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Author Giorgio Gandaglia

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Contemporary Outcomes of Patients with Nonmuscle-Invasive Bladder Cancer Treated with bacillus Calmette-Guérin. Letter.

Francesco Montorsi, Marco Moschini, Andrea Necchi, Federico Deho, Giorgio Gandaglia, Alberto Briganti,

J Urol (The Journal of urology)
[2021, :101097JU0000000000002237]

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The impact of race/ethnicity on upstaging and/or upgrading rates among intermediate risk prostate cancer patients treated with radical prostatectomy.

Luigi Nocera, Mike Wenzel, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Felix K H Chun, Vincenzo Mirone, Markus Graefen, Fred Saad, Shahrokh F Shariat, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Race/ethnicity may predispose to less favorable prostate cancer characteristics in intermediate risk prostate cancer (IR PCa) patients. We tested this hypothesis in a subgroup of IR PCa patients treated with radical prostatectomy (RP).<h4>Methods</h4>We relied on the Surveillance, Epidemiology and End Results 2004-2016. The effect of race/ethnicity was tested in univariable ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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A real-world comparison of docetaxel versus abiraterone acetate for metastatic hormone-sensitive prostate cancer.

Igor Tsaur, Isabel Heidegger, Jasmin Bektic, Mona Kafka, Roderick C N van den Bergh, Jarmo C B Hunting, Anita Thomas, Maximilian P Brandt, Thomas Höfner, Eliott Debedde, Constance Thibault, Paola Ermacora, Fabio Zattoni, Silvia Foti, Alexander Kretschmer, Guillaume Ploussard, Severin Rodler, Gunhild von Amsberg, Derya Tilki, Christian Surcel, Barak Rosenzweig, Moran Gadot, Giorgio Gandaglia, Robert Dotzauer, ,

<h4>Background</h4>Docetaxel (D) or secondary hormonal therapy (SHT) each combined with androgen deprivation therapy (ADT) represent possible treatment options in males with metastasized hormone-sensitive prostate cancer (mHSPC). Real-world data comparing different protocols are lacking yet. Thus, our objective was to compare the efficacy and safety of abiraterone acetate (AA)+ADT versus D+ADT ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Risk Stratification of Patients Candidate to Radical Prostatectomy Based on Clinical and Multiparametric Magnetic Resonance Imaging Parameters: Development and External Validation of Novel Risk Groups.

Elio Mazzone, Giorgio Gandaglia, Guillame Ploussard, Giancarlo Marra, Massimo Valerio, Riccardo Campi, Andrea Mari, Andrea Minervini, Sergio Serni, Marco Moschini, Alessandro Marquis, Jean Baptiste Beauval, Roderick van den Bergh, Razvan-George Rahota, Timo Soeterik, Mathieu Roumiguiè, Luca Afferi, Junlong Zhuang, Hongqian Tuo, Agostino Mattei, Paolo Gontero, Vito Cucchiara, Armando Stabile, Nicola Fossati, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>Despite the key importance of magnetic resonance imaging (MRI) parameters, risk classification systems for biochemical recurrence (BCR) in prostate cancer (PCa) patients treated with radical prostatectomy (RP) are still based on clinical variables alone.<h4>Objective</h4>We aimed at developing and validating a novel classification integrating clinical and radiological parameters.<h4>Design, setting, and participants</h4>A ... Read more >>

Eur Urol (European urology)
[2021, :]

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Followup of Men with PI-RADS™ 4 or 5 Abnormality on Prostate Magnetic Resonance Imaging and Nonmalignant Pathological Findings on Initial Targeted Prostate Biopsy. Letter.

Francesco Montorsi, Armando Stabile, Giorgio Gandaglia, Federico Dehò, Andrea Salonia, Alberto Briganti,

J Urol (The Journal of urology)
[2021, :101097JU0000000000002144]

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Focal Therapy for Prostate Cancer: Complications and Their Treatment.

