Full Text Journal Articles by
Author Giovanni B Forleo

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Reduction of admissions for urgent and elective pacemaker implant during the COVID-19 outbreak in Northern Italy.

Gabriele Dell'Era, Crizia Colombo, Giovanni B Forleo, Antonio Curnis, Lina Marcantoni, Marco Racheli, Paolo Sartori, Pasquale Notarstefano, Alberto De Salvia, Federico Guerra, Matteo Ziacchi, Claudio Tondo, Edoardo Gandolfi, Federica De Vecchi, Giosué Mascioli, Aldo Coppolino, Bruna Catuzzo, Claudia Amellone, Massimo Mantica, Fabrizio D'Ascenzo, Giuseppe Patti,

<h4>Aims</h4>The coronavirus disease-19 (COVID-19) outbreak has been recently associated with lower hospitalization rates for acute coronary syndromes. Aim of the study was to investigate whether a similar behaviour is observed in admissions for urgent pacemaker implant.<h4>Methods</h4>This retrospective study included 1315 patients from 18 hospitals in Northern Italy with a high ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2022, 23(1):22-27]

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Intraoperative sensing increase predicts long-term pacing threshold in leadless pacemakers.

Gianfranco Mitacchione, Gianmarco Arabia, Marco Schiavone, Manuel Cerini, Alessio Gasperetti, Francesca Salghetti, Luca Bontempi, Maurizio Viecca, Antonio Curnis, Giovanni B Forleo,

<h4>Purpose</h4>High pacing threshold (HPT) and very high pacing threshold (VHPT) are known to have a negative impact on leadless pacemaker battery longevity, representing the most common reason for device repositioning. In this study, we evaluated if intraoperative electrical parameters recorded during Micra™ VR implant would be able to predict device ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2022, :]

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Targeting non-pulmonary vein triggers in persistent atrial fibrillation: results from a prospective, multicentre, observational registry.

Domenico G Della Rocca, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Jorge Romero, Nicola Tarantino, Michele Magnocavallo, Mohamed Bassiouny, Veronica N Natale, Angel Quintero Mayedo, Bryan Macdonald, Carlo Lavalle, Ghulam Murtaza, Krishna Akella, Giovanni B Forleo, Amin Al-Ahmad, John David Burkhardt, Gerald Joseph Gallinghouse, Javier E Sanchez, Rodney P Horton, Juan F Viles-Gonzalez, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Aims</h4>We evaluated the efficacy of an ablation strategy empirically targeting pulmonary veins (PVs) and posterior wall (PW) and the prevalence and clinical impact of extrapulmonary trigger inducibility and ablation in a large cohort of patients with persistent atrial fibrillation (PerAF).<h4>Methods and results</h4>A total of 1803 PerAF patients were prospectively enrolled. ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(12):1939-1949]

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One-year mortality after implantable defibrillator implantation: do risk stratification models help improving clinical practice?

Valeria Calvi, Gabriele Zanotto, Antonio D'Onofrio, Caterina Bisceglia, Saverio Iacopino, Carlo Pignalberi, Ennio C Pisanò, Francesco Solimene, Massimo Giammaria, Mauro Biffi, Giampiero Maglia, Massimiliano Marini, Gaetano Senatore, Stefano Pedretti, Giovanni B Forleo, Vincenzo E Santobuono, Antonio Curnis, Antonio Dello Russo, Antonio Rapacciuolo, Fabio Quartieri, Patrizia Bertocchi, Fabrizio Caravati, Michele Manzo, Davide Saporito, Daniela Orsida, Matteo Santamaria, Giuseppe Bottaro, Daniele Giacopelli, Alessio Gargaro, Paolo Della Bella,

<h4>Purpose</h4>The purpose of this study was to assess the available mortality risk stratification models for implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy defibrillator (CRT-D) patients.<h4>Methods</h4>We conducted a review of mortality risk stratification models and tested their ability to improve prediction of 1-year survival after implant in a database of ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2021, :]

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Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy-A Multicenter Study.

Alessio Gasperetti, Cynthia A James, Liang Chen, Niklas Schenker, Michela Casella, Shinwan Kany, Shibu Mathew, Paolo Compagnucci, Andreas Müssigbrodt, Henrik K Jensen, Anneli Svensson, Sarah Costa, Giovanni B Forleo, Pyotr G Platonov, Claudio Tondo, Jiang-Ping Song, Antonio Dello Russo, Frank Ruschitzka, Corinna Brunckhorst, Hugh Calkins, Firat Duru, Ardan M Saguner,

<b>Background:</b> Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. <b>Objective</b>: To assess the safety and efficacy of CA ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Intraprocedural PRAETORIAN score for early assessment of S-ICD implantation: A proof-of-concept study.

