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Author Gina S Ogilvie

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Women's acceptability of and experience with primary human papillomavirus testing for cervix screening: HPV FOCAL trial cross-sectional online survey results.

Laurie W Smith, C Sarai Racey, Lovedeep Gondara, Mel Krajden, Marette Lee, Ruth Elwood Martin, Gavin Stuart, Stuart Peacock, Andrew J Coldman, Eduardo L Franco, Dirk van Niekerk, Gina S Ogilvie,

<h4>Objective</h4>To study participant's acceptability of and attitudes towards human papillomavirus (HPV) testing compared with cytology for cervical cancer screening and what impact having an HPV positive result may have in future acceptability of screening.<h4>Design</h4>Cross-sectional online survey of clinical trial participants.<h4>Setting</h4>Primary care, population-based Cervix Screening Program, British Columbia, Canada.<h4>Participants</h4>A total of ... Read more >>

BMJ Open (BMJ open)
[2021, 11(10):e052084]

Cited: 0 times

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Population-level outcomes of partner notification among gay, bisexual, and other men who report sex with men diagnosed with infectious syphilis in British Columbia, Canada.

Christine D Lukac, Theodora Consolacion, Venessa Ryan, Emma Cumming, Janyn Mercado, Bccdc Syphilis Nurses, Geoffrey Ford, Gina S Ogilvie, Mark Gilbert, Troy Grennan, Jason Wong,

<h4>Background</h4>Syphilis testing, treatment, and partner notification (PN) are centrally coordinated in British Columbia (BC), Canada. Public health (PH) nurses (PHNs) contact almost all syphilis patients and either notify partners of syphilis exposure (PH-initiated PN), or support patients to notify their own partners (patient-initiated PN). In the context of an ongoing ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2021, :]

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Long-term cervical precancer outcomes after a negative DNA- or RNA-based human papillomavirus test result.

Talia H R Strang, Anna Gottschlich, Darrel A Cook, Laurie W Smith, Lovedeep Gondara, Eduardo L Franco, Dirk J van Niekerk, Gina S Ogilvie, Mel Krajden,

<h4>Background</h4>Cervical cancer, a preventable disease associated with the human papillomavirus, is responsible for significant morbidity and mortality globally. Primary human papillomavirus testing is more sensitive in detecting precancerous cervical lesions than cytologic screening and can be conducted using either DNA- or RNA-based assays. Screening programs must select the most appropriate ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, :]

Cited: 0 times

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Intention to receive a COVID-19 vaccine: results from a population-based survey in Canada.

Gina S Ogilvie, Shanlea Gordon, Laurie W Smith, Arianne Albert, C Sarai Racey, Amy Booth, Anna Gottschlich, David Goldfarb, Melanie C M Murray, Liisa A M Galea, Angela Kaida, Lori A Brotto, Manish Sadarangani,

<h4>Background</h4>The success of any COVID-19 vaccine program ultimately depends on high vaccine uptake. This study determined overall intention to receive a COVID-19 vaccine and identified factors that predict intentions to be vaccinated against COVID-19 in Canada, specifically in key priority groups identified by the American Committee on Immunization Practice (ACIP) ... Read more >>

BMC Public Health (BMC public health)
[2021, 21(1):1017]

Cited: 2 times

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Impacts of Human Papillomavirus Immunization Programs on Rates of Anogenital Warts in British Columbia, Canada, 2000 to 2017.

Christine D Lukac, Robine Donken, Michael Otterstatter, Olga Mazo, Stanley Wong, Fawziah Marra, Laurie Smith, Monika Naus, Deborah Money, Mel Krajden, Troy Grennan, Mark Gilbert, Jason Wong, Gina S Ogilvie,

<h4>Background</h4>In 2008, British Columbia (BC) implemented a school-based quadrivalent human papillomavirus (HPV-4) immunization program for girls born in 1994 or later. In 2015, an expanded clinic-based program included men who report sex with men (MSM) born in 1989 or later. To evaluate the impacts of HPV-4 programs on anogenital warts ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2020, 47(10):691-697]

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Association between human papillomavirus vaccine status and sexually transmitted infection outcomes among females aged 18-35 with a history of sexual activity in the United States: A population survey-based cross-sectional analysis.