Arnas Rakauskas, Giancarlo Marra, Isabel Heidegger, Veeru Kasivisvanathan, Alexander Kretschmer, Fabio Zattoni, Felix Preisser, Derya Tilki, Igor Tsaur, Roderick van den Bergh, Claudia Kesch, Francesco Ceci, Christian Fankhauser, Giorgio Gandaglia, Massimo Valerio,

Focal therapy is a modern alternative to selectively treat a specific part of the prostate harboring clinically significant disease while preserving the rest of the gland. The aim of this therapeutic approach is to retain the oncological benefit of active treatment and to minimize the side-effects of common radical treatments. ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:696242]

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Radiation Therapy After Radical Prostatectomy: What Has Changed Over Time?

Fabio Zattoni, Isabel Heidegger, Veeru Kasivisvanathan, Alexander Kretschmer, Giancarlo Marra, Alessandro Magli, Felix Preisser, Derya Tilki, Igor Tsaur, Massimo Valerio, Roderick van den Bergh, Claudia Kesch, Francesco Ceci, Christian Fankhauser, Giorgio Gandaglia,

The role and timing of radiotherapy (RT) in prostate cancer (PCa) patients treated with radical prostatectomy (RP) remains controversial. While recent trials support the oncological safety of early salvage RT (SRT) compared to adjuvant RT (ART) in selected patients, previous randomized studies demonstrated that ART might improve recurrence-free survival in ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:691473]

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Definition and Impact on Oncologic Outcomes of Persistently Elevated Prostate-specific Antigen After Salvage Lymph Node Dissection for Node-only Recurrent Prostate Cancer After Radical Prostatectomy: Clinical Implications for Multimodal Therapy.

Carlo A Bravi, Matteo Droghetti, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Vito Cucchiara, Simone Scuderi, Francesco Barletta, Riccardo Schiavina, Daniar Osmonov, Klaus-Peter Juenemann, Luca Boeri, R Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Alessandro Nini, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Bernhard Grubmüller, Shahrokh F Shariat, Axel Heidenreich, David Pfister, Derya Tilki, Markus Graefen, Inderbir S Gill, Alexandre Mottrie, Pierre I Karakiewicz, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>The optimal definition and prognostic significance of persistently elevated prostate-specific antigen (PSA) after salvage lymph node dissection (sLND) for node-only recurrent prostate cancer (PCa) remain unknown.<h4>Objective</h4>To assess the definition and clinical implications of persistently elevated PSA after sLND for node-only recurrent PCa after radical prostatectomy.<h4>Design, setting, and participants</h4>The study included ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Evaluation of Oncological Outcomes and Data Quality in Studies Assessing Nerve-sparing Versus Non-Nerve-sparing Radical Prostatectomy in Nonmetastatic Prostate Cancer: A Systematic Review.

Lisa Moris, Giorgio Gandaglia, Antoni Vilaseca, Thomas Van den Broeck, Erik Briers, Maria De Santis, Silke Gillessen, Nikos Grivas, Shane O'Hanlon, Ann Henry, Thomas B Lam, Michael Lardas, Malcolm Mason, Daniela Oprea-Lager, Guillaume Ploussard, Olivier Rouviere, Ivo G Schoots, Henk van der Poel, Thomas Wiegel, Peter-Paul Willemse, Cathy Y Yuan, Jeremy P Grummet, Derya Tilki, Roderick C N van den Bergh, Philip Cornford, Nicolas Mottet,

<h4>Context</h4>Surgical techniques aimed at preserving the neurovascular bundles during radical prostatectomy (RP) have been proposed to improve functional outcomes. However, it remains unclear if nerve-sparing (NS) surgery adversely affects oncological metrics.<h4>Objective</h4>To explore the oncological safety of NS versus non-NS (NNS) surgery and to identify factors affecting the oncological outcomes of ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Reply by Authors.