Alessio Gasperetti, Marco Schiavone, Mauro Biffi, Michela Casella, Paolo Compagnucci, Gianfranco Mitacchione, Andrea Angeletti, Julia Vogler, Riccardo Proietti, Matteo Ziacchi, Antonio Dello Russo, Andrea Natale, Roland R Tilz, Giovanni B Forleo,

<h4>Introduction</h4>The PRAETORIAN score (PS) was developed to assess the implant position and predict defibrillation success of the subcutaneous implantable cardioverter defibrillators (S-ICD). The main critique moved to the routine use of PS has been its postprocedural timing, that limits its usefulness on procedure guidance. The aim of this proof-of-concept study ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(11):3035-3041]

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Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion.

Domenico G Della Rocca, Michele Magnocavallo, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Nicola Tarantino, Carola Gianni, Carlo Lavalle, Christoffel Johannes Van Niekerk, Jorge Romero, David F Briceño, Mohamed Bassiouny, Amin Al-Ahmad, J David Burkhardt, Veronica N Natale, G Joseph Gallinghouse, Armando Del Prete, Giovanni B Forleo, Javier Sanchez, Dhanunjaya Lakkireddy, Rodney P Horton, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study evaluated the long-term efficacy of a standard antithrombotic strategy versus half-dose direct oral anticoagulation (DOAC) after Watchman implantation.<h4>Background</h4>No consensus currently exists on the selection of the most effective antithrombotic strategy to prevent device-related thrombosis (DRT) in patients undergoing endocardial left atrial appendage closure.<h4>Methods</h4>After successful left atrial appendage closure, ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(21):2353-2364]

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Second-generation laser balloon ablation for the treatment of atrial fibrillation assessed by continuous rhythm monitoring: the LIGHT-AF study.

Giovanni Rovaris, Giuseppe Ciconte, Marco Schiavone, Gianfranco Mitacchione, Alessio Gasperetti, Elena Piazzi, Gabriele Negro, Elisabetta Montemerlo, Roberto Rondine, Mattia Pozzi, Mirko Casiraghi, Sergio De Ceglia, Daniele Giacopelli, Maurizio Viecca, Gabriele Vicedomini, Giovanni B Forleo, Carlo Pappone,

<h4>Aims</h4>Balloon-based technologies have been developed to simplify catheter ablation of atrial fibrillation (AF), to improve the clinical outcome of the procedure and to achieve durable pulmonary vein isolation (PVI). The objective of this study is to evaluate the safety and efficacy of second-generation laser balloon (LB2) ablation in the treatment ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, 23(9):1380-1390]

Cited: 1 time

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Radiofrequency Energy Applications Targeting Significant Residual Leaks After Watchman Implantation: A Prospective, Multicenter Experience.

Domenico G Della Rocca, Ghulam Murtaza, Luigi Di Biase, Krishna Akella, Subramaniam C Krishnan, Michele Magnocavallo, Sanghamitra Mohanty, Carola Gianni, Chintan Trivedi, Carlo Lavalle, Giovanni B Forleo, Veronica N Natale, Nicola Tarantino, Jorge Romero, Rakesh Gopinathannair, Philip J Patel, Mohamed Bassiouny, Armando Del Prete, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Shephal K Doshi, Rodney P Horton, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Objectives</h4>The aim of this study was to evaluate the efficacy of radiofrequency (RF) energy applications targeting the atrial side of a significant residual leak in patients with acute and chronic evidence of incomplete percutaneous left atrial appendage (LAA) occlusion.<h4>Background</h4>RF applications have been proved to prevent recanalization of intracranial aneurysms after ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(12):1573-1584]

Cited: 1 time

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Clinical presentation, diagnosis, and treatment of atrioesophageal fistula resulting from atrial fibrillation ablation.

