Full Text Journal Articles by
Author Gerard Sheehan

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Immune priming: the secret weapon of the insect world.

Gerard Sheehan, Gemma Farrell, Kevin Kavanagh,

Insects are a highly successful group of animals that inhabit almost every habitat and environment on Earth. Part of their success is due to a rapid and highly effective immune response that identifies, inactivates, and eliminates pathogens. Insects possess an immune system that shows many similarities to the innate immune ... Read more >>

Virulence (Virulence)
[2020, 11(1):238-246]

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What is the clinical course of patients hospitalised for COVID-19 treatment Ireland: a retrospective cohort study in Dublin’s North Inner City (the ‘Mater 100’)

Brendan O’Kelly*, Colm Cronin*, Stephen Peter Connolly*, Walter Cullen, Gordana Avramovic, Tina McHugh, Eileen O’Connor, Aoife Cotter, Peter Doran, Tara McGinty, Dermot O’Callaghan, Sean Gaine, Gerard Sheehan, Eamonn Brazil, Brian Marsh, John Lambert,

Abstract Background: Since March 2020, Ireland has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, while several cohorts from China have been described, our understanding is limited, with no data describing the epidemiological and clinical characteristics of patients with ... Read more >>

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Seizure with CSF lymphocytosis as a presenting feature of COVID-19 in an otherwise healthy young man.

Shane Lyons, Brendan O'Kelly, Sara Woods, Colm Rowan, Deirdre Brady, Gerard Sheehan, Shane Smyth,

Seizure (Seizure)
[2020, 80:113-114]

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Investigating the effect of antiretroviral switch to tenofovir alafenamide on lipid profiles in people living with HIV.

Aoife Lacey, Stefano Savinelli, Elena Alvarez Barco, Alan Macken, Aoife G Cotter, Gerard Sheehan, John S Lambert, Eavan Muldoon, Eoin Feeney, Patrick W Mallon, Willard Tinago, ,

BACKGROUND:Whilst reporting improved renal and bone safety profiles, studies have noted changes in lipid profiles among people living with HIV (PLWH) receiving antiretroviral therapy (ART) switching away from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF). We aimed to characterize changes in lipids observed after switching to TAF-containing ART in ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(8):1161-1170]

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Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection.

Inês T Freitas, Willard Tinago, Hirofumi Sawa, Julie McAndrews, Brenda Doak, Charlotte Prior-Fuller, Gerard Sheehan, John S Lambert, Eavan Muldoon, Aoife G Cotter, William W Hall, Patrick W G Mallon, Michael J Carr,

BACKGROUND:The objectives of this study were to investigate the relationships between polymorphisms at the interferon lambda (IFNL) locus and CD4+:CD8+ ratio normalisation in people living with HIV (PLWH) on effective antiretroviral therapy (ART); and to examine whether these polymorphisms influence the composition of T lymphocyte compartments in long-term treated HIV-1 ... Read more >>

AIDS Res Ther (AIDS research and therapy)
[2020, 17(1):13]

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Outcome of a patient with refractory Hodgkin lymphoma on pembrolizumab, infected with SARS-CoV-2.

Brendan O'Kelly, Padraig McGettrick, Daniel Angelov, Michael Fay, Tara McGinty, Aoife G Cotter, Gerard Sheehan, John S Lambert,

Br. J. Haematol. (British journal of haematology)
[2020, 190(1):e1-e3]

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Zinc Chelators as Carbapenem Adjuvants for Metallo-β-Lactamase-Producing Bacteria: In Vitro and In Vivo Evaluation.