Armando Stabile, Rafael Sanchez-Salas, Rafael Tourinho-Barbosa, Petr Macek, Francesco Pellegrino, Giorgio Gandaglia, Marco Moschini, Nathalie Cathala, Annick Mombet, Francesco Montorsi, Alberto Briganti, Xavier Cathelineau,

J Urol (The Journal of urology)
[2021, 206(3):645]

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Radical Prostatectomy: Sequelae in the Course of Time.

Claudia Kesch, Isabel Heidegger, Veeru Kasivisvanathan, Alexander Kretschmer, Giancarlo Marra, Felix Preisser, Derya Tilki, Igor Tsaur, Massimo Valerio, Roderick C N van den Bergh, Christian D Fankhauser, Fabio Zattoni, Giorgio Gandaglia,

<b>Objective:</b> Radical prostatectomy (RP) is a frequent treatment for men suffering from localized prostate cancer (PCa). Whilst offering a high chance for cure, it does not come without a significant impact on health-related quality of life. Herein we review the common adverse effects RP may have over the course of ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:684088]

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Re: Paolo Dell'Oglio, Elio Mazzone, Edward Lambert, et al. The Effect of Surgical Experience on Perioperative and Oncological Outcomes After Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Evidence from a Referral Centre with Extensive Experience in Robotic Surgery. Eur Urol Focus 2021;7:352-8.

Francesco Montorsi, Giorgio Gandaglia, Federico Dehò, Andrea Gallina, Marco Moschini, Andrea Salonia, Alberto Briganti,

Eur Urol Focus (European urology focus)
[2021, :]

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Multiparametric magnetic resonance imaging of the prostate underestimates tumour volume of small visible lesions.

Gabriele Sorce, Armando Stabile, Roberta Lucianò, Giovanni Motterle, Simone Scuderi, Francesco Barletta, Francesco Pellegrino, Vito Cucchiara, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Objective</h4>To assess the relationship between the volume of the index lesion (IL) measured at multiparametric magnetic resonance imaging (mpMRI; MRIvol) and at radical prostatectomy (RPvol), stratifying it according to Prostate Imaging-Reporting and Data System (PI-RADS) score.<h4>Patients and methods</h4>We identified 332 men with a positive mpMRI (single lesion with PI-RADS ≥3) ... Read more >>

BJU Int (BJU international)
[2021, :]

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Re: Histological comparison between predictive value of preoperative 3-T multiparametric MRI and 68 Ga-PSMA PET/CT scan for pathological outcomes at radical prostatectomy and pelvic lymph node dissection for prostate cancer.

Francesco Montorsi, Giorgio Gandaglia, Nicola Fossati, Federico Dehò, Alberto Briganti,

BJU Int (BJU international)
[2021, 127(6):746]

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Research Protocol for an Observational Health Data Analysis to Assess the Long-term Outcomes of Prostate Cancer Patients Undergoing Non-Interventional Management (i.e., Watchful Waiting) and the Impact of Comorbidities and Life Expectancy – PIONEER IMI’s “Big Data for Better Outcomes” program

Giorgio Gandaglia, Kees van Bochove, Anders Bjartell, Alberto Briganti, Phil Conford, Susan Evans Axelsson, Asieh Golozar, Mieke Van Hemelrijck, Katharina Beyer, Peter-Paul Willemse, Muhammad Imran Omar, James N’Dow, Alex Asiimwe, Monique Roobol, Robert Snijder, Carl Steinbeisser, Roderick Van Den Bergh, Samuel Fatoba, Ariel Achtman, Thamir Alshammari, Nicolas Thurin, Adam Kinnaird, Sebastian Remmers, Emma Jane Smith, Riccardo Campi, Isabella Greco,

This is a study protocol for an observational health data analysis, submitted as a preprint to facilitate transparency and open science. Watchful waiting (WW) represents a deferred treatment option for prostate cancer (PCa) patients when curative treatment seems overtreatment right from the outset. Patients are ‘watched’ for the development of ... Read more >>

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor variant histology (VH) bladder cancer (BCa) at radical cystectomy. We aimed to create a personalized followup scheme that dynamically weighs other cause mortality (OCM) vs the risk of recurrence for VH BCa, and to compare ... Read more >>

J Urol (The Journal of urology)
[2021, 206(4):885-893]

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Optimizing prostate-targeted biopsy schemes in men with multiple mpMRI visible lesions: should we target all suspicious areas? Results of a two institution series.

