h4>Between November 5 2009 and October 14 2020, in our centre 212 patients with first DES-ISR were treated with PCB (Restore®; Cardionovum GmbH, Bonn, Germany), whereas 230 patients were treated with ... Read more >>

Panminerva Med (Panminerva medica)
[2021, :]

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Predictors, Treatments, and Outcomes of Do-Not-Resuscitate Status in Acute Myocardial Infarction Patients (from a Nationwide Inpatient Cohort Study).

Ofer Kobo, Saadiq M Moledina, Michael Slawnych, Aynharan Sinnarajah, Jessica Simon, Harriette G C Van Spall, Louise Y Sun, Giuseppe Biondi Zoccai, Ariel Roguin, Mohamed O Mohamed, Mamas A Mamas,

Little is known about how frequently do-not-resuscitate (DNR) orders are placed in patients with acute myocardial infarction (AMI), the types of patients in which they are placed, treatment strategies or clinical outcomes of such patients. Using the United States (US) National Inpatient Sample (NIS) database from 2015 to 2018, we ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2021, 159:8-18]

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COVID-19, Acute Myocardial Injury and Infarction

Armando Del Prete, Francesca Conway, Domenico Giovanni Della Rocca, Giuseppe Biondi-Zoccai, Francesco De Felice, Carmine Musto, Marco Picichè, Eugenio Martuscelli, Andrea Natale, Francesco Versaci,

Synopsis SARS-CoV-2 can affect the cardiovascular system yielding a wide range of complications, including acute myocardial injury. The myocardium can be damaged by direct viral invasion or indirect mechanisms, sustained by systemic inflammation, immune-mediated response and dysregulation of the renin-angiotensin system. Myocardial injury affects about one-quarter of patients with COVID-19, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Cardiovascular medicine: a year in review.

Andrea Matteucci, Michela Bonanni, Francesco Versaci, Giacomo Frati, Mariangela Peruzzi, Giuseppe Sangiorgi, Giuseppe Biondi-Zoccai, Gianluca Massaro,

Cardiovascular medicine is facing several challenges in the current era, dominated by the rapid spread of a previously unknown virus around the world. Indeed, the 2020 COVID-19 pandemic set the course of cardiovascular science and education in an extraordinary way, hogging the attention of the medical community. Notably, while COVID-19 ... Read more >>

Minerva Cardiol Angiol (Minerva cardiology and angiology)
[2021, :]

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European Society of Cardiology Quality Indicators for Cardiovascular Disease Prevention: developed by the Working Group for Cardiovascular Disease Prevention Quality Indicators in collaboration with the European Association for Preventive Cardiology of the European Society of Cardiology.

Suleman Aktaa, Baris Gencer, Elena Arbelo, Constantinos H Davos, Ileana Désormais, Monika Hollander, Ana Abreu, Marco Ambrosetti, Maria Bäck, David Carballo, Carolyn Crawford, Christi Deaton, Paul Dendale, Thijs M H Eijsvogels, Mary Galbraith, Massimo Francesco Piepoli, Annett Salzwedel, Yvo Smulders, Matthias Wilhelm, Giuseppe Biondi-Zoccai, François Mach, Frank L J Visseren, Chris P Gale,

<h4>Aims</h4>To develop a set of quality indicators (QIs) for the evaluation of the care and outcomes for atherosclerotic cardiovascular disease (ASCVD) prevention.<h4>Methods and results</h4>The Quality Indicator Committee of the European Society of Cardiology (ESC) formed the Working Group for Cardiovascular Disease Prevention Quality Indicators in collaboration with Task Force members ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2021, :]

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Renal arteries denervation: from the treatment of resistant hypertension to the treatment of atrial fibrillation.

