Full Text Journal Articles by
Author Ger van Zandbergen

Advertisement

Find full text journal articles






The Flagellin:Allergen Fusion Protein rFlaA:Betv1 Induces a MyD88- and MAPK-Dependent Activation of Glucose Metabolism in Macrophages.

Yen-Ju Lin, Garibald Papp, Csaba Miskey, Anna Fiedler, Alexandra Goretzki, Sonja Wolfheimer, Jennifer Zimmermann, Peter Crauwels, Zoltán Ivics, Ger van Zandbergen, Stefan Vieths, Stephan Scheurer, Stefan Schülke,

TLR5 ligand flagellin-containing fusion proteins are potential vaccine candidates for many diseases. A recombinant fusion protein of flagellin A and the major birch pollen allergen Bet v 1 (rFlaA:Betv1) modulates immune responses in vitro and in vivo. We studied the effects of rFlaA:Betv1 on bone marrow-derived macrophages (BMDMs). BMDMs differentiated ... Read more >>

Cells (Cells)
[2021, 10(10):]

Cited: 0 times

View full text PDF listing >>



Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response.

Laura Roßmann, Katrin Bagola, Tharshana Stephen, Anna-Lisa Gerards, Bianca Walber, Anja Ullrich, Stefan Schülke, Christel Kamp, Ingo Spreitzer, Milena Hasan, Brigitte David-Watine, Spencer L Shorte, Max Bastian, Ger van Zandbergen,

The COVID-19 pandemic highlights the importance of efficient and safe vaccine development. Vaccine adjuvants are essential to boost and tailor the immune response to the corresponding pathogen. To allow for an educated selection, we assessed the effect of different adjuvants on human monocyte-derived dendritic cells (DCs) and their ability to ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(39):]

Cited: 0 times

View full text PDF listing >>



Advertisement

The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies.

Patricia Gogesch, Simone Dudek, Ger van Zandbergen, Zoe Waibler, Martina Anzaghe,

Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indications. In order to ensure clinical efficacy ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(16):]

Cited: 0 times

View full text PDF listing >>



Enhanced activation of blood neutrophils and monocytes in patients with Ethiopian localized cutaneous leishmaniasis in response to Leishmania aethiopica Neutrophil activation in Ethiopian cutaneous leishmaniasis.

Menberework Chanyalew, Markos Abebe, Birtukan Endale, Selfu Girma, Geremew Tasew, Kidist Bobosha, Martha Zewide, Rawleigh Howe, Ger van Zandbergen, Uwe Ritter, Endalamaw Gadisa, Abraham Aseffa, Tamás Laskay,

Recent studies suggest an essential role of the innate immune effector cells neutrophils and monocytes in protection or disease progression in the early course of Leishmania infection. In areas endemic for cutaneous leishmaniasis in Ethiopia most individuals are exposed to bites of infected sandflies. Still only a minor ratio of ... Read more >>

Acta Trop (Acta tropica)
[2021, 220:105967]

Cited: 0 times

View full text PDF listing >>



Human monocyte-derived type 1 and 2 macrophages recognize Ara h 1, a major peanut allergen, by different mechanisms.

Maren Krause, Peter Crauwels, Frank Blanco-Pérez, Martin Globisch, Andrea Wangorsch, Thomas Henle, Jonas Lidholm, Ger van Zandbergen, Stefan Vieths, Stephan Scheurer, Masako Toda,

Evidence has suggested that major peanut allergen Ara h 1 activates dendritic cells (DCs) via interaction with DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin), a C-type lectin receptor, and contributes to development of peanut allergy. Since macrophages, as well as DCs, play a crucial role in innate immunity, we investigated ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):10141]

Cited: 0 times

View full text PDF listing >>



Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.

Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L Shorte, Brigitte David-Watine, ,

[This corrects the article DOI: 10.3389/fimmu.2020.569331.]. ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:685768]

Cited: 0 times

View full text PDF listing >>



[Therapeutic vaccination for tumors and neurodegenerative diseases].

Verena Scheer, Mark Goldammer, Sven Flindt, Ger van Zandbergen, Thomas Hinz,

Therapeutic vaccines are intended for the treatment of established diseases by harnessing the patient's own immune system. In this article we discuss therapeutic areas that are of relevance for therapeutic vaccination, i.e., oncology and neurodegenerative diseases. Clinical and regulatory aspects related to the manufacture and clinical use of actively personalized ... Read more >>

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
[2020, 63(11):1373-1379]

Cited: 0 times

View full text PDF listing >>



[Checkpoint inhibitors for cancer therapy].

