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Author Giorgio Gandaglia

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Re: Paolo Dell'Oglio, Elio Mazzone, Edward Lambert, et al. The Effect of Surgical Experience on Perioperative and Oncological Outcomes After Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion: Evidence from a Referral Centre with Extensive Experience in Robotic Surgery. Eur Urol Focus 2021;7:352-8.

Francesco Montorsi, Giorgio Gandaglia, Federico Dehò, Andrea Gallina, Marco Moschini, Andrea Salonia, Alberto Briganti,

Eur Urol Focus (European urology focus)
[2021, :]

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Re: Histological comparison between predictive value of preoperative 3-T multiparametric MRI and 68 Ga-PSMA PET/CT scan for pathological outcomes at radical prostatectomy and pelvic lymph node dissection for prostate cancer.

Francesco Montorsi, Giorgio Gandaglia, Nicola Fossati, Federico Dehò, Alberto Briganti,

BJU Int (BJU international)
[2021, 127(6):746]

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Multiparametric MRI of the prostate underestimates tumor volume of small visible lesions.

Gabriele Sorce, Armando Stabile, Roberta Lucianò, Giovanni Motterle, Simone Scuderi, Francesco Barletta, Francesco Pellegrino, Vito Cucchiara, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Objective</h4>To assess the relationship between the volume of the index lesion (IL) measured at mpMRI (MRIvol) and at radical prostatectomy (RPvol), stratifying it according to PI-RADS score.<h4>Materials and methods</h4>We identified 332 men with a positive mpMRI (single lesion with PI-RADS≥3) who underwent systematic plus targeted biopsy and subsequent RP at ... Read more >>

BJU Int (BJU international)
[2021, :]

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Research Protocol for an Observational Health Data Analysis to Assess the Long-term Outcomes of Prostate Cancer Patients Undergoing Non-Interventional Management (i.e., Watchful Waiting) and the Impact of Comorbidities and Life Expectancy – PIONEER IMI’s “Big Data for Better Outcomes” program

Giorgio Gandaglia, Kees van Bochove, Anders Bjartell, Alberto Briganti, Phil Conford, Susan Evans Axelsson, Asieh Golozar, Mieke Van Hemelrijck, Katharina Beyer, Peter-Paul Willemse, Muhammad Imran Omar, James N’Dow, Alex Asiimwe, Monique Roobol, Robert Snijder, Carl Steinbeisser, Roderick Van Den Bergh, Samuel Fatoba, Ariel Achtman, Thamir Alshammari, Nicolas Thurin, Adam Kinnaird, Sebastian Remmers, Emma Jane Smith, Riccardo Campi, Isabella Greco,

This is a study protocol for an observational health data analysis, submitted as a preprint to facilitate transparency and open science. Watchful waiting (WW) represents a deferred treatment option for prostate cancer (PCa) patients when curative treatment seems overtreatment right from the outset. Patients are ‘watched’ for the development of ... Read more >>

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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The effect of race/ethnicity on active treatment rates among septuagenarian or older low risk prostate cancer patients.

Luigi Nocera, Mike Wenzel, Claudia Collà Ruvolo, Christoph Würnschimmel, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Felix K H Chun, Vincenzo Mirone, Markus Graefen, Shahrokh F Shariat, Fred Saad, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Race/ethnicity may predispose to higher active treatment rates in septuagenarian or older low risk prostate cancer (CaP) patients. We tested this hypothesis within a contemporary North American cohort.<h4>Material and methods</h4>We relied on the Surveillance, Epidemiology and End Results (SEER) database 2010-2016. The effect of race/ethnicity was tested in univariable and ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Optimizing prostate-targeted biopsy schemes in men with multiple mpMRI visible lesions: should we target all suspicious areas? Results of a two institution series.

