Full Text Journal Articles by
Author George du Toit

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Preventing food allergy in infancy and childhood: systematic review of randomised controlled trials.

Debra de Silva, Susanne Halken, Chris Singh, Muraro Antonella, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Kirsten Beyer, Robert Boyle, George du Toit, Philippe Eigenmann, Kate Grimshaw, Arne Hoest, Carla Jones, Ekaterina Khaleva, Gideon Lack, Hania Szajewska, Carina Venter, Valérie Verhasselt, Graham Roberts, ,

BACKGROUND:This systematic review of ways to prevent immediate-onset/IgE-mediated food allergy will inform guidelines by the European Academy of Allergy and Immunology (EAACI). METHODS:The GRADE approach was used. Eleven databases were searched from 1946 to October 2019 for randomised controlled trials (and large prospective cohort studies in the case of breastfeeding). ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

Cited: 0 times

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Ara h 2 is the dominant peanut allergen despite similarities with Ara h 6.

Oliver Hemmings, George Du Toit, Suzana Radulovic, Gideon Lack, Alexandra F Santos,

BACKGROUND:Arachis hypogaea 2 (Ara h 2)-specific IgE is to date the best serologic marker to diagnose peanut allergy. Ara h 6 shares approximately 60% sequence identity and multiple epitopes with Ara h 2. OBJECTIVE:Our aim was to assess the diagnostic utility and relative importance of Ara h 2 and Ara ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Biomarkers of severity and threshold of allergic reactions during oral peanut challenges.

Alexandra F Santos, George Du Toit, Colin O'Rourke, Natalia Becares, Natália Couto-Francisco, Suzana Radulovic, Ekaterina Khaleva, Monica Basting, Kristina M Harris, David Larson, Peter Sayre, Marshall Plaut, Graham Roberts, Henry T Bahnson, Gideon Lack,

BACKGROUND:Oral food challenge (OFC) is the gold-standard to assess peanut allergy (PA) but involves a risk of allergic reactions of unpredictable severity. OBJECTIVE:To identify biomarkers for risk of severe reactions or low dose threshold during OFC to peanut. METHODS:We assessed LEAP, LEAP-On and PAS participants with basophil activation test (BAT), ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Biologicals in atopic disease in pregnancy: an EAACI position paper.

Birgit Pfaller, Juan José Yepes-Nuñez, Ioana Agache, Cezmi A Akdis, Mohammad Alsalamah, Sevim Bavbek, Apostolos Bossios, Onur Boyman, Adam Chaker, Susan Chan, Alexia Chatzipetrou, George du Toit, Marek Jutel, Paula Kauppi, Antonios Kolios, Carmen Li, Andrea Matucci, Alanna Marson, Sarah Bendien, Oscar Palomares, Barbara Rogala, Zsolt Szepfalusi, Eva Untersmayr, Alessandra Vultaggio, Thomas Eiwegger,

Biologicals have transformed the management of severe disease phenotypes in asthma, atopic dermatitis, and chronic spontaneous urticaria. As a result, the number of approved biologicals for the treatment of atopic diseases is continuously increasing. Although atopic diseases are among the most common diseases in the reproductive age, investigations, and information ... Read more >>

Allergy (Allergy)
[2020, :]

Cited: 0 times

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EAACI position paper on diet diversity in pregnancy, infancy and childhood: Novel concepts and implications for studies in allergy and asthma.

