Full Text Journal Articles by
Author Geoff Higgins


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Whole-Genome Sequencing of SARS-CoV-2 from Quarantine Hotel Outbreak.

Lex E X Leong, Julien Soubrier, Mark Turra, Emma Denehy, Luke Walters, Karin Kassahn, Geoff Higgins, Tom Dodd, Robert Hall, Katina D'Onise, Nicola Spurrier, Ivan Bastian, Chuan K Lim,

Hotel quarantine for international travelers has been used to prevent coronavirus disease spread into Australia. A quarantine hotel-associated community outbreak was detected in South Australia. Real-time genomic sequencing enabled rapid confirmation tracking the outbreak to a recently returned traveler and linked 2 cases of infection in travelers at the same ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(8):2219-2221]

Cited: 0 times

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Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Michael Skwarski, Daniel R McGowan, Elizabeth Belcher, Francesco Di Chiara, Dionisios Stavroulias, Mark McCole, Jennifer L Derham, Kwun-Ye Chu, Eugene Teoh, Jagat Chauhan, Dawn O'Reilly, Benjamin H L Harris, Philip S Macklin, Joshua A Bull, Marcus Green, Gonzalo Rodriguez-Berriguete, Remko Prevo, Lisa K Folkes, Leticia Campo, Petra Ferencz, Paula L Croal, Helen Flight, Cathy Qi, Jane Holmes, James P B O'Connor, Fergus V Gleeson, W Gillies McKenna, Adrian L Harris, Daniel Bulte, Francesca M Buffa, Ruth E Macpherson, Geoff S Higgins,

<h4>Purpose</h4>Tumor hypoxia fuels an aggressive tumor phenotype and confers resistance to anticancer treatments. We conducted a clinical trial to determine whether the antimalarial drug atovaquone, a known mitochondrial inhibitor, reduces hypoxia in non-small cell lung cancer (NSCLC).<h4>Patients and methods</h4>Patients with NSCLC scheduled for surgery were recruited sequentially into two cohorts: ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(9):2459-2469]

Cited: 2 times

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The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress.

James T T Coates, Gonzalo Rodriguez-Berriguete, Rathi Puliyadi, Thomas Ashton, Remko Prevo, Archie Wing, Giovanna Granata, Giacomo Pirovano, Gillies W McKenna, Geoff S Higgins,

Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk and provide effective treatment options for many cancers. Here, we repurpose atovaquone (ATQ), a well-tolerated & FDA-approved anti-malarial agent by demonstrating that it potentiates cancer cell death of a subset ... Read more >>

Cell Death Discov (Cell death discovery)
[2020, 6:110]

Cited: 2 times

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Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.

Katharine J Herbert, Rathi Puliyadi, Remko Prevo, Gonzalo Rodriguez-Berriguete, Anderson Ryan, Kristijan Ramadan, Geoff S Higgins,

T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development of targeted therapeutics. Results presented in this paper confirm ... Read more >>

Cell Death Differ (Cell death and differentiation)
[2021, 28(4):1333-1346]

Cited: 2 times

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Determining a sampling regime for PCR detection of respiratory tract viral infection at coronial post-mortem examinations.

Caitlin Gilsenan-Reed, Geoff Higgins, Neil Langlois,

Death due to respiratory infection is commonly encountered at autopsy. With only one opportunity to obtain samples for identification of a causative agent, it is important to ensure that sampling regimes are optimized to provide the greatest detection, without the expense and redundancy that can arise from over-sampling. This study ... Read more >>

Forensic Sci Med Pathol (Forensic science, medicine, and pathology)
[2020, 16(3):457-462]

Cited: 0 times

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Corrigendum: Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?

Joseph D Wilson, Ester M Hammond, Geoff S Higgins, Kristoffer Petersson,

[This corrects the article DOI: 10.3389/fonc.2019.01563.]. ...

Front Oncol (Frontiers in oncology)
[2020, 10:210]

Cited: 1 time

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Reply to 'The use of buparlisib as a radiosensitiser: What about toxicity?'

