Full Text Journal Articles by
Author George Grimes

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Occupational Exposure to Secondhand Cannabis Smoke Among Law Enforcement Officers Providing Security at Outdoor Concert Events.

Douglas M Wiegand, Mark M Methner, George Reed Grimes, James R Couch, Lanqing Wang, Li Zhang, Benjamin C Blount,

OBJECTIVES:Numerous states within the USA have legalized cannabis for medical or non-medical (adult/recreational) use. With the increased availability and use of cannabis, occupational and environmental exposures to secondhand cannabis smoke (SHCS) raise concerns over whether non-users may be at risk for a 'contact high', impaired neurocognitive function, harm from irritants ... Read more >>

Ann Work Expo Health (Annals of work exposures and health)
[2020, :]

Cited: 0 times

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Review of NIOSH Cannabis-Related Health Hazard Evaluations and Research.

James R Couch, George Reed Grimes, Brett J Green, Douglas M Wiegand, Bradley King, Mark M Methner,

Since 2004, the National Institute for Occupational Safety and Health (NIOSH) has received 10 cannabis-related health hazard evaluation (HHE) investigation requests from law enforcement agencies (n = 5), state-approved cannabis grow operations (n = 4), and a coroner's office (n = 1). Earlier requests concerned potential illicit drug exposures (including ... Read more >>

Ann Work Expo Health (Annals of work exposures and health)
[2020, :]

Cited: 0 times

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Potential occupational and respiratory hazards in a Minnesota cannabis cultivation and processing facility.

James R Couch, George R Grimes, Douglas M Wiegand, Brett J Green, Eric K Glassford, Leonard M Zwack, Angela R Lemons, Stephen R Jackson, Donald H Beezhold,

BACKGROUND:Cannabis has been legalized in some form for much of the United States. The National Institute for Occupational Safety and Health (NIOSH) received a health hazard evaluation request from a Minnesota cannabis facility and their union to undertake an evaluation. METHODS:NIOSH representatives visited the facility in August 2016 and April ... Read more >>

Am. J. Ind. Med. (American journal of industrial medicine)
[2019, 62(10):874-882]

Cited: 0 times

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Stability of isoniazid injection in i.v. solutions.

Jun H Lee, Brad Moriyama, Stacey A Henning, Robert L Danner, Thomas J Walsh, Scott R Penzak, George J Grimes, Gopal K Potti,

PURPOSE:Results of an assessment of the chemical stability of isoniazid injection in 0.9% sodium chloride injection and 5% dextrose injection are reported. METHODS:Triplicate solutions of isoniazid (0.5 and 6.0 mg/mL) in the 2 diluents were prepared in ethylene and propylene copolymer i.v. containers and stored under light protection at room ... Read more >>

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2018, 75(10):622-626]

Cited: 0 times

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Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin,

Dietary NO3- (nitrate) and NO2- (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3-and NO2-metabolism and the impact ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(3):634-644]

Cited: 5 times

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Dose-escalation study of octanoic acid in patients with essential tremor.

Bernhard Voller, Emily Lines, Gayle McCrossin, Sule Tinaz, Codrin Lungu, George Grimes, Judith Starling, Gopal Potti, Peter Buchwald, Dietrich Haubenberger, Mark Hallett,

Recently, 1-octanol has been shown to have efficacy in treating patients with essential tremor (ET). The primary metabolite of 1-octanol is octanoic acid (OA), which is now thought to be the active substance that mediates tremor suppression. Our aim was to describe the maximum tolerated dose (MTD) of oral OA ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2016, 126(4):1451-1457]

Cited: 3 times

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Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial.

Caterina P Minniti, Alexander M Gorbach, Dihua Xu, Yuen Yi Hon, Kara-Marie Delaney, Miles Seidel, Nitin Malik, Marlene Peters-Lawrence, Carly Cantilena, James S Nichols, Laurel Mendelsohn, Anna Conrey, George Grimes, Gregory J Kato,

BACKGROUND:Well-tolerated and effective treatments are needed for chronic leg ulcers in sickle cell anaemia. Topical sodium nitrite, a known nitric oxide donor, enhances blood flow in ulcers and has known bacteriostatic effects. We aimed to assess the safety, tolerability, and pharmacokinetics of topical sodium nitrite in patients with sickle cell ... Read more >>

Lancet Haematol (The Lancet. Haematology)
[2014, 1(3):e95-e103]

Cited: 14 times

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A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor.

