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Author Giovanna Pepe

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Impact of COVID-19 on Cardiovascular Testing in the United States Versus the Rest of the World.

Cole B Hirschfeld, Leslee J Shaw, Michelle C Williams, Ryan Lahey, Todd C Villines, Sharmila Dorbala, Andrew D Choi, Nishant R Shah, David A Bluemke, Daniel S Berman, Ron Blankstein, Maros Ferencik, Jagat Narula, David Winchester, Eli Malkovskiy, Benjamin Goebel, Michael J Randazzo, Juan Lopez-Mattei, Purvi Parwani, Joao V Vitola, Rodrigo J Cerci, Nathan Better, Paolo Raggi, Bin Lu, Vladimir Sergienko, Valentin Sinitsyn, Takashi Kudo, Bjarne Linde Nørgaard, Pál Maurovich-Horvat, Yosef A Cohen, Thomas N B Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez, Andrew J Einstein, ,

<h4>Objectives</h4>This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-U.S. institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.<h4>Background</h4>The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2021, 14(9):1787-1799]

Cited: 2 times

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International Impact of COVID-19 on the Diagnosis of Heart Disease.

Andrew J Einstein, Leslee J Shaw, Cole Hirschfeld, Michelle C Williams, Todd C Villines, Nathan Better, Joao V Vitola, Rodrigo Cerci, Sharmila Dorbala, Paolo Raggi, Andrew D Choi, Bin Lu, Valentin Sinitsyn, Vladimir Sergienko, Takashi Kudo, Bjarne Linde Nørgaard, Pál Maurovich-Horvat, Roxana Campisi, Elisa Milan, Lizette Louw, Adel H Allam, Mona Bhatia, Eli Malkovskiy, Benjamin Goebel, Yosef Cohen, Michael Randazzo, Jagat Narula, Thomas N B Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez, , ,

<h4>Background</h4>The coronavirus disease 2019 (COVID-19) pandemic has adversely affected diagnosis and treatment of noncommunicable diseases. Its effects on delivery of diagnostic care for cardiovascular disease, which remains the leading cause of death worldwide, have not been quantified.<h4>Objectives</h4>The study sought to assess COVID-19's impact on global cardiovascular diagnostic procedural volumes and ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(2):173-185]

Cited: 16 times

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Pancreatic serous cystoadenoma (CSA) showing increased tracer uptake at 68-GaDOTA-peptide Positron Emission Tomography (68Ga-DOTA-peptide PET-CT): a case report.

Gennaro Nappo, Niccola Funel, Simone Giudici, Paola Spaggiari, Giovanni Capretti, Silvia Carrara, Giovanna Pepe, Alessandro Zerbi,

<h4>Background</h4>Serous cysto-adenoma (SCA) is a rare benign neoplasm of the pancreas. SCA can mimic other pancreatic lesions, such as neuroendocrine tumours. 68Gallium-DOTA-peptide Positron Emission Tomography (PET) is able to image in vivo the over-expression of the somatostatin receptors, playing an important role for the identification of neuroendocrine neoplasms.<h4>Case presentation</h4>We reported ... Read more >>

BMC Surg (BMC surgery)
[2020, 20(1):331]

Cited: 0 times

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Reciprocal interference between the NRF2 and LPS signaling pathways on the immune-metabolic phenotype of peritoneal macrophages.

Federica Mornata, Giovanna Pepe, Chiara Sfogliarini, Electra Brunialti, Gianenrico Rovati, Massimo Locati, Adriana Maggi, Elisabetta Vegeto,

The metabolic and immune adaptation to extracellular signals allows macrophages to carry out specialized functions involved in immune protection and tissue homeostasis. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that coordinates cell redox and metabolic responses to stressors. However, the individual and concomitant activation of NRF2 ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2020, 8(4):e00638]

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Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging.

Nicolò Gennaro, Andrea Marrari, Salvatore Lorenzo Renne, Ferdinando Carlo Maria Cananzi, Vittorio Lorenzo Quagliuolo, Lucia Di Brina, Marta Scorsetti, Giovanna Pepe, Arturo Chiti, Armando Santoro, Luca Balzarini, Letterio Salvatore Politi, Alexia Francesca Bertuzzi,

Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role ... Read more >>

Br J Radiol (The British journal of radiology)
[2020, 93(1112):20200250]

Cited: 3 times

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Morphometric vertebral fractures in patients with castration-resistant prostate cancer undergoing treatment with radium-223: a longitudinal study in the real-life clinical practice.