Luigi Principe, Graziella Vecchio, Gerard Sheehan, Kevin Kavanagh, Gianluca Morroni, Valentina Viaggi, Alessandra di Masi, Daniele Roberto Giacobbe, Francesco Luzzaro, Roberto Luzzati, Stefano Di Bella,

Infections caused by metallo-β-lactamase (MBL)-producing bacteria are emerging and carry a significant impact on patients' outcome. MBL producers are spread worldwide, both in community and hospital setting, with increasingly reported epidemic clusters and the search for MBL inhibitors is an important topic for public health. MBLs are zinc-dependent enzymes whose ... Read more >>

Microb. Drug Resist. (Microbial drug resistance (Larchmont, N.Y.))
[2020, :]

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Exposure of Aspergillus fumigatus to Atorvastatin Leads to Altered Membrane Permeability and Induction of an Oxidative Stress Response.

Ahmad Ajdidi, Gerard Sheehan, Kevin Kavanagh,

Aspergillus fumigatus is a serious cause of disease in immune-deficient patients and in those with pulmonary malfunction (e.g., cystic fibrosis (CF), asthma). Atorvastatin is a member of the statin drug family, which are the main therapeutic agents used to decrease high serum cholesterol levels by inhibiting (HMG-CoA) reductase enzyme. The ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2020, 6(2):]

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Candida albicans increases the pathogenicity of Staphylococcus aureus during polymicrobial infection of Galleria mellonella larvae.

Gerard Sheehan, Laura Tully, Kevin A Kavanagh,

This study detailed the responses of Galleria mellonella larvae to disseminated infection caused by co-infection with Candida albicans and Staphylococcus aureus. Doses of C. albicans (1×105 larva-1) and S. aureus (1×104 larva-1) were non-lethal in mono-infection but when combined significantly (P<0.05) reduced larval survival at 24, 48 and 72 h relative ... Read more >>

Microbiology (Reading, Engl.) (Microbiology (Reading, England))
[2020, 166(4):375-385]

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Characterisation of the interaction of Pseudomonas putida and Pseudomonas tolaasii with Trichoderma aggressivum

Dejana Kosanovic, Helen Grogan, Kevin Kavanagh, Gerard Sheehan,

Green mould disease is caused by Trichoderma aggressivum which colonizes mushroom compost and reduces yield. Two Pseudomonas species are associated with mushroom compost: Pseudomonas putida, which stimulates mushroom pinning, and Pseudomonas tolaasii which has a negative effect on crop production. The aim of this work was to characterize T. aggressivum ... Read more >>

Eur. J. Plant Pathol. (European journal of plant pathology)
[2020, 156(1):111-121]

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Assessment of the in vitro and in vivo activity of atorvastatin against Candida albicans.

Ahmad Ajdidi, Gerard Sheehan, Khaled Abu Elteen, Kevin Kavanagh,

Aim. The aim of this work was to characterize the response of Candida albicans to atorvastatin, and to assess its in vivo antifungal capability.Methodology. The effect of atorvastatin on the growth and viability of C. albicans was assessed. The ability of the statin to alter cell permeability was quantified by ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2019, 68(10):1497-1506]

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Synthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity.

Farooq Ahmad Wani, Amaduddin, Babita Aneja, Gerard Sheehan, Kevin Kavanagh, Rabia Ahmad, Mohammad Abid, Rajan Patel,

Owing to the rise in antimicrobial and chemotherapeutic drug resistance, there is a desperate need to formulate newer as well as more effective agents. With this perspective, here we outline the synthesis of two novel gemini surfactants with different substitutions at the nitrogen atom of the benzimidazolium ring. Both the ... Read more >>

ACS Omega (ACS omega)
[2019, 4(7):11871-11879]

Cited: 1 time

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Utilization of Galleria mellonella larvae to characterize the development of Staphylococcus aureus infection.

Gerard Sheehan, Amy Dixon, Kevin Kavanagh,

Staphylococcus aureus is a human opportunistic pathogen that causes a wide range of superficial and systemic infections in susceptible patients. Here we describe how an inoculum of S. aureus activates the cellular and humoral response of Galleria mellonella larvae while growing and disseminating throughout the host, forming nodules and ultimately ... Read more >>

Microbiology (Reading, Engl.) (Microbiology (Reading, England))
[2019, 165(8):863-875]

Cited: 1 time

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Assessment of trabecular bone score, an index of bone microarchitecture, in HIV positive and HIV negative persons within the HIV UPBEAT cohort.

