Full Text Journal Articles by
Author Giancarlo Aldini

Advertisement

Find full text journal articles






Erratum: Altomare et al. In-Depth AGE and ALE Profiling of Human Albumin in Heart Failure: Ex Vivo Studies. Antioxidants 2021, 10, 358.

Alessandra Altomare, Giovanna Baron, Marta Balbinot, Alma Martínez Fernández, Alessandro Pedretti, Beatrice Zoanni, Maura Brioschi, Piergiuseppe Agostoni, Marina Carini, Cristina Banfi, Giancarlo Aldini,

The authors of this paper [...]. ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(10):]

Cited: 0 times

View full text PDF listing >>



Novel insights about albumin in cardiovascular diseases: Focus on heart failure.

Beatrice Zoanni, Maura Brioschi, Alice Mallia, Erica Gianazza, Sonia Eligini, Marina Carini, Giancarlo Aldini, Cristina Banfi,

The Human Plasma Proteome has always been the most investigated compartment in proteomics-based biomarker discovery, and is considered the largest and deepest version of the human proteome, reflecting the state of the body in health and disease. Even if efforts have been always dedicated to the refinement of proteomic approaches ... Read more >>

Mass Spectrom Rev (Mass spectrometry reviews)
[2021, :e21743]

Cited: 0 times

View full text PDF listing >>



Advertisement

Effect of Extraction Solvent and Temperature on Polyphenol Profiles, Antioxidant and Anti-Inflammatory Effects of Red Grape Skin By-Product.

Giovanna Baron, Giulio Ferrario, Cristina Marinello, Marina Carini, Paolo Morazzoni, Giancarlo Aldini,

A fully-detailed LC-MS qualitative profiling of red grape skin, extracted with a mixture of ethanol and water (70:30 <i>v</i>:<i>v</i>) has permitted the identification of 65 compounds which can be classified into the following chemical classes: organic and phenolic acids (14 compounds), stilbenoids (1 compound), flavanols (21 compounds), flavonols (15 compounds) ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(18):]

Cited: 0 times

View full text PDF listing >>



Study of Carnosine's effect on nude mice skin to prevent UV-A damage.

Silvia Radrezza, Marina Carini, Giovanna Baron, Giancarlo Aldini, Anne Negre-Salvayre, Alfonsina D'Amato,

The skin is an important barrier against external attacks from bacteria, radicals, or radiations. UV-A radiations cause significant impairment of this barrier, inducing inflammation, oxidative stress, and wrinkle formation, thereby promoting photoaging. Previous studies reported that carnosine, a potent antioxidant, and carbonyl scavenger agent, may prevent photoaging features in the ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 173:97-103]

Cited: 1 time

View full text PDF listing >>



Synthesis and characterization of 13C labeled carnosine derivatives for isotope dilution mass spectrometry measurements in biological matrices.

Marco Maspero, Ettore Gilardoni, Chiara Bonfanti, Graziella Messina, Luca Regazzoni, Marco De Amici, Marina Carini, Giancarlo Aldini, Clelia Dallanoce,

Due to the physiological properties of l-carnosine (l-1), supplementation of this dipeptide has both a nutritional ergogenic application and a therapeutic potential for the treatment of numerous diseases in which ischemic or oxidative stress are involved. Quantitation of carnosine and its analogs in biological matrices results to be crucial for ... Read more >>

Talanta (Talanta)
[2021, 235:122742]

Cited: 0 times

View full text PDF listing >>



A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study to Evaluate the Efficacy of AqualiefTM Mucoadhesive Tablets in Head and Neck Cancer Patients Who Developed Radiation-Induced Xerostomia.

Nicola Alessandro Iacovelli, Rossana Ingargiola, Nadia Facchinetti, Marzia Franceschini, Domenico Attilio Romanello, Paolo Bossi, Cristiana Bergamini, Salvatore Alfieri, Stefano Cavalieri, Giovanna Baron, Giancarlo Aldini, Laura Locati, Ester Orlandi,

Xerostomia, the subjective complaint of dry mouth, is caused by therapeutic interventions or diseases. Nowadays, radiotherapy (RT) in patients with head and neck cancer (HNC) stands out as one of the most important causes of xerostomia. Currently available therapies for the treatment of xerostomia are still less than optimal and ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(14):]

Cited: 0 times

View full text PDF listing >>



Candida albicans Biofilm Inhibition by Two Vaccinium macrocarpon (Cranberry) Urinary Metabolites: 5-(3',4'-DihydroxyPhenyl)-γ-Valerolactone and 4-Hydroxybenzoic Acid.