Gherardo Mazziotti, Marcello Rodari, Fabrizia Gelardi, Giovanni Tosi, Paolo A Zucali, Giovanna Pepe, Arturo Chiti,

<h4>Purpose</h4>Radium-223 was associated with high incidence of non-vertebral fractures in patients with castration-resistant prostate cancer (CRPC). However, it is still unclear whether radium-223 may induce skeletal fragility regardless of other therapies for CRPC. We aimed at evaluating the prevalence, incidence, and determinants of vertebral fractures (VFs), i.e., the most frequent ... Read more >>

Endocrine (Endocrine)
[2020, 69(1):204-211]

Cited: 0 times

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Prevention of Orbitopathy by Oral or Intravenous Steroid Prophylaxis in Short Duration Graves' Disease Patients Undergoing Radioiodine Ablation: A Prospective Randomized Control Trial Study.

Guia Vannucchi, Danila Covelli, Irene Campi, Nicola Currò, Davide Dazzi, Marcello Rodari, Giovanna Pepe, Arturo Chiti, Claudio Guastella, Elisa Lazzaroni, Mario Salvi,

<b><i>Background:</i></b> Radioiodine (RAI) is a known risk factor for activation or <i>de novo</i> occurrence of Graves' orbitopathy (GO). Several studies demonstrated that GO can be prevented by glucocorticoids (GCs) in patients with pre-existing GO. We have previously shown that Graves' disease duration (GDd) <5 years is a risk factor for ... Read more >>

Thyroid (Thyroid : official journal of the American Thyroid Association)
[2019, 29(12):1828-1833]

Cited: 5 times

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18F-FDG uptake of brown fat and cancer: casualty or causality?

Nicolò Gennaro, Giovanna Pepe, Lidija Antunovic,

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2019, 46(7):1395-1396]

Cited: 0 times

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Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state.

Alessandro Villa, Barbara Klein, Bieneke Janssen, Jordi Pedragosa, Giovanna Pepe, Bastian Zinnhardt, Danielle J Vugts, Paolo Gelosa, Luigi Sironi, Wissam Beaino, Annelaure Damont, Frédéric Dollé, Benoit Jego, Alexandra Winkeler, Dieter Ory, Olof Solin, Johnny Vercouillie, Uta Funke, Sandra Laner-Plamberger, Linda V Blomster, Palle Christophersen, Elisabetta Vegeto, Ludwig Aigner, Andreas Jacobs, Anna M Planas, Adriana Maggi, Albert D Windhorst,

Microglia are potential targets for therapeutic intervention in neurological and neurodegenerative diseases affecting the central nervous system. In order to assess the efficacy of therapies aimed to reduce the tissue damaging activities of microglia and/or to promote the protective potential of these cells, suitable pre-clinical and clinical tools for the ... Read more >>

Theranostics (Theranostics)
[2018, 8(19):5400-5418]

Cited: 9 times

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The estrogen-macrophage interplay in the homeostasis of the female reproductive tract.

Giovanna Pepe, Massimo Locati, Sara Della Torre, Federica Mornata, Andrea Cignarella, Adriana Maggi, Elisabetta Vegeto,

<h4>Background</h4>Estrogens are known to orchestrate reproductive events and to regulate the immune system during infections and following tissue damage. Recent findings suggest that, in the absence of any danger signal, estrogens trigger the physiological expansion and functional specialization of macrophages, which are immune cells that populate the female reproductive tract ... Read more >>

Hum Reprod Update (Human reproduction update)
[2018, 24(6):652-672]

Cited: 7 times

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Performance of FDG-PET/CT in solitary pulmonary nodule based on pre-test likelihood of malignancy: results from the ITALIAN retrospective multicenter trial.

Laura Evangelista, Alberto Cuocolo, Leonardo Pace, Luigi Mansi, Silvana Del Vecchio, Paolo Miletto, Silvia Sanfilippo, Sara Pellegrino, Luca Guerra, Giovanna Pepe, Giuseppina Peluso, Marco Salvatore, Rosj Galicchio, Michele Zuffante, Salvatore Annunziata, Mohsen Farsad, Agostino Chiaravalloti, Marco Spadafora,

<h4>Purpose</h4>The aim of this study was to determine the performance of <sup>18</sup>F-FDG-PET/CT in patients with solitary pulmonary nodule (SPN), stratifying the risk according to the likelihood of pulmonary malignancy.<h4>Methods</h4>FDG-PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed. FDG uptake in SPN was assessed by a 4-point scoring ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2018, 45(11):1898-1907]

Cited: 3 times

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Risk-related 18F-FDG PET/CT and new diagnostic strategies in patients with solitary pulmonary nodule: the ITALIAN multicenter trial.