Francesco Versaci, Sebastiano Sciarretta, Massimiliano Scappaticci, Riccardo Di Pietro, Simone Calcagno, Armando Del Prete, Carlo Gaspardone, Giuseppe Biondi Zoccai,

Renal denervation (RDN) is a therapeutic strategy for patients with uncontrolled arterial hypertension characterized by considerable fluctuations during its progression. After initial strong enthusiasm, the procedure came to an abrupt halt following the publication of the Symplicity HTN-3 study results. The results of recently published studies highlight the reduction in ... Read more >>

Eur Heart J Suppl (European heart journal supplements : journal of the European Society of Cardiology)
[2021, 23(Suppl E):E177-E183]

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Effect of Interleukin-1 Blockade with Anakinra on Leukocyte Count in Patients with ST-Segment Elevation Acute Myocardial Infarction

MARCO GIUSEPPE DEL BUONO, Juan Ignacio Damonte, Cory Trankle, Dinesh Kadariya, Salvatore Carbone, Georgia Thomas, Jeremy Turlington, Roshanak Markley, Justin Canada, Giuseppe Biondi-Zoccai, Michael Kontos, Benjamin Van Tassell, Antonio Abbate,

<h4>Background: </h4> Leukocytosis is a common finding in patients with ST elevation myocardial infarction (STEMI) and portends a poor prognosis. Interleukin 1-b regulates leukopoiesis and pre-clinical studies suggest that anakinra (recombinant human interleukin-1 [IL-1] receptor antagonist) suppresses leukocytosis in myocardial infarction. However, the effect of IL-1 blockade with anakinra on ... Read more >>

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Perirenal Fat and Chronic Kidney Disease in Patients With Diabetes.

Leonardo Roever, Gary Tse, Giuseppe Biondi-Zoccai,

Diabetes (Diabetes)
[2021, 70(10):2190-2191]

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Interleukin-1 blockade with Anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical trials.

Antonio Abbate, George F Wohlford, Marco Giuseppe Del Buono, Juan Guido Chiabrando, Roshanak Markley, Jeremy Turlington, Dinesh Kadariya, Cory R Trankle, Giuseppe Biondi-Zoccai, Michael J Lipinski, Benjamin W Van Tassell,

<h4>Aims</h4>ST segment elevation myocardial infarction (STEMI) is associated with an intense acute inflammatory response and an increased risk of death and heart failure (HF). In this study we sought to evaluate the effect of anakinra, a recombinant interleukin-1 receptor antagonist, on the incidence of HF.<h4>Methods and results</h4>We performed a pooled ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, :]

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Percutaneous Coronary Intervention Compared to Coronary Artery Bypass Grafting in Patients with Non-ST-Elevation Acute Coronary Syndrome – A Systematic Review and Meta-Analysis

Hristo Kirov, Tulio Caldonazo, Mohamed Rahouma, Bryce Robinson, Michelle Demetres, Patrick Serruys, Giuseppe Biondi-Zoccai, Mario Gaudino, Torsten Doenst,

<h4>Objectives: </h4> Non-ST-elevation acute coronary syndrome (NSTE-ACS) affects millions of patients. Although an invasive strategy can improve survival, the optimal treatment (i.e., percutaneous coronary intervention [PCI] or coronary artery bypass grafting [CABG]) is not clear. We performed a meta-analysis of studies reporting outcomes between PCI and CABG in patients with ... Read more >>

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Meta-Analysis of Placebo-Controlled Trials of Levosimendan in Acute Myocardial Infarction.

Gabriele Tumminello, Alberto Cereda, Lucia Barbieri, Giuseppe Biondi-Zoccai, Stefano Lucreziotti, Antonio Mafrici, Stefano Carugo,

The treatment of acute myocardial infarction is early revascularization. Heart failure and cardiogenic shock may complicate acute myocardial infarction despite applying the best available strategy. Levosimendan is a relatively new drug to treat heart failure with a peculiar mechanism of action: calcium sensitization of myocardial fibres. Levosimendan has a direct ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(10):]

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Effects of resistance training on muscle strength, body composition and immune-inflammatory markers in people living with HIV: a systematic review and Meta-analysis of randomized controlled trials.