Emerenziana Ottaviano, Giovanna Baron, Laura Fumagalli, Jessica Leite, Elisa Adele Colombo, Angelica Artasensi, Giancarlo Aldini, Elisa Borghi,

<i>Candida</i> spp. are pathobionts, as they can switch from commensals to pathogens, responsible for a variety of pathological processes. Adhesion to surfaces, morphological switch and biofilm-forming ability are the recognized virulence factors promoting yeast virulence. Sessile lifestyle also favors fungal persistence and antifungal tolerance. In this study, we investigated, in ... Read more >>

Microorganisms (Microorganisms)
[2021, 9(7):]

Cited: 0 times

View full text PDF listing >>



Gamma-oryzanol reduces renal inflammation and oxidative stress by modulating AGEs/RAGE axis in animals submitted to high sugar-fat diet.

Fabiane Valentini Francisqueti-Ferron, Artur Junio Togneri Ferron, Alessandra Altomare, Jéssica Leite Garcia, Fernando Moreto, Ana Lúcia A Ferreira, Igor Otávio Minatel, Giancarlo Aldini, Camila Renata Corrêa,

<h4>Introduction</h4>The receptor for AGEs (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface receptors expressed in many organs, among them, the kidneys. When activated, RAGE leads to a sequence of signaling that results in inflammation and oxidative stress, both involved in kidney disease pathogenesis. Gamma-oryzanol (γOz) comprises ... Read more >>

J Bras Nefrol (Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia)
[2021, :]

Cited: 0 times

View full text PDF listing >>



PHoral: Effects of carnosine supplementation on quantity/quality of oral salivae in healthy volunteer and in subjects affected by common oral pathologies.

Michele M Ciulla, Dino Re, Ettore Gilardoni, Alfonsina D'Amato, Alessandra Altomare, Giovanna Baron, Stefano Carugo, Giancarlo Aldini,

<h4>Background</h4>Diseases of the oral cavity (OC) with an infectious trigger such as caries and periodontal disease are extremely common in the general population and can also have effects at the cardiovascular level. The oral salivary flow, with its buffering capacity, is able to regulate the pH of the OC and, ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(25):e26369]

Cited: 1 time

View full text PDF listing >>



Reactive Carbonyl Species and Protein Adducts: Identification Strategies, Biological Mechanisms and Molecular Approaches for Their Detoxification.

Giancarlo Aldini, Alessandra A Altomare,

The Special issue is composed of 13 contributions: 9 research papers and 4 reviews [...]. ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(5):]

Cited: 0 times

View full text PDF listing >>



Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation.

Sonia Eligini, Susanna Colli, Aida Habib, Giancarlo Aldini, Alessandra Altomare, Cristina Banfi,

The exposure of human endothelial cells to 3-morpholinosydnonimine (SIN-1) induced the expression of cyclooxygenase-2 (COX-2) in a dose- and time-dependent manner. Interestingly, after a prolonged incubation (>8 h) several proteoforms were visualized by Western blot, corresponding to different states of glycosylation of the protein. This effect was specific for SIN-1 ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(3):]

Cited: 1 time

View full text PDF listing >>



Differentially expressed proteins obtained by label-free quantitative proteomic analysis reveal affected biological processes and functions in Western diet-induced steatohepatitis.

Fernando Moreto, Artur J T Ferron, Fabiane V Francisqueti-Ferron, Alfonsina D'Amato, Jessica L Garcia, Mariane R Costa, Carol Cristina V A Silva, Alessandra Altomare, Camila Renata Correa, Giancarlo Aldini, Ana Lucia A Ferreira,

Nonalcoholic steatohepatitis (NASH) is a pathological manifestation with a progressive incidence in response to the epidemic of hepatic steatosis caused primarily by excessive energy intake. The present study unravels affected biological processes and functions by the presence of NASH in rats using a label-free quantitative proteomic strategy. NASH was induced ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(6):1-11]

Cited: 0 times

View full text PDF listing >>



Phenolic profiles and anti-inflammatory activities of sixteen table grape (Vitis vinifera L.) varieties.

