Full Text Journal Articles by
Author George W Huntley


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Non-Motor Symptoms of Parkinson's Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction.

Ayan Hussein, Christopher A Guevara, Pamela Del Valle, Swati Gupta, Deanna L Benson, George W Huntley,

Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well, and among these, psychiatric symptoms of depression and anxiety and cognitive impairment are common and can appear earlier than motor ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211011979]

Cited: 0 times

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Presenilin1 familial Alzheimer disease mutants inactivate EFNB1- and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-aspartate receptor.

Md Al Rahim, Yonejung Yoon, Christina Dimovasili, Zhiping Shao, Qian Huang, Emily Zhang, Nebojsa Kezunovic, Lei Chen, Adam Schaffner, George W Huntley, Iban Ubarretxena-Belandia, Anastasios Georgakopoulos, Nikolaos K Robakis,

Excitotoxicity is thought to play key roles in brain neurodegeneration and stroke. Here we show that neuroprotection against excitotoxicity by trophic factors EFNB1 and brain-derived neurotrophic factor (called here factors) requires <i>de novo</i> formation of 'survival complexes' which are factor-stimulated complexes of <i>N</i>-methyl-d-aspartate receptor with factor receptor and presenilin 1. ... Read more >>

Brain Commun (Brain communications)
[2020, 2(2):fcaa100]

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LRRK2 mutation alters behavioral, synaptic, and nonsynaptic adaptations to acute social stress.

Christopher A Guevara, Bridget A Matikainen-Ankney, Nebojsa Kezunovic, Katherine LeClair, Alexander P Conway, Caroline Menard, Meghan E Flanigan, Madeline Pfau, Scott J Russo, Deanna L Benson, George W Huntley,

Parkinson's disease (PD) risk is increased by stress and certain gene mutations, including the most prevalent PD-linked mutation <i>LRRK2</i>-G2019S. Both PD and stress increase risk for psychiatric symptoms, yet it is unclear how PD-risk genes alter neural circuitry in response to stress that may promote psychopathology. Here we show significant ... Read more >>

J Neurophysiol (Journal of neurophysiology)
[2020, 123(6):2382-2389]

Cited: 3 times

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Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice.

Meghan E Flanigan, Hossein Aleyasin, Long Li, C Joseph Burnett, Kenny L Chan, Katherine B LeClair, Elizabeth K Lucas, Bridget Matikainen-Ankney, Romain Durand-de Cuttoli, Aki Takahashi, Caroline Menard, Madeline L Pfau, Sam A Golden, Sylvain Bouchard, Erin S Calipari, Eric J Nestler, Ralph J DiLeone, Akihiro Yamanaka, George W Huntley, Roger L Clem, Scott J Russo,

Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have various negative effects on patients, their families and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, domination of subordinate social targets is reinforcing. In ... Read more >>

Nat Neurosci (Nature neuroscience)
[2020, 23(5):638-650]

Cited: 6 times

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Origins of Parkinson's Disease in Brain Development: Insights From Early and Persistent Effects of LRRK2-G2019S on Striatal Circuits.

George W Huntley, Deanna L Benson,

Late-onset Parkinson's disease (PD) is dominated clinically and experimentally by a focus on dopamine neuron degeneration and ensuing motor system abnormalities. There are, additionally, a number of non-motor symptoms - including cognitive and psychiatric - that can appear much earlier in the course of the disease and also significantly impair ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:265]

Cited: 1 time

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Are we listening to everything the PARK genes are telling us?

Deanna L Benson, George W Huntley,

The cardinal motor symptoms that define Parkinson's disease (PD) clinically have been recognized for over 200 years. That these symptoms arise following the loss of dopamine neurons in the substantia nigra has been known for the last 50. These long-established facts have fueled a broadly held expectation that degenerating dopaminergic neurons ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2019, 527(9):1527-1540]

Cited: 2 times

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Functional and behavioral consequences of Parkinson's disease-associated LRRK2-G2019S mutation.

