Full Text Journal Articles by
Author Giancarlo Ruocco

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Bioprinting stem cells: building physiological tissues one cell at a time.

Chiara Scognamiglio, Alessandro Soloperto, Giancarlo Ruocco, Gianluca Cidonio,

Bioprinting aims to direct the spatial arrangement in three dimensions of cells, biomaterials, and growth factors. The biofabrication of clinically relevant constructs for the repair or modeling of either diseased or damaged tissues is rapidly advancing, resulting in the ability to three-dimensional (3D) print biomimetic platforms which imitate a large ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2020, 319(3):C465-C480]

Cited: 0 times

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Optonongenetic enhancement of activity in primary cortical neurons.

Silvia Ghirga, Francesca Pagani, Maria Rosito, Silvia Di Angelantonio, Giancarlo Ruocco, Marco Leonetti,

It has been recently demonstrated that the exposure of naive neuronal cells to light-at the basis of optogenetic techniques and calcium imaging measurements-may alter neuronal firing. Indeed, understanding the effect of light on nongenetically modified neurons is crucial for a correct interpretation of calcium imaging and optogenetic experiments. Here we ... Read more >>

J Opt Soc Am A Opt Image Sci Vis (Journal of the Optical Society of America. A, Optics, image science, and vision)
[2020, 37(4):643-652]

Cited: 2 times

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In-Silico evidence for two receptors based strategy of SARS-CoV-2

Edoardo Milanetti, Mattia Miotto, Lorenzo Di Rienzo, Michele Monti, Giorgio Gosti, Giancarlo Ruocco,

We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of protein surfaces. This innovative and general procedure, based on the representation of the molecular iso-electron density surface in terms of 2D Zernike polynomials, allows the rapid and quantitative assessment of the ... Read more >>

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Simulated Epidemics in 3D Protein Structures to Detect Functional Properties.

Mattia Miotto, Lorenzo Di Rienzo, Pietro Corsi, Giancarlo Ruocco, Domenico Raimondo, Edoardo Milanetti,

The outcome of an epidemic is closely related to the network of interactions between individuals. Likewise, protein functions depend on the 3D arrangement of their residues and the underlying energetic interaction network. Borrowing ideas from the theoretical framework that has been developed to address the spreading of real diseases, we ... Read more >>

J Chem Inf Model (Journal of chemical information and modeling)
[2020, 60(3):1884-1891]

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Investigation of the binding between olfactory receptors and odorant molecules in C. elegans organism.

Edoardo Milanetti, Giorgio Gosti, Luca De Flaviis, Pier Paolo Olimpieri, Silvia Schwartz, Davide Caprini, Giancarlo Ruocco, Viola Folli,

The molecular mechanisms regulating the complex sensory system that underlies olfaction are still not completely understood. The compounds formed from the interaction of Olfactory Receptors (ORs) with volatile molecules play a crucial role in producing the sense of olfaction. Therefore, it is necessary to investigate the binding mechanisms between these ... Read more >>

Biophys. Chem. (Biophysical chemistry)
[2019, 255:106264]

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Brillouin microscopy: an emerging tool for mechanobiology.

Robert Prevedel, Alba Diz-Muñoz, Giancarlo Ruocco, Giuseppe Antonacci,

The role and importance of mechanical properties of cells and tissues in cellular function, development and disease has widely been acknowledged, however standard techniques currently used to assess them exhibit intrinsic limitations. Recently, Brillouin microscopy, a type of optical elastography, has emerged as a non-destructive, label- and contact-free method that ... Read more >>

Nat. Methods (Nature methods)
[2019, 16(10):969-977]

Cited: 5 times

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Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis.

Alfonso Grimaldi, Natalia Pediconi, Francesca Oieni, Rocco Pizzarelli, Maria Rosito, Maria Giubettini, Tiziana Santini, Cristina Limatola, Giancarlo Ruocco, Davide Ragozzino, Silvia Di Angelantonio,

Alzheimer's disease (AD), a primary cause of dementia in the aging population, is characterized by extracellular amyloid-beta peptides aggregation, intracellular deposits of hyperphosphorylated tau, neurodegeneration and glial activation in the brain. It is commonly thought that the lack of early diagnostic criteria is among the main causes of pharmacological therapy ... Read more >>

(Frontiers in neuroscience)
[2019, 13:925]

Cited: 2 times

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Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD.

Martina Nicoletti, Alessandro Loppini, Letizia Chiodo, Viola Folli, Giancarlo Ruocco, Simonetta Filippi,

C. elegans neuronal system constitutes the ideal framework for studying simple, yet realistic, neuronal activity, since the whole nervous system is fully characterized with respect to the exact number of neurons and the neuronal connections. Most recent efforts are devoted to investigate and clarify the signal processing and functional connectivity, ... Read more >>

PLoS One (PloS one)
[2019, 14(7):e0218738]

Cited: 2 times

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Quantifying cellular forces and biomechanical properties by correlative micropillar traction force and Brillouin microscopy.