Armando Stabile, Francesco Barletta, Giovanni Motterle, Francesco Pellegrino, Gabriele Sorce, Elio Mazzone, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Alberto Briganti,

<h4>Background</h4>To assess the diagnostic added value of sampling secondary lesions at prostate mpMRI (SL) in addition to index lesion (IL) in detecting significant prostate cancer (csPCa) when also systematic biopsy (SBx) is performed.<h4>Methods</h4>We relied on a cohort of 312 men with two suspicious lesions at prostate mpMRI who underwent subsequent ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, :]

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A Systematic Review of the Impact of Surgeon and Hospital Caseload Volume on Oncological and Nononcological Outcomes After Radical Prostatectomy for Nonmetastatic Prostate Cancer.

Thomas Van den Broeck, Daniela Oprea-Lager, Lisa Moris, Mithun Kailavasan, Erik Briers, Philip Cornford, Maria De Santis, Giorgio Gandaglia, Silke Gillessen Sommer, Jeremy P Grummet, Nikos Grivas, Thomas B L Lam, Michael Lardas, Matthew Liew, Malcolm Mason, Shane O'Hanlon, Jakub Pecanka, Guillaume Ploussard, Olivier Rouviere, Ivo G Schoots, Derya Tilki, Roderick C N van den Bergh, Henk van der Poel, Thomas Wiegel, Peter-Paul Willemse, Cathy Y Yuan, Nicolas Mottet,

<h4>Context</h4>The impact of surgeon and hospital volume on outcomes after radical prostatectomy (RP) for localised prostate cancer (PCa) remains unknown.<h4>Objective</h4>To perform a systematic review on the association between surgeon or hospital volume and oncological and nononcological outcomes following RP for PCa.<h4>Evidence acquisition</h4>Medline, Medline In-Process, Embase, and the Cochrane Central Register ... Read more >>

Eur Urol (European urology)
[2021, :]

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Patient- and Tumour-related Prognostic Factors for Urinary Incontinence After Radical Prostatectomy for Nonmetastatic Prostate Cancer: A Systematic Review and Meta-analysis.

Michael Lardas, Nikos Grivas, Thomas P A Debray, Fabio Zattoni, Christopher Berridge, Marcus Cumberbatch, Thomas Van den Broeck, Erik Briers, Maria De Santis, Andrea Farolfi, Nicola Fossati, Giorgio Gandaglia, Silke Gillessen, Shane O'Hanlon, Ann Henry, Matthew Liew, Malcolm Mason, Lisa Moris, Daniela Oprea-Lager, Guillaume Ploussard, Olivier Rouviere, Ivo G Schoots, Theodorus van der Kwast, Henk van der Poel, Thomas Wiegel, Peter-Paul Willemse, Cathy Y Yuan, Jeremy P Grummet, Derya Tilki, Roderick C N van den Bergh, Thomas B Lam, Philip Cornford, Nicolas Mottet,

<h4>Context</h4>While urinary incontinence (UI) commonly occurs after radical prostatectomy (RP), it is unclear what factors increase the risk of UI development.<h4>Objective</h4>To perform a systematic review of patient- and tumour-related prognostic factors for post-RP UI. The primary outcome was UI within 3 mo after RP. Secondary outcomes included UI at 3-12 ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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The importance of an adequate surgical template during salvage lymph node dissection for node-recurrent prostate cancer.

Carlo Andrea Bravi, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Francesco Montorsi, Alberto Briganti,

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2021, :]

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Improving the stratification of intermediate risk prostate cancer.

Luigi Nocera, Claudia Collà Ruvolo, Lara F Stolzenbach, Marina Deuker, Zhe Tian, Giorgio Gandaglia, Nicola Fossati, Firas Abdollah, Nazareno Suardi, Vincenzo Mirone, Markus Graefen, Felix K Chun, Fred Saad, Francesco Montorsi, Alberto Briganti, Pierre I Karakiewicz,

<h4>Background</h4>Intermediate risk prostate cancer (IR PCa) may exhibit a wide array of phenotypes, from favorable to unfavorable. NCCN criteria help distinguishing between favorable versus unfavorable subgroups. We studied and attempted to improve this classification.<h4>Methods</h4>Within the SEER database 2010-2016, we identified 19,193 IR PCa patients treated with radical prostatectomy. A multivariable ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

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Association Between Lesion Location and Oncological Outcomes after Focal Therapy for Localized Prostate Cancer Using Either High Intensity Focused Ultrasound or Cryotherapy.