Hugo R Zanetti, Leandro T P Lopes, Alexandre Gonçalves, Vitor L Soares, Weverton F Soares, Adrian V Hernandez, Gary Tse, Tong Liu, Giuseppe Biondi-Zoccai, Leonardo Roever, Edmar L Mendes,

<b>Purpose:</b> The purpose of this review is to evaluate the effect of resistance training (RT) as a unique intervention on muscle strength, body composition, and immune-inflammatory markers in people living with HIV (PLHIV).<b>Methods:</b> The searches were conducted in seven databases and included published randomized clinical trials that assessed the effect ... Read more >>

HIV Res Clin Pract (HIV research & clinical practice)
[2021, 22(5):119-127]

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Unraveling diagnostic co-morbidity makeup of each HF category as characteristically derived by ECG- and ECHO-findings, a prevalence analysis

Azfar Zaman, Simone Calcagno, Giuseppe Biondi Zoccai, Niall Campbell, Georgios Koulaouzidis, Dionissios Tsipas, Istvan Kecskes,

Heart Failure (HF) relies mainly on measurements from Echocardiography, in particular Echo-Findings, to estimate Left Ventricle Ejection Fraction (LVEF) and evaluating structural heart disease criteria. As Echocardiography is not available in primary care, the key structural (heart chamber enlargements) and functiona l abnormality related measurements are not available precluding the ... Read more >>

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Interpersonal violence: Serious sequelae for heart disease in women.

Marianna Mazza, Giuseppe Marano, Angela Gonsalez Del Castillo, Daniela Chieffo, Gabriella Albano, Giuseppe Biondi-Zoccai, Leonarda Galiuto, Gabriele Sani, Enrico Romagnoli,

Experiencing various forms of violence in either childhood or adulthood has been associated with cardiovascular disease, both shortly after the event and during follow-up, particularly in women. The coronavirus disease 2019 pandemic has heightened the risk of domestic violence with serious sequelae for mental and cardiovascular health in women, possibly ... Read more >>

World J Cardiol (World journal of cardiology)
[2021, 13(9):438-445]

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Pharmacologic treatment of acute and recurrent pericarditis: a systematic review and meta-analysis of controlled clinical trials.

Stefano Avondo, Alessandro Andreis, Matteo Casula, Giuseppe Biondi-Zoccai, Massimo Imazio,

<h4>Introduction</h4>Recurrence is the most frequent complication following acute pericarditis and may occur in 30% patients, rising to 50% in case of multiple recurrences, lack of colchicine treatment or use of glucocorticoids. Available treatments include aspirin or non-steroidal anti-inflammatory drugs (NSAIDs), colchicine, glucocorticoids, immunosuppressive agents, immunoglobulins, anti-interleukin-1 (IL-1) agents.<h4>Evidence acquisition</h4>This systematic ... Read more >>

Panminerva Med (Panminerva medica)
[2021, 63(3):314-323]

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Antithrombotic Therapy for Vascular Disease and Intervention: The Best Is Yet to Come?

Martino Pepe, Mariangela Peruzzi, Giuseppe Biondi-Zoccai, Arturo Giordano,

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2021, 78(3):334-335]

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A snapshot global survey on side effects of COVID-19 vaccines among healthcare professionals and armed forces with a focus on headache.

Armando Perrotta, Giuseppe Biondi-Zoccai, Wael Saade, Fabio Miraldi, Andrea Morelli, Antonino G Marullo, Elena Cavarretta, Roberto Carnevale, Elena DE Falco, Isotta Chimenti, Sebastiano Sciarretta, Paola Frati, Mamas A Mamas, Sara Ciardi, Luigi Frati, Giacomo Frati, Mariangela Peruzzi,

<h4>Background</h4>New messenger RNA (mRNA) and adenovirus-based vaccines (AdV) against Coronavirus disease 2019 (COVID-19) have entered large scale clinical trials. Since healthcare professionals (HCPs) and armed forces personnel (AFP) represent a high-risk category, they act as a suitable target population to investigate vaccine-related side effects, including headache, which has emerged as ... Read more >>

Panminerva Med (Panminerva medica)
[2021, 63(3):324-331]

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Differential impact of type 1 and type 2 diabetes mellitus on outcomes among 1.4 million US patients undergoing percutaneous coronary intervention.

