Full Text Journal Articles by
Author Gil D Rabinovici

Advertisement

Find full text journal articles






New insights into atypical Alzheimer's disease in the era of biomarkers.

Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray,

Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, over-represented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction. In the past, these individuals often received a late diagnosis; however, availability of CSF and PET biomarkers of Alzheimer's disease pathologies ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):222-234]

Cited: 0 times

View full text PDF listing >>



Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET.

Elena Tsoy, Amelia Strom, Leonardo Iaccarino, Sabrina J Erlhoff, Collette A Goode, Anne-Marie Rodriguez, Gil D Rabinovici, Bruce L Miller, Joel H Kramer, Katherine P Rankin, Renaud La Joie, Katherine L Possin,

<h4>Background</h4>β-amyloid (Aβ) and tau positron emission tomography (PET) detect the pathological changes that define Alzheimer's disease (AD) in living people. Cognitive measures sensitive to Aβ and tau burden may help streamline identification of cases for confirmatory AD biomarker testing.<h4>Methods</h4>We examined the association of Brain Health Assessment (BHA) tablet-based cognitive measures ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2021, 13(1):36]

Cited: 0 times

View full text PDF listing >>



Advertisement

Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.

Breton M Asken, Fanny M Elahi, Renaud La Joie, Amelia Strom, Adam M Staffaroni, Cutter A Lindbergh, Alexandra C Apple, Michelle You, Sophia Weiner-Light, Nivetha Brathaban, Nicole Fernandes, Anna Karydas, Paul Wang, Julio C Rojas, Adam L Boxer, Bruce L Miller, Gil D Rabinovici, Joel H Kramer, Kaitlin B Casaletto,

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Outcomes of clinical utility in amyloid-PET studies: state of art and future perspectives.

Matteo Cotta Ramusino, Giulia Perini, Daniele Altomare, Paola Barbarino, Wendy Weidner, Gabriella Salvini Porro, Frederik Barkhof, Gil D Rabinovici, Wiesje M van der Flier, Giovanni B Frisoni, Valentina Garibotto, Stefan Teipel, Marina Boccardi,

<h4>Purpose</h4>To review how outcomes of clinical utility are operationalized in current amyloid-PET validation studies, to prepare for formal assessment of clinical utility of amyloid-PET-based diagnosis.<h4>Methods</h4>Systematic review of amyloid-PET research studies published up to April 2020 that included outcomes of clinical utility. We extracted and analyzed (a) outcome categories, (b) their ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Sex differences in the behavioral variant of frontotemporal dementia: A new window to executive and behavioral reserve.

Ignacio Illán-Gala, Kaitlin B Casaletto, Sergi Borrego-Écija, Eider M Arenaza-Urquijo, Amy Wolf, Yann Cobigo, Sheng Yang M Goh, Adam M Staffaroni, Daniel Alcolea, Juan Fortea, Rafael Blesa, Jordi Clarimon, Maria Florencia Iulita, Anna Brugulat-Serrat, Albert Lladó, Lea T Grinberg, Katherine Possin, Katherine P Rankin, Joel H Kramer, Gil D Rabinovici, Adam Boxer, William W Seeley, Virginia E Sturm, Maria Luisa Gorno-Tempini, Bruce L Miller, Raquel Sánchez-Valle, David C Perry, Alberto Lleó, Howard J Rosen,

<h4>Introduction</h4>Biological sex is an increasingly recognized factor driving clinical and structural heterogeneity in Alzheimer's disease, but its role in the behavioral variant of frontotemporal dementia (bvFTD) is unknown.<h4>Methods</h4>We included 216 patients with bvFTD and 235 controls with magnetic resonance imaging (MRI) from a large multicenter cohort. We compared the clinical ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Rapid Progress Toward Reliable Blood Tests for Alzheimer Disease.

Elisabeth H Thijssen, Gil D Rabinovici,

JAMA Neurol (JAMA neurology)
[2021, 78(2):143-145]

Cited: 0 times

View full text PDF listing >>



Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts.

