Full Text Journal Articles by
Author Giovanni Scambia

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High resolution melting profiles (HRMPs) obtained by magnetic induction cycler (MIC) have been used to monitor the BRCA2 status highlighted by next generation tumor sequencing (NGTS): a combined approach in a diagnostic environment.

Giorgia Mazzuccato, Maria De Bonis, Vittoria Carboni, Claudia Marchetti, Andrea Urbani, Giovanni Scambia, Ettore Capoluongo, Anna Fagotti, Angelo Minucci,

Resistance can be the result of secondary tissue variants (STVs), which restore the open reading frame of the germline BRCA allele, producing functional BRCA protein in germline BRCA1/2 (BRCA) pathogenic variant (PV) carriers, treated with platinum-based chemotherapy or poly-(ADP-ribose) polymerase inhibitors (PARP-1). We reported recently a BRCA2 mutant high grade ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2020, :]

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BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic.

Angelo Minucci, Giovanni Scambia, Concetta Santonocito, Paola Concolino, Andrea Urbani,

The first person-to-person transmission of the 2019-novel coronavirus in Italy on 21 February 2020 led to an infection chain that represents one of the largest known COVID-19 outbreaks outside Asia. Hospitals have been forced to reorganized their units in response to prepare for an unforeseen healthcare emergency. In this context, ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2020, :]

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Spectrum of Germline BRCA1 and BRCA2 Variants Identified in 2351 Ovarian and Breast Cancer Patients Referring to a Reference Cancer Hospital of Rome.

Concetta Santonocito, Roberta Rizza, Ida Paris, Laura De Marchis, Carmela Paolillo, Giordana Tiberi, Giovanni Scambia, Ettore Capoluongo,

Pathogenic variants (PVs) carriers in BRCA1 or BRCA2 are associated with an elevated lifetime risk of developing breast cancer (BC) and/or ovarian cancer (OC). The prevalence of BRCA1 and BRCA2 germline alterations is extremely variable among different ethnic groups. Particularly, the rate of variants in Italian BC and/or OC families ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

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Enhanced binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesis

Flavio De Maio, Ettore Lo Cascio, Gabriele Babini, Michela Sali, Stefano Della Longa, Bruno Tilocca, Paola Roncada, Alessandro Arcovito, Maurizio Sanguinetti, Giovanni Scambia, Andrea Urbani,

Abstract Background: The Envelope (E) protein of SARS-CoV-2 is the most enigmatic protein among the four structural ones on the viral genome. Most of the current knowledge on the E protein is based on the direct comparison to the SARS E protein, initially mistakenly undervalued and subsequently proved to be ... Read more >>

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Neuroendocrine Carcinoma of the Uterine Cervix: A Clinicopathologic and Immunohistochemical Study with Focus on Novel Markers (Sst2-Sst5).

Frediano Inzani, Angela Santoro, Giuseppe Angelico, Angela Feraco, Saveria Spadola, Damiano Arciuolo, Michele Valente, Angela Carlino, Alessia Piermattei, Giulia Scaglione, Giovanni Scambia, Guido Rindi, Gian Franco Zannoni,

BACKGROUND:Gynecological neuroendocrine neoplasms (NENs) are extremely rare, accounting for 1.2-2.4% of the NENs. The aim of this study was to test cervical NENs for novel markers of potential utility for differential diagnosis and target therapy. METHODS:All cases of our center (n = 16) were retrieved and tested by immunohistochemistry (IHC) ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(5):]

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Laparoscopic Ethanol Sclerotherapy for Ovarian Endometriomas: Preliminary Results.

De Cicco Nardone Alessandra, Carfagna Pietro, De Cicco Nardone Carlo, Scambia Giovanni, Marana Riccardo, De Cicco Nardone Fiorenzo,

STUDY OBJECTIVE:The purpose of this study was to evaluate laparoscopic aspiration of endometriomas via 95% ethanol sclerotherapy. DESIGN:A single center, retrospective study. SETTING:Endometriosis outpatient clinic of a tertiary university hospital, gynecological department of Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy PATIENTS: Fifty-three females with 64 identified endometriomas measuring 4 to ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2020, :]

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Palliative electrochemotherapy in primary or recurrent vulvar cancer.