Francesca Colombo, Chiara Di Lorenzo, Luca Regazzoni, Marco Fumagalli, Enrico Sangiovanni, Luís Peres de Sousa, Luigi Bavaresco, Diego Tomasi, Antonella Bosso, Giancarlo Aldini, Patrizia Restani, Mario Dell'Agli,

Several studies have shown that fresh grape and its derivatives contain phenolic compounds exhibiting antioxidant and health promoting effects, particularly in relation to the cardiovascular system. In this study, two methods were developed to characterize sixteen varieties of table and wine grapes: (1) a LC-MS method to identify major and ... Read more >>

Food Funct (Food & function)
[2019, 10(4):1797-1807]

Cited: 8 times

View full text PDF listing >>



Understanding the antioxidant and carbonyl sequestering activity of carnosine: direct and indirect mechanisms.

Giancarlo Aldini, Barbora de Courten, Luca Regazzoni, Ettore Gilardoni, Giulio Ferrario, Giovanna Baron, Alessandra Altomare, Alfonsina D'Amato, Giulio Vistoli, Marina Carini,

Carnosine is an endogenous dipeptide whose oral administration has been found to prevent several oxidative based diseases including lung disease, type 2 diabetes and its micro and macrovascular complications, cardiovascular disorders, neurodegenerative and kidney disease. While it is generally accepted that the beneficial effects of carnosine are due to its ... Read more >>

Free Radic Res (Free radical research)
[2021, 55(4):321-330]

Cited: 2 times

View full text PDF listing >>



Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases.

Erica Gianazza, Maura Brioschi, Alma Martinez Fernandez, Federica Casalnuovo, Alessandra Altomare, Giancarlo Aldini, Cristina Banfi,

<b><i>Significance:</i></b> Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and they constitute an ever-growing global burden that has a considerable socioeconomic impact on society. The ACVDs encompass diverse pathologies such as ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, 34(1):49-98]

Cited: 8 times

View full text PDF listing >>



Development of a direct LC-ESI-MS method for the measurement of human serum carnosinase activity.

Ettore Gilardoni, Silvia Gervasoni, Marco Maspero, Clelia Dallanoce, Giulio Vistoli, Marina Carini, Giancarlo Aldini, Luca Regazzoni,

Carnosine (β-alanyl-L-histidine) is a natural peptide that have been described as a potential pharmacological agent owing to some positive outcomes from several pharmacological tests in animal models of human diseases. However, carnosine has limited activity in humans since the peptide upon absorption is rapidly hydrolyzed in the serum by the ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2020, 189:113440]

Cited: 0 times

View full text PDF listing >>



Unveiling the molecular mechanisms underpinning biorecognition of early-glycated human serum albumin and receptor for advanced glycation end products.

Anna Tramarin, Marina Naldi, Genny Degani, Loredana Lupu, Pascal Wiegand, Angelica Mazzolari, Alessandra Altomare, Giancarlo Aldini, Laura Popolo, Giulio Vistoli, Michael Przybylski, Manuela Bartolini,

Serum levels of early-glycated albumin are significantly increased in patients with diabetes mellitus and may play a role in worsening inflammatory status and sustaining diabetes-related complications. To investigate possible pathological recognition involving early-glycated albumin and the receptor for advanced glycation end products (RAGE), an early-glycated human serum albumin (HSAgly), with ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2020, 412(18):4245-4259]

Cited: 0 times

View full text PDF listing >>



Binding modes identification through molecular dynamic simulations: A case study with carnosine enantiomers and the Teicoplanin A2-2-based chiral stationary phase.

Roccaldo Sardella, Federica Ianni, Lina Cossignani, Giancarlo Aldini, Andrea Carotti,

In the present study, an in silico methodology able to define the binding modes adopted by carnosine enantiomers in the setting of the chiral recognition process is described. The inter- and intramolecular forces involved in the enantioseparation process with the Teicoplanin A2-2 chiral selector and carnosine as model compound are ... Read more >>

J Sep Sci (Journal of separation science)
[2020, 43(9-10):1728-1736]

Cited: 1 time

View full text PDF listing >>



Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study.