Karine Provost, Leonardo Iaccarino, David N Soleimani-Meigooni, Suzanne Baker, Lauren Edwards, Udo Eichenlaub, Oskar Hansson, William Jagust, Mustafa Janabi, Renaud La Joie, Orit Lesman-Segev, Taylor J Mellinger, Bruce L Miller, Rik Ossenkoppele, Julie Pham, Ruben Smith, Ida Sonni, Amelia Strom, Niklas Mattsson-Carlgren, Gil D Rabinovici, ,

<h4>Purpose</h4>To compare rates of tau biomarker positivity (T-status) per the 2018 Alzheimer's Disease (AD) Research Framework derived from [<sup>18</sup>F]flortaucipir (FTP) PET visual assessment, FTP quantification, and cerebrospinal fluid (CSF) phosphorylated Tau-181 (PTau181).<h4>Methods</h4>We included 351 subjects with varying clinical diagnoses from three cohorts with available FTP PET and CSF PTau181 within ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum.

Leonardo Iaccarino, Renaud La Joie, Lauren Edwards, Amelia Strom, Daniel R Schonhaut, Rik Ossenkoppele, Julie Pham, Taylor Mellinger, Mustafa Janabi, Suzanne L Baker, David Soleimani-Meigooni, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici,

A deeper understanding of the spatial relationships of β-amyloid (Aβ), tau, and neurodegeneration in Alzheimer's disease (AD) could provide insight into pathogenesis and clinical trial design. We included 81 amyloid-positive patients (age 64.4 ± 9.5) diagnosed with AD dementia or mild cognitive impairment due to AD and available 11C-PiB (PIB), 18F-Flortaucipir (FTP),18F-FDG-PET, ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(1):1-14]

Cited: 0 times

View full text PDF listing >>



Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults.

Breton M Asken, William G Mantyh, Renaud La Joie, Amelia Strom, Kaitlin B Casaletto, Adam M Staffaroni, Alexandra C Apple, Cutter A Lindbergh, Leonardo Iaccarino, Michelle You, Harli Grant, Corrina Fonseca, Charles Windon, Kyan Younes, Jeremy Tanner, Gil D Rabinovici, Joel H Kramer, Raquel C Gardner,

We investigated whether clinically normal older adults with remote, mild traumatic brain injury (mTBI) show evidence of higher cortical Aβ burden. Our study included 134 clinically normal older adults (age 74.1 ± 6.8 years, 59.7% female, 85.8% white) who underwent Aβ positron emission tomography (Aβ-PET) and who completed the Ohio State University ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Relationship Between Tau and Cognition in the Evolution of Alzheimer's Disease: New Insights from Tau PET.

Jeremy A Tanner, Gil D Rabinovici,

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Association of APOE4 and Clinical Variability in Alzheimer Disease With the Pattern of Tau- and Amyloid-PET.

Renaud La Joie, Adrienne V Visani, Orit H Lesman-Segev, Suzanne L Baker, Lauren Edwards, Leonardo Iaccarino, David N Soleimani-Meigooni, Taylor Mellinger, Mustafa Janabi, Zachary A Miller, David C Perry, Julie Pham, Amelia Strom, Maria Luisa Gorno-Tempini, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici,

<h4>Objective</h4>To assess whether Alzheimer disease (AD) clinical presentation and <i>APOE4</i> relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET imaging.<h4>Methods</h4>We studied 119 Aβ-positive symptomatic patients aged 48-95 years, including 29 patients with logopenic variant primary progressive aphasia (lvPPA) and 21 with posterior cortical ... Read more >>

Neurology (Neurology)
[2021, 96(5):e650-e661]

Cited: 0 times

View full text PDF listing >>



Diagnostic Accuracy of Amyloid versus 18 F-Fluorodeoxyglucose Positron Emission Tomography in Autopsy-Confirmed Dementia.