Armando Stabile, Rafael Sanchez-Salas, Rafael Tourinho-Barbosa, Petr Macek, Francesco Pellegrino, Giorgio Gandaglia, Marco Moschini, Nathalie Cathala, Annick Mombet, Francesco Montorsi, Alberto Briganti, Xavier Cathelineau,

<h4>Purpose</h4>To assess whether PCa location might affect oncological outcomes after focal therapy (FT) for prostate cancer (PCa).<h4>Materials and methods</h4>We identified 274 men receiving FT for prostate cancer (PCa) using either HIFU or cryotherapy at a high volume centre between 2009 to 2018. Survival analyses using Kaplan Meier method were used ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001787]

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Reducing the Risk of Postoperative Complications After Robot-assisted Radical Prostatectomy in Prostate Cancer Patients: Results of an Audit and Feedback Intervention Following the Implementation of Prospective Data Collection.

Giuseppe Rosiello, Giorgio Gandaglia, Simone Scuderi, Francesco Barletta, Nicola Fossati, Armando Stabile, Andrea Gallina, Elio Mazzone, Luca Maria Vitale, Antony Pellegrino, Carlo Bravi, Alberto Martini, Vito Cucchiara, Pierre I Karakiewicz, Alexandre Mottrie, Alberto Briganti, Francesco Montorsi,

<h4>Background</h4>Prospective data collection for perioperative outcomes might increase awareness of surgical results obtained for patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). This would prompt the implementation of measures aimed at reducing the risk of adverse outcomes.<h4>Objective</h4>To assess the efficacy of an audit and feedback process aimed at ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Age and gleason score upgrading between prostate biopsy and radical prostatectomy: Is this still true in the multiparametric resonance imaging era?

Elio Mazzone, Armando Stabile, Gabriele Sorce, Francesco Pellegrino, Francesco Barletta, Giovanni Motterle, Simone Scuderi, Giuseppe Ottone Cirulli, Vito Cucchiara, Giorgio Brembilla, Antonio Esposito, Giorgio Gandaglia, Nicola Fossati, Francesco De Cobelli, Francesco Montorsi, R Jeffrey Karnes, Ilaria Guccini, Alberto Briganti,

<h4>Introduction</h4>Several studies have invariably shown that the risk of Grade Group (GG) upgrading between biopsy and radical prostatectomy (RP) is higher in elderly men. Whether this is due to a real biological effect or to a diagnostic bias is still unknown. We hypothesized that the introduction of multiparametric magnetic resonance ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Metastatic hormone-sensitive prostate cancer: local treatment strategies.

Francesco Montorsi, Alberto Martini, Giorgio Gandaglia, Nicola Fossati, Armando Stabile, Federico Dehò, Andrea Salonia, Alberto Briganti,

World J Urol (World journal of urology)
[2021, :]

Cited: 1 time

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The Long-Term Risks of Metastases in Men on Active Surveillance for Early Stage Prostate Cancer. Letter.

Francesco Montorsi, Giorgio Gandaglia, Alberto Briganti,

J Urol (The Journal of urology)
[2021, 206(1):173]

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Re: Jean F.P. Lestingi, Giuliano B. Guglielmetti, Quoc-Dien Trinh, et al. Extended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.11.040: Time for a Change? Clinically Meaningful Reasons Why We Will Continue Performing Extended Pelvic Lymph Node Dissection in Selected Patients with Prostate Cancer.