Daniel R McGowan, Michael Skwarski, Geoff S Higgins,

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 119:196-197]

Cited: 0 times

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2135. Streptococcus pneumoniae DNA (lytA) Detection in Clinical Samples Sent for a Respiratory Viral Polymerase Chain Reaction: Is There Bacterial-Viral Association?

Matthew Roberts, Tania Sadlon, Geoff D Higgins,

Abstract <h4>Background</h4> Streptococcus pneumoniae (SPNEU) is a major cause of community-acquired pneumonia and frequently complicates respiratory viral infections. Clinical differentiation of viral and bacterial respiratory tract infection can be difficult, as can predicting which patients with respiratory viral infection will develop bacterial infection. A SPNEU polymerase chain reaction (PCR) to ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S723-S723]

Cited: 0 times

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Intense interseasonal influenza outbreaks, Australia, 2018/19.

Ian G Barr, Yi Mo Deng, Miguel L Grau, Alvin X Han, Robin Gilmour, Melissa Irwin, Peter Markey, Kevin Freeman, Geoff Higgins, Mark Turra, Naomi Komadina, Heidi Peck, Robert Booy, Sebastian Maurer-Stroh, Vijaykrishna Dhanasekaran, Sheena Sullivan,

BackgroundInterseasonal influenza outbreaks are not unusual in countries with temperate climates and well-defined influenza seasons. Usually, these are small and diminish before the main influenza season begins. However, the 2018/19 summer-autumn interseasonal influenza period in Australia saw unprecedented large and widespread influenza outbreaks.AimOur objective was to determine the extent of ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2019, 24(33):]

Cited: 6 times

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[18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model.

Giacomo Pirovano, Sheryl Roberts, Christian Brand, Patrick L Donabedian, Christian Mason, Paula Demétrio de Souza, Geoff S Higgins, Thomas Reiner,

<h4>Purpose</h4>Lymphokine-activated killer T cell-originated protein kinase (TOPK) is a fairly new cancer biomarker with great potential for clinical applications. The labeling of a TOPK inhibitor with F-18 can be exploited for positron emission tomography (PET) imaging allowing more accurate patient identification, stratification, and disease monitoring.<h4>Procedures</h4>[<sup>18</sup>F]FE-OTS964 was produced starting from OTS964, ... Read more >>

Mol Imaging Biol (Molecular imaging and biology)
[2019, 21(4):705-712]

Cited: 5 times

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Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma.

Daniel R McGowan, Michael Skwarski, Kevin M Bradley, Leticia Campo, John D Fenwick, Fergus V Gleeson, Marcus Green, Amanda Horne, Timothy S Maughan, Mark G McCole, Seid Mohammed, Ruth J Muschel, Stasya M Ng, Niki Panakis, Remko Prevo, Victoria Y Strauss, Robert Stuart, Eliana M C Tacconi, Katherine A Vallis, W Gillies McKenna, Ruth E Macpherson, Geoff S Higgins,

<h4>Background</h4>Pre-clinically, phosphoinositide 3-kinase (PI3K) inhibition radiosensitises tumours by increasing intrinsic radiosensitivity and by reducing tumour hypoxia. We assessed whether buparlisib, a class 1 PI3K inhibitor, can be safely combined with radiotherapy in patients with non-small cell lung carcinoma (NSCLC) and investigated its effect on tumour hypoxia.<h4>Methods</h4>This was a 3 + 3 dose ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 113:87-95]

Cited: 7 times

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Tumor pH and Protein Concentration Contribute to the Signal of Amide Proton Transfer Magnetic Resonance Imaging.

Kevin J Ray, Manon A Simard, James R Larkin, James Coates, Paul Kinchesh, Sean C Smart, Geoff S Higgins, Michael A Chappell, Nicola R Sibson,

Abnormal pH is a common feature of malignant tumors and has been associated clinically with suboptimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to noninvasively measure tumor pH, yet multiple factors collectively make quantification of tumor pH from APT MRI data challenging. The ... Read more >>

Cancer Res (Cancer research)
[2019, 79(7):1343-1352]

Cited: 9 times

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Whole tumor kinetics analysis of 18F-fluoromisonidazole dynamic PET scans of non-small cell lung cancer patients, and correlations with perfusion CT blood flow.

Daniel R McGowan, Michael