Giacomo Corrado, Giuseppe Cutillo, Simona Maria Fragomeni, Valentina Bruno, Luca Tagliaferri, Emanuela Mancini, Camilla Certelli, Ida Paris, Enrico Vizza, Giovanni Scambia, Giorgia Garganese,

OBJECTIVE:Since vulvar cancer is such a rare disease, the international experience with electrochemotherapy has been derived from only a few centers. The aim of this study was to evaluate clinical outcome and side effects profile with the use of electrochemotherapy in patients with primary or recurrent vulvar cancer. METHODS:Data were ... Read more >>

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Molecular pathways in vulvar squamous cell carcinoma: implications for target therapeutic strategies.

Giulia Mantovani, Simona Maria Fragomeni, Frediano Inzani, Anna Fagotti, Luigi Della Corte, Stefano Gentileschi, Luca Tagliaferri, Gian Franco Zannoni, Giovanni Scambia, Giorgia Garganese,

BACKGROUND:Additional prognostic factors and personalized therapeutic alternatives for vulvar squamous cell carcinoma (VSCC), especially for advanced stages with poor prognosis, are urgently needed. OBJECTIVES:To review and assess literature regarding underlying molecular mechanisms of VSCC target therapeutic and prognostic approaches. METHODS:We performed a narrative literature review from the inception of the ... Read more >>

J. Cancer Res. Clin. Oncol. (Journal of cancer research and clinical oncology)
[2020, 146(7):1647-1658]

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Minimally-invasive cytoreduction in recurrent endometrial cancer: laparoscopic and uniportal video-assisted thoracoscopic surgery combined approach.

Nicolò Bizzarri, Elisa Meacci, Felice Giuliante, Valentina Ghirardi, Giovanni Scambia, Anna Fagotti,

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Rucaparib for patients with platinum-sensitive, recurrent ovarian carcinoma (ARIEL3): post-progression outcomes and updated safety results from a randomised, placebo-controlled, phase 3 trial.

Jonathan A Ledermann, Amit M Oza, Domenica Lorusso, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne I Weberpals, Andrew R Clamp, Giovanni Scambia, Alexandra Leary, Robert W Holloway, Margarita Amenedo Gancedo, Peter C Fong, Jeffrey C Goh, David M O'Malley, Deborah K Armstrong, Susana Banerjee, Jesus García-Donas, Elizabeth M Swisher, Terri Cameron, Lara Maloney, Sandra Goble, Robert L Coleman,

BACKGROUND:In ARIEL3, rucaparib maintenance treatment significantly improved progression-free survival versus placebo. Here, we report prespecified, investigator-assessed, exploratory post-progression endpoints and updated safety data. METHODS:In this ongoing (enrolment complete) randomised, placebo-controlled, phase 3 trial, patients aged 18 years or older who had platinum-sensitive, high-grade serous or endometrioid ovarian, primary peritoneal, or ... Read more >>

Lancet Oncol. (The Lancet. Oncology)
[2020, 21(5):710-722]

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Laparoscopic laterally extended endopelvic resection procedure for gynecological malignancies.

Giulio Sozzi, Marco Petrillo, Valerio Gallotta, Mariano Catello Di Donna, Marco Ferreri, Giovanni Scambia, Vito Chiantera,

OBJECTIVES:Pelvic side wall infiltration by gynecological malignancies has been considered for a long time an absolute contraindication to curative resection. The development of the laterally extended endopelvic resection (LEER) has challenged this surgical paradigm. Although the LEER has been standardized in open surgery, only small studies have been published about ... Read more >>

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Ovarian cancer treatment is evolving: more choices, more chances.

Claudia Marchetti, Giovanni Scambia, Alessia Romito, Anna Fagotti,

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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CDT reference values for monitoring chronic alcohol abuse in pregnancy.