Armando Stabile, Francesco Barletta, Giovanni Motterle, Francesco Pellegrino, Gabriele Sorce, Elio Mazzone, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Alberto Briganti,

<h4>Background</h4>To assess the diagnostic added value of sampling secondary lesions at prostate mpMRI (SL) in addition to index lesion (IL) in detecting significant prostate cancer (csPCa) when also systematic biopsy (SBx) is performed.<h4>Methods</h4>We relied on a cohort of 312 men with two suspicious lesions at prostate mpMRI who underwent subsequent ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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The effect of race/ethnicity on active treatment rates among septuagenarian or older low risk prostate cancer patients.

Luigi Nocera, Mike Wenzel, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Felix K H Chun, Vincenzo Mirone, Markus Graefen, Shahrokh F Shariat, Fred Saad, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Race/ethnicity may predispose to higher active treatment rates in septuagenarian or older low risk prostate cancer (CaP) patients. We tested this hypothesis within a contemporary North American cohort.<h4>Material and methods</h4>We relied on the Surveillance, Epidemiology and End Results (SEER) database 2010-2016. The effect of race/ethnicity was tested in univariable and ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Patient- and Tumour-related Prognostic Factors for Urinary Incontinence After Radical Prostatectomy for Nonmetastatic Prostate Cancer: A Systematic Review and Meta-analysis.

Michael Lardas, Nikos Grivas, Thomas P A Debray, Fabio Zattoni, Christopher Berridge, Marcus Cumberbatch, Thomas Van den Broeck, Erik Briers, Maria De Santis, Andrea Farolfi, Nicola Fossati, Giorgio Gandaglia, Silke Gillessen, Shane O'Hanlon, Ann Henry, Matthew Liew, Malcolm Mason, Lisa Moris, Daniela Oprea-Lager, Guillaume Ploussard, Olivier Rouviere, Ivo G Schoots, Theodorus van der Kwast, Henk van der Poel, Thomas Wiegel, Peter-Paul Willemse, Cathy Y Yuan, Jeremy P Grummet, Derya Tilki, Roderick C N van den Bergh, Thomas B Lam, Philip Cornford, Nicolas Mottet,

<h4>Context</h4>While urinary incontinence (UI) commonly occurs after radical prostatectomy (RP), it is unclear what factors increase the risk of UI development.<h4>Objective</h4>To perform a systematic review of patient- and tumour-related prognostic factors for post-RP UI. The primary outcome was UI within 3 mo after RP. Secondary outcomes included UI at 3-12 ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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The Importance of an Adequate Surgical Template During Salvage Lymph Node Dissection for Node-Recurrent Prostate Cancer.

Carlo Andrea Bravi, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Francesco Montorsi, Alberto Briganti,

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2021, 62(7):1021]

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A Systematic Review of the Impact of Surgeon and Hospital Caseload Volume on Oncological and Nononcological Outcomes After Radical Prostatectomy for Nonmetastatic Prostate Cancer.