Orit H Lesman-Segev, Renaud La Joie, Leonardo Iaccarino, Iryna Lobach, Howard J Rosen, Sang Won Seo, Mustafa Janabi, Suzanne L Baker, Lauren Edwards, Julie Pham, John Olichney, Adam Boxer, Eric Huang, Marilu Gorno-Tempini, Charles DeCarli, Mackenzie Hepker, Ji-Hye L Hwang, Bruce L Miller, Salvatore Spina, Lea T Grinberg, William W Seeley, William J Jagust, Gil D Rabinovici,

<h4>Objective</h4>The purpose of this study was to compare the diagnostic accuracy of antemortem <sup>11</sup> C-Pittsburgh compound B (PIB) and <sup>18</sup> F-fluorodeoxyglucose (FDG) positron emission tomography (PET) versus autopsy diagnosis in a heterogenous sample of patients.<h4>Methods</h4>One hundred one participants underwent PIB and FDG PET during life and neuropathological assessment. PET scans ... Read more >>

Ann Neurol (Annals of neurology)
[2021, 89(2):389-401]

Cited: 0 times

View full text PDF listing >>



18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases.

David N Soleimani-Meigooni, Leonardo Iaccarino, Renaud La Joie, Suzanne Baker, Viktoriya Bourakova, Adam L Boxer, Lauren Edwards, Rana Eser, Maria-Luisa Gorno-Tempini, William J Jagust, Mustafa Janabi, Joel H Kramer, Orit H Lesman-Segev, Taylor Mellinger, Bruce L Miller, Julie Pham, Howard J Rosen, Salvatore Spina, William W Seeley, Amelia Strom, Lea T Grinberg, Gil D Rabinovici,

Few studies have evaluated the relationship between in vivo18F-flortaucipir PET and post-mortem pathology. We sought to compare antemortem 18F-flortaucipir PET to neuropathology in a consecutive series of patients with a broad spectrum of neurodegenerative conditions. Twenty patients were included [mean age at PET 61 years (range 34-76); eight female; median ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(11):3477-3494]

Cited: 0 times

View full text PDF listing >>



Evaluation of a visual interpretation method for tau-PET with 18F-flortaucipir.

Ida Sonni, Orit H Lesman Segev, Suzanne L Baker, Leonardo Iaccarino, Deniz Korman, Gil D Rabinovici, William J Jagust, Susan M Landau, Renaud La Joie, ,

<h4>Introduction</h4>Positron emission tomography targeting tau (tau-PET) is a promising diagnostic tool for the identification of Alzheimer's disease (AD). Currently available data rely on quantitative measures, and a visual interpretation method, critical for clinical translation, is needed.<h4>Methods</h4>We developed a visual interpretation method for <sup>18</sup>F-flortaucipir tau-PET and tested it on 274 individuals ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2020, 12(1):e12133]

Cited: 1 time

View full text PDF listing >>



The impact of demographic, clinical, genetic, and imaging variables on tau PET status.

Rik Ossenkoppele, Antoine Leuzy, Hanna Cho, Carole H Sudre, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Tomas Olsson, Jonas Jögi, Erik Stormrud, Young Hoon Ryu, Jae Yong Choi, , , Adam L Boxer, Maria L Gorno-Tempini, Bruce L Miller, David Soleimani-Meigooni, Leonardo Iaccarino, Renaud La Joie, Edilio Borroni, Gregory Klein, Michael J Pontecorvo, Michael D Devous, Sylvia Villeneuve, Chul Hyoung Lyoo, Gil D Rabinovici, Oskar Hansson,

<h4>Purpose</h4>A substantial proportion of amyloid-β (Aβ)+ patients with clinically diagnosed Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI) are tau PET-negative, while some clinically diagnosed non-AD neurodegenerative disorder (non-AD) patients or cognitively unimpaired (CU) subjects are tau PET-positive. We investigated which demographic, clinical, genetic, and imaging variables contributed to ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease.

Ignacio Illán-Gala, Alberto Lleo, Anna Karydas, Adam M Staffaroni, Henrik Zetterberg, Rajeev Sivasankaran, Lea T Grinberg, Salvatore Spina, Joel H Kramer, Eliana M Ramos, Giovanni Coppola, Renaud La Joie, Gil D Rabinovici, David C Perry, Maria Luisa Gorno-Tempini, William W Seeley, Bruce L Miller, Howard J Rosen, Kaj Blennow, Adam L Boxer, Julio C Rojas,

<h4>Objective</h4>To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (FTLD-S) and clinically diagnosed Alzheimer disease syndromes (AD-S), we determined their diagnostic and prognostic value in FTLD-S and AD-S and their sensitivity ... Read more >>

Neurology (Neurology)
[2021, 96(5):e671-e683]

Cited: 0 times

View full text PDF listing >>



Investigating the clinico-anatomical dissociation in the behavioral variant of Alzheimer disease.