Domenico G Della Rocca, Michele Magnocavallo, Veronica N Natale, Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Carlo Lavalle, Giovanni B Forleo, Nicola Tarantino, Jorge Romero, Xiadong Zhang, Mohamed Bassiouny, Amin Al-Ahmad, David J Burkhardt, Joseph G Gallinghouse, Javier E Sanchez, Rodney P Horton, Luigi Di Biase, Andrea Natale,

<h4>Background</h4>Atrioesophageal fistula (AEF) is a worrisome complication of atrial fibrillation (AF) ablation. Its clinical manifestations and time course are unpredictable and may contribute to diagnostic and treatment delays. We conducted a systematic review of all available cases of AEF, aiming at characterizing clinical presentation, time course, diagnostic pitfalls, and outcomes.<h4>Methods</h4>The ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2441-2450]

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Subcutaneous implantable cardioverter-defibrillator and defibrillation testing: A propensity-matched pilot study.

Giovanni B Forleo, Alessio Gasperetti, Alexander Breitenstein, Mikael Laredo, Marco Schiavone, Matteo Ziacchi, Julia Vogler, Danilo Ricciardi, Pietro Palmisano, Agostino Piro, Paolo Compagnucci, Xavier Waintraub, Gianfranco Mitacchione, Gianmarco Carrassa, Giulia Russo, Silvana De Bonis, Andrea Angeletti, Antonio Bisignani, Francesco Picarelli, Michela Casella, Edoardo Bressi, Giovanni Rovaris, Leonardo Calò, Luca Santini, Carlo Pignalberi, Carlo Lavalle, Maurizio Viecca, Ennio Pisanò, Iacopo Olivotto, Antonio Curnis, Antonio Dello Russo, Claudio Tondo, Charles J Love, Luigi Di Biase, Jan Steffel, Roland Tilz, Nicolas Badenco, Mauro Biffi,

<h4>Background</h4>To date, only a few comparisons between subcutaneous implantable cardioverter-defibrillator (S-ICD) patients undergoing and those not undergoing defibrillation testing (DT) at implantation (DT+ vs DT-) have been reported.<h4>Objective</h4>The purpose of this study was to compare long-term clinical outcomes of 2 propensity-matched cohorts of DT+ and DT- patients.<h4>Methods</h4>Among consecutive S-ICD patients ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(12):2072-2079]

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Acute heart failure in elderly patients: a review of invasive and non-invasive management.

Gregorio Tersalvi, Alessio Gasperetti, Marco Schiavone, Jeroen Dauw, Cecilia Gobbi, Marialessia Denora, Joel Daniel Krul, Giacomo Maria Cioffi, Gianfranco Mitacchione, Giovanni B Forleo,

Acute heart failure (AHF) is a major cause of unplanned hospitalisations in the elderly and is associated with high mortality. Its prevalence has grown in the last years due to population aging and longer life expectancy of chronic heart failure patients. Although international societies have provided guidelines for the management ... Read more >>

J Geriatr Cardiol (Journal of geriatric cardiology : JGC)
[2021, 18(7):560-576]

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Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy.

Domenico G Della Rocca, Rodney P Horton, Luigi Di Biase, Carola Gianni, Chintan Trivedi, Sanghamitra Mohanty, Alisara Anannab, Michele Magnocavallo, Qiong Chen, Nicola Tarantino, Mohamed Bassiouny, Carlo Lavalle, Veronica N Natale, Giovanni B Forleo, Armando Del Prete, Christoffel Johannes Van Niekerk, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Dhanunjaya Lakkireddy, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study sought to report the incidence of device-related thrombosis (DRT) and thromboembolic (TE) events when an alternative to clopidogrel is prescribed in loss-of-function (LOF) allele carriers of the cytochrome P450 2C19 (CYP2C19) gene.<h4>Background</h4>LOF polymorphisms of the CYP2C19 gene are associated with reduced hepatic bioactivation of clopidogrel.<h4>Methods</h4>A total of 1,002 ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(12):1533-1543]

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Factors affecting signal quality in implantable cardiac monitors with long sensing vector.

Giovanni B Forleo, Claudia Amellone, Riccardo Sacchi, Leonida Lombardi, Maria Teresa Lucciola, Valentina Scotti, Maurizio Viecca, Marco Schiavone, Daniele Giacopelli, Massimo Giammaria,

<h4>Purpose</h4>Electrical artefacts are frequent in implantable cardiac monitors (ICMs). We analyzed the subcutaneous electrogram (sECG) provided by an ICM with a long sensing vector and factors potentially affecting its quality.<h4>Methods</h4>Consecutive ICM recipients underwent a follow-up where demographics, body mass index (BMI), implant location, and surface ECG were collected. The sECG ... Read more >>

J Arrhythm (Journal of arrhythmia)
[2021, 37(4):1061-1068]

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Atrioventricular and intraventricular blocks in the setting of acute coronary syndromes: a narrative review.

