Full Text Journal Articles by
Author Giovanni Corso

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Hereditary breast cancer: translation into clinical practice of recent American Society of Clinical Oncology, American Society of Radiation Oncology, and Society of Surgical Oncology recommendations.

Giovanni Corso, Francesca Magnoni,

Scientific acquisitions concerning the risk of breast cancer in the context of hereditary breast cancer syndrome are constantly evolving: alongside the BRCA1 and BRCA2 mutations, further ones have been identified, also associated with malignancies in different sites. Therefore, management of these clinical conditions requires a multidisciplinary and shared approach, based ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(4):311-314]

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Is Nipple-Sparing Mastectomy Indicated after Previous Breast Surgery? A Series of 387 Institutional Cases.

Elisa Vicini, Francesca De Lorenzi, Alessandra Invento, Giovanni Corso, Davide Radice, Samantha Bozzo, Sabrina Kahler Ribeiro Fontana, Pietro Caldarella, Paolo Veronesi, Viviana Galimberti,

<h4>Background</h4>Previous breast surgery does not represent an absolute contraindication for nipple-sparing mastectomy, although it may negatively interfere with surgical outcomes. The aim of the authors' study was to confirm the feasibility of nipple-sparing mastectomy after previous breast surgery, focusing on skin incisions and risk factors, complications, and oncologic outcomes.<h4>Methods</h4>The authors ... Read more >>

Plast Reconstr Surg (Plastic and reconstructive surgery)
[2021, 148(1):21-30]

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Economic implications of ACOSOG Z0011 trial application into clinical practice at the European Institute of Oncology.

Denise Mattar, Antonio Di Filippo, Alessandra Invento, Davide Radice, Marius Burcuta, Vincenzo Bagnardi, Francesca Magnoni, Giorgia Santomauro, Giovanni Corso, Giovanni Mazzarol, Giuseppe Viale, Virgilio Sacchini, Viviana Galimberti, Paolo Veronesi, Mattia Intra,

<h4>Background and objectives</h4>The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial demonstrated that in clinically node-negative women undergoing breast-conserving therapy (BCT) and found to have metastases to 1 or 2 sentinel nodes, sentinel lymph node biopsy (SLNB) alone resulted in rates of local control, disease-free survival, and overall survival ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, :]

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Biological and clinical features of triple negative Invasive Lobular Carcinomas of the breast. Clinical outcome and actionable molecular alterations.

Fabio Conforti, Laura Pala, Eleonora Pagan, Elena Guerini Rocco, Vincenzo Bagnardi, Emilia Montagna, Giulia Peruzzotti, Tommaso De Pas, Caterina Fumagalli, Silvana Pileggi, Chiara Pesenti, Sergio Marchini, Giovanni Corso, Caterina Marchio', Anna Sapino, Rossella Graffeo, Laetitia Collet, Philippe Aftimos, Christos Sotiriou, Martine Piccart, Richard D Gelber, Giuseppe Viale, Marco Colleoni, Aron Goldhirsch,

<h4>Background</h4>We report here for the first time, a comprehensive characterization of biological and clinical features of early-stage triple negative Invasive Lobular Carcinomas(TN-ILCs) METHODS: We analyzed all consecutive patients with early-stage TN-ILC operated at two reference cancer-centers between 1994 and 2012. Primary objective was to assess the invasive disease-free survival(iDFS). Co-primary ... Read more >>

Breast (Breast (Edinburgh, Scotland))
[2021, 59:94-101]

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Frequency of CDH1 Germline Mutations in Non-Gastric Cancers.

Giulia Massari, Francesca Magnoni, Giorgio Favia, Nickolas Peradze, Paolo Veronesi, Carlo La Vecchia, Giovanni Corso,

Hereditary Diffuse Gastric Cancer (HDGC) is a complex inherited syndrome caused by <i>CDH1</i> germline mutations. DGC is the hallmark cancer of this genetic predisposition, but several other cancers are associated with these <i>CDH1</i> mutations. In this review, we revised all studies reporting <i>CDH1</i> mutations in non-GC patients. The selected studies ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(10):]

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CDH1 germline mutations in families with hereditary lobular breast cancer.

Antonia Girardi, Francesca Magnoni, Elisa Vicini, Andriana Kouloura, Carlo La Vecchia, Paolo Veronesi, Giovanni Corso,

Pathogenic CDH1 germline mutations are associated with lobular breast cancer in the so-called hereditary lobular breast cancer (HLBC) syndrome, without apparent correlation with the classic hereditary diffuse gastric cancer (HDGC). Recent international guidelines recommend CDH1 screening also in absence of diffuse gastric cancer (DGC) history. Genomic characteristics underlying gastric and ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, :]

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Mastectomy alone for pT1-2 pN0-1 breast cancer patients: when postmastectomy radiotherapy is indicated.

