Full Text Journal Articles by
Author George C Velmahos

Advertisement

Find full text journal articles






Validation of the artificial intelligence-based trauma outcomes predictor (TOP) in patients 65 years and older.

Majed El Hechi, Anthony Gebran, Hamza Tazi Bouardi, Lydia R Maurer, Mohamad El Moheb, Daisy Zhuo, Jack Dunn, Dimitris Bertsimas, George C Velmahos, Haytham M A Kaafarani,

<h4>Background</h4>The Trauma Outcomes Predictor tool was recently derived using a machine learning methodology called optimal classification trees and validated for prediction of outcomes in trauma patients. The Trauma Outcomes Predictor is available as an interactive smartphone application. In this study, we sought to assess the performance of the Trauma Outcomes ... Read more >>

Surgery (Surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Underuse and Variability in Substance Use Screening Among Adult Trauma Patients in the U.S. - A Nationwide Retrospective Cohort Study.

Osaid Alser, Numa P Perez, Anthony Gebran, Lydia R Maurer, Gezzer Ortega, George C Velmahos, Haytham M A Kaafarani, Peter T Masiakos,

OBJECTIVE:To characterize the rates and variability in substance screening among adult trauma patients in the U.S. SUMMARY BACKGROUND DATA:Emergency Department trauma visits provide a unique opportunity to identify patients with substance use disorders. Despite the existence of screening guidelines, underscreening and variability in screening practices remain. METHODS:Retrospective cohort study including ... Read more >>

Ann Surg (Annals of surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Challenging Traditional Paradigms in Posttraumatic Pulmonary Thromboembolism.

M Margaret Knudson, Ernest E Moore, Lucy Z Kornblith, Amy M Shui, Scott Brakenridge, Brandon R Bruns, Mark D Cipolle, Todd W Costantini, Bruce A Crookes, Elliot R Haut, Andrew J Kerwin, Laszlo N Kiraly, Lisa M Knowlton, Matthew J Martin, Michelle K McNutt, David J Milia, Alicia Mohr, Ram Nirula, Fredrick B Rogers, Thomas M Scalea, Sherry L Sixta, David A Spain, Charles E Wade, George C Velmahos,

<h4>Importance</h4>Pulmonary clots are seen frequently on chest computed tomography performed after trauma, but recent studies suggest that pulmonary thrombosis (PT) and pulmonary embolism (PE) after trauma are independent clinical events.<h4>Objective</h4>To assess whether posttraumatic PT represents a distinct clinical entity associated with the nature of the injury, different from the traditional ... Read more >>

JAMA Surg (JAMA surgery)
[2021, :e216356]

Cited: 0 times

View full text PDF listing >>



Bowel Ischemia in COVID-19 Infection: One-Year Surgical Experience.

John O Hwabejire, Haytham M A Kaafarani, Hassan Mashbari, Joseph Misdraji, Peter J Fagenholz, Rajshri M Gartland, Diane R Abraczinskas, Raaj S Mehta, Charudutt N Paranjape, George Eng, Noelle N Saillant, Jonathan Parks, Jason A Fawley, Jarone Lee, David R King, April E Mendoza, George C Velmahos,

<h4>Background</h4>COVID-19 is a deadly multisystemic disease, and bowel ischemia, the most consequential gastrointestinal manifestation, remains poorly described. Our goal is to describe our institution's surgical experience with management of bowel ischemia due to COVID-19 infection over a one-year period.<h4>Methods</h4>All patients admitted to our institution between March 2020 and March 2021 ... Read more >>

Am Surg (The American surgeon)
[2021, 87(12):1893-1900]

Cited: 1 time

View full text PDF listing >>



Factors that Predict Survival From Mesenteric Ischemia in the Geriatric Patient: Not a Death Sentence.

Anthony Gebran, Ander Dorken Gallastegi, Peter Fagenholz, David King, Haytham M A Kaafarani, Charu Paranjape, George C Velmahos, John O Hwabejire,

<h4>Background</h4>The mortality rate from mesenteric ischemia is reported to be as high as 80%. The goal of our study was to identify demographic and clinical predictors of post-operative mortality and discharge disposition among elderly patients with mesenteric ischemia.<h4>Methods</h4>All patients 65 years and older who underwent emergency surgery (ES) for the management ... Read more >>

Am Surg (The American surgeon)
[2021, :31348211050585]

Cited: 0 times

View full text PDF listing >>



Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis: A Multi-institutional Genome-Wide Association Study.