Carina Venter, Matthew Greenhawt, Rosan W Meyer, Carlo Agostoni, Imke Reese, George du Toit, Mary Feeney, Kate Maslin, Bright I Nwaru, Caroline Roduit, Eva Untersmayr, Berber Vlieg-Boerstra, Isabella Pali-Schöll, Graham C Roberts, Peter Smith, Cezmi A Akdis, Ioana Agache, Miriam Ben-Adallah, Stephan Bischoff, Remo Frei, Holger Garn, Kate Grimshaw, Karin Hoffmann-Sommergruber, Nonhlanhla Lunjani, Antonella Muraro, Lars K Poulsen, Harald Renz, Milena Sokolowska, Catherine Stanton, Liam O'Mahony,

To fully understand the role of diet diversity on allergy outcomes and to set standards for conducting research in this field, the European Academy of Allergy and Clinical Immunology Task Force on Diet and Immunomodulation has systematically explored the association between diet diversity and allergy outcomes. In addition, a detailed ... Read more >>

Allergy (Allergy)
[2020, 75(3):497-523]

Cited: 2 times

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Perioperative anaphylaxis in children: Etiology, time sequence, and patterns of clinical reactivity.

Ekaterina Khaleva, Amber Franz, Lene Heise Garvey, Nicola Jay, Alyssa Ylescupidez, Henry T Bahnson, George du Toit,

BACKGROUND:Perioperative anaphylaxis (PA) in children is an uncommon but potentially life-threatening complication associated with anesthesia. Early identification and management of PA is essential to optimize clinical outcomes. METHODS:We performed a retrospective study of anesthesia records from pediatric patients with PA from centers in the United Kingdom, France, and the United ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31(1):85-94]

Cited: 0 times

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Preventing immediate-onset food allergy in infants, children and adults: Systematic review protocol.

Debra de Silva, Susanne Halken, Chris Singh, Antonella Muraro, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Kirsten Beyer, Robert Boyle, Philippe Eigenmann, Kate Grimshaw, Arne Hoest, Carla Jones, Gideon Lack, Hania Szajewska, George du Toit, Carina Venter, Valérie Verhasselt, Graham Roberts,

BACKGROUND:More than 17 million people across Europe have allergies to food and the burden of food allergies is increasing. In 2014, the European Academy of Allergy and Clinical Immunology (EAACI) published guidelines for preventing food allergy. Important research has been published since then and it is essential to ensure the ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31(3):243-249]

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Conflicting verdicts on peanut oral immunotherapy from the Institute for Clinical and Economic Review and US Food and Drug Administration Advisory Committee: Where do we go from here?

Thomas Eiwegger, Katherine Anagnostou, Stefania Arasi, Philippe Bégin, Moshe Ben-Shoshan, Kirsten Beyer, Katharina Blumchen, Helen Brough, Jean-Christoph Caubet, Edmond S Chan, Meng Chen, Sharon Chinthrajah, Carla M Davis, Anne Des Roches, George Du Toit, Arnon Elizur, Stephen J Galli, Geir Håland, Karin Hoffmann-Sommergruber, Harold Kim, Donald Y M Leung, Andrew Long, Antonella Muraro, Ulugbek B Nurmatov, Giovanni B Pajno, Vanitha Sampath, Jamie Saxena, Sayantani Sindher, Julia Upton, Margitta Worm, Kari C Nadeau,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 145(4):1153-1156]

Cited: 0 times

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Cow's Milk and Vitamin D Supplementation in Infants-Timing Is Everything.

George du Toit, Arnon Elizur, Kari C Nadeau,

JAMA Pediatr (JAMA pediatrics)
[2019, :]

Cited: 0 times

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ICER report for peanut OIT comes up short.

Thomas Eiwegger, Katherine Anagnostou, Stefania Arasi, Philippe Bégin, Moshe Ben-Shoshan, Kirsten Beyer, Katharina Blumchen, Helen Brough, Jean-Christoph Caubet, Edmond S Chan, Sharon Chinthrajah, Carla M Davis, Anne Des Roches, George Du Toit, Arnon Elizur, Stephen J Galli, Geir Håland, Karin Hoffmann-Sommergruber, Harold Kim, Donald Y M Leung, Antonella Muraro, Ulugbek B Nurmatov, Giovanni B Pajno, Sayantani Sindher, Zsolt Szepfalusi, Maria Jose Torres, Julia Upton, Margitta Worm, Kari Nadeau,

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2019, 123(5):430-432]

Cited: 0 times

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Psychological services for food allergy: The unmet need for patients and families in the United Kingdom.