Alberto Briganti, Giorgio Gandaglia, Markus Graefen, Steven Joniau, R Jeffrey Karnes, Francesco Montorsi,

Eur Urol (European urology)
[2021, 79(5):e154-e156]

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Re: Sophie Knipper, Luigi Ascalone, Benjamin Ziegler, et al. Salvage Surgery in Patients with Local Recurrence After Radical Prostatectomy. Eur Urol 2021;79:537-44: Surgical Treatment of Local Recurrence Following Radical Prostatectomy: Reality or Illusion?

Francesco Montorsi, Nicola Fossati, Carlo A Bravi, Giorgio Gandaglia, Nazareno Suardi, Alberto Briganti,

Eur Urol (European urology)
[2021, 79(5):e132-e133]

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Diagnostic and prognostic factors in patients with prostate cancer: a systematic review protocol.

Katharina Beyer, Lisa Moris, Michael Lardas, Anna Haire, Francesco Barletta, Simone Scuderi, Eleni Vradi, Giorgio Gandaglia, Muhammad Imran Omar, Steven MacLennan, Jihong Zong, Bahman Farahmand, Sara J Maclennan, Zsuzsanna Devecseri, Alex Asiimwe, Laurence Collette, Anders Bjartell, James Ndow, Alberto Briganti, Mieke Van Hemelrijck, ,

<h4>Introduction</h4>As part of the PIONEER (Prostate Cancer Diagnosis and Treatment Enhancement Through the Power of Big Data in Europe) Consortium, we will explore which diagnostic and prognostic factors (DPFs) are currently being researched to previously defined clinical and patient-reported outcomes for prostate cancer (PCa).<h4>Methods and analysis</h4>This research project will follow ... Read more >>

BMJ Open (BMJ open)
[2021, 11(2):e040531]

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Letter - Can micro-ultrasound be the new first-choice test for patients with a suspicion of prostate cancer? RE: Comparison of micro-ultrasound and multiparametric magnetic resonance imaging for prostate cancer, CUAJ, Jan 2021 (with author reply).

Francesco Montorsi, Armando Stabile, Giorgio Gandaglia, Federico Deho, Andrea Gallina, Alberto Briganti,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(2):E127-E128]

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RE: Retzius Sparing Prostatectomy Effect on Symptomatic Lymphocele Rates.

Francesco Montorsi, Giorgio Gandaglia, Armando Stabile,

Urology (Urology)
[2021, 152:205]

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Prostate-specific Membrane Antigen Imaging in Clinical Guidelines: European Association of Urology, National Comprehensive Cancer Network, and Beyond.

Giorgio Gandaglia, Riccardo Leni, Nicola Fossati, Vito Cucchiara, Francesco Montorsi, Alberto Briganti,

Prostate-specific membrane antigen (PSMA) imaging is characterized by superior accuracy compared to conventional imaging for identification of nodal and distant metastases in prostate cancer. The majority of international clinical guidelines recommend PSMA positron emission tomography/computed tomography for patients experiencing biochemical recurrence, even at low prostate-specific antigen values, to identify candidates ... Read more >>

Eur Urol Focus (European urology focus)
[2021, 7(2):245-249]

Cited: 1 time

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Molecular biomarkers in the context of focal therapy for prostate cancer: recommendations of a Delphi Consensus from the Focal Therapy Society.

Giancarlo Marra, Maria Pilar Laguna, Jochen Walz, Christian P Pavlovich, Fernando Bianco, Justin Gregg, Amir H Lebastchi, Herbert Lepor, Petr Macek, Soroush Rais-Bahrami, Cary Robertson, Daniel Rukstalis, Georg Salomon, Osamu Ukimura, Andre L Abreu, Yann Barbe, Xavier Cathelineau, Giorgio Gandaglia, Arvin K George, Juan Gomez Rivas, Rajan T Gupta, Nathan Lawrentschuk, Veeru Kasivisvanathan, Derek Lomas, Bernard Malavaud, Daniel Margolis, Yoh Matsuoka, Sherif Mehralivand, Marco Moschini, Marco Oderda, Hazem Orabi, Ardeshir R Rastinehad, Mesut Remzi, Ariel Schulman, Toshitaka Shin, Takumi Shiraishi, Abhinav Sidana, Sunao Shoji, Armando Stabile, Massimo Valerio, Varaha S Tammisetti, Wei Phin Tan, Willemien Van Den Bos, Arnaud Villers, Peter-Paul Willemse, Jean de la Rosette, Thomas Polascik, Rafael Sanchez-Salas, ,