Andrija Matetic, Gemina Doolub, Aditya Bharadwaj, Mohammed Osman, Giuseppe Biondi-Zoccai, Waqas Ullah, Rodrigo Bagur, Poonam Velagapudi, M Chadi Alraies, Mohamed Osama Mohamed, Mamas A Mamas,

<h4>Background</h4>The aim was to determine the impact of diabetes mellitus (DM) on outcomes after percutaneous coronary intervention (PCI). There is limited data on the impact of DM and its subtypes among patients who underwent PCI during hospitalization.<h4>Methods</h4>All PCI hospitalizations from the National Inpatient Sample (October 2015-December 2018) were stratified by ... Read more >>

Cardiovasc Revasc Med (Cardiovascular revascularization medicine : including molecular interventions)
[2021, :]

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Characteristics and outcomes of MitraClip in octogenarians: Evidence from 1853 patients in the GIOTTO registry.

Arturo Giordano, Giuseppe Biondi-Zoccai, Filippo Finizio, Paolo Ferraro, Paolo Denti, Antonio Popolo Rubbio, Anna Sonia Petronio, Antonio L Bartorelli, Annalisa Mongiardo, Francesco De Felice, Marianna Adamo, Matteo Montorfano, Cesare Baldi, Giuseppe Tarantini, Francesco Giannini, Federico Ronco, Ida Monteforte, Emmanuel Villa, Maurizio Ferrario, Luigi Fiocca, Fausto Castriota, Corrado Tamburino,

<h4>Background</h4>We aimed at appraising features and outcomes of patients undergoing MitraClip treatment according to their age.<h4>Methods</h4>We queried the prospective GIse registry Of Transcatheter treatment of mitral valve regurgitaTiOn (GIOTTO) multicenter registry dataset including 19 Italian centers performing MitraClip implantation, distinguishing patients <80 vs ≥80 years of age.<h4>Results</h4>In total, 1853 patients were ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 342:65-71]

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Autoimmune diseases in patients undergoing percutaneous coronary intervention: A risk factor for in-stent restenosis?

Martino Pepe, Gianluigi Napoli, Eugenio Carulli, Marco Moscarelli, Cinzia Forleo, Palma Luisa Nestola, Giuseppe Biondi-Zoccai, Arturo Giordano, Stefano Favale,

<h4>Background and aims</h4>Despite the relation between autoimmune diseases and increased atherosclerotic risk is established, the influence of autoimmune disorders on in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) is only partly known. ISR is an aberrant reparative process mainly characterized by an increased number of vascular smooth muscle cells and ... Read more >>

Atherosclerosis (Atherosclerosis)
[2021, 333:24-31]

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Prediction of radial crossover in acute coronary syndromes: derivation and validation of the MATRIX score.

Felice Gragnano, Sanjit S Jolly, Shamir R Mehta, Mattia Branca, David van Klaveren, Enrico Frigoli, Giuseppe Gargiulo, Sergio Leonardi, Pascal Vranckx, Dario Di Maio, Emanuele Monda, Luigi Fimiani, Vincenzo Fioretti, Salvatore Chianese, Giuseppe Andò, Giovanni Esposito, Giuseppe Massimo Sangiorgi, Giuseppe Biondi-Zoccai, Dik Heg, Paolo Calabrò, Stephan Windecker, Enrico Romagnoli, Marco Valgimigli,

<h4>Background</h4>The radial artery is recommended by international guidelines as the default vascular access in patients with acute coronary syndromes (ACS) managed invasively. However, crossover from radial to femoral access is required in 4-10% of cases and has been associated with worse outcomes. No standardised algorithm exists to predict the risk ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2021, :]

Cited: 1 time

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Is COVID-19 the deadliest event of the last century?

Riccardo Di Pietro, Simone Calcagno, Giuseppe Biondi-Zoccai, Francesco Versaci,

Eur Heart J (European heart journal)
[2021, 42(30):2876-2879]

Cited: 1 time

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