Tara McGinty, Aoife G Cotter, Caroline A Sabin, Alan Macken, Eoin Kavanagh, Juliet Compston, Gerard Sheehan, John Lambert, Patrick W G Mallon, ,

INTRODUCTION:Increased prevalence of low bone mineral density (BMD) and increased fracture incidence are observed in persons living with HIV (PLWH). The trabecular bone score (TBS) is a novel index of bone microarchitecture which improves fracture prediction independent of BMD. METHODS:The HIV UPBEAT study is a single centre, prospective cohort study ... Read more >>

PLoS ONE (PloS one)
[2019, 14(3):e0213440]

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Proteomic Analysis of the Responses of Candida albicans during Infection of Galleria mellonella Larvae.

Gerard Sheehan, Kevin Kavanagh,

This study assessed the development of disseminated candidiasis within Galleria mellonella larvae and characterized the proteomic responses of Candida albicans to larval hemolymph. Infection of larvae with an inoculum of 1 × 10⁶ yeast cells reduced larval viability 24 (53.33 ± 3.33%), 48 (33.33 ± 3.33%) and 72 (6.66 ± ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2019, 5(1):]

Cited: 1 time

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Exposure to N-chlorotaurine induces oxidative stress responses in Aspergillus fumigatus.

Gerard Sheehan, Markus Nagl, Kevin Kavanagh,

PURPOSE:The neutrophil-derived oxidant N-chlorotaurine (NCT) displays remarkable in vivo tolerability and efficacy against a range of pathogens. The aim of this study was to characterize the response of the pulmonary pathogen Aspergillus fumigatus to NCT. METHODOLOGY:The effect of NCT on the growth and viability of A. fumigatus was characterized. NCT-induced ... Read more >>

J. Med. Microbiol. (Journal of medical microbiology)
[2019, 68(2):279-288]

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The Use of Galleria mellonella Larvae to Identify Novel Antimicrobial Agents against Fungal Species of Medical Interest.

Kevin Kavanagh, Gerard Sheehan,

The immune system of insects and the innate immune response of mammals share many similarities and, as a result, insects may be used to assess the virulence of fungal pathogens and give results similar to those from mammals. Larvae of the greater wax moth Galleria mellonella are widely used in ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2018, 4(3):]

Cited: 6 times

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The Human Cathelicidin Antimicrobial Peptide LL-37 Promotes the Growth of the Pulmonary Pathogen Aspergillus fumigatus.

Gerard Sheehan, Gudmundur Bergsson, Noel G McElvaney, Emer P Reeves, Kevin Kavanagh,

The pulmonary mucus of cystic fibrosis (CF) patients displays elevated levels of the cathelicidin antimicrobial peptide LL-37, and the aim of this work was to assess the effect of LL-37 on the growth of Aspergillus fumigatus, a common pathogen of CF patients. Exposure of A. fumigatus to LL-37 and its ... Read more >>

Infect. Immun. (Infection and immunity)
[2018, 86(7):]

Cited: 1 time

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Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis.

Gerard Sheehan, Gráinne Clarke, Kevin Kavanagh,

BACKGROUND:Galleria mellonella larvae were infected with conidia of Aspergillus fumigatus and the cellular and humoral immune responses of larvae to the pathogen were characterized as invasive aspergillosis developed. RESULTS:At 2 h post-infection there was an increase in hemocyte density to 7.43 ± 0.50 × 106/ml from 0.98 ± 0.08 × 106/ml at 0 h. Hemocytes from larvae immune primed for ... Read more >>

BMC Microbiol. (BMC microbiology)
[2018, 18(1):63]

Cited: 6 times

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Innate humoral immune defences in mammals and insects: The same, with differences ?