Marco Schiavone, Federica Sabato, Cecilia Gobbi, Marialessia Denora, Lucrezia Zanchi, Alessio Gasperetti, Giovanni B Forleo,

Acute coronary syndromes (ACS) might be complicated by atrioventricular (AV) and intraventricular (IV) blocks in a significant number of cases, and often represent a diagnostic and a therapeutic challenge. These conduction disturbances are predictors of adverse prognosis, with complete AV blocks presenting the most severe outcomes, showing an increased in-hospital ... Read more >>

Rev Cardiovasc Med (Reviews in cardiovascular medicine)
[2021, 22(2):287-294]

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Atrioventricular synchronous leadless pacemaker: state of art and broadened indications.

Gianfranco Mitacchione, Marco Schiavone, Alessio Gasperetti, Maurizio Viecca, Antonio Curnis, Giovanni B Forleo,

Leadless pacemakers (LLPMs) have become a major breakthrough in the management of bradyarrhythmia as an attractive alternative to the standard transvenous pacemakers (TV-PMs). Recently, the introduction of a second-generation LLPMs (Micra AV-MC1AVR1) has expanded pacing modes to obtain atrioventricular (AV) synchronous pacing, providing an interesting alternative in the actual scenario ... Read more >>

Rev Cardiovasc Med (Reviews in cardiovascular medicine)
[2021, 22(2):395-401]

Cited: 1 time

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Electrocardiographic Criteria for Differentiating Left from Right Idiopathic Outflow Tract Ventricular Arrhythmias.

Marco V Mariani, Agostino Piro, Domenico G Della Rocca, Giovanni B Forleo, Naga Venkata Pothineni, Jorge Romero, Luigi Di Biase, Francesco Fedele, Carlo Lavalle,

Idiopathic ventricular arrhythmias are ventricular tachycardias or premature ventricular contractions presumably not related to myocardial scar or disorders of ion channels. Of the ventricular arrhythmias (VAs) without underlying structural heart disease, those arising from the ventricular outflow tracts (OTs) are the most common. The right ventricular outflow tract (RVOT) is ... Read more >>

Arrhythm Electrophysiol Rev (Arrhythmia & electrophysiology review)
[2021, 10(1):10-16]

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Effective nonapical left ventricular pacing with quadripolar leads for cardiac resynchronization therapy.

Giovanni B Forleo, Marco Schiavone, Domenico Della Rocca, Francesco Solimene, Vincenzo Schillaci, Gregorio Covino, Massimo Sassara, Gianluca Savarese, Stefano Donzelli, Sandra Badolati, Carmelo Gerosa, Carlo Lavalle, Alessio Gasperetti, Gianfranco Mitacchione, Mariolina Lovecchio, Sergio Valsecchi, Luca Santini,

<h4>Background</h4>Current guidelines recommend avoiding apical left ventricular (LV) pacing for cardiac resynchronization therapy (CRT).<h4>Aims</h4>We investigated the feasibility of nonapical pacing with the current quadripolar LV lead technology.<h4>Methods</h4>We analyzed consecutive patients who received CRT with an LV quadripolar lead. The post--implantation position of each electrode of the LV lead was designated ... Read more >>

Kardiol Pol (Kardiologia polska)
[2021, 79(4):442-448]

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Targeting Bachmann's bundle in hybrid ablation for long-standing persistent atrial fibrillation: a proof of concept study.

Giuseppe De Martino, Giuseppe Nasso, Alessio Gasperetti, Marco Moscarelli, Carmine Mancusi, Giuseppe Della Ratta, Claudia Calvanese, Gianfranco Mitacchione, Raffaele Bonifazi, Nicola Di Bari, Enrico Vassallo, Marco Schiavone, Mario Gaudino, Giovanni B Forleo, Giuseppe Speziale,

<h4>Background</h4>Catheter-based or surgical procedures in patients with long-standing persistent atrial fibrillation (LSPAF) remain a challenge. As a result, different approaches including hybrid (surgical and endocardial) ablation have been developed. Bachmann's bundle (BB) is a mainly epicardial structure capable of sustaining arrhythmic reentry that could be involved in the development and ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2021, :]

Cited: 3 times

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Reply to: Assessment of administering antithrombosis in COVID-19 patients with acute hypoxemic respiratory failure.