Rebecca Knibb, Mary Halsey, Polly James, George du Toit, Judith Young,

Research over the past 20 years has demonstrated the significant impact food allergy can have on quality of life and mental health of patients and their families, yet there is a paucity of psychological services to support families in coping with this condition. This paper provides a short overview of the ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2019, 49(11):1390-1394]

Cited: 0 times

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Diagnosis and management of Non-IgE gastrointestinal allergies in breastfed infants-An EAACI Position Paper.

Rosan Meyer, Adriana Chebar Lozinsky, David M Fleischer, Mario C Vieira, George Du Toit, Yvan Vandenplas, Christophe Dupont, Rebecca Knibb, Piınar Uysal, Ozlem Cavkaytar, Anna Nowak-Wegrzyn, Neil Shah, Carina Venter,

It is well-established that food proteins, such as egg, soya, cow's milk and wheat, are detectable in breastmilk for many hours or days after ingestion. Exposure to these proteins is important to the process of developing tolerance but can also sometimes elicit IgE-mediated and non-IgE-mediated allergic symptoms in breastfed infants. ... Read more >>

Allergy (Allergy)
[2020, 75(1):14-32]

Cited: 0 times

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2019 ARIA Care pathways for allergen immunotherapy.

Jean Bousquet, Oliver Pfaar, Alkis Togias, Holger J Schünemann, Ignacio Ansotegui, Nikolaos G Papadopoulos, Ioanna Tsiligianni, Ioana Agache, Josep M Anto, Claus Bachert, Anna Bedbrook, Karl-Christian Bergmann, Sinthia Bosnic-Anticevich, Isabelle Bosse, Jan Brozek, Moises A Calderon, Giorgio W Canonica, Luigi Caraballo, Victoria Cardona, Thomas Casale, Lorenzo Cecchi, Derek Chu, Elisio Costa, Alvaro A Cruz, Wienczyslawa Czarlewski, Stephen R Durham, George Du Toit, Mark Dykewicz, Motohiro Ebisawa, Jean Luc Fauquert, Montserrat Fernandez-Rivas, Wytske J Fokkens, João Fonseca, Jean-François Fontaine, Roy Gerth van Wijk, Tari Haahtela, Susanne Halken, Peter W Hellings, Despo Ierodiakonou, Tomohisa Iinuma, Juan Carlos Ivancevich, Lars Jacobsen, Marek Jutel, Igor Kaidashev, Musa Khaitov, Omer Kalayci, Jörg Kleine Tebbe, Ludger Klimek, Marek L Kowalski, Piotr Kuna, Violeta Kvedariene, Stefania La Grutta, Désirée Larenas-Linemann, Susanne Lau, Daniel Laune, Lan Le, Karin Lodrup Carlsen, Olga Lourenço, Hans-Jørgen Malling, Gert Marien, Enrica Menditto, Gregoire Mercier, Joaquim Mullol, Antonella Muraro, Robyn O'Hehir, Yoshitaka Okamoto, Giovanni B Pajno, Hae-Sim Park, Petr Panzner, Giovanni Passalacqua, Nhan Pham-Thi, Graham Roberts, Ruby Pawankar, Christine Rolland, Nelson Rosario, Dermot Ryan, Bolesław Samolinski, Mario Sanchez-Borges, Glenis Scadding, Mohamed H Shamji, Aziz Sheikh, Gunter J Sturm, Ana Todo Bom, Sanna Toppila-Salmi, Maryline Valentin-Rostan, Arunas Valiulis, Erkka Valovirta, Maria-Teresa Ventura, Ulrich Wahn, Samantha Walker, Dana Wallace, Susan Waserman, Arzu Yorgancioglu, Torsten Zuberbier, ,

Allergen immunotherapy (AIT) is a proven therapeutic option for the treatment of allergic rhinitis and/or asthma. Many guidelines or national practice guidelines have been produced but the evidence-based method varies, many are complex and none propose care pathways. This paper reviews care pathways for AIT using strict criteria and provides ... Read more >>

Allergy (Allergy)
[2019, 74(11):2087-2102]

Cited: 0 times

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Early introduction of infant-safe peanut protein to reduce the risk of peanut allergy.

