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Author Georgi Guruli

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ROBOT-ASSISTED URETERAL REIMPLANTATION: A SINGLE CENTER COMPARATIVE STUDY.

Umberto Carbonara, Brandee Branche, Theodore Cisu, Fabio Crocerossa, Georgi Guruli, Mayer B Grob, Tyler Roseman, Lance J Hampton, Riccardo Autorino,

<h4>Background</h4>To report a single-center experience with robot-assisted ureteral reimplantation (RAUR) and to compare its outcomes with those of open ureteral reimplantation (OUR).<h4>Materials and methods</h4>Patients who underwent RAUR or OUR for ureteral disease between 2016 and 2020 were identified. Data collected included baseline, pathological, perioperative and postoperative features. The RAUR outcomes ... Read more >>

J Endourol (Journal of endourology)
[2021, :]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Corrigendum to 'Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC)' [European Urology Oncology 3 (2021) 256-263].

Michele Marchioni, Maximilian Kriegmair, Mathias Heck, Thomas Amiel, Francesco Porpiglia, Enrico Checcucci, Riccardo Campi, Andrea Minervini, Andrea Mari, Siska Van Bruwaene, Estefania Linares, Vital Hevia, Mireia Musquera, Mauricio D'Anna, Ithaar Derweesh, Aaron Bradshaw, Riccardo Autorino, Georgi Guruli, Alessandro Veccia, Eduard Roussel, Maarten Albersen, Nicola Pavan, Francesco Claps, Alessandro Antonelli, Carlotta Palumbo, Tobias Klatte, Selcuk Erdem, Maria Carmen Mir, ,

Eur Urol Oncol (European urology oncology)
[2021, 4(3):517]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC).

Michele Marchioni, Maximilian Kriegmair, Mathias Heck, Thomas Amiel, Francesco Porpiglia, Enrico Ceccucci, Riccardo Campi, Andrea Minervini, Andrea Mari, Siska Van Bruwaene, Estefania Linares, Vital Hevia, Mireia Musquera, Mauricio D'Anna, Ithaar Derweesh, Aaron Bradshaw, Riccardo Autorino, Georgi Guruli, Alessandro Veccia, Eduard Roussel, Maarten Albersen, Nicola Pavan, Francesco Claps, Alessandro Antonelli, Carlotta Palumbo, Tobias Klatte, Selcuk Erdem, Maria Carmen Mir, ,

<h4>Background</h4>Selection of patients for upfront cytoreductive nephrectomy (CN) in metastatic renal cell carcinoma (mRCC) has to be improved.<h4>Objective</h4>To evaluate a new scoring system for the prediction of overall mortality (OM) in mRCC patients undergoing CN.<h4>Design, setting, and participants</h4>We identified a total of 519 patients with synchronous mRCC undergoing CN between ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(2):256-263]

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Combining Two Classes of Epigenetic Modifiers and Their Effect on Prostate Cancer Cells

Mudassir Lodi, Ekaterine Goliadze, Masoud Manjili, Georgi Guruli,

The main objective of this experiment was to determine and study the effects of combining two epigenetic modifiers, 5-azacyticidine (5-AzaC) and SB939, on a RM-1 murine prostate cancer cell model. The effectiveness of this combination on prostate cancer cells has not been previously studied. The study was implemented on ex ... Read more >>

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A Preoperative Nomogram to Predict Renal Function Insufficiency for Cisplatin-based Adjuvant Chemotherapy Following Minimally Invasive Radical Nephroureterectomy (ROBUUST Collaborative Group).

Zhenjie Wu, Qi Chen, Hooman Djaladat, Andrea Minervini, Robert G Uzzo, Chandru P Sundaram, Koon H Rha, Mark L Gonzalgo, Reza Mehrazin, Elio Mazzone, Jamil Marcus, Alyssa Danno, James Porter, Aeen Asghar, Fady Ghali, Georgi Guruli, Antoin Douglawi, Giovanni Cacciamani, Alireza Ghoreifi, Giuseppe Simone, Vitaly Margulis, Matteo Ferro, Riccardo Tellini, Andrea Mari, Abhishek Srivastava, James Steward, Ali Al-Qathani, Ahmad Al-Mujalhem, Amit Satish Bhattu, Alexander Mottrie, Firas Abdollah, Daniel D Eun, Ithaar Derweesh, Alessandro Veccia, Riccardo Autorino, Linhui Wang,

<h4>Background</h4>Postoperative renal function impairment represents a main limitation for delivering adjuvant chemotherapy after radical nephroureterectomy (RNU).<h4>Objective</h4>To create a model predicting renal function decline after minimally invasive RNU.<h4>Design, setting, and participants</h4>A total of 490 patients with nonmetastatic UTUC who underwent minimally invasive RNU were identified from a collaborative database including 17 ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Trimodal therapy in muscle invasive bladder cancer management.