Kalysha Closson, Mohammad E Karim, Manish Sadarangani, Monika Naus, Gina S Ogilvie, Robine Donken,

<h4>Background</h4>Current human papillomavirus (HPV) vaccine coverage in the United States (in 2019, 66-70%), remains below the Healthy People 2020 coverage goal of 80%. HPV vaccine misinformation, including parental concerns of sexual risk-compensation influence vaccine uptake. We examined the association between HPV vaccination and sexually transmitted infection (STI) outcomes.<h4>Methods</h4>Of the 20,146 ... Read more >>

Vaccine (Vaccine)
[2020, 38(52):8396-8404]

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HPV self-sampling acceptability in rural and indigenous communities in Guatemala: a cross-sectional study.

Audrey R Murchland, Anna Gottschlich, Kristin Bevilacqua, Andres Pineda, Berner Andrée Sandoval-Ramírez, Christian S Alvarez, Gina S Ogilvie, Thomas E Carey, Mark Prince, Michael Dean, Carlos Mendoza Montano, Alvaro Rivera-Andrade, Rafael Meza,

<h4>Introduction</h4>Cervical cancer disproportionately burdens low-income and middle-income countries (LMICs) such as Guatemala. Self-collection testing for human papillomavirus (HPV) has been suggested as a form of cervical cancer screening to facilitate access in LMICs. This study assessed and compared the acceptability of self-collection HPV testing in two rural, indigenous and ethnically ... Read more >>

BMJ Open (BMJ open)
[2019, 9(10):e029158]

Cited: 4 times

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Disease detection at the 48-month exit round of the HPV FOCAL cervical cancer screening trial in women per-protocol eligible for routine screening.

Andrew J Coldman, Dirk van Niekerk, Mel Krajden, Laurie W Smith, Darrel Cook, Lovedeep Gondara, Kathy Ceballos, David J Quinlan, Marette Lee, Ruth Elwood-Martin, Laura Gentile, Stuart Peacock, Gavin C E Stuart, Eduardo L Franco, Gina S Ogilvie,

HPV FOCAL is a randomized control trial of cervical cancer screening. The intervention arm received baseline screening for high-risk human papillomavirus (HPV) and the control arm received liquid-based cytology (LBC) at baseline and 24 months. Both arms received 48-month exit HPV and LBC cotesting. Exit results are presented for per-protocol ... Read more >>

Int J Cancer (International journal of cancer)
[2020, 146(7):1810-1818]

Cited: 0 times

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Evaluation of a validated methylation triage signature for human papillomavirus positive women in the HPV FOCAL cervical cancer screening trial.

Darrel A Cook, Mel Krajden, Adam R Brentnall, Lovedeep Gondara, Tracy Chan, Jennifer H Law, Laurie W Smith, Dirk J van Niekerk, Gina S Ogilvie, Andrew J Coldman, Rhian Warman, Caroline Reuter, Jack Cuzick, Attila T Lorincz,

Human papillomavirus (HPV)-based cervical cancer screening requires triage of HPV positive women to identify those at risk of cervical intraepithelial neoplasia grade 2 (CIN2) or worse. We conducted a blinded case-control study within the HPV FOCAL randomized cervical cancer screening trial of women aged 25-65 to examine whether baseline methylation ... Read more >>

Int J Cancer (International journal of cancer)
[2019, 144(10):2587-2595]

Cited: 13 times

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Population-level sexual behaviours in adolescent girls before and after introduction of the human papillomavirus vaccine (2003-2013).

Gina S Ogilvie, Felicia Phan, Heather N Pedersen, Simon R Dobson, Monika Naus, Elizabeth M Saewyc,

<h4>Background</h4>The human papillomavirus (HPV) vaccine is delivered widely through school-based immunization programs. Some groups have expressed concern that HPV vaccination programs will result in an increase in sexual risk-taking behaviours among adolescents. We aimed to evaluate population-level changes in sexual behaviours before and after implementation of the school-based HPV vaccination ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2018, 190(41):E1221-E1226]

Cited: 3 times

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Understanding Men's Perceptions of Human Papillomavirus and Cervical Cancer Screening in Kampala, Uganda.