Apostolos Gaitanidis, Haytham M A Kaafarani, Mathias A Christensen, Kerry Breen, April Mendoza, Peter J Fagenholz, George C Velmahos, Maha R Farhat,

<h4>Importance</h4>The familial aspect of acute appendicitis (AA) has been proposed, but its hereditary basis remains undetermined.<h4>Objective</h4>To identify genomic variants associated with AA.<h4>Design, setting, and participants</h4>This genome-wide association study, conducted from June 21, 2019, to February 4, 2020, used a multi-institutional biobank to retrospectively identify patients with AA across 8 single-nucleotide ... Read more >>

JAMA Surg (JAMA surgery)
[2021, 156(10):917-923]

Cited: 1 time

View full text PDF listing >>



Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis.

Charlie J Nederpelt, Leon Naar, Pieta Krijnen, Saskia le Cessie, Haytham M A Kaafarani, Menno V Huisman, George C Velmahos, Inger B Schipper,

<h4>Objectives</h4>To combine evidence on andexanet alfa and prothrombin complex concentrates for factor Xa inhibitor-associated bleeding to guide clinicians on reversal strategies.<h4>Data sources</h4>Embase, Pubmed, Web of Science, and the Cochrane Library.<h4>Study selection</h4>Observational studies and randomized clinical trials studying hemostatic effectiveness of andexanet alfa or prothrombin complex concentrate for acute reversal of ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(10):e1025-e1036]

Cited: 2 times

View full text PDF listing >>



Early versus late enteral nutrition in critically ill patients receiving vasopressor support.

Ander Dorken Gallastegi, Anthony Gebran, Apostolos Gaitanidis, Leon Naar, John O Hwabejire, Jonathan Parks, Jarone Lee, Haytham M A Kaafarani, George C Velmahos, April E Mendoza,

<h4>Background</h4>Outcomes of early enteral nutrition (EEN) in critically ill patients on vasoactive medications remain unclear. We aimed to compare in-hospital outcomes for EEN vs late EN (LEN) in mechanically ventilated patients receiving vasopressor support.<h4>Methods</h4>This was a retrospective study using the national eICU Collaborative Research Database. Adult patients requiring vasopressor support ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Lower Mortality with Cryoprecipitate During Massive Transfusion in Penetrating but Not Blunt Trauma.

Apostolos Gaitanidis, Robert T Sinyard, Charlie J Nederpelt, Lydia R Maurer, Mathias A Christensen, Hassan Mashbari, George C Velmahos, Haytham M A Kaafarani,

<h4>Background</h4>Balanced blood product transfusion improves the outcomes of trauma patients with exsanguinating hemorrhage, but it remains unclear whether administering cryoprecipitate improves mortality. We aimed to examine the impact of early cryoprecipitate transfusion on the outcomes of the trauma patients needing massive transfusion (MT).<h4>Methods</h4>All MT patients 18 years or older in ... Read more >>

J Surg Res (The Journal of surgical research)
[2022, 269:94-102]

Cited: 0 times

View full text PDF listing >>



Clinicopathological findings in patients with COVID-19-associated ischaemic enterocolitis.

M Lisa Zhang, Frank Jacobsen, Brian J Pepe-Mooney, Mari Mino-Kenudson, Vikram Deshpande, Angela R Shih, Anthony R Mattia, Wolfram Goessling, John O Hwabejire, George C Velmahos, Joseph Misdraji,

<h4>Aims</h4>Coronavirus disease 2019 (COVID-19) has been recognised as a predominantly respiratory tract infection, but some patients manifest severe systemic symptoms/coagulation abnormalities. The aim of this study was to evaluate the impact of severe COVID-19 infection on the gastrointestinal tract.<h4>Methods and results</h4>We examined clinicopathological findings in 28 resected ischaemic bowels from ... Read more >>

Histopathology (Histopathology)
[2021, 79(6):1004-1017]

Cited: 2 times

View full text PDF listing >>



Low-Molecular Weight Heparin is Superior to Unfractionated Heparin for Elderly Trauma Patients.