<h4>Background</h4>Focal Therapy (FT) for Prostate Cancer (PCa) is promising. However, long-term oncological results are awaited and there is no consensus on follow-up strategies. Molecular biomarkers (MB) may be useful in selecting, treating and following up men undergoing FT, though there is limited evidence in this field to guide practice. We ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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A Systematic Review of Focal Ablative Therapy for Clinically Localised Prostate Cancer in Comparison with Standard Management Options: Limitations of the Available Evidence and Recommendations for Clinical Practice and Further Research.

Anthony S Bates, Jennifer Ayers, Nikolaos Kostakopoulos, Thomas Lumsden, Ivo G Schoots, Peter-Paul M Willemse, Yuhong Yuan, Roderick C N van den Bergh, Jeremy P Grummet, Henk G van der Poel, Olivier Rouvière, Lisa Moris, Marcus G Cumberbatch, Michael Lardas, Matthew Liew, Thomas Van den Broeck, Giorgio Gandaglia, Nicola Fossati, Erik Briers, Maria De Santis, Stefano Fanti, Silke Gillessen, Daniela E Oprea-Lager, Guillaume Ploussard, Ann M Henry, Derya Tilki, Theodorus H van der Kwast, Thomas Wiegel, James N'Dow, Malcolm D Mason, Philip Cornford, Nicolas Mottet, Thomas B L Lam,

<h4>Context</h4>The clinical effectiveness of focal therapy (FT) for localised prostate cancer (PCa) remains controversial.<h4>Objective</h4>To analyse the evidence base for primary FT for localised PCa via a systematic review (SR) to formulate clinical practice recommendations.<h4>Evidence acquisition</h4>A protocol-driven, PRISMA-adhering SR comparing primary FT (sub-total, focal, hemi-gland, or partial ablation) versus standard options ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(3):405-423]

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Oncological outcomes of salvage radical prostatectomy for recurrent prostate cancer in the contemporary era: A multicenter retrospective study.

Giancarlo Marra, Robert Jeffrey Karnes, Giorgio Calleris, Marco Oderda, Paolo Alessio, Anna Palazzetti, Antonino Battaglia, Francesca Pisano, Stefania Munegato, Fernando Munoz, Claudia Filippini, Umberto Ricardi, Estefania Linares, Rafael Sanchez-Salas, Sanchia Goonewardene, Prokar Dasgupta, Ben Challacombe, Rick Popert, Declan Cahill, David Gillatt, Raj Persad, Juan Palou, Steven Joniau, Salvatore Smelzo, Thierry Piechaud, Alexandre De La Taille, Morgan Roupret, Simone Albisinni, Roland van Velthoven, Alessandro Morlacco, Sharma Vidit, Giorgio Gandaglia, Alexander Mottrie, Joseph Smith, Shreyas Joshi, Gabriel Fiscus, Andre Berger, Monish Aron, Andre Abreu, Inderbir S Gill, Henk Van Der Poel, Derya Tilki, Declan Murphy, Nathan Lawrentschuk, John Davis, Paolo Gontero,

<h4>Background</h4>Salvage radical prostatectomy (sRP) historically yields poor functional outcomes and high complication rates. However, recent reports on robotic sRP show improved results. Our objectives were to evaluate sRP oncological outcomes and predictors of positive margins and biochemical recurrence (BCR).<h4>Methods</h4>We retrospectively collected data of sRP for recurrent prostate cancer after local ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(5):296.e21-296.e29]

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