Marco Schiavone, Alessio Gasperetti, Cecilia Gobbi, Mattia Busana, Giovanni B Forleo,

Int J Cardiol (International journal of cardiology)
[2021, 332:238]

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Prevalence and outcome of silent hypoxemia in COVID-19.

Mattia Busana, Alessio Gasperetti, Lorenzo Giosa, Giovanni B Forleo, Marco Schiavone, Gianfranco Mitacchione, Cecilia Bonino, Paolo Villa, Massimo Galli, Claudio Tondo, Ardan Saguner, Peter Steiger, Antonio Curnis, Antonio Dello Russo, Francesco Pugliese, Massimo Mancone, John J Marini, Luciano Gattinoni,

<h4>Background</h4>In the early stages of COVID-19 pneumonia, hypoxemia has been described in absence of dyspnea ("silent" or "happy" hypoxemia). Our aim was to report its prevalence and outcome in a series of hypoxemic patients upon Emergency Department admission.<h4>Methods</h4>In this retrospective observational cohort study we enrolled a study population consisting of ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(3):325-333]

Cited: 10 times

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Catheter Ablation of Life-Threatening Ventricular Arrhythmias in Athletes.

Nicola Tarantino, Domenico G Della Rocca, Nicole S De Leon De La Cruz, Eric D Manheimer, Michele Magnocavallo, Carlo Lavalle, Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Amin Al-Ahmad, Rodney P Horton, Mohamed Bassiouny, J David Burkhardt, G Joseph Gallinghouse, Giovanni B Forleo, Luigi Di Biase, Andrea Natale,

A recent surveillance analysis indicates that cardiac arrest/death occurs in ≈1:50,000 professional or semi-professional athletes, and the most common cause is attributable to life-threatening ventricular arrhythmias (VAs). It is critically important to diagnose any inherited/acquired cardiac disease, including coronary artery disease, since it frequently represents the arrhythmogenic substrate in a ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2021, 57(3):]

Cited: 2 times

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QT Interval Monitoring and Drugs Management During COVID-19 Pandemic.

Alessio Gasperetti, Marco Schiavone, Claudio Tondo, Gianfranco Mitacchione, Maurizio Viecca, Massimo Galli, Piercarlo Sarzi-Puttini, Giovanni B Forleo,

While facing potentially high morbidity from COVID-19 without known effective therapies, the off-label use of several non-specific drugs has been advocated, including re-purposed anti- viral (e.g., remdesivir or the lopinavir/ritonavir combination), biologic agents (e.g., tocilizumab), and antimalarial drugs such as chloroquine and hydroxychloroquine, in association with or without azithromycin. Data ... Read more >>

Curr Rev Clin Exp Pharmacol (Current reviews in clinical and experimental pharmacology)
[2021, 16(4):306-317]

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Impact of prior statin use on clinical outcomes in COVID-19 patients: data from tertiary referral hospitals during COVID-19 pandemic in Italy.

Gianfranco Mitacchione, Marco Schiavone, Antonio Curnis, Marcello Arca, Spinello Antinori, Alessio Gasperetti, Giosuè Mascioli, Paolo Severino, Federica Sabato, Maria M Caracciolo, Gianmarco Arabia, Laura D'Erasmo, Maurizio Viecca, Massimo Mancone, Massimo Galli, Giovanni B Forleo,

<h4>Background</h4>Epidemiological evidence suggests that anti-inflammatory and immunomodulatory properties of statins may reduce the risk of infections and infection-related complications.<h4>Objective</h4>We aimed to assess the impact of prior statin use on coronavirus disease (COVID-19) severity and mortality.<h4>Methods</h4>In this observational multicenter study, consecutive patients hospitalized for COVID-19 were enrolled. In-hospital mortality and severity ... Read more >>

J Clin Lipidol (Journal of clinical lipidology)
[2021, 15(1):68-78]

Cited: 21 times

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Evidence of systemic endothelial injury and microthrombosis in hospitalized COVID-19 patients at different stages of the disease.

Domenico G Della Rocca, Michele Magnocavallo, Carlo Lavalle, Jorge Romero, Giovanni B Forleo, Nicola Tarantino, Cristina Chimenti, Isabella Alviz, Maria T Gamero, Mario J Garcia, Luigi Di Biase, Andrea Natale,

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(3):571-576]

Cited: 5 times

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