Apostolos Gaitanidis, Kerry A Breen, Mathias A Christensen, Noelle N Saillant, Haytham M A Kaafarani, George C Velmahos, April E Mendoza,

<h4>Background</h4>Several studies have demonstrated that low-molecular weight heparin (LMWH) is superior to unfractionated heparin (UFH) in trauma patients. The superiority of either one has not been established for the elderly. In this study, we compared LMWH to UFH in elderly trauma patients.<h4>Methods</h4>A retrospective analysis of the American College of Surgeons' ... Read more >>

J Surg Res (The Journal of surgical research)
[2021, 268:432-439]

Cited: 0 times

View full text PDF listing >>



Trauma outcome predictor: An artificial intelligence interactive smartphone tool to predict outcomes in trauma patients.

Lydia R Maurer, Dimitris Bertsimas, Hamza Tazi Bouardi, Majed El Hechi, Mohamad El Moheb, Katerina Giannoutsou, Daisy Zhuo, Jack Dunn, George C Velmahos, Haytham M A Kaafarani,

<h4>Background</h4>Classic risk assessment tools often treat patients' risk factors as linear and additive. Clinical reality suggests that the presence of certain risk factors can alter the impact of other factors; in other words, risk modeling is not linear. We aimed to use artificial intelligence (AI) technology to design and validate ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 91(1):93-99]

Cited: 0 times

View full text PDF listing >>



Intensive Care Unit Volume of Sepsis Patients Does Not Affect Mortality: Results of a Nationwide Retrospective Analysis.

Leon Naar, Majed W El Hechi, Ander Dorken Gallastegi, B Christian Renne, Jason Fawley, Jonathan J Parks, April E Mendoza, Noelle N Saillant, George C Velmahos, Haytham M A Kaafarani, Jarone Lee,

<h4>Background</h4>There is little research evaluating outcomes from sepsis in intensive care units (ICUs) with lower sepsis patient volumes as compared to ICUs with higher sepsis patient volumes. Our objective was to compare the outcomes of septic patients admitted to ICUs with different sepsis patient volumes.<h4>Materials and methods</h4>We included all patients ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, :8850666211024184]

Cited: 0 times

View full text PDF listing >>



The Emergency Surgery Score is a powerful predictor of outcomes across multiple surgical specialties: Results of a retrospective nationwide analysis.

Reem AlSowaiegh, Leon Naar, Mohamad El Moheb, Jonathan J Parks, Jason Fawley, April E Mendoza, Noelle N Saillant, George C Velmahos, Haytham M A Kaafarani,

<h4>Background</h4>The Emergency Surgery Score was recently validated in a prospective multicenter study as an accurate predictor of mortality in emergency general surgery patients. The Emergency Surgery Score is easily calculated using multiple demographic, comorbidity, laboratory, and acuity of disease variables. We aimed to investigate whether the Emergency Surgery Score can ... Read more >>

Surgery (Surgery)
[2021, 170(5):1501-1507]

Cited: 1 time

View full text PDF listing >>



Deep immune profiling of whole blood to identify early immune signatures that correlate to patient outcome after major trauma.

April E Mendoza, Susan Raju Paul, Majed El Hechi, Leon Naar, Charlie Nederpelt, Sarah Mikdad, Inge van Erp, Joshua M Hess, George C Velmahos, Mark Poznansky, Patrick Reeves,

<h4>Background</h4>Major injury results in an early cascade of immunologic responses that increase susceptibility to infection and multiorgan dysfunction. Detailed immune profiling by mass cytometry has the potential to identify immune signatures that correspond to patient outcomes. Our objective was to determine the prognostic value of immune signatures early after major ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(6):959-966]

Cited: 0 times

View full text PDF listing >>



Development of a field artificial intelligence triage tool: Confidence in the prediction of shock, transfusion, and definitive surgical therapy in patients with truncal gunshot wounds.

Charlie J Nederpelt, Ava K Mokhtari, Osaid Alser, Theodoros Tsiligkaridis, Jay Roberts, Miriam Cha, Jason A Fawley, Jonathan J Parks, April E Mendoza, Peter J Fagenholz, Haytham M A Kaafarani, David R King, George C Velmahos, Noelle Saillant,

<h4>Background</h4>In-field triage tools for trauma patients are limited by availability of information, linear risk classification, and a lack of confidence reporting. We therefore set out to develop and test a machine learning algorithm that can overcome these limitations by accurately and confidently making predictions to support in-field triage in the ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(6):1054-1060]

Cited: 0 times

View full text PDF listing >>



Multisystem outcomes and predictors of mortality in critically ill patients with COVID-19: Demographics and disease acuity matter more than comorbidities or treatment modalities.