Elvira Polo-Alonso, Cynthia Kuk, Georgi Guruli, Asit K Paul, George Thalmann, Ashish Kamat, Eduardo Solsona, George Thalmann, Alfredo I Urdaneta, Alexandre R Zlotta, Maria C Mir,

<h4>Introduction</h4>Radical cystectomy (RC) is the current mainstay for muscle-invasive bladder cancer (MIBC). Concerns regarding morbidity, mortality and quality of life have favored the introduction of bladder sparing strategies. Trimodal therapy, combining transurethral resection, chemotherapy and radiotherapy is the current standard of care for bladder preservation strategies in selected patients with ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2020, 72(6):650-662]

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Ureteral location is associated with survival outcomes in upper tract urothelial carcinoma: A population-based analysis.

Alessandro Veccia, Alessandro Antonelli, Alberto Martini, Ugo Falagario, Giuseppe Carrieri, Mayer B Grob, Georgi Guruli, Claudio Simeone, Peter Wiklund, Francesco Porpiglia, Riccardo Autorino,

<h4>Objectives</h4>To evaluate the prognostic value of tumor location in patients with upper tract urothelial carcinoma.<h4>Methods</h4>Within the Surveillance, Epidemiology and End Results Incidence Database, 6619 upper tract urothelial carcinoma cases were identified, including 3719 confined to the renal pelvis and 2971 to the ureter. Predictors of surgical technique (kidney sparing surgery ... Read more >>

Int J Urol (International journal of urology : official journal of the Japanese Urological Association)
[2020, 27(11):966-972]

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Local and distant tumor dormancy during early stage breast cancer are associated with the predominance of infiltrating T effector subsets.

Hussein F Aqbi, Cara Coleman, Melika Zarei, Saeed H Manjili, Laura Graham, Jennifer Koblinski, Chunquing Guo, Yibin Xie, Georgi Guruli, Harry D Bear, Michael O Idowu, Mehran Habibi, Xiang-Yang Wang, Masoud H Manjili,

<h4>Background</h4>Although breast cancer mortality is a result of distant recurrences associated with the establishment of tumor dormancy, current clinical practice guidelines recommend a wait and watch approach for tumor recurrences. This is because of our limited understanding of tumor dormancy and insufficient evidence in support of immunological control of tumor ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2020, 22(1):116]

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Raman chemometric urinalysis (Rametrix) as a screen for bladder cancer.

Herbert M Huttanus, Tommy Vu, Georgi Guruli, Andrew Tracey, William Carswell, Neveen Said, Pang Du, Bing G Parkinson, Giuseppe Orlando, John L Robertson, Ryan S Senger,

Bladder cancer (BCA) is relatively common and potentially recurrent/progressive disease. It is also costly to detect, treat, and control. Definitive diagnosis is made by examination of urine sediment, imaging, direct visualization (cystoscopy), and invasive biopsy of suspect bladder lesions. There are currently no widely-used BCA-specific biomarker urine screening tests for ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0237070]

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Rates and Predictors of Perioperative Complications in Cytoreductive Nephrectomy: Analysis of the Registry for Metastatic Renal Cell Carcinoma.

Eduard Roussel, Riccardo Campi, Alessandro Larcher, Annelies Verbiest, Alessandro Antonelli, Carlotta Palumbo, Ithaar Derweesh, Fady Ghali, Aaron Bradshaw, Margaret F Meagher, Matthias Heck, Thomas Amiel, Maximilian C Kriegmair, Jose Rubio, Mireia Musquera, Maurizio D'Anna, Riccardo Autorino, Georgi Guruli, Alessandro Veccia, Estefania Linares-Espinos, Siska Van Bruwaene, Vital Hevia, Francesco Porpiglia, Enrico Checcucci, Andrea Minervini, Andrea Mari, Nicola Pavan, Francesco Claps, Michele Marchioni, Umberto Capitanio, Benoit Beuselinck, Maria C Mir, Maarten Albersen, ,

<h4>Background</h4>Cytoreductive nephrectomy (CN) plays an important role in the treatment of a subgroup of metastatic renal cell carcinoma (mRCC) patients.<h4>Objective</h4>We aimed to evaluate morbidity associated with this procedure and identify potential predictors thereof to aid patient selection for this procedure and potentially improve patient outcomes.<h4>Design, setting, and participants</h4>Data from 736 ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(4):523-529]

Cited: 2 times

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Radical penectomy, a compromise for life: results from the PECAD study.