Marco Spadafora, Leonardo Pace, Laura Evangelista, Luigi Mansi, Francesco Del Prete, Giorgio Saladini, Paolo Miletto, Stefano Fanti, Silvana Del Vecchio, Luca Guerra, Giovanna Pepe, Giuseppina Peluso, Emanuele Nicolai, Giovanni Storto, Marco Ferdeghini, Alessandro Giordano, Mohsen Farsad, Orazio Schillaci, Cesare Gridelli, Alberto Cuocolo,

<h4>Purpose</h4>Diagnosis of solitary pulmonary nodule (SPN) is an important public health issue and <sup>18</sup>F-FDG PET/CT has proven to be more effective than CT alone. Pre-test risk stratification and clinical presentation of SPN could affect the diagnostic strategy. A relevant issue is whether thoracic segmental (s)-PET/CT could be implemented in patients ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2018, 45(11):1908-1914]

Cited: 2 times

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Sex-Specific Features of Microglia from Adult Mice.

Alessandro Villa, Paolo Gelosa, Laura Castiglioni, Mauro Cimino, Nicoletta Rizzi, Giovanna Pepe, Federica Lolli, Elena Marcello, Luigi Sironi, Elisabetta Vegeto, Adriana Maggi,

Sex has a role in the incidence and outcome of neurological illnesses, also influencing the response to treatments. Neuroinflammation is involved in the onset and progression of several neurological diseases, and the fact that estrogens have anti-inflammatory activity suggests that these hormones may be a determinant in the sex-dependent manifestation ... Read more >>

Cell Rep (Cell reports)
[2018, 23(12):3501-3511]

Cited: 119 times

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Selective proliferative response of microglia to alternative polarization signals.

Giovanna Pepe, Marcella De Maglie, Lucia Minoli, Alessandro Villa, Adriana Maggi, Elisabetta Vegeto,

<h4>Background</h4>Microglia are resident myeloid cells of the central nervous system (CNS) that are maintained by self-renewal and actively participate in tissue homeostasis and immune defense. Under the influence of endogenous or pathological signals, microglia undertake biochemical transformations that are schematically classified as the pro-inflammatory M1 phenotype and the alternatively activated ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2017, 14(1):236]

Cited: 15 times

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Self-renewal and phenotypic conversion are the main physiological responses of macrophages to the endogenous estrogen surge.

Giovanna Pepe, Daniele Braga, Tiziana A Renzi, Alessandro Villa, Chiara Bolego, Francesca D'Avila, Cristina Barlassina, Adriana Maggi, Massimo Locati, Elisabetta Vegeto,

Beyond the physiology of reproduction, estrogen controls the homeostasis of several tissues. Although macrophages play a key role in tissue remodeling, the interplay with estrogen is still ill defined. Using a transcriptomic approach we first obtained a comprehensive list of genes that are differentially expressed in peritoneal macrophages in response ... Read more >>

Sci Rep (Scientific reports)
[2017, 7:44270]

Cited: 18 times

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Endoscopic ultrasound-guided tattooing of a retroesophageal parathyroid adenoma.

Silvia Carrara, Luca Cozzaglio, Manol Jovani, Giovanna Pepe, Cristiana Bonifacio, Andrea Anderloni, Alessandro Repici,

Endoscopy (Endoscopy)
[2014, 46 Suppl 1 UCTN:E496-7]

Cited: 0 times

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Heterogeneous induction of microglia M2a phenotype by central administration of interleukin-4.

Giovanna Pepe, Giorgia Calderazzi, Marcella De Maglie, Alessandro Maria Villa, Elisabetta Vegeto,

<h4>Background</h4>Acquisition of the M1 or M2 phenotypes by microglia has been shown to occur during the development of pathological conditions, with M1 activation being widely involved in neurotoxicity in relation with the anatomical localization and the reactivity of subtypes of microglia cells. On the contrary, little is known on the ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2014, 11:211]

Cited: 34 times

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Single-photon emission computed tomography tracers in the diagnostics of neuroendocrine tumors.