Giulio Vistoli, Giancarlo Aldini, Laura Fumagalli, Clelia Dallanoce, Andrea Angeli, Claudiu T Supuran,

l-Carnosine (β-Ala-l-His) and several other histidine-containing peptides, including two N-methylated forms on the imidazole ring (l-anserine and l-balenine), two derivatives modified on the carboxyl function (carcinine and l-carnosinamide), two analogues differing in the length of the N-terminal residue (l-homocarnosine and Gly-l-His) and the N-acetyl derivatives, were investigated as activators of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

Cited: 5 times

View full text PDF listing >>



Author Correction: Effect of carnosine supplementation on the plasma lipidome in overweight and obese adults: a pilot randomised controlled trial.

Estifanos Baye, Jozef Ukropec, Maximilian P J de Courten, Silvia Vallova, Patrik Krumpolec, Timea Kurdiova, Giancarlo Aldini, Barbara Ukropcova, Barbora de Courten,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4384]

Cited: 0 times

View full text PDF listing >>



Advanced quantitative proteomics to evaluate molecular effects of low-molecular-weight hyaluronic acid in human dermal fibroblasts.

Silvia Radrezza, Giovanna Baron, Sarath Babu Nukala, Gabriele Depta, Giancarlo Aldini, Marina Carini, Alfonsina D'Amato,

Hyaluronic acid (HA) is physiologically synthesized by several human cells types but it is also a widespread ingredient of commercial products, from pharmaceuticals to cosmetics. Despite its extended use, the precise intra- and extra-cellular effects of HA at low-molecular-weight (LWM-HA) are currently unclear. At this regard, the aim of this ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2020, 185:113199]

Cited: 1 time

View full text PDF listing >>



In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism.

Igor Petkovic, Nikolaus Bresgen, Ettore Gilardoni, Luca Regazzoni, Koji Uchida, Giancarlo Aldini, Werner Siems, Peter Eckl,

Evidence suggests that the increased production of free radicals and reactive oxygen species lead to cellular aging. One of the consequences is lipid peroxidation generating reactive aldehydic products, such as 4-hydroxynonenal (HNE) that modify proteins and form adducts with DNA bases. To prevent damage by HNE, it is metabolized. The ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2020, 9(2):]

Cited: 0 times

View full text PDF listing >>



The Disposal of Reactive Carbonyl Species through Carnosine Conjugation: What We Know Now.

Ettore Gilardoni, Giovanna Baron, Alessandra Altomare, Marina Carini, Giancarlo Aldini, Luca Regazzoni,

Reactive Carbonyl Species are electrophiles generated by the oxidative cleavage of lipids and sugars. Such compounds have been described as important molecules for cellular signaling, whilst their accumulation has been found to be cytotoxic as they may trigger aberrant modifications of proteins (a process often referred to as carbonylation). A ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2020, 27(11):1726-1743]

Cited: 2 times

View full text PDF listing >>



Profiling Vaccinium macrocarpon components and metabolites in human urine and the urine ex-vivo effect on Candida albicans adhesion and biofilm-formation.

Giovanna Baron, Alessandra Altomare, Luca Regazzoni, Laura Fumagalli, Angelica Artasensi, Elisa Borghi, Emerenziana Ottaviano, Cristian Del Bo, Patrizia Riso, Pietro Allegrini, Giovanna Petrangolini, Paolo Morazzoni, Antonella Riva, Lolita Arnoldi, Marina Carini, Giancarlo Aldini,

The aim of this work was to profile, by using an HPLC-MS/MS method, cranberry compounds and metabolites found in human urine after ingestion of a highly standardized cranberry extract (Anthocran®). Two different strategies were adopted for the data analysis: a targeted and an untargeted approach. These strategies allowed the identification ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2020, 173:113726]

Cited: 7 times

View full text PDF listing >>



Differentially Expressed Proteins in Primary Endothelial Cells Derived From Patients With Acute Myocardial Infarction.

Sarath Babu Nukala, Luca Regazzoni, Giancarlo Aldini, Erika Zodda, Olga Tura-Ceide, Nicholas L Mills, Marta Cascante, Marina Carini, Alfonsina D'Amato,

Endothelial dysfunction is one of the primary factors in the onset and progression of atherothrombosis resulting in acute myocardial infarction (AMI). However, the pathological and cellular mechanisms of endothelial dysfunction in AMI have not been systematically studied. Protein expression profiling in combination with a protein network analysis was used by ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 74(4):947-956]

Cited: 3 times

View full text PDF listing >>



Advertisement


Disclaimer

1.0039 s