Erin Moses, Heather N Pedersen, Emily C Wagner, Musa Sekikubo, Deborah M Money, Gina S Ogilvie, Sheona M Mitchell-Foster,

<h4>Purpose</h4>This preliminary study explores Ugandan men's knowledge and attitudes about human papillomavirus (HPV), cervical cancer, and screening.<h4>Methods</h4>A local physician led an education session about cervical cancer for 62 men in Kisenyi, Kampala in Uganda. Trained nurse midwives administered surveys to assess knowledge and attitudes before and after the education session.<h4>Results</h4>From ... Read more >>

J Glob Oncol (Journal of global oncology)
[2018, 4:1-9]

Cited: 1 time

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Effect of human papillomavirus vaccination on sexual behaviour among young females.

Robine Donken, Gina S Ogilvie, Julie A Bettinger, Manish Sadarangani, Ran D Goldman,

<b>Question</b> At the time of implementation of human papillomavirus (HPV) vaccine immunization programs, concerns were raised by parents, clinicians, and public health professionals about HPV vaccination possibly leading to riskier sexual health choices among young females. If HPV vaccination influences sexual behaviour among vaccinated females, this might influence the effect ... Read more >>

Can Fam Physician (Canadian family physician Medecin de famille canadien)
[2018, 64(7):509-513]

Cited: 1 time

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Comparative performance of human papillomavirus messenger RNA versus DNA screening tests at baseline and 48 months in the HPV FOCAL trial.

Darrel A Cook, Laurie W Smith, Jennifer H Law, Wendy Mei, Lovedeep Gondara, Dirk J van Niekerk, Kathy M Ceballos, Dan Jang, Max Chernesky, Eduardo L Franco, Gina S Ogilvie, Andrew J Coldman, Mel Krajden,

<h4>Background</h4>HPV FOCAL is a randomized trial comparing high-risk HPV [Hybrid Capture 2 (HC2)] vs. liquid-based cytology (LBC) for primary cervical screening.<h4>Objective</h4>The present study objective was to compare Aptima HPV (AHPV) and HC2 assay performance at the intervention arm baseline and 48 mo. screens in relation to the rates of cervical ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2018, 108:32-37]

Cited: 6 times

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Community-based HPV self-collection versus visual inspection with acetic acid in Uganda: a cost-effectiveness analysis of the ASPIRE trial.

Alex K Mezei, Heather N Pedersen, Stephen Sy, Catherine Regan, Sheona M Mitchell-Foster, Josaphat Byamugisha, Musa Sekikubo, Heather Armstrong, Angeli Rawat, Joel Singer, Gina S Ogilvie, Jane J Kim, Nicole G Campos,

BACKGROUND:Cervical cancer is the leading cause of cancer death for women in Uganda, despite the potential for prevention through organised screening. Community-based self-collected human papillomavirus (HPV) testing has been proposed to reduce barriers to screening. OBJECTIVE:Our objective was to evaluate the cost-effectiveness of the Advances in Screening and Prevention of ... Read more >>

BMJ Open (BMJ open)
[2018, 8(6):e020484]

Cited: 8 times

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Severe menopausal symptoms associated with reduced adherence to antiretroviral therapy among perimenopausal and menopausal women living with HIV in Metro Vancouver.

Putu K Duff, Deborah M Money, Gina S Ogilvie, Florence Ranville, Mary Kestler, Melissa C Braschel, Neora Pick, Kate Shannon, ,

OBJECTIVES:Although more women living with HIV (WLWH) are entering midlife, the experiences of perimenopausal and menopausal WLWH, including the effects of menopausal symptoms severity, remain understudied. This study longitudinally investigated the correlates of antiretroviral therapy (ART) adherence among perimenopausal and menopausal WLWH from Metro Vancouver. METHODS:Analyses drew on longitudinal data ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2018, 25(5):531-537]

Cited: 6 times

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Cost-effectiveness of cervical cancer screening methods in low- and middle-income countries: A systematic review.