David H McDermott, Qian Liu, Daniel Velez, Lizbeeth Lopez, Sandra Anaya-O'Brien, Jean Ulrick, Nana Kwatemaa, Judy Starling, Thomas A Fleisher, Debra A Long Priel, Melissa A Merideth, Robert L Giuntoli, Moses O Evbuomwan, Patricia Littel, Martha M Marquesen, Dianne Hilligoss, Rosamma DeCastro, George J Grimes, Samuel T Hwang, Stefania Pittaluga, Katherine R Calvo, Pamela Stratton, Edward W Cowen, Douglas B Kuhns, Harry L Malech, Philip M Murphy,

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare immunodeficiency disorder caused by gain-of-function mutations in the G protein-coupled chemokine receptor CXCR4. The CXCR4 antagonist plerixafor, which is approved by the US Food and Drug Administration (FDA) for stem cell mobilization in cancer and administered for that indication at ... Read more >>

Blood (Blood)
[2014, 123(15):2308-2316]

Cited: 56 times

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Assays for biological agents--author's reply.

Justin T Goldspiel, Barry R Goldspiel, George Grimes, Peng Yuan, Gopal Potti,

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2013, 70(13):1102]

Cited: 0 times

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Paranitroanaline poisoning: a failure in basic prevention?

Kathleen M Fagan, Rosemary K Sokas, George R Grimes, Justin B Sternes,

The Occupational Medicine Forum is prepared by the ACOEM Occupational and Environmental Medical Practice Committee and does not necessarily represent an official ACOEM position. The Forum is intended for health professionals and is not intended to provide medical or legal advice, including illness prevention, diagnosis or treatment, or regulatory compliance. ... Read more >>

J. Occup. Environ. Med. (Journal of occupational and environmental medicine)
[2014, 56(1):112-114]

Cited: 0 times

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Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study.

Dietrich Haubenberger, Gayle McCrossin, Codrin Lungu, Elaine Considine, Camilo Toro, Fatta B Nahab, Sungyoung Auh, Peter Buchwald, George J Grimes, Judith Starling, Gopal Potti, Linda Scheider, Daniel Kalowitz, Daniel Bowen, Andrea Carnie, Mark Hallett,

To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in subjects with alcohol-responsive essential tremor (ET).We conducted a double-blind, placebo-controlled, crossover, phase I/II clinical trial evaluating the effect of 4 mg/kg OA in 19 subjects with ET. The primary outcome was accelerometric postural tremor ... Read more >>

Neurology (Neurology)
[2013, 80(10):933-940]

Cited: 14 times

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A pilot clinical trial testing mutant von Hippel-Lindau peptide as a novel immune therapy in metastatic renal cell carcinoma.

Osama E Rahma, Ed Ashtar, Ramy Ibrahim, Antoun Toubaji, Barry Gause, Vincent E Herrin, W Marston Linehan, Seth M Steinberg, Frank Grollman, George Grimes, Sarah A Bernstein, Jay A Berzofsky, Samir N Khleif,

Due to the lack of specific tumor antigens, the majority of tested cancer vaccines for renal cell carcinoma (RCC) are based on tumor cell lysate. The identification of the von Hippel-Lindau (VHL) gene mutations in RCC patients provided the potential for developing a novel targeted vaccine for RCC. In this ... Read more >>

J Transl Med (Journal of translational medicine)
[2010, 8:8]

Cited: 18 times

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Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation.