Maria Cristina Leonardi, Ida Rosalia Scognamiglio, Patrick Maisonneuve, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Marianna Alessandra Gerardi, Mattia Zaffaroni, Alessandra De Scalzi, Antonia Girardi, Francesca Magnoni, Emilia Montagna, Cristiana Iuliana Fodor, Viviana Enrica Galimberti, Paolo Veronesi, Roberto Orecchia, Roberto Pacelli, Barbara Alicja Jereczek-Fossa, Giovanni Corso,

<h4>Purpose</h4>To assess outcome of breast cancer (BC) stages pT1-2 N0-1 after mastectomy alone and to identify prognostic factors calling for the need of postmastectomy radiotherapy.<h4>Methods</h4>Patients who were not eligible for breast conserving surgery (BCS) were operated on with mastectomy between 1998 and 2008. Locoregional (LRR), distant (DM) control and breast ... Read more >>

Breast Cancer Res Treat (Breast cancer research and treatment)
[2021, 188(2):511-524]

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Second Reply to: "Metaplastic Breast Carcinoma and Other Triple-Negative Subtype Breast Cancers: Which is the Worst?"

Giovanni Corso,

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Impact of radiation and hormonal therapy on the locoregional recurrence of elderly breast cancer: Are these necessary after breast-conserving surgery?

Giovanni Corso, Patrick Maisonneuve, Paolo Veronesi,

Cancer (Cancer)
[2021, 127(15):2807-2808]

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Long-term outcome and axillary recurrence in elderly women (≥70 years) with breast cancer: 10-years follow-up from a matched cohort study.

Giovanni Corso, Francesca Magnoni, Giacomo Montagna, Patrick Maisonneuve, Andrea Polizzi, Giulia Massari, Alessandra Invento, Antonia Girardi, Alessandra Margherita De Scalzi, Paolo Veronesi,

<h4>Background and objectives</h4>The oncological benefit of axillary surgery (AS), with sentinel lymph node biopsy (SLNB) or axillary dissection (ALND), in elderly women affected by breast cancer (BC) is controversial. We evaluated AS trends over a 10-year follow-up period as well as locoregional and survival outcomes in this subset of patients.<h4>Methods</h4>Patients ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, 47(7):1593-1600]

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Metaplastic Breast Carcinoma and Other Triple-Negative Subtype Breast Cancers: Which Is Worst?

Giovanni Corso,

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

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Geographical Distribution of E-cadherin Germline Mutations in the Context of Diffuse Gastric Cancer: A Systematic Review.

Giovanni Corso, Federica Corso, Federica Bellerba, Patrícia Carneiro, Susana Seixas, Antonio Cioffi, Carlo La Vecchia, Francesca Magnoni, Bernardo Bonanni, Paolo Veronesi, Sara Gandini, Joana Figueiredo,

Hereditary diffuse gastric cancer (HDGC) is a complex and multifactorial inherited cancer predisposition syndrome caused by <i>CDH1</i> germline mutations. Nevertheless, current <i>CDH1</i> genetic screening recommendations disregard an unbalanced worldwide distribution of <i>CDH1</i> variants, impacting testing efficacy and patient management. In this systematic review, we collected and analyzed all studies describing ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

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Anticoagulant selection in relation to the SAMe-TT2R2 score in patients with atrial fibrillation: The GLORIA-AF registry.

George Ntaios, Menno V Huisman, Hans-Christoph Diener, Jonathan L Halperin, Christine Teutsch, Sabrina Marler, Venkatesh K Gurusamy, Milla Thompson, Gregory Y H Lip, Brian Olshansky, ,

<h4>Aim</h4>The SAMe-TT<sub>2</sub>R<sub>2</sub> score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA) and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently ... Read more >>

Hellenic J Cardiol (Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese)
[2021, 62(2):152-157]

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Axillary management after neoadjuvant treatment.

Giacomo Montagna, Giovanni Corso, Rosa Di Micco, Nathalie Van Den Rul, Nicola Rocco,

Since its introduction nearly 30 years ago, sentinel lymph node biopsy (SLNB) has become the standard technique to stage the axilla for the great majority of patients with early breast cancer. While the accuracy of SLNB in clinically node-negative patients who undergo neoadjuvant chemotherapy (NAC) is similar to the upfront ... Read more >>

Minerva Chir (Minerva chirurgica)
[2020, 75(6):400-407]

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Axillary surgery in breast cancer: An updated historical perspective.

Francesca Magnoni, Viviana Galimberti, Giovanni Corso, Mattia Intra, Virgilio Sacchini, Paolo Veronesi,

This historical surgical retrospection focuses on the temporal de-escalation axillary surgery, focusing on the unceasing efforts of researchers toward new challenges, as documented by extensive studies and trials. Axillary surgery has evolved, aiming to offer the best oncologic treatment and improve the quality of life of women. Axillary lymph-node dissection ... Read more >>

Semin Oncol (Seminars in oncology)
[2020, 47(6):341-352]

Cited: 2 times

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Metaplastic breast cancer: Prognostic and therapeutic considerations.