Hilke Zander, Susanne Müller-Egert, Michal Zwiewka, Steffen Groß, Ger van Zandbergen, Jörg Engelbergs,

In recent years, a breakthrough in tumor therapy was achieved with the development of checkpoint inhibitors. Checkpoint inhibitors activate the immune defense against tumors by overcoming the inhibitory effect of specific cell surface proteins acting as control points, the so-called checkpoints. This article provides an overview of the mode of ... Read more >>

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
[2020, 63(11):1322-1330]

Cited: 0 times

View full text PDF listing >>



Enhanced production of pro-inflammatory cytokines and chemokines in Ethiopian cutaneous leishmaniasis upon exposure to Leishmania aethiopica.

Menberework Chanyalew, Markos Abebe, Birtukan Endale, Selfu Girma, Geremew Tasew, Ger van Zandbergen, Uwe Ritter, Endalamaw Gadisa, Abraham Aseffa, Tamás Laskay,

The clinical course and outcome of cutaneous leishmaniasis (CL) vary due to the infecting Leishmania species and host genetic makeup that result in different immune responses against the parasites. The host immune response to Leishmania aethiopica (L.aethiopica), the causative agent of CL in Ethiopia, is poorly understood. To contribute to ... Read more >>

Cytokine (Cytokine)
[2021, 145:155289]

Cited: 0 times

View full text PDF listing >>



Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols.

Audrey Chansard, Nelly Dubrulle, Mathilde Poujol de Molliens, Pierre B Falanga, Tharshana Stephen, Milena Hasan, Ger van Zandbergen, Nathalie Aulner, Spencer L Shorte, Brigitte David-Watine,

The <i>LabEx Milieu Interieur</i> (<i>MI</i>) project is a clinical study centered on the detailed characterization of the baseline and induced immune responses in blood samples from 1,000 healthy donors. Analyses of these samples has lay ground for seminal studies on the genetic and environmental determinants of immunologic variance in a ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:569331]

Cited: 0 times

View full text PDF listing >>



Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages.

Peter Crauwels, Elena Bank, Bianca Walber, Ulf Alexander Wenzel, Birgitta Agerberth, Menberework Chanyalew, Markos Abebe, Renate König, Uwe Ritter, Norbert Reiling, Ger van Zandbergen,

In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of the human cathelicidin <i>CAMP</i> in skin lesions of Ethiopian patients with cutaneous leishmaniasis. Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP) play an important role in the elimination of invading microorganisms. ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:2697]

Cited: 4 times

View full text PDF listing >>



HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.

Patrick Neubert, Andrea Weichselbaum, Carmen Reitinger, Valentin Schatz, Agnes Schröder, John R Ferdinand, Michaela Simon, Anna-Lorena Bär, Christoph Brochhausen, Roman G Gerlach, Stefan Tomiuk, Karin Hammer, Stefan Wagner, Ger van Zandbergen, Katrina J Binger, Dominik N Müller, Kento Kitada, Menna R Clatworthy, Christian Kurts, Jens Titze, Zeinab Abdullah, Jonathan Jantsch,

Infection and inflammation are able to induce diet-independent Na<sup>+</sup>-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na<sup>+</sup>-boosted host defense against the protozoan parasite <i>Leishmania major</i> is mediated by increased expression of the leishmanicidal NOS2 ... Read more >>

Autophagy (Autophagy)
[2019, 15(11):1899-1916]

Cited: 17 times

View full text PDF listing >>



Anti-Tumor Necrosis Factor α Therapeutics Differentially Affect Leishmania Infection of Human Macrophages.

Katharina Arens, Christodoulos Filippis, Helen Kleinfelder, Arthur Goetzee, Gabriele Reichmann, Peter Crauwels, Zoe Waibler, Katrin Bagola, Ger van Zandbergen,

Tumor necrosis factor α (TNFα) drives the pathophysiology of human autoimmune diseases and consequently, neutralizing antibodies (Abs) or Ab-derived molecules directed against TNFα are essential therapeutics. As treatment with several TNFα blockers has been reported to entail a higher risk of infectious diseases such as leishmaniasis, we established an <i>in ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:1772]

Cited: 1 time

View full text PDF listing >>



Type-1 interferons prolong the lifespan of neutrophils by interfering with members of the apoptotic cascade.