Amitha Kalaichandran, Tom Marrs, George du Toit,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2019, 191(29):E816]

Cited: 1 time

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Food-dependent exercise-induced anaphylaxis.

Ru-Xin Foong, Mattia Giovannini, George du Toit,

PURPOSE OF REVIEW:The following article provides an overview of food-dependent exercise-induced anaphylaxis (FD-EIAn). The review focuses on the epidemiology, pathophysiology, and clinical findings of FD-EIAn and details current practice in terms of the investigation, management, and treatment options available. RECENT FINDINGS:The management of FD-EIAn has not changed significantly over the ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2019, 19(3):224-228]

Cited: 1 time

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Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity.

Olympia Tsilochristou, George du Toit, Peter H Sayre, Graham Roberts, Kaitie Lawson, Michelle L Sever, Henry T Bahnson, Suzana Radulovic, Monica Basting, Marshall Plaut, Gideon Lack, ,

BACKGROUND:Staphylococcus aureus has been implicated in the pathophysiology of eczema, allergic rhinitis, asthma, and food allergy. S aureus is a marker of more severe eczema, which is a risk factor for food sensitization/allergy. Therefore it might be that the association between S aureus and food allergy in eczematous patients is ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 144(2):494-503]

Cited: 0 times

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EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis.

Carina Venter, Rosan W Meyer, Bright I Nwaru, Caroline Roduit, Eva Untersmayr, Karine Adel-Patient, Ioana Agache, Carlo Agostoni, Cezmi A Akdis, Stephan C Bischoff, George du Toit, Mary Feeney, Remo Frei, Holger Garn, Matthew Greenhawt, Karin Hoffmann-Sommergruber, Nonhlanhla Lunjani, Kate Maslin, Clare Mills, Antonella Muraro, Isabella Pali-Schöll, Lars K Poulson, Imke Reese, Harald Renz, Graham C Roberts, Peter Smith, Sylwia Smolinska, Milena Sokolowska, Catherine Stanton, Berber Vlieg-Boerstra, Liam O'Mahony,

The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review was to highlight the potential role for dietary fatty acids, in the prevention ... Read more >>

Allergy (Allergy)
[2019, 74(8):1429-1444]

Cited: 3 times

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Diagnosis and management of drug-induced anaphylaxis in children: An EAACI position paper.

Marina Atanaskovic-Markovic, Eva Gomes, Josefina Rodrigues Cernadas, George du Toit, Mona Kidon, Semanur Kuyucu, Francesca Mori, Claude Ponvert, Ingrid Terreehorst, Jean-Christoph Caubet,

Drug hypersensitivity reactions (DHR) constitute a major and common public health problem, particularly in children. One of the most severe manifestations of DHR is anaphylaxis, which might be associated with a life-threatening risk. During those past decades, anaphylaxis has received particularly a lot of attention and international consensus guidelines have ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(3):269-276]

Cited: 0 times

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The MALT1 locus and peanut avoidance in the risk for peanut allergy.

Alexandra Winters, Henry T Bahnson, Ingo Ruczinski, Meher P Boorgula, Claire Malley, Ali R Keramati, Sameer Chavan, David Larson, Karen Cerosaletti, Peter H Sayre, Marshall Plaut, George Du Toit, Gideon Lack, Kathleen C Barnes, Gerald T Nepom, Rasika A Mathias, ,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 143(6):2326-2329]

Cited: 0 times

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Solid foods should be introduced into susceptible infants' diets in early life-PRO.

Helen R Fisher, Gideon Lack, George Du Toit,

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2019, 122(6):583-585]

Cited: 0 times

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Preventing Peanut Allergy: Where Are We Now?