Giovanna Pepe, Emilio Bombardieri, Alice Lorenzoni, Arturo Chiti,

Different imaging strategies have been developed targeting the peculiar features of neuroendocrine tumors (NETs). Metabolic characteristics and receptor expression on the tumor surface have been studied, and expertise and knowledge are increasing as a result of the implementation of fusion imaging and the development of more detailed positron emission tomography ... Read more >>

PET Clin (PET clinics)
[2014, 9(1):11-26]

Cited: 5 times

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Imaging acute spinal myelitis with 18F-FDG PET/CT.

Egesta Lopci, Marcello Rodari, Giovanna Pepe, Lidija Antunovic, Arturo Chiti,

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2014, 41(2):399-400]

Cited: 1 time

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[11C]choline PET/CT impacts treatment decision making in patients with prostate cancer referred for radiotherapy.

Barbara Alicja Jereczek-Fossa, Marcello Rodari, Maria Bonora, Paola Fanti, Cristiana Fodor, Giovanna Pepe, Egesta Lopci, Dario Zerini, Barbara Vischioni, Guido Baroni, Deliu Victor Matei, Ottavio De Cobelli, Arturo Chiti, Roberto Orecchia,

<h4>Background</h4>The purpose of our study was to analyze the role of [(11)C]choline-positron emission tomography/computed tomography (cho-PET/CT) in the management of patients with prostate cancer referred for radiotherapy.<h4>Patients and methods</h4>Inclusion criteria for this retrospective study were (1) presence of prostate cancer, (2) referral for first radiotherapy course (for primary or recurrent ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2014, 12(3):155-159]

Cited: 10 times

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Reply to comment on Pepe et al.: Somatostatin receptor SPECT.

Giovanna Pepe, Arturo Chiti,

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2013, 40(2):302]

Cited: 0 times

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Revisiting the clinical value of 18F-FDG PET/CT in detection of recurrent epithelial ovarian carcinomas: correlation with histology, serum CA-125 assay, and conventional radiological modalities.

Lidija Antunovic, Marino Cimitan, Eugenio Borsatti, Tanja Baresic, Roberto Sorio, Giorgio Giorda, Agostino Steffan, Luca Balestreri, Rosa Tatta, Giovanna Pepe, Domenico Rubello, Diego Cecchin, Vincenzo Canzonieri,

<h4>Objective</h4>This study aimed to evaluate the efficiency of 18F-FDG PET/CT in suspected recurrence of epithelial ovarian cancer, after treatment, comparing outcomes of PET/CT with histological tumor subtype, CA-125 serum levels, and findings of conventional diagnostic imaging modalities (CI).<h4>Methods</h4>Data from 121 women who underwent FDG PET/CT for suspected recurrence of epithelial ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2012, 37(8):e184-8]

Cited: 16 times

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Somatostatin receptor SPECT.

Giovanna Pepe, Roy Moncayo, Emilio Bombardieri, Arturo Chiti,

Somatostatin is a peptide with a broad distribution in the nervous system and acts as a neurotransmitter in several organs, having a wide range of mainly inhibiting effects, such as the suppression of growth hormone release, as well as the inhibition of pancreatic and gastrointestinal hormone release. Five somatostatin receptor ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2012, 39 Suppl 1:S41-51]

Cited: 13 times

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Matched pairs dosimetry: 124I/131I metaiodobenzylguanidine and 124I/131I and 86Y/90Y antibodies.

Egesta Lopci, Arturo Chiti, Maria Rita Castellani, Giovanna Pepe, Lidija Antunovic, Stefano Fanti, Emilio Bombardieri,

The technological advances in imaging and production of radiopharmaceuticals are driving an innovative way of evaluating the targets for antineoplastic therapies. Besides the use of imaging to better delineate the volume of external beam radiation therapy in oncology, modern imaging techniques are able to identify targets for highly specific medical ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2011, 38 Suppl 1:S28-40]

Cited: 15 times

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[11C]-choline PET/CT in imaging locally advanced prostate cancer.

Marcello Rodari, Egesta Lopci, Giovanna Pepe, Lidija Antunovic, Arturo Chiti,

PET Imaging with [11C]-choline has become a useful tool in the investigation of prostate cancer, with as main application the assessment of previously treated patients presenting with rising PSA and negative conventional imaging procedures. In this case report we describe [11C]-choline PET/CT findings in a patient with a locally advanced ... Read more >>

Nucl Med Rev Cent East Eur (Nuclear medicine review. Central & Eastern Europe)
[2011, 14(2):118-119]

Cited: 1 time

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