Eresso Aga, Arkajyoti Mukherjee, Deepti Rane, Vasundhara More, Tejaswini Patil, Ger van Zandbergen, Werner Solbach, Jagneswar Dandapat, Heidi Tackenberg, Mareike Ohms, Arup Sarkar, Tamás Laskay,

Polymorphonuclear Neutrophils (PMNs) are metabolically highly active phagocytes, present in abundant numbers in the circulation. These active cells take the onus of clearing invading pathogens by crowding at inflammatory sites in huge numbers. Though PMNs are extremely short living and die upon spontaneous apoptosis, extended lifespan has been observed among ... Read more >>

Cytokine (Cytokine)
[2018, 112:21-26]

Cited: 3 times

View full text PDF listing >>



Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development.

Nicole Zimara, Menberework Chanyalew, Abraham Aseffa, Ger van Zandbergen, Bernd Lepenies, Maximilian Schmid, Richard Weiss, Anne Rascle, Anja Kathrin Wege, Jonathan Jantsch, Valentin Schatz, Gordon D Brown, Uwe Ritter,

Resistant mouse strains mount a protective T cell-mediated immune response upon infection with <i>Leishmania</i> (L.) parasites. Healing correlates with a T helper (Th) cell-type 1 response characterized by a pronounced IFN-γ production, while susceptibility is associated with an IL-4-dependent Th2-type response. It has been shown that dermal dendritic cells are ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:263]

Cited: 4 times

View full text PDF listing >>



Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner.

Christodoulos Filippis, Katharina Arens, Gaetan Aime Noubissi Nzeteu, Gabriele Reichmann, Zoe Waibler, Peter Crauwels, Ger van Zandbergen,

Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector functions, which are required for parasite control during leishmaniasis. The aim ... Read more >>

Front Immunol (Frontiers in immunology)
[2017, 8:1880]

Cited: 2 times

View full text PDF listing >>



LC3-associated phagocytosis in microbial pathogenesis.

Stefan Schille, Peter Crauwels, Rebecca Bohn, Katrin Bagola, Paul Walther, Ger van Zandbergen,

Phagocytosis is essential for uptake and elimination of pathogenic microorganisms. Autophagy is a highly conserved mechanism for incorporation of cellular constituents to replenish nutrients by degradation. Recently, parts of the autophagy machinery - above all microtubule-associated protein 1 light chain 3 (LC3) - were found to be specifically recruited to ... Read more >>

Int J Med Microbiol (International journal of medical microbiology : IJMM)
[2018, 308(1):228-236]

Cited: 15 times

View full text PDF listing >>



In silico prediction of Leishmania major-specific CD8+ epitopes.

Kirsten Dietze-Schwonberg, Beatrix Grewe, Sven Brosch, Joerg Kuharev, Ger van Zandbergen, Hans-Georg Rammensee, Stefan Tenzer, Esther von Stebut,

Infections with Leishmania (L.) major induce protective IFN-γ-dependent Th1/Tc1 immunity in C57BL/6 mice as well as in immunocompetent humans. Even though antigen-specific immunity provides lifelong immunity against reinfection, a vaccine against this pathogen does not yet exist. Here, we compared the results obtained from in silico predictions of murine CD8-specific ... Read more >>

Exp Dermatol (Experimental dermatology)
[2017, 26(9):838-840]

Cited: 1 time

View full text PDF listing >>



Past, present and future of immunology in Mainz.

Ari Waisman, Nadine Hövelmeyer, Andreas Diefenbach, Detlef Schuppan, Mathhias J Reddehase, Hartmut Kleinert, Bernd Kaina, Stephan Grabbe, Peter R Galle, Matthias Theobald, Frauke Zipp, Ugur Sahin, Öslem Türeci, Sebastian Kreiter, Peter Langguth, Heinz Decker, Ger van Zandbergen, Hansjörg Schild,

Cell Immunol (Cellular immunology)
[2016, 308:1-6]

Cited: 0 times

View full text PDF listing >>



In vitro permissiveness of bovine neutrophils and monocyte derived macrophages to Leishmania donovani of Ethiopian isolate.