Federica Bortolotti, Ricciarda Raffaelli, Nicoletta Di Simone, Michela Semprebon, Mariateresa Mirandola, Chiara Simonetto, Francesca De Marchi, Maria Teresa Trevisan, Giovanna Carli, Romolo M Dorizzi, Giovanni Scambia, Massimo Franchi, Franco Tagliaro,

INTRODUCTION AND AIM:Carbohydrate Deficient Transferrin (CDT) is one of the most used biomarkers for monitoring alcohol use in pregnancy. However, its effective application in this context is hampered by the demonstrated physiological progressive increase during pregnancy (even in abstinent women) of CDT values, which in the third trimester can reach ... Read more >>

Clin. Chim. Acta (Clinica chimica acta; international journal of clinical chemistry)
[2020, 507:156-160]

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Novel preoperative predictive score to evaluate lymphovascular space involvement in endometrial cancer: an aid to the sentinel lymph node algorithm.

Vito Andrea Capozzi, Giulio Sozzi, Stefano Uccella, Valentina Ceni, Alessandra Cianciolo, Giulia Gambino, Giulia Armano, Martina Pugliese, Giovanni Scambia, Vito Chiantera, Roberto Berretta,

INTRODUCTION:Sentinel lymph node (SLN) dissection has been recognized as a valid tool for staging in patients with endometrial cancer. Several factors are predictors of recurrence and survival in endometrial cancer, including positive lymphovascular space invasion. The aim of this study is to formulate a pre-operative score that, in the event ... Read more >>

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Value of indocyanine green and laparoscopic near-infrared technology in the surgical management of endometriosis: What is the evidence?

Luigi C Turco, Giuseppe Vizzielli, Maria De Ninno, Giovanni Scambia, Francesco Cosentino,

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, :]

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Minimally invasive surgery in urogynecology: a comparison of standard laparoscopic, minilaparoscopic, percutaneous surgical system and Robotic sacral colpopexy.

Giovanni Panico, Giuseppe Campagna, Lorenzo Vacca, Daniela Caramazza, Vito Iannone, Cristiano Rossitto, Valerio Rumolo, Giovanni Scambia, Alfredo Ercoli,

We compared surgical outcome of sacral colpopexy (SCP) performed with the most recent minimally invasive surgery such as 3 mm laparoscopy (MiniLPS), percutaneous system (PSS), standard laparoscopy (LPS) and robotic. This is a multicenter retrospective cohort study conducted at Urogynecological department of the Fondazione Policlinico Universitario A. Gemelli IRCCS of ... Read more >>

Minerva Med. (Minerva medica)
[2020, :]

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Real three-dimensional approach vs two-dimensional camera with and without real-time near-infrared imaging with indocyanine green for detection of endometriosis: A case-control study.

Giuseppe Vizzielli, Francesco Cosentino, Diego Raimondo, Luigi C Turco, Virginia Vargiu, Raffaella Iodice, Manuela Mastronardi, Mohamed Mabrouk, Giovanni Scambia, Renato Seracchioli,

INTRODUCTION:The complete surgical removal of endometriosis lesions is not always feasible because some implants may be very small or hidden. The use of intraoperative near-infrared radiation (NIR) imaging after intravenous injection of indocyanine green (ICG) coupled with robotic technical advances, including 3-dimensional (3D) and high-resolution vision, might improve detection rates. ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, :]

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Valacyclovir in primary maternal CMV infection for prevention of vertical transmission: A case-series.

Marco De Santis, Massimo Apicella, Carmen De Luca, Luisa D'Oria, Piero Valentini, Maurizio Sanguinetti, Antonio Lanzone, Giovanni Scambia, Rosaria Santangelo, Lucia Masini,

BACKGROUND:No treatment is currently approved for cytomegalovirus infection in pregnancy. Valacyclovir has been studied in symptomatic cytomegalovirus infected fetuses and seems to reduce the risk of serious sequelae. OBJECTIVES:We used off-label valacyclovir on pregnant women with primary cytomegalovirus infection to reduce the risk of fetal infection. STUDY DESIGN:We treated 12 ... Read more >>

J. Clin. Virol. (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 127:104351]

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Surgical outcomes of segmental ureteral resection with ureteroneocystostomy after major gynecologic surgery.