Deanna L Benson, Bridget A Matikainen-Ankney, Ayan Hussein, George W Huntley,

<i>LRRK2</i> mutation is the most common inherited, autosomal dominant cause of Parkinson's disease (PD) and has also been observed in sporadic cases. Most mutations result in increased LRRK2 kinase activity. LRRK2 is highly expressed in brain regions that receive dense, convergent innervation by dopaminergic and glutamatergic axons, and its levels ... Read more >>

Biochem Soc Trans (Biochemical Society transactions)
[2018, 46(6):1697-1705]

Cited: 4 times

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Parkinson's Disease-Linked LRRK2-G2019S Mutation Alters Synaptic Plasticity and Promotes Resilience to Chronic Social Stress in Young Adulthood.

Bridget A Matikainen-Ankney, Nebojsa Kezunovic, Caroline Menard, Meghan E Flanigan, Yue Zhong, Scott J Russo, Deanna L Benson, George W Huntley,

The G2019S mutation in leucine-rich repeat kinase 2 (<i>LRRK2</i>) is a prevalent cause of late-onset Parkinson's disease, producing psychiatric and motor symptoms, including depression, that are indistinguishable from sporadic cases. Here we tested how this mutation impacts depression-related behaviors and associated synaptic responses and plasticity in mice expressing a <i>Lrrk2</i>-G2019S ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2018, 38(45):9700-9711]

Cited: 15 times

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Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.

Daisuke Ibi, Mario de la Fuente Revenga, Nebojsa Kezunovic, Carolina Muguruza, Justin M Saunders, Supriya A Gaitonde, José L Moreno, Maryum K Ijaz, Vishaka Santosh, Alexey Kozlenkov, Terrell Holloway, Jeremy Seto, Aintzane García-Bea, Mitsumasa Kurita, Grace E Mosley, Yan Jiang, Daniel J Christoffel, Luis F Callado, Scott J Russo, Stella Dracheva, Juan F López-Giménez, Yongchao Ge, Carlos R Escalante, J Javier Meana, Schahram Akbarian, George W Huntley, Javier González-Maeso,

Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic medications leads to cognitive deficits in both schizophrenia patients and animal models. The molecular mechanisms underlying these negative effects on cognition remain to be elucidated. Here we demonstrate that chronic ... Read more >>

Nat Neurosci (Nature neuroscience)
[2017, 20(9):1247-1259]

Cited: 17 times

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Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation.

Yunjiao Zhu, Oscar G Vidaurre, Kadidia P Adula, Nebojsa Kezunovic, Maureen Wentling, George W Huntley, Patrizia Casaccia,

Calcium-dependent nuclear export of histone deacetylase 1 (HDAC1) was shown previously to precede axonal damage in culture, but the <i>in vivo</i> relevance of these findings and the potential posttranslational modifications of HDAC1 remained elusive. Using acute hippocampal slices from mice of either sex with genetic conditional ablation of <i>Hdac1</i> in ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2017, 37(31):7547-7559]

Cited: 13 times

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Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation.

Bridget A Matikainen-Ankney, Nebojsa Kezunovic, Roxana E Mesias, Yuan Tian, Frances M Williams, George W Huntley, Deanna L Benson,

<h4>Unlabelled</h4>Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) can cause Parkinson's disease (PD), and the most common disease-associated mutation, G2019S, increases kinase activity. Because LRRK2 expression levels rise during synaptogenesis and are highest in dorsal striatal spiny projection neurons (SPNs), we tested the hypothesis that the LRRK2-G2019S mutation ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2016, 36(27):7128-7141]

Cited: 39 times

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Erratum. The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.