Gerard Sheehan, Amy Garvey, Michael Croke, Kevin Kavanagh,

The insect immune response demonstrates many similarities to the innate immune response of mammals and a wide range of insects is now employed to assess the virulence of pathogens and produce results comparable to those obtained using mammals. Many of the humoral responses in insects and mammals are similar (e.g. ... Read more >>

Virulence (Virulence)
[2018, 9(1):1625-1639]

Cited: 3 times

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Analysis of the early cellular and humoral responses of Galleria mellonella larvae to infection by Candida albicans.

Gerard Sheehan, Kevin Kavanagh,

Galleria mellonella larvae were administered an inoculum of Candida albicans and the response to infection over 24 hours was monitored. The yeast cell density in infected larvae declined initially but replication commenced six hours post-infection. The hemocyte density decreased from 5.2 × 106/ml to 2.5 × 106/ml at 2 hours but increased ... Read more >>

Virulence (Virulence)
[2018, 9(1):163-172]

Cited: 12 times

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Extracorporeal membrane oxygenation in an HIV-positive man with severe acute respiratory distress syndrome secondary to pneumocystis and cytomegalovirus pneumonia.

Deirdre Morley, Almida Lynam, Edmund Carton, Ignacio Martin-Loeches, Gerard Sheehan, Niamh Lynn, Serena O'Brien, Fiona Mulcahy,

The management of critically ill human immunodeficiency virus (HIV)-positive patients is challenging; however, intensive care unit-related mortality has declined significantly in recent years. There are 10 case reports in the literature of extracorporeal membrane oxygenation (ECMO) use in HIV-positive patients, of whom seven survived to hospital discharge. We describe a ... Read more >>

Int J STD AIDS (International journal of STD & AIDS)
[2018, 29(2):198-202]

Cited: 1 time

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Experience of dolutegravir in HIV-infected treatment-naive patients from a tertiary care University Hospital in Ireland.

Sarmad Waqas, Mairead O'Connor, Ciara Levey, Paddy Mallon, Gerard Sheehan, Anjali Patel, Gordana Avramovic, John S Lambert,

Dolutegravir, an HIV integrase inhibitor, is a relatively new treatment option. To assess the tolerability, side effects, and time to viral decline to non-detectable in patients newly started on dolutegravir.Retrospective health care record of 61 consecutive HIV treatment-naive patients started on dolutegravir was reviewed and analysed on SPSS.The mean initial ... Read more >>

SAGE Open Med (SAGE open medicine)
[2016, 4:2050312116675813]

Cited: 1 time

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Injection of new psychoactive substance snow blow associated with recently acquired HIV infections among homeless people who inject drugs in Dublin, Ireland, 2015.

Coralie Giese, Derval Igoe, Zorina Gibbons, Caroline Hurley, Siobhan Stokes, Sinead McNamara, Orla Ennis, Kate O'Donnell, Eamon Keenan, Cillian De Gascun, Fiona Lyons, Mary Ward, Kostas Danis, Ronan Glynn, Allison Waters, Margaret Fitzgerald, ,

In February 2015, an outbreak of recently acquired HIV infections among people who inject drugs (PWID) was identified in Dublin, following similar outbreaks in Greece and Romania in 2011. We compared drug and risk behaviours among 15 HIV cases and 39 controls. Injecting a synthetic cathinone, snow blow, was associated ... Read more >>

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2015, 20(40):]

Cited: 9 times

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Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: effect of naïve and memory T-cell subsets.

Willard Tinago, Elizabeth Coghlan, Alan Macken, Julie McAndrews, Brenda Doak, Charlotte Prior-Fuller, John S Lambert, Gerard J Sheehan, Patrick W G Mallon, ,

BACKGROUND: Although effective antiretroviral therapy(ART) increases CD4+ T-cell count, responses to ART vary considerably and only a minority of patients normalise their CD4+/CD8+ ratio. Although retention of naïve CD4+ T-cells is thought to predict better immune responses, relationships between CD4+ and CD8+ T-cell subsets and CD4+/CD8+ ratio have not been ... Read more >>

PLoS ONE (PloS one)
[2014, 9(5):e97011]

Cited: 24 times

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