Thomas Van den Broeck, Daniela Oprea-Lager, Lisa Moris, Mithun Kailavasan, Erik Briers, Philip Cornford, Maria De Santis, Giorgio Gandaglia, Silke Gillessen Sommer, Jeremy P Grummet, Nikos Grivas, Thomas B L Lam, Michael Lardas, Matthew Liew, Malcolm Mason, Shane O'Hanlon, Jakub Pecanka, Guillaume Ploussard, Olivier Rouviere, Ivo G Schoots, Derya Tilki, Roderick C N van den Bergh, Henk van der Poel, Thomas Wiegel, Peter-Paul Willemse, Cathy Y Yuan, Nicolas Mottet,

<h4>Context</h4>The impact of surgeon and hospital volume on outcomes after radical prostatectomy (RP) for localised prostate cancer (PCa) remains unknown.<h4>Objective</h4>To perform a systematic review on the association between surgeon or hospital volume and oncological and nononcological outcomes following RP for PCa.<h4>Evidence acquisition</h4>Medline, Medline In-Process, Embase, and the Cochrane Central Register ... Read more >>

Eur Urol (European urology)
[2021, :]

Cited: 1 time

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Association between Lesion Location and Oncologic Outcomes after Focal Therapy for Localized Prostate Cancer Using Either High Intensity Focused Ultrasound or Cryotherapy.

Armando Stabile, Rafael Sanchez-Salas, Rafael Tourinho-Barbosa, Petr Macek, Francesco Pellegrino, Giorgio Gandaglia, Marco Moschini, Nathalie Cathala, Annick Mombet, Francesco Montorsi, Alberto Briganti, Xavier Cathelineau,

<h4>Purpose</h4>We assessed whether prostate cancer (PCa) location might affect oncologic outcomes after focal therapy (FT) for PCa.<h4>Materials and methods</h4>We identified 274 men receiving FT for PCa using either high intensity focused ultrasound (HIFU) or cryotherapy at a high volume center between 2009 and 2018. Survival analyses using Kaplan-Meier method were ... Read more >>

J Urol (The Journal of urology)
[2021, 206(3):638-645]

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Improving the stratification of intermediate risk prostate cancer.

Luigi Nocera, Claudia Collà Ruvolo, Lara F Stolzenbach, Marina Deuker, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Firas Abdollah, Nazareno Suardi, Vincenzo Mirone, Markus Graefen, Felix K Chun, Fred Saad, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Intermediate risk prostate cancer (IR PCa) may exhibit a wide array of phenotypes, from favorable to unfavorable. NCCN criteria help distinguishing between favorable versus unfavorable subgroups. We studied and attempted to improve this classification.<h4>Methods</h4>Within the SEER database 2010-2016, we identified 19,193 IR PCa patients treated with radical prostatectomy. A multivariable ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

Cited: 1 time

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Reducing the Risk of Postoperative Complications After Robot-assisted Radical Prostatectomy in Prostate Cancer Patients: Results of an Audit and Feedback Intervention Following the Implementation of Prospective Data Collection.

Giuseppe Rosiello, Giorgio Gandaglia, Simone Scuderi, Francesco Barletta, Nicola Fossati, Armando Stabile, Andrea Gallina, Elio Mazzone, Luca Maria Vitale, Antony Pellegrino, Carlo Bravi, Alberto Martini, Vito Cucchiara, Pierre I Karakiewicz, Alexandre Mottrie, Alberto Briganti, Francesco Montorsi,

<h4>Background</h4>Prospective data collection for perioperative outcomes might increase awareness of surgical results obtained for patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). This would prompt the implementation of measures aimed at reducing the risk of adverse outcomes.<h4>Objective</h4>To assess the efficacy of an audit and feedback process aimed at ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Age and gleason score upgrading between prostate biopsy and radical prostatectomy: Is this still true in the multiparametric resonance imaging era?

Elio Mazzone, Armando Stabile, Gabriele Sorce, Francesco Pellegrino, Francesco Barletta, Giovanni Motterle, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Giorgio Brembilla, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Introduction</h4>Several studies have invariably shown that the risk of Grade Group (GG) upgrading between biopsy and radical prostatectomy (RP) is higher in elderly men. Whether this is due to a real biological effect or to a diagnostic bias is still unknown. We hypothesized that the introduction of multiparametric magnetic resonance ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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