Samira Fargali, Angelo L Garcia, Masato Sadahiro, Cheng Jiang, William G Janssen, Wei-Jye Lin, Valeria Cogliani, Alice Elste, Steven Mortillo, Cheryl Cero, Britta Veitenheimer, Gallia Graiani, Giulio M Pasinetti, Sushil K Mahata, John W Osborn, George W Huntley, Greg R Phillips, Deanna L Benson, Alessandro Bartolomucci, Stephen R Salton,

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2015, 29(6):2679]

Cited: 0 times

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Maturation of cortical circuits requires Semaphorin 7A.

Ioana Carcea, Shekhar B Patil, Alfred J Robison, Roxana Mesias, Molly M Huntsman, Robert C Froemke, Joseph D Buxbaum, George W Huntley, Deanna L Benson,

Abnormal cortical circuits underlie some cognitive and psychiatric disorders, yet the molecular signals that generate normal cortical networks remain poorly understood. Semaphorin 7A (Sema7A) is an atypical member of the semaphorin family that is GPI-linked, expressed principally postnatally, and enriched in sensory cortex. Significantly, SEMA7A is deleted in individuals with ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(38):13978-13983]

Cited: 13 times

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N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo.

Jessica S Nikitczuk, Shekhar B Patil, Bridget A Matikainen-Ankney, Joseph Scarpa, Matthew L Shapiro, Deanna L Benson, George W Huntley,

N-Cadherin and β-catenin form a transsynaptic adhesion complex required for spine and synapse development. In adulthood, N-cadherin mediates persistent synaptic plasticity, but whether the role of N-cadherin at mature synapses is similar to that at developing synapses is unclear. To address this, we conditionally ablated N-cadherin from excitatory forebrain synapses ... Read more >>

Hippocampus (Hippocampus)
[2014, 24(8):943-962]

Cited: 22 times

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Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry.

Paven K Aujla, George W Huntley,

Matrix metalloproteinases (MMPs) are extracellular proteolytic enzymes that contribute to pericellular remodeling in a variety of tissues, including brain, where they function in adult hippocampal synaptic structural and functional plasticity. Synaptic plasticity and remodeling are also important for development of connectivity, but it is unclear whether MMPs--particularly MMP-2 and -9, ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2014, 522(6):1249-1263]

Cited: 12 times

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CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation.

Amy A Arguello, Xiaojing Ye, Ozlem Bozdagi, Gabriella Pollonini, Sophie Tronel, Dhananjay Bambah-Mukku, George W Huntley, Daniela Platano, Cristina M Alberini,

A newly formed memory is temporarily fragile and becomes stable through a process known as consolidation. Stable memories may again become fragile if retrieved or reactivated, and undergo a process of reconsolidation to persist and strengthen. Both consolidation and reconsolidation require an initial phase of transcription and translation that lasts ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2013, 33(8):3646-3658]

Cited: 19 times

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Synaptic circuit remodelling by matrix metalloproteinases in health and disease.

George W Huntley,

Matrix metalloproteinases (MMPs) are extracellularly acting enzymes that have long been known to have deleterious roles in brain injury and disease. In particular, widespread and protracted MMP activity can contribute to neuronal loss and synaptic dysfunction. However, recent studies show that rapid and focal MMP-mediated proteolysis proactively drives synaptic structural ... Read more >>

Nat Rev Neurosci (Nature reviews. Neuroscience)
[2012, 13(11):743-757]

Cited: 141 times

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Synapse adhesion: a dynamic equilibrium conferring stability and flexibility.

Deanna L Benson, George W Huntley,

Cell adhesion molecules (CAMs) linked to cytoskeleton generate stable cell-cell junctions. Cadherins provide a canonical example, but paradoxically, they participate in a multitude of transient and regulatable interactions. Their extracellular binding generates weak adhesion that is modified by clustering; interactions with F-actin are regulated, can be transient, and can alter ... Read more >>

Curr Opin Neurobiol (Current opinion in neurobiology)
[2012, 22(3):397-404]

Cited: 28 times

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Building and remodeling synapses.