Jamil Ghahhari, Michele Marchioni, Philippe E Spiess, Juan J Chipollini, Peter Nyirády, Judith Varga, Pasquale Ditonno, Stefano Boccasile, Giulia Primiceri, Cosimo De Nunzio, Giorgia Tema, Andrea Tubaro, Alessandro Veccia, Alessandro Antonelli, Gennaro Musi, Ottavio De Cobelli, Andrea Conti, Stefano Puliatti, Salvatore Micali, Mario Álvarez-Maestro, José Quesada Olarte, Erico Diogenes, Marcos Venicio Alves Lima, Andrew Tracey, Georgi Guruli, Riccardo Autorino, Petros Sountoulides, Roman Sosnowski, Luigi Schips, Luca Cindolo,

<h4>Background</h4>The use of organ sparing strategies to treat penile cancer (PC) is currently supported by evidence that has indicated the safety, efficacy and benefit of this surgery. However, radical penectomy still represents up to 15-20% of primary tumor treatments in PC patients. The aim of the study was to evaluate ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(3):1306-1313]

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Robotic versus other nephroureterectomy techniques: a systematic review and meta-analysis of over 87,000 cases.

Alessandro Veccia, Alessandro Antonelli, Simone Francavilla, Claudio Simeone, Georgi Guruli, Homayoun Zargar, Sisto Perdoná, Matteo Ferro, Giuseppe Carrieri, Lance J Hampton, Francesco Porpiglia, Riccardo Autorino,

<h4>Purpose</h4>To perform a systematic review and meta-analysis of the literature inherent robotic nephroureterectomy (RNU) and to compare its outcomes with those of other nephroureterectomy (NU) techniques.<h4>Methods</h4>A systematic literature search was performed up to April 2019 using PubMed, Embase®, and Web of Science. The Preferred Reporting Items for Systematic Review and ... Read more >>

World J Urol (World journal of urology)
[2020, 38(4):845-852]

Cited: 2 times

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Segmental Ureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review and Meta-analysis of Comparative Studies.

Alessandro Veccia, Alessandro Antonelli, Enrico Checcucci, Ugo Falagario, Giuseppe Carrieri, Georgi Guruli, Marco De Sio, Claudio Simeone, Francesco Porpiglia, Riccardo Autorino,

Radical nephroureterectomy (RNU) represents the standard of care for high-risk upper tract urothelial carcinoma (UTUC). In selected patients with ureteral UTUC, a conservative approach such as segmental ureterectomy (SU) can be considered. However, this therapeutic option remains controversial. The aim of this study was to perform a systematic review and ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2020, 18(1):e10-e20]

Cited: 1 time

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Expanding the feasibility of nephron-sparing surgery: time for a paradigm shift?

Alessandro Veccia, Georgi Guruli, Ithaar Derweesh, Riccardo Autorino,

BJU Int (BJU international)
[2019, 123(5):746-748]

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Impact of Perioperative Blood Transfusions on the Outcomes of Patients Undergoing Kidney Cancer Surgery: A Systematic Review and Pooled Analysis.

Davide Arcaniolo, Celeste Manfredi, Luca Cindolo, Michele Marchioni, Eduardo P Zukovski, Vincenzo Mirone, Uzoma A Anele, Georgi Guruli, Baruch Mayer Grob, Marco De Sio, Riccardo Autorino,

The aim of the present study is to systematically review current evidence regarding the association between perioperative blood transfusions (PBT) and oncological outcomes of patients with renal cell carcinoma undergoing nephrectomy procedures. A computerized bibliographic search was conducted to identify pertinent studies. The Population, Intervention, Comparator, Outcome (PICO) study design ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(1):e72-e79]

Cited: 1 time

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Adherence to EAU guidelines on penile cancer translates into better outcomes: a multicenter international study.

Luca Cindolo, Philippe E Spiess, Maida Bada, Juan J Chipollini, Peter Nyirády, Paolo Chiodini, Judith Varga, Pasquale Ditonno, Michele Battaglia, Cosimo De Nunzio, Giorgia Tema, Alessandro Veccia, Alessandro Antonelli, Gennaro Musi, Ottavio De Cobelli, Andrea Conti, Salvatore Micali, Mario Álvarez-Maestro, José Quesada Olarte, Erico Diogenes, Marcos Venicio Alves Lima, Andrew Tracey, Georgi Guruli, Riccardo Autorino, Petros Sountoulides, Luigi Schips,

<h4>Introduction</h4>We aimed to evaluate adherence to the EAU guidelines (GL) on penile cancer (PC) with regard to primary surgical treatment and management of lymph nodes and to estimate the influence of adherence to GL on clinical outcome.<h4>Materials and methods</h4>This is a retrospective multicenter study (PEnile Cancer ADherence study, PECAD Study) ... Read more >>

World J Urol (World journal of urology)
[2019, 37(8):1649-1657]

Cited: 7 times

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Dendritic cell trafficking in tumor-bearing mice.