Ellen H Singleton, Yolande A L Pijnenburg, Carole H Sudre, Colin Groot, Elena Kochova, Frederik Barkhof, Renaud La Joie, Howard J Rosen, William W Seeley, Bruce Miller, M Jorge Cardoso, Janne Papma, Philip Scheltens, Gil D Rabinovici, Rik Ossenkoppele,

<h4>Background</h4>We previously found temporoparietal-predominant atrophy patterns in the behavioral variant of Alzheimer's disease (bvAD), with relative sparing of frontal regions. Here, we aimed to understand the clinico-anatomical dissociation in bvAD based on alternative neuroimaging markers.<h4>Methods</h4>We retrospectively included 150 participants, including 29 bvAD, 28 "typical" amnestic-predominant AD (tAD), 28 behavioral variant ... Read more >>

Alzheimers Res Ther (Alzheimer's research & therapy)
[2020, 12(1):148]

Cited: 1 time

View full text PDF listing >>



Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias.

Gaël Chételat, Javier Arbizu, Henryk Barthel, Valentina Garibotto, Ian Law, Silvia Morbelli, Elsmarieke van de Giessen, Federica Agosta, Frederik Barkhof, David J Brooks, Maria C Carrillo, Bruno Dubois, Anders M Fjell, Giovanni B Frisoni, Oskar Hansson, Karl Herholz, Brian F Hutton, Clifford R Jack, Adriaan A Lammertsma, Susan M Landau, Satoshi Minoshima, Flavio Nobili, Agneta Nordberg, Rik Ossenkoppele, Wim J G Oyen, Daniela Perani, Gil D Rabinovici, Philip Scheltens, Victor L Villemagne, Henrik Zetterberg, Alexander Drzezga,

Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) PET, which assesses glucose metabolism, provide valuable and complementary information. However, uncertainty remains regarding the optimal timepoint, combination, and an ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(11):951-962]

Cited: 4 times

View full text PDF listing >>



Symptomatic amyloid-related imaging abnormalities in an APOE ε4/ε4 patient treated with aducanumab.

Lawren VandeVrede, Daniel M Gibbs, Mary Koestler, Renaud La Joie, Peter A Ljubenkov, Karine Provost, David Soleimani-Meigooni, Amelia Strom, Elena Tsoy, Gil D Rabinovici, Adam L Boxer,

<h4>Introduction</h4>Amyloid-related imaging abnormalities (ARIA) are a common, dose-dependent effect of amyloid-targeting antibodies, strongly associated with the apolipoprotein E (APOE) ε4 allele.<h4>Methods</h4>We describe the clinical course and management of a 66-year-old white male (APOE ε4/ε4) enrolled in an observational study that included amyloid and tau positron emission tomography (PET), who received ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2020, 12(1):e12101]

Cited: 0 times

View full text PDF listing >>



Predicting amyloid status using self-report information from an online research and recruitment registry: The Brain Health Registry.

Miriam T Ashford, John Neuhaus, Chengshi Jin, Monica R Camacho, Juliet Fockler, Diana Truran, R Scott Mackin, Gil D Rabinovici, Michael W Weiner, Rachel L Nosheny,

<h4>Introduction</h4>This study aimed to predict brain amyloid beta (Aβ) status in older adults using collected information from an online registry focused on cognitive aging.<h4>Methods</h4>Aβ positron emission tomography (PET) was obtained from multiple in-clinic studies. Using logistic regression, we predicted Aβ using self-report variables collected in the Brain Health Registry in ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2020, 12(1):e12102]

Cited: 0 times

View full text PDF listing >>



Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants.