Geremew Tasew, Endalamaw Gadisa, Adugna Abera, Aboma Zewude, Menberework Chanyalew, Abraham Aseffa, Markos Abebe, Uwe Ritter, Ger van Zandbergen, Tamás Laskay, Ketema Tafess,

<h4>Background</h4>Epidemiological studies in Ethiopia have documented that the risk of visceral leishmaniasis (VL, Kala-azar) is higher among people living with domestic animals. The recent report on isolation of Leishmania donovani complex DNA and the detected high prevalence of anti-leishmanial antibodies in the blood of domestic animals further strengthen the potential ... Read more >>

Parasit Vectors (Parasites & vectors)
[2016, 9:218]

Cited: 1 time

View full text PDF listing >>



An Emerging Approach for Parallel Quantification of Intracellular Protozoan Parasites and Host Cell Characterization Using TissueFAXS Cytometry.

Maximilian Schmid, Bianca Dufner, Julius Dürk, Konstanze Bedal, Kristina Stricker, Lukas Ali Prokoph, Christoph Koch, Anja K Wege, Henner Zirpel, Ger van Zandbergen, Rupert Ecker, Bogdan Boghiu, Uwe Ritter,

Characterization of host-pathogen interactions is a fundamental approach in microbiological and immunological oriented disciplines. It is commonly accepted that host cells start to change their phenotype after engulfing pathogens. Techniques such as real time PCR or ELISA were used to characterize the genes encoding proteins that are associated either with ... Read more >>

PLoS One (PloS one)
[2015, 10(10):e0139866]

Cited: 6 times

View full text PDF listing >>



Mechanisms of apoptosis inhibition in Chlamydia pneumoniae-infected neutrophils.

Arup Sarkar, Sonja Möller, Asima Bhattacharyya, Martina Behnen, Jan Rupp, Ger van Zandbergen, Werner Solbach, Tamás Laskay,

The obligatory intracellular bacterium Chlamydia pneumoniae (C. pneumoniae) can survive and multiply in neutrophil granulocytes. Since neutrophils are short living cells, inhibition of neutrophil apoptosis appears to play a major role in the productive infection of neutrophils by C. pneumoniae. In the present study, we have investigated which survival pathways ... Read more >>

Int J Med Microbiol (International journal of medical microbiology : IJMM)
[2015, 305(6):493-500]

Cited: 14 times

View full text PDF listing >>



Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell-mediated parasite elimination.

Peter Crauwels, Rebecca Bohn, Meike Thomas, Stefan Gottwalt, Florian Jäckel, Susi Krämer, Elena Bank, Stefan Tenzer, Paul Walther, Max Bastian, Ger van Zandbergen,

Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis-like cell death has been described. Moreover upon infection, the apoptotic-like population is essential for disease development, in part by silencing host phagocytes. Nevertheless, the ... Read more >>

Autophagy (Autophagy)
[2015, 11(2):285-297]

Cited: 31 times

View full text PDF listing >>



Recombinant human IgA1 and IgA2 autoantibodies to type VII collagen induce subepidermal blistering ex vivo.

Andreas Recke, Luisa M Trog, Hendri H Pas, Artem Vorobyev, Aida Abadpour, Marcel F Jonkman, Ger van Zandbergen, Claudia Kauderer, Detlef Zillikens, Gestur Vidarsson, Ralf J Ludwig,

Subepidermal autoimmune blistering dermatoses (AIBD) are prototypic autoantibody-mediated diseases. In epidermolysis bullosa acquisita (EBA), an autoimmune disease with severe and chronic skin blistering, autoantibodies are directed against type VII collagen. IgG is the predominant autoantibody isotype of EBA, the pathogenicity of which has been demonstrated in a variety of in ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2014, 193(4):1600-1608]

Cited: 10 times

View full text PDF listing >>



The β-hemolysin and intracellular survival of Streptococcus agalactiae in human macrophages.

Anubha Sagar, Carolin Klemm, Lara Hartjes, Stefanie Mauerer, Ger van Zandbergen, Barbara Spellerberg,

S. agalactiae (group B streptococci, GBS) is a major microbial pathogen in human neonates and causes invasive infections in pregnant women and immunocompromised individuals. The S. agalactiae β-hemolysin is regarded as an important virulence factor for the development of invasive disease. To examine the role of β-hemolysin in the interaction ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e60160]

Cited: 11 times

View full text PDF listing >>



Advertisement


Disclaimer

1.6474 s