Alex K Mezei, Heather L Armstrong, Heather N Pedersen, Nicole G Campos, Sheona M Mitchell, Musa Sekikubo, Josaphat K Byamugisha, Jane J Kim, Stirling Bryan, Gina S Ogilvie,

The incidence of cervical cancer in low- and middle-income countries (LMICs) is five times higher than that observed in high-income countries (HICs). This discrepancy is largely attributed to the implementation of cytology-based screening programmes in HICs. However, due to reduced health system infrastructure requirements, HPV testing (self- and provider-collected) and ... Read more >>

Int J Cancer (International journal of cancer)
[2017, 141(3):437-446]

Cited: 30 times

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On the duration of the period between exposure to HIV and detectable infection.

Bernhard P Konrad, Darlene Taylor, Jessica M Conway, Gina S Ogilvie, Daniel Coombs,

HIV infection cannot be detected immediately after exposure because plasma viral loads are too small initially. The duration of this phase of infection (the "eclipse period") is difficult to estimate because precise dates of exposure are rarely known. Therefore, the reliability of clinical HIV testing during the first few weeks ... Read more >>

Epidemics (Epidemics)
[2017, 20:73-83]

Cited: 9 times

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Self-collection based HPV testing for cervical cancer screening among women living with HIV in Uganda: a descriptive analysis of knowledge, intentions to screen and factors associated with HPV positivity.

Sheona M Mitchell, Heather N Pedersen, Evelyn Eng Stime, Musa Sekikubo, Erin Moses, David Mwesigwa, Christine Biryabarema, Jan Christilaw, Josaphat K Byamugisha, Deborah M Money, Gina S Ogilvie,

<h4>Background</h4>Women living with HIV (WHIV) are disproportionately impacted by cervical dysplasia and cancer. The burden is greatest in low-income countries where limited or no access to screening exists. The goal of this study was to describe knowledge and intentions of WHIV towards HPV self-collection for cervical cancer screening, and to ... Read more >>

BMC Womens Health (BMC women's health)
[2017, 17(1):4]

Cited: 6 times

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Disease detection and resource use in the safety and control arms of the HPV FOCAL cervical cancer screening trial.

Andrew J Coldman, Lovedeep Gondara, Laurie W Smith, Dirk van Niekerk, Kathy Ceballos, Mel Krajden, Darrel Cook, David J Quinlan, Marette Lee, Gavin Ce Stuart, Stuart Peacock, Ruth Elwood Martin, Laura Gentile, Eduardo L Franco, Gina S Ogilvie,

<h4>Background</h4>The HPV FOCAL Trial is a RCT comparing human papilloma virus (HPV) with Liquid Based Cytology (LBC) screening for cervical cancer. Results are presented for the comparison of the Safety and Control arms after two rounds.<h4>Methods</h4>HPV FOCAL included randomisation of women aged 25-65 into the Safety arm, where they were ... Read more >>

Br J Cancer (British journal of cancer)
[2016, 115(12):1487-1494]

Cited: 5 times

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HPV for cervical cancer screening (HPV FOCAL): Complete Round 1 results of a randomized trial comparing HPV-based primary screening to liquid-based cytology for cervical cancer.

Gina S Ogilvie, Mel Krajden, Dirk van Niekerk, Laurie W Smith, Darrel Cook, Kathy Ceballos, Marette Lee, Laura Gentile, Lovedeep Gondara, Ruth Elwood-Martin, Stuart Peacock, Gavin Stuart, Eduardo L Franco, Andrew J Coldman,

Complete Round 1 data (baseline and 12-month follow-up) for HPV FOCAL, a randomized trial establishing the efficacy of HPV DNA testing with cytology triage as a primary screen for cervical cancer are presented. Women were randomized to one of three arms: Control arm - Baseline liquid-based cytology (LBC) with ASCUS ... Read more >>

Int J Cancer (International journal of cancer)
[2017, 140(2):440-448]

Cited: 32 times

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Aptima HPV Assay versus Hybrid Capture® 2 HPV test for primary cervical cancer screening in the HPV FOCAL trial.