Helen R Fisher, Corinne A Keet, Gideon Lack, George du Toit,

Peanut allergy affects 1% to 3% of the Western world, usually begins in early childhood, is rarely outgrown, and has no currently approved treatment. The identification and application of prevention strategies is therefore essential. In 2015, the Learning Early About Peanuts study findings found that early consumption of peanut protein ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2019, 7(2):367-373]

Cited: 1 time

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Pink peppercorn: A cross-reactive risk for cashew- and pistachio-allergic patients.

Andrew Timothy Fong, George Du Toit, Serge A Versteeg, Ronald van Ree,

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2019, 7(2):724-725.e1]

Cited: 1 time

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AR101 Oral Immunotherapy for Peanut Allergy.

, Brian P Vickery, Andrea Vereda, Thomas B Casale, Kirsten Beyer, George du Toit, Jonathan O Hourihane, Stacie M Jones, Wayne G Shreffler, Annette Marcantonio, Rezi Zawadzki, Lawrence Sher, Warner W Carr, Stanley Fineman, Leon Greos, Rima Rachid, M Dolores Ibáñez, Stephen Tilles, Amal H Assa’ad, Caroline Nilsson, Ned Rupp, Michael J Welch, Gordon Sussman, Sharon Chinthrajah, Katharina Blumchen, Ellen Sher, Jonathan M Spergel, Frederick E Leickly, Stefan Zielen, Julie Wang, Georgiana M Sanders, Robert A Wood, Amarjit Cheema, Carsten Bindslev-Jensen, Stephanie Leonard, Rita Kachru, Douglas T Johnston, Frank C Hampel, Edwin H Kim, Aikaterini Anagnostou, Jacqueline A Pongracic, Moshe Ben-Shoshan, Hemant P Sharma, Allan Stillerman, Hugh H Windom, William H Yang, Antonella Muraro, José M Zubeldia, Vibha Sharma, Morna J Dorsey, Hey J Chong, Jason Ohayon, J Andrew Bird, Tara F Carr, Dareen Siri, Montserrat Fernández-Rivas, David K Jeong, David M Fleischer, Jay A Lieberman, Anthony E J Dubois, Marina Tsoumani, Christina E Ciaccio, Jay M Portnoy, Lyndon E Mansfield, Stephen B Fritz, Bruce J Lanser, Jonathan Matz, Hanneke N G Oude Elberink, Pooja Varshney, Stephen G Dilly, Daniel C Adelman, A Wesley Burks,

BACKGROUND:Peanut allergy, for which there are no approved treatment options, affects patients who are at risk for unpredictable and occasionally life-threatening allergic reactions. METHODS:In a phase 3 trial, we screened participants 4 to 55 years of age with peanut allergy for allergic dose-limiting symptoms at a challenge dose of 100 ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2018, 379(21):1991-2001]

Cited: 10 times

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Characteristics of NSAID-induced hypersensitivity reactions in childhood.

Ozlem Cavkaytar, George du Toit, Davide Caimmi,

Non-steroidal anti-inflammatory drugs (NSAIDs) are available as over-the-counter drugs, and they are commonly used in children for their antipyretic, analgesic, and anti-inflammatory effects. NSAIDs are among the most frequently reported drugs associated with hypersensitivity reactions and even with anaphylaxis. A complete evaluation of the patients based on reported clinical manifestations, ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(1):25-35]

Cited: 2 times

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The challenges of preventing food allergy: Lessons learned from LEAP and EAT.

Helen R Fisher, George Du Toit, Henry T Bahnson, Gideon Lack,

OBJECTIVE:To highlight challenges associated with this novel preventive strategy. DATA SOURCES:The Learning Early About Peanuts (LEAP) and Enquiring About Tolerance (EAT) Studies, with reference to other oral tolerance induction studies. STUDY SELECTIONS:Randomized clinial trials seeking to prevent food allergy through allergen introduction in infancy. RESULTS:Oral tolerance induction programs that use ... Read more >>

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2018, 121(3):313-319]

Cited: 5 times

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