Stefano Coppola, Thomas Schmidt, Giancarlo Ruocco, Giuseppe Antonacci,

Cells sense and respond to external physical forces and substrate rigidity by regulating their cell shape, internal cytoskeletal tension, and stiffness. Here we show that the combination of micropillar traction force and noncontact Brillouin microscopy provides access to cell-generated forces and intracellular mechanical properties at optical resolution. Actin-rich cytoplasmic domains ... Read more >>

(Biomedical optics express)
[2019, 10(5):2202-2212]

Cited: 1 time

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Scattering Assisted Imaging.

Marco Leonetti, Alfonso Grimaldi, Silvia Ghirga, Giancarlo Ruocco, Giuseppe Antonacci,

Standard imaging systems provide a spatial resolution that is ultimately dictated by the numerical aperture (NA) of the illumination and collection optics. In biological tissues, the resolution is strongly affected by scattering, which limits the penetration depth to a few tenths of microns. Here, we exploit the properties of speckle ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):4591]

Cited: 0 times

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Cancellation of Bessel beam side lobes for high-contrast light sheet microscopy.

Giuseppe Di Domenico, Giancarlo Ruocco, Cristina Colosi, Eugenio DelRe, Giuseppe Antonacci,

An ideal illumination for light sheet fluorescence microscopy entails both a localized and a propagation invariant optical field. Bessel beams and Airy beams satisfy these conditions, but their non-diffracting feature comes at the cost of the presence of high-energy side lobes that notably degrade the imaging contrast and induce photobleaching. ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):17178]

Cited: 1 time

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Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer's disease in the 3xTg-AD mouse model.

Alfonso Grimaldi, Carlo Brighi, Giovanna Peruzzi, Davide Ragozzino, Valentina Bonanni, Cristina Limatola, Giancarlo Ruocco, Silvia Di Angelantonio,

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. In the pathogenesis of AD a pivotal role is played by two neurotoxic proteins that aggregate and accumulate in the central nervous system: amyloid beta and hyper-phosphorylated tau. Accumulation of extracellular amyloid beta plaques and intracellular hyper-phosphorylated ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(6):685]

Cited: 15 times

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Effect of dilution in asymmetric recurrent neural networks.

Viola Folli, Giorgio Gosti, Marco Leonetti, Giancarlo Ruocco,

We study with numerical simulation the possible limit behaviors of synchronous discrete-time deterministic recurrent neural networks composed of N binary neurons as a function of a network's level of dilution and asymmetry. The network dilution measures the fraction of neuron couples that are connected, and the network asymmetry measures to ... Read more >>

Neural Netw (Neural networks : the official journal of the International Neural Network Society)
[2018, 104:50-59]

Cited: 1 time

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Hyperuniformity in amorphous speckle patterns.

Diego Di Battista, Daniele Ancora, Giannis Zacharakis, Giancarlo Ruocco, Marco Leonetti,

Hyperuniform structures possess the ability to confine and drive light, although their fabrication is extremely challenging. Here we demonstrate that speckle patterns obtained by a superposition of randomly arranged sources of Bessel beams can be used to generate hyperunifrom scalar fields. By exploiting laser light tailored with a spatial filter, ... Read more >>

Opt Express (Optics express)
[2018, 26(12):15594-15608]

Cited: 2 times

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What is the Right Theory for Anderson Localization of Light? An Experimental Test.

Walter Schirmacher, Behnam Abaie, Arash Mafi, Giancarlo Ruocco, Marco Leonetti,

Anderson localization of light is traditionally described in analogy to electrons in a random potential. Within this description, the random potential depends on the wavelength of the incident light. For transverse Anderson localization, this leads to the prediction that the distribution of localization lengths-and, hence, its average-strongly depends on the ... Read more >>

Phys. Rev. Lett. (Physical review letters)
[2018, 120(6):067401]

Cited: 0 times

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Perspectives on cavitation enhanced endothelial layer permeability.

Giovanna Peruzzi, Giorgia Sinibaldi, Giulia Silvani, Giancarlo Ruocco, Carlo Massimo Casciola,

Traditional drug delivery systems, where pharmaceutical agents are conveyed to the target tissue through the blood circulation, suffer of poor therapeutic efficiency and limited selectivity largely due to the low permeability of the highly specialised biological interface represented by the endothelial layer. Examples concern cancer therapeutics or degenerative disorders where ... Read more >>

Colloids Surf B Biointerfaces (Colloids and surfaces. B, Biointerfaces)
[2018, 168:83-93]

Cited: 4 times

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Disorder-induced single-mode transmission.

Giancarlo Ruocco, Behnam Abaie, Walter Schirmacher, Arash Mafi, Marco Leonetti,

Localized states trap waves propagating in a disordered potential and play a crucial role in Anderson localization, which is the absence of diffusion due to disorder. Some localized states are barely coupled with neighbours because of differences in wavelength or small spatial overlap, thus preventing energy leakage to the surroundings. ... Read more >>

Nat Commun (Nature communications)
[2017, 8:14571]

Cited: 2 times

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Isotopic Effect on the Gel and Glass Formation of a Charged Colloidal Clay: Laponite.