Deanna L Benson, George W Huntley,

Synaptic junctions are generated by adhesion proteins that bridge the synaptic cleft to firmly anchor pre- and postsynaptic membranes. Several cell adhesion molecule (CAM) families localize to synapses, but it is not yet completely understood how each synaptic CAM family contributes to synapse formation and/or structure, and whether or how ... Read more >>

Hippocampus (Hippocampus)
[2012, 22(5):954-968]

Cited: 15 times

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Neuropathic pain- and glial derived neurotrophic factor-associated regulation of cadherins in spinal circuits of the dorsal horn.

Shekhar B Patil, John H Brock, David R Colman, George W Huntley,

Neuropathic pain is associated with reorganization of spinal synaptic circuits, implying that adhesion proteins that normally build and modify synapses must be involved. The adhesion proteins E- and N-cadherin delineate different synapses furnished by nociceptive primary afferents, but dynamic aspects of cadherin localization in relationship to onset, maintenance or reversibility ... Read more >>

Pain (Pain)
[2011, 152(4):924-935]

Cited: 11 times

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Astrocyte-neuron lactate transport is required for long-term memory formation.

Akinobu Suzuki, Sarah A Stern, Ozlem Bozdagi, George W Huntley, Ruth H Walker, Pierre J Magistretti, Cristina M Alberini,

We report that, in the rat hippocampus, learning leads to a significant increase in extracellular lactate levels that derive from glycogen, an energy reserve selectively localized in astrocytes. Astrocytic glycogen breakdown and lactate release are essential for long-term but not short-term memory formation, and for the maintenance of long-term potentiation ... Read more >>

Cell (Cell)
[2011, 144(5):810-823]

Cited: 630 times

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Developmental and comparative aspects of posterior medial thalamocortical innervation of the barrel cortex in mice and rats.

Elizabeth A Kichula, George W Huntley,

The thalamocortical projection to the rodent barrel cortex consists of inputs from the ventral posterior medial (VPM) and posterior medial (POm) nuclei that terminate in largely nonoverlapping territories in and outside of layer IV. This projection in both rats and mice has been used extensively to study development and plasticity ... Read more >>

J Comp Neurol (The Journal of comparative neurology)
[2008, 509(3):239-258]

Cited: 21 times

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The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism.

Ozlem Bozdagi, Erin Rich, Sophie Tronel, Masato Sadahiro, Kamara Patterson, Matthew L Shapiro, Cristina M Alberini, George W Huntley, Stephen R J Salton,

VGF is a neurotrophin-inducible, activity-regulated gene product that is expressed in CNS and PNS neurons, in which it is processed into peptides and secreted. VGF synthesis is stimulated by BDNF, a critical regulator of hippocampal development and function, and two VGF C-terminal peptides increase synaptic activity in cultured hippocampal neurons. ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2008, 28(39):9857-9869]

Cited: 64 times

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Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately.

Xiao-bin Wang, Ozlem Bozdagi, Jessica S Nikitczuk, Zu Wei Zhai, Qiang Zhou, George W Huntley,

Persistent dendritic spine enlargement is associated with stable long-term potentiation (LTP), and the latter is thought to underlie long-lasting memories. Extracellular proteolytic remodeling of the synaptic microenvironment could be important for such plasticity, but whether or how proteolytic remodeling contributes to persistent modifications in synapse structure and function is unknown. ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2008, 105(49):19520-19525]

Cited: 186 times

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The extracellular protease matrix metalloproteinase-9 is activated by inhibitory avoidance learning and required for long-term memory.

Vanja Nagy, Ozlem Bozdagi, George W Huntley,

Matrix metalloproteinases (MMPs) are a family of extracellularly acting proteolytic enzymes with well-recognized roles in plasticity and remodeling of synaptic circuits during brain development and following brain injury. However, it is now becoming increasingly apparent that MMPs also function in normal, nonpathological synaptic plasticity of the kind that may underlie ... Read more >>

Learn Mem (Learning & memory (Cold Spring Harbor, N.Y.))
[2007, 14(10):655-664]

Cited: 59 times

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