Jessica de Leon, Stephanie M Grasso, Ariane Welch, Zachary Miller, Wendy Shwe, Gil D Rabinovici, Bruce L Miller, Maya L Henry, Maria Luisa Gorno-Tempini,

<h4>Introduction</h4>The effect of bilingualism on age at onset has yet to be examined within different clinical variants of Alzheimer's disease.<h4>Methods</h4>We reviewed the research charts of 287 well-characterized participants with either amnestic Alzheimer's dementia or logopenic variant primary progressive aphasia (lvPPA) and identified bilingual speakers based on regular use of two ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(12):1704-1713]

Cited: 1 time

View full text PDF listing >>



Diagnostic Assessment in Primary Progressive Aphasia: An Illustrative Case Example.

Eduardo Europa, Leonardo Iaccarino, David C Perry, Elizabeth Weis, Ariane E Welch, Gil D Rabinovici, Bruce L Miller, Maria Luisa Gorno-Tempini, Maya L Henry,

Purpose Diagnosis and classification of primary progressive aphasia (PPA) requires confirmation of specific speech and language symptoms, highlighting the important role of speech-language pathologists in the evaluation process. The purpose of this case report is to inform speech-language pathologists regarding current practices for diagnostic assessment in PPA, describing standard approaches ... Read more >>

Am J Speech Lang Pathol (American journal of speech-language pathology)
[2020, 29(4):1833-1849]

Cited: 1 time

View full text PDF listing >>



Chronic Traumatic Encephalopathy: A Comparison with Alzheimer's Disease and Frontotemporal Dementia.

Orit H Lesman-Segev, Lauren Edwards, Gil D Rabinovici,

The clinical diagnosis of chronic traumatic encephalopathy (CTE) is challenging due to heterogeneous clinical presentations and overlap with other neurodegenerative dementias. Depending on the clinical presentation, the differential diagnosis of CTE includes Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease, amyotrophic lateral sclerosis, primary mood disorders, posttraumatic stress ... Read more >>

Semin Neurol (Seminars in neurology)
[2020, 40(4):394-410]

Cited: 0 times

View full text PDF listing >>



Latent atrophy factors related to phenotypical variants of posterior cortical atrophy.

Colin Groot, B T Thomas Yeo, Jacob W Vogel, Xiuming Zhang, Nanbo Sun, Elizabeth C Mormino, Yolande A L Pijnenburg, Bruce L Miller, Howard J Rosen, Renaud La Joie, Frederik Barkhof, Philip Scheltens, Wiesje M van der Flier, Gil D Rabinovici, Rik Ossenkoppele,

<h4>Objective</h4>To determine whether atrophy relates to phenotypical variants of posterior cortical atrophy (PCA) recently proposed in clinical criteria (i.e., dorsal, ventral, dominant-parietal, and caudal) we assessed associations between latent atrophy factors and cognition.<h4>Methods</h4>We employed a data-driven Bayesian modeling framework based on latent Dirichlet allocation to identify latent atrophy factors in ... Read more >>

Neurology (Neurology)
[2020, 95(12):e1672-e1685]

Cited: 0 times

View full text PDF listing >>



BHA-CS: A novel cognitive composite for Alzheimer's disease and related disorders.

Elena Tsoy, Sabrina J Erlhoff, Collette A Goode, Karen A Dorsman, Suchanan Kanjanapong, Cutter A Lindbergh, Renaud La Joie, Amelia Strom, Gil D Rabinovici, Serggio C Lanata, Bruce L Miller, Sarah E Tomaszewski Farias, Joel H Kramer, Katherine P Rankin, Katherine L Possin,

<h4>Introduction</h4>Composite scores based on psychometrically rigorous cognitive assessments are well suited for early diagnosis and disease monitoring.<h4>Methods</h4>We developed and cross-validated the Brain Health Assessment-Cognitive Score (BHA-CS), based on a brief computerized battery, in 451 cognitively normal (CN) and 399 cognitively impaired (mild cognitive impairment [MCI] or dementia) older adults. We ... Read more >>

Alzheimers Dement (Amst) (Alzheimer's & dementia (Amsterdam, Netherlands))
[2020, 12(1):e12042]

Cited: 1 time

View full text PDF listing >>



Advertisement

Disclaimer
1.2906 s