Alex Federico, Valerio Gallotta, Nazario Foschi, Barbara Costantini, Carmine Conte, Francesco Pinto, Alfredo Ercoli, Gabriella Ferrandina, Fabrizio Dal Moro, Pierfrancesco Bassi, Filiberto Zattoni, Giovanni Scambia, Giuseppe Vizzielli,

Describing the surgical and oncological outcome of bladder-preserving ureter reconstruction (BPUR) with segmental ureteral resection after major gynecologic surgery. Patients with BPUR admitted at a single institution between March 2012 and July 2018 were retrospectively analyzed. Surgical and oncological data were assessed. Forty-six women with gynecologic tumors involving the ureter ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, :]

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Laparoscopic laterally extended pelvic resection for gynecological malignancies.

Mariano Catello Di Donna, Giulio Sozzi, Carla Cicero, Giuseppe Vizzielli, Giovanni Scambia, Vito Chiantera,

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(4):555]

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Correction to: Translational immune correlates of indirect antibody immunization in a randomized phase II study using scheduled combination therapy with carboplatin/paclitaxel plus oregovomab in ovarian cancer patients.

Alessandra Battaglia, Alexia Buzzonetti, Marco Fossati, Giovanni Scambia, Andrea Fattorossi, Madi R Madiyalakan, Yolanda D Mahnke, Christopher Nicodemus,

The original version of this article unfortunately contained a mistake. ... Read more >>

Cancer Immunol. Immunother. (Cancer immunology, immunotherapy : CII)
[2020, :]

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Letrozole in the management of advanced ovarian cancer: an old drug as a new targeted therapy.

Claudia Marchetti, Francesca De Felice, Raffaella Ergasti, Giovanni Scambia, Anna Fagotti,

At present, there is no standard of care on the use of letrozole in ovarian cancer management. We performed a systematic review of the available literature addressing this issue. Data demonstrated a role for letrozole in ovarian cancer, in both the primary and recurrent setting. Letrozole, which has a favorable ... Read more >>

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis.

Daniele Di Mascio, Asma Khalil, Gabriele Saccone, Giuseppe Rizzo, Danilo Buca, Marco Liberati, Jacopo Vecchiet, Luigi Nappi, Giovanni Scambia, Vincenzo Berghella, Francesco D'Antonio,

Objective:The aim of this systematic review was to report pregnancy and perinatal outcomes of Coronavirus (CoV) spectrum infections, and particularly COVID-19 disease due to SARS-COV-2 infection during pregnancy. Data sources:Medline, Embase, Cinahl and Clinicaltrials.gov databases were searched electronically utilizing combinations of word variants for "coronavirus" or "severe acute respiratory syndrome" ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2020, :100107]

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Skeletal muscle mass as a prognostic indicator of outcomes in ovarian cancer: a systematic review and meta-analysis.

Emanuele Rinninella, Anna Fagotti, Marco Cintoni, Pauline Raoul, Giuseppe Scaletta, Giovanni Scambia, Antonio Gasbarrini, Maria Cristina Mele,

BACKGROUND:Muscle mass plays a key role in predicting clinical outcomes in cancer. This systematic review and meta-analysis aimed to evaluate whether computed tomography (CT) scan indexes of muscle mass quantity and quality could be used as prognostic factors in ovarian cancer. METHODS:Three electronic bibliographic databases (MEDLINE, Web of Science, and ... Read more >>

Int. J. Gynecol. Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(5):654-663]

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Laparoscopic sacral colpopexy for pelvic organ prolapse recurrence after transvaginal mesh surgery.

Giuseppe Campagna, Giovanni Panico, Lorenzo Vacca, Daniela Caramazza, Valeria Gallucci, Valerio Rumolo, Giovanni Scambia, Alfredo Ercoli,

OBJECTIVE:Pelvic organ prolapse (POP) recurrence in transvaginal mesh surgery patients has become increasingly common, due to widespread mesh use before the FDA alert. The aim was to assess feasibility, effectiveness and safety of laparoscopic sacral colpopexy (LSCP) in recurrent POP after previous vaginal surgery with polypropylene mesh. STUDY DESIGN:Medical records ... Read more >>

Eur. J. Obstet. Gynecol. Reprod. Biol. (European journal of obstetrics, gynecology, and reproductive biology)
[2020, 248:222-226]

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