Giovanni Corso, Samuele Frassoni, Antonia Girardi, Elisa De Camilli, Emilia Montagna, Mattia Intra, Luca Bottiglieri, Alessandra Margherita De Scalzi, Denise Mattar Fanianos, Francesca Magnoni, Alessandra Invento, Antonio Toesca, Fabio Conforti, Vincenzo Bagnardi, Giuseppe Viale, Marco Angelo Colleoni, Paolo Veronesi,

<h4>Introduction</h4>Metaplastic breast cancer (MBC) is a rare condition of breast tumor with different subtypes, considered a disease with worse prognosis; treatments and survival are often unclear and conflicting.<h4>Methods</h4>We consecutively collected 153 primary MBCs of different subtypes. Breast surgery, neoadjuvant or adjuvant treatment, clinic-pathological factors, number and type of events during ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2021, 123(1):61-70]

Cited: 2 times

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E-Cadherin (CDH1 Gene) Germline Mutations in Gastric Cancer: Evolutions and Innovations.

Giovanni Corso, Bernardo Bonanni,

Family history has contributed greatly to understanding inherited diseases throughout the centuries, in particular familial and hereditary cancer syndromes [...]. ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

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Axillary surgery in breast cancer: evolution and de-escalation.

Paolo Veronesi, Federico Ghidinelli, Giovanni Corso,

Minerva Chir (Minerva chirurgica)
[2020, 75(6):383-385]

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Impact of COVID-19 pandemic on clinical and surgical breast cancer management.

Paolo Veronesi, Giovanni Corso,

EClinicalMedicine (EClinicalMedicine)
[2020, 26:100523]

Cited: 1 time

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Long-term standard sentinel node biopsy after neoadjuvant treatment in breast cancer: a single institution ten-year follow-up.

Sabrina Kahler-Ribeiro-Fontana, Eleonora Pagan, Francesca Magnoni, Elisa Vicini, Consuelo Morigi, Giovanni Corso, Mattia Intra, Fiorella Canegallo, Silvia Ratini, Maria Cristina Leonardi, Eliana La Rocca, Vincenzo Bagnardi, Emilia Montagna, Marco Colleoni, Giuseppe Viale, Luca Bottiglieri, Chiara Maria Grana, Jorge Villanova Biasuz, Paolo Veronesi, Viviana Galimberti,

<h4>Introduction</h4>In patients with positive lymph nodes (cN+) prior to neoadjuvant treatment (NAT), which convert to a clinically negative axilla (cN0) after treatment, the use of sentinel node biopsy (SNB) is still debatable, since the false-negative rate (FNR) is significantly high (12.6-14.2%). The objective of this retrospective mono-institutional study, with a ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, 47(4):804-812]

Cited: 4 times

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How Useful Are Tumor Markers in Detecting Metastases with FDG-PET/CT during Breast Cancer Surveillance?

Giovanni Corso, Laura Gilardi, Antonia Girardi, Alessandra Margherita De Scalzi, Gianmatteo Pagani, Elisabetta Maria Cristina Rossi, Giacomo Montagna, Paolo Veronesi, Eleonora Pagan, Vincenzo Bagnardi, Chiara Maria Grana,

<h4>Background</h4>To assess the clinical usefulness of serum tumor markers for early detection of distant breast cancer recurrence using FDG-PET/CT.<h4>Methods</h4>We retrospectively analyzed 561 consecutive patients who underwent surgery for invasive primary breast cancer and had increased tumor markers (CA 15-3 and CEA) after completion of locoregional therapy. FDG-PET/CT data were reviewed ... Read more >>

Oncology (Oncology)
[2020, 98(10):714-718]

Cited: 1 time

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Letter Regarding: Is Prophylactic Total Gastrectomy Always Indicated in CDH1 Germline Mutant Carriers?

Giovanni Corso,

J Surg Res (The Journal of surgical research)
[2020, 255:647-648]

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Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review.

Giovanni Corso, Giacomo Montagna, Joana Figueiredo, Carlo La Vecchia, Uberto Fumagalli Romario, Maria Sofia Fernandes, Susana Seixas, Franco Roviello, Cristina Trovato, Elena Guerini-Rocco, Nicola Fusco, Gabriella Pravettoni, Serena Petrocchi, Anna Rotili, Giulia Massari, Francesca Magnoni, Francesca De Lorenzi, Manuela Bottoni, Viviana Galimberti, João Miguel Sanches, Mariarosaria Calvello, Raquel Seruca, Bernardo Bonanni,

E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an inherited predisposition of lobular breast carcinoma. In 2019, the international gastric cancer linkage consortium revised the clinical criteria and established guidelines for the ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(6):]

Cited: 2 times

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Germline mutations of the E-cadherin gene (CDH1) in early onset gastric cancer.

Giovanni Corso, Franco Roviello,

Semin Oncol (Seminars in oncology)
[2020, 47(2-3):125-126]

Cited: 1 time

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E-cadherin deregulation in breast cancer.

Giovanni Corso, Joana Figueiredo, Simone Pietro De Angelis, Federica Corso, Antonia Girardi, Joana Pereira, Raquel Seruca, Bernardo Bonanni, Patricia Carneiro, Gabriella Pravettoni, Elena Guerini Rocco, Paolo Veronesi, Giacomo Montagna, Virgilio Sacchini, Sara Gandini,

E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, 24(11):5930-5936]

Cited: 6 times

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