André Dejam, Christian J Hunter, Carole Tremonti, Ryszard M Pluta, Yuen Yi Hon, George Grimes, Kristine Partovi, Mildred M Pelletier, Edward H Oldfield, Richard O Cannon, Alan N Schechter, Mark T Gladwin,

BACKGROUND: The recent discovery that nitrite is an intrinsic vasodilator and signaling molecule at near-physiological concentrations has raised the possibility that nitrite contributes to hypoxic vasodilation and to the bioactivity of nitroglycerin and mediates the cardiovascular protective effects of nitrate in the Mediterranean diet. However, important questions of potency, kinetics, ... Read more >>

Circulation (Circulation)
[2007, 116(16):1821-1831]

Cited: 188 times

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Comparative evaluation of oral and intranasal priming with replication-competent adenovirus 5 host range mutant (Ad5hr)-simian immunodeficiency virus (SIV) recombinant vaccines on immunogenicity and protective efficacy against SIV(mac251).

Qifeng Zhou, Rachmat Hidajat, Bo Peng, David Venzon, M Kristine Aldrich, Ersell Richardson, Eun Mi Lee, V S Kalyanaraman, George Grimes, V Raúl Gómez-Román, L Ebonita Summers, Nina Malkevich, Marjorie Robert-Guroff,

Oral, replication-competent Ad-HIV vaccines are advancing to human trials. Previous evaluation of protective efficacy in non-human primates has primarily followed upper respiratory tract administrations. Here we compared sequential oral (O/O) versus intranasal/oral (I/O) priming of rhesus macaques with Ad5 host range mutant-SIV recombinants expressing SIV env/rev, gag, and nef genes ... Read more >>

Vaccine (Vaccine)
[2007, 25(47):8021-8035]

Cited: 37 times

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Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaques.

V Raúl Gómez-Román, George J Grimes, Gopal K Potti, Bo Peng, Thorsten Demberg, Luisa Gravlin, James Treece, Ranajit Pal, Eun Mi Lee, W Gregory Alvord, Phillip D Markham, Marjorie Robert-Guroff,

Although replication-competent adenovirus (Ad) vectors are promising in AIDS vaccine design, their safety in immune compromised hosts is unknown. To initially address this question, enteric-coated tablets containing a replicating Ad vector were orally administered to SHIV- and SIV-infected rhesus macaques with normal, intermediate or low CD4 T cell counts and ... Read more >>

Vaccine (Vaccine)
[2006, 24(23):5064-5072]

Cited: 18 times

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Safety and pharmacokinetics of a preservative-free triamcinolone acetonide formulation for intravitreal administration.

Hyuncheol Kim, Karl G Csaky, Luisa Gravlin, Peng Yuan, Robert J Lutz, Peter M Bungay, Ginger Tansey, Francisco DE Monasterio, Gopal K Potti, George Grimes, Michael R Robinson,

PURPOSE:The safety and pharmacokinetics of a triamcinolone acetonide (TA) preservative-free (TA-PF) formulation were investigated after intravitreal administration in rabbits. METHODS:A TA-PF formulation was prepared as a sterile 40-mg/mL or 160-mg/mL suspension in single-use vials by adding TA powder to 0.5% hydroxypropyl methylcellulose in normal saline. TA-PF (4-mg and 16-mg doses) ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2006, 26(5):523-530]

Cited: 36 times

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Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug.

David J Waterhouse, Joseph E Saavedra, Keith M Davies, Michael L Citro, Xia Xu, Douglas A Powell, George J Grimes, Gopal K Potti, Larry K Keefer,

PROLI/NO is an agent of structure XN(O)==NONa (X = L-prolyl) whose 2-s half-life for nitric oxide (NO) release at physiological pH makes it an excellent prodrug for localizing NO's therapeutic effects at the site of application, but a difficult one to formulate and certify as pure. Despite its extraordinary thermal ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2006, 95(1):108-115]

Cited: 9 times

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Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.

Ryszard M Pluta, Andre Dejam, George Grimes, Mark T Gladwin, Edward H Oldfield,

Delayed cerebral vasospasm causes permanent neurological deficits or death in at least 15% of patients following otherwise successful treatment for ruptured intracranial aneurysm. Decreased bioavailability of nitric oxide has been associated with the development of cerebral vasospasm.To determine whether infusions of nitrite will prevent delayed cerebral vasospasm.A total of 14 ... Read more >>

JAMA (JAMA)
[2005, 293(12):1477-1484]

Cited: 137 times

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