Flavio Augusto de Melo Marques, Roberta Angelini, Giancarlo Ruocco, Barbara Ruzicka,

The time evolution of both dynamic and static structure factors of a charged colloidal clay, Laponite, dispersed in both H2O and D2O solvents has been investigated through multiangle dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) as a function of weight concentration. The aging phenomenology and the formation of ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2017, 121(17):4576-4582]

Cited: 3 times

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On the Maximum Storage Capacity of the Hopfield Model.

Viola Folli, Marco Leonetti, Giancarlo Ruocco,

Recurrent neural networks (RNN) have traditionally been of great interest for their capacity to store memories. In past years, several works have been devoted to determine the maximum storage capacity of RNN, especially for the case of the Hopfield network, the most popular kind of RNN. Analyzing the thermodynamic limit ... Read more >>

(Frontiers in computational neuroscience)
[2016, 10:144]

Cited: 2 times

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Collective excitations in soft-sphere fluids.

Taras Bryk, Federico Gorelli, Giancarlo Ruocco, Mario Santoro, Tullio Scopigno,

Despite that the thermodynamic distinction between a liquid and the corresponding gas ceases to exist at the critical point, it has been recently shown that reminiscence of gaslike and liquidlike behavior can be identified in the supercritical fluid region, encoded in the behavior of hypersonic waves dispersion. By using a ... Read more >>

Phys Rev E Stat Nonlin Soft Matter Phys (Physical review. E, Statistical, nonlinear, and soft matter physics)
[2014, 90(4):042301]

Cited: 5 times

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Structural and microscopic relaxations in a colloidal glass.

Flavio Augusto de Melo Marques, Roberta Angelini, Emanuela Zaccarelli, Bela Farago, Beatrice Ruta, Giancarlo Ruocco, Barbara Ruzicka,

The aging dynamics of a colloidal glass has been studied by multiangle dynamic light scattering, neutron spin echo, X-ray photon correlation spectroscopy and molecular dynamics simulations. The two relaxation processes, microscopic (fast) and structural (slow), have been investigated in an unprecedentedly wide range of time and length scales covering both ... Read more >>

Soft Matter (Soft matter)
[2015, 11(3):466-471]

Cited: 3 times

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Dual aging behaviour in a clay-polymer dispersion.

Laura Zulian, Flavio Augusto de Melo Marques, Elisa Emilitri, Giancarlo Ruocco, Barbara Ruzicka,

Clay-polymer compounds have recently attracted increasing attention due to their intriguing physical properties in colloidal science and their rheological non-trivial behaviour in technological applications. Aqueous solutions of Laponite clay spontaneously age from a liquid up to an arrested state of different nature (gel or glass) depending on the colloidal volume ... Read more >>

Soft Matter (Soft matter)
[2014, 10(25):4513-4521]

Cited: 1 time

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Glass-glass transition during aging of a colloidal clay.

Roberta Angelini, Emanuela Zaccarelli, Flavio Augusto de Melo Marques, Michael Sztucki, Andrei Fluerasu, Giancarlo Ruocco, Barbara Ruzicka,

Colloidal suspensions are characterized by a variety of microscopic interactions, which generate unconventional phase diagrams encompassing fluid, gel and glassy states and offer the possibility to study new phase and/or state transitions. Among these, glass-glass transitions are rare to be found, especially at ambient conditions. Here, through a combination of ... Read more >>

Nat Commun (Nature communications)
[2014, 5:4049]

Cited: 10 times

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Dynamical crossover at the liquid-liquid transformation of a compressed molten alkali metal.

Taras Bryk, Simone De Panfilis, Federico A Gorelli, Eugene Gregoryanz, Michael Krisch, Giancarlo Ruocco, Mario Santoro, Tullio Scopigno, Ari P Seitsonen,

Density-driven phase transformations are a known phenomenon in liquids. Pressure-driven transitions from an open low-density to a higher-density close-packed structure were observed for a number of systems. Here, we show a less intuitive, inverse behavior. We investigated the electronic, atomic, and dynamic structures of liquid Rb along an isothermal line ... Read more >>

Phys. Rev. Lett. (Physical review letters)
[2013, 111(7):077801]

Cited: 6 times

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Measurement of the four-point susceptibility of an out-of-equilibrium colloidal solution of nanoparticles using time-resolved light scattering.

Claudio Maggi, Roberto Di Leonardo, Giancarlo Ruocco, Jeppe C Dyre,

The spatial fluctuations of the dynamics of a colloidal system composed of nanoparticles are probed by a novel experimental setup, which combines homodyne and heterodyne dynamic light scattering focused onto a micron-sized volume via a microscope objective. The technique is used to measure the four-point susceptibility of an aging colloidal ... Read more >>

Phys. Rev. Lett. (Physical review letters)
[2012, 109(9):097401]

Cited: 5 times

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