Darrel A Cook, Laurie W Smith, Jennifer Law, Wendy Mei, Dirk J van Niekerk, Kathy Ceballos, Lovedeep Gondara, Eduardo L Franco, Andrew J Coldman, Gina S Ogilvie, Dan Jang, Max Chernesky, Mel Krajden,

<h4>Background</h4>Cervical cancer screening programs are switching from Pap screening to high-risk HPV testing.<h4>Objectives</h4>To compare the Aptima HPV Assay (AHPV) with the Hybrid Capture<sup>®</sup> 2 High-Risk HPV DNA Test<sup>®</sup> (HC2) for primary cervical screening.<h4>Study design</h4>HPV FOCAL is a randomized trial comparing HC2 to liquid-based cytology (LBC) for screening women aged 25-65. ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2017, 87:23-29]

Cited: 14 times

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Monitoring the impact of HPV vaccine in males-Considerations and challenges.

Julia M L Brotherton, Anna R Giuliano, Lauri E Markowitz, Eileen F Dunne, Gina S Ogilvie,

In this article, we examine the issues involved if national or sub-national programs are considering extending post HPV vaccine introduction monitoring to include males. Vaccination programs are now being extended to include males in some countries, in order to improve population level HPV infection control and to directly prevent HPV-related ... Read more >>

Papillomavirus Res (Papillomavirus research (Amsterdam, Netherlands))
[2016, 2:106-111]

Cited: 7 times

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Strategies for Community Education Prior to Clinical Trial Recruitment for a Cervical Cancer Screening Intervention in Uganda.

Sheona M Mitchell, Heather N Pedersen, Musa Sekikubo, Christine Biryabarema, Josaphat J K Byamugisha, David Mwesigwa, Malcolm Steinberg, Deborah M Money, Gina S Ogilvie,

<h4>Introduction</h4>Community engagement and education can improve acceptability and participation in clinical trials conducted in Kisenyi, Uganda. In preparation for a randomized controlled trial exploring different methods for cervical cancer screening, we explored optimal engagement strategies from the perspective of community members and health professionals.<h4>Methods</h4>We conducted key informant interviews followed by ... Read more >>

Front Oncol (Frontiers in oncology)
[2016, 6:90]

Cited: 1 time

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Comparison of the Roche cobas® 4800 and Digene Hybrid Capture® 2 HPV tests for primary cervical cancer screening in the HPV FOCAL trial.

Darrel A Cook, Wendy Mei, Laurie W Smith, Dirk J van Niekerk, Kathy Ceballos, Eduardo L Franco, Andrew J Coldman, Gina S Ogilvie, Mel Krajden,

<h4>Background</h4>HPV FOCAL is a randomized trial (ISRCTN79347302, registered 20 Apr 2007) comparing high-risk (hr) HPV testing vs. liquid-based cytology (LBC) for cervical cancer screening of women aged 25-65. We compared the Digene Hybrid Capture® 2 High-Risk HPV DNA Test® (HC2) and the Roche cobas® 4800 HPV Test (COBAS) for primary ... Read more >>

BMC Cancer (BMC cancer)
[2015, 15:968]

Cited: 15 times

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Correlates of women's intentions to be screened for human papillomavirus for cervical cancer screening with an extended interval.

Gina S Ogilvie, Laurie W Smith, Dirk van Niekerk, Fareeza Khurshed, Heather N Pedersen, Darlene Taylor, Katharine Thomson, Sandra B Greene, Suzanne M Babich, Eduardo L Franco, Andrew J Coldman,

<h4>Background</h4>High-risk HPV DNA testing has been proposed as a primary tool for cervical cancer screening (HPV-CCS) as an alternative to the Papanicolaou cytology- method. This study describes factors associated with women's intentions to attend cervical cancer screening if high-risk HPV DNA testing (HPV-CCS) was implemented as a primary screening tool, ... Read more >>

BMC Public Health (BMC public health)
[2016, 16:213]

Cited: 9 times

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