Osaid Alser, Ava Mokhtari, Leon Naar, Kimberly Langeveld, Kerry A Breen, Mohamad El Moheb, Carolijn Kapoen, Apostolos Gaitanidis, Mathias A Christensen, Lydia R Maurer, Hassan Mashbari, Brittany Bankhead-Kendall, Jonathan Parks, Jason Fawley, Noelle Saillant, April Mendoza, Charudutt Paranjape, Peter Fagenholz, David King, Jarone Lee, Maha R Farhat, George C Velmahos, Haytham M A Kaafarani,

<h4>Background</h4>We sought to describe characteristics, multisystem outcomes, and predictors of mortality of the critically ill COVID-19 patients in the largest hospital in Massachusetts.<h4>Methods</h4>This is a prospective cohort study. All patients admitted to the intensive care unit (ICU) with reverse-transcriptase-polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus 2 infection between March ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(5):880-890]

Cited: 2 times

View full text PDF listing >>



Modified Frailty Index-5 Score and Post-Operative Infectious Complications in Patients Undergoing Surgery for Intestinal-Cutaneous Fistula: A Nationwide Retrospective Cohort Analysis.

Osaid Alser, Ander Dorken Gallastegi, Mathias A Christensen, Hassan Mashbari, Noelle Saillant, Jonathan Parks, April Mendoza, Peter Fagenholz, David King, John Hwabejire, Haytham M A Kaafarani, George C Velmahos, Jason A Fawley,

<b><i>Background:</i></b> Post-operative infectious complications after repair of intestinal-cutaneous fistulas (ICF) represent a substantial burden and these outcomes vary widely in the literature. We aimed to evaluate the use of the modified frailty index-5 (mFI-5) to account for physiologic reserve to predict infectious complications in patients with ICF undergoing operative repair. ... Read more >>

Surg Infect (Larchmt) (Surgical infections)
[2021, 22(9):903-909]

Cited: 0 times

View full text PDF listing >>



Association between alcohol intoxication and mortality in severe traumatic brain injury in the emergency department: a retrospective cohort.

Suzanne F van Wijck, Napaporn Kongkaewpaisan, Kelsey Han, Nikolaos Kokoroskos, Manasnun Kongwibulwut, David R King, Gwendolyn M van der Wilden, Pieta Krijnen, Inger B Schipper, George C Velmahos,

<h4>Background</h4>Acute alcohol intoxication is very common in patients with severe traumatic brain injury (TBI). Whether there is an independent association between alcohol intoxication and mortality is debated. This study hypothesized that alcohol intoxication is independently associated with less mortality after severe TBI (sTBI).<h4>Methods</h4>This retrospective observational cohort study included all patients ... Read more >>

Eur J Emerg Med (European journal of emergency medicine : official journal of the European Society for Emergency Medicine)
[2021, 28(2):97-103]

Cited: 0 times

View full text PDF listing >>



Rhabdomyolysis in Severe COVID-19: Male Sex, High Body Mass Index, and Prone Positioning Confer High Risk.

Ava K Mokhtari, Lydia R Maurer, Mathias A Christensen, Mohamad El Moheb, Leon Naar, Osaid Alser, Apostolos Gaitanidis, Kimberly Langeveld, Carolijn Kapoen, Kerry Breen, George C Velmahos, Haytham M A Kaafarani,

<h4>Background</h4>Bedside experience and studies of critically ill patients with coronavirus disease 2019 (COVID-19) indicate COVID-19 to be a devastating multisystem disease. We aim to describe the incidence, associated variables, and outcomes of rhabdomyolysis in critically ill COVID-19 patients.<h4>Materials and methods</h4>Data for all critically ill adult patients (≥18 years old) admitted ... Read more >>

J Surg Res (The Journal of surgical research)
[2021, 266:35-43]

Cited: 1 time

View full text PDF listing >>



Peri-operative blood transfusion and risk of infectious complications following intestinal-cutaneous fistula surgical repair: A retrospective nationwide analysis.