Sarah C Krzastek, Ekaterine Goliadze, Shaoqing Zhou, Albert Petrossian, Fatma Youniss, Gobalakrishnan Sundaresan, Li Wang, Jamal Zweit, Georgi Guruli,

Prostate cancer is one of the leading causes of cancer deaths, with no curative treatments once it spreads. Alternative therapies, including immunotherapy, have shown limited efficacy. Dendritic cells (DC) have been widely used in the treatment of various malignancies. DC capture antigens and move to the lymphoid organs where they ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2018, 67(12):1939-1947]

Cited: 5 times

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Urologic Surgery with Multisystem Comorbidities: A Case Report.

Upendra Maddineni, Eric F Worrall, Erik A Baker, Madhavi Earasi, Francis Mathieu, Georgi Guruli,

BACKGROUND Originally implemented for colorectal surgery, enhanced perioperative protocols have been incorporated into many surgical fields in an effort to improve outcomes. The cornerstone of many strategies includes patient education, liberalized oral intake on the day of surgery, no routine bowel prep, targeted multimodal analgesia, cautious use of IV hydration, ... Read more >>

Am J Case Rep (The American journal of case reports)
[2018, 19:1047-1052]

Cited: 0 times

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Immunotherapy of cancer: targeting cancer during active disease or during dormancy?

Syed Ammer Shah, Melika Zarei, Saeed H Manjili, Georgi Guruli, Xiang-Yang Wang, Masoud H Manjili,

Immunotherapeutic targeting of advanced stage cancers has prolonged the survival of cancer patients, yet its curative efficacy is limited due to tumor immunoediting and escape. On the other hand, human vaccines have been able to eradicate smallpox and control several other infectious diseases. The success has resulted from the administration ... Read more >>

Immunotherapy (Immunotherapy)
[2017, 9(11):943-949]

Cited: 2 times

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Impact of diagnostic ureteroscopy on intravesical recurrence in patients undergoing radical nephroureterectomy for upper tract urothelial cancer: a systematic review and meta-analysis.

Michele Marchioni, Giulia Primiceri, Luca Cindolo, Lance J Hampton, Mayer B Grob, Georgi Guruli, Luigi Schips, Shahrokh F Shariat, Riccardo Autorino,

Aim of this study was to analyse the association between the use of diagnostic ureteroscopy (URS) and the development of intravesical recurrence (IVR) in patients undergoing radical nephroureterectomy (RNU) for high-risk upper tract urothelial carcinoma. A systematic review of the published data was performed up to December 2016, using multiple ... Read more >>

BJU Int (BJU international)
[2017, 120(3):313-319]

Cited: 22 times

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Conditioning neoadjuvant therapies for improved immunotherapy of cancer.

Zachary Benson, Saeed H Manjili, Mehran Habibi, Georgi Guruli, Amir A Toor, Kyle K Payne, Masoud H Manjili,

Recent advances in the treatment of melanoma and non-small cell lung cancer (NSCLC) by combining conventional therapies with anti-PD1/PD-L1 immunotherapies, have renewed interests in immunotherapy of cancer. The emerging concept of conventional cancer therapies combined with immunotherapy differs from the classical concept in that it is not simply taking advantage ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2017, 145:12-17]

Cited: 5 times

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Role of Epigenetic Modification and Immunomodulation in a Murine Prostate Cancer Model.

Jay E Sulek, Samuel P Robinson, Albert A Petrossian, Shaoqing Zhou, Ekaterine Goliadze, Masoud H Manjili, Amir Toor, Georgi Guruli,

<h4>Introduction</h4>Decreased expression of highly immunogenic cancer-testis antigens (CTA) might help tumor to achieve low immunogenicity, escape immune surveillance and grow unimpeded. Our aim was to evaluate CTA expression in tumor and normal tissues and to investigate possible means of improving the immune response in a murine prostate cancer (CaP) model ... Read more >>

Prostate (The Prostate)
[2017, 77(4):361-373]

Cited: 2 times

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Low amplitude rhythmic contraction frequency in human detrusor strips correlates with phasic intravesical pressure waves.

Andrew F Colhoun, John E Speich, Lauren F Cooley, Eugene D Bell, R Wayne Barbee, Georgi Guruli, Paul H Ratz, Adam P Klausner,

<h4>Purpose</h4>Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate with in vivo ... Read more >>

World J Urol (World journal of urology)
[2017, 35(8):1255-1260]

Cited: 5 times

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