Osaid Alser, Mathias A Christensen, Noelle Saillant, Jonathan Parks, April Mendoza, Peter Fagenholz, David King, Haytham M A Kaafarani, George C Velmahos, Jason Fawley,

<h4>Background</h4>Peri-operative blood transfusion (BT) may lead to transfusion-induced immunomodulation. We aimed to investigate the association between peri-operative BT and infectious complications in patients undergoing intestinal-cutaneous fistulas (ICF) repair.<h4>Methods</h4>We queried the ACS-NSQIP 2006-2017 database to include patients who underwent ICF repair. The main outcome was 30-day infectious complications. Univariate and multivariable ... Read more >>

Am J Surg (American journal of surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients.

Robert V O'Toole, Deborah M Stein, Katherine P Frey, Nathan N O'Hara, Daniel O Scharfstein, Gerard P Slobogean, Tara J Taylor, Bryce E Haac, Anthony R Carlini, Theodore T Manson, Kuladeep Sudini, C Daniel Mullins, Stephen T Wegener, Reza Firoozabadi, Elliott R Haut, Michael J Bosse, Rachel B Seymour, Martha B Holden, Ida Leah Gitajn, Samuel Z Goldhaber, Alexander L Eastman, Gregory J Jurkovich, Heather A Vallier, Joshua L Gary, Conor P Kleweno, Joseph Cuschieri, Debra Marvel, Renan C Castillo, ,

<h4>Introduction</h4>Patients who sustain orthopaedic trauma are at an increased risk of venous thromboembolism (VTE), including fatal pulmonary embolism (PE). Current guidelines recommend low-molecular-weight heparin (LMWH) for VTE prophylaxis in orthopaedic trauma patients. However, emerging literature in total joint arthroplasty patients suggests the potential clinical benefits of VTE prophylaxis with aspirin. ... Read more >>

BMJ Open (BMJ open)
[2021, 11(3):e041845]

Cited: 0 times

View full text PDF listing >>



Does the Emergency Surgery Score predict failure to discharge the patient home? A nationwide analysis.

Reem AlSowaiegh, Leon Naar, Ava Mokhtari, Jonathan J Parks, Jason Fawley, April E Mendoza, Noelle N Saillant, George C Velmahos, Haytham M A Kaafarani,

<h4>Background</h4>The Emergency Surgery Score (ESS) is a point-based scoring system validated to predict mortality and morbidity in emergency general surgery (EGS). In addition to demographics and comorbidities, ESS accounts for the acuity of disease at presentation. We sought to examine whether ESS can predict the destination of discharge of EGS ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(3):471-476]

Cited: 0 times

View full text PDF listing >>



Validation of the Artificial Intelligence-Based Predictive Optimal Trees in Emergency Surgery Risk (POTTER) Calculator in Emergency General Surgery and Emergency Laparotomy Patients.

Majed W El Hechi, Lydia R Maurer, Jordan Levine, Daisy Zhuo, Mohamad El Moheb, George C Velmahos, Jack Dunn, Dimitris Bertsimas, Haytham Ma Kaafarani,

<h4>Background</h4>The Predictive Optimal Trees in Emergency Surgery Risk (POTTER) tool is an artificial intelligence-based calculator for the prediction of 30-day outcomes in patients undergoing emergency operations. In this study, we sought to assess the performance of POTTER in the emergency general surgery (EGS) population in particular.<h4>Methods</h4>All patients who underwent EGS ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2021, 232(6):912-919.e1]

Cited: 0 times

View full text PDF listing >>



Preoperative frailty predicts postoperative outcomes in intestinal-cutaneous fistula repair.

Osaid Alser, Leon Naar, Mathias A Christensen, Noelle Saillant, Jonathan Parks, April Mendoza, Peter Fagenholz, David King, Haytham M A Kaafarani, George C Velmahos, Jason Fawley,

<h4>Background</h4>The outcomes of operative repair of intestinal-cutaneous fistulas vary widely throughout the literature. We aimed to investigate whether the modified frailty index-5 is a reliable tool to account for physiologic reserve and whether it serves as a predictor of Clavien-Dindo grade IV complications in those with intestinal-cutaneous fistulas undergoing operative ... Read more >>

Surgery (Surgery)
[2021, 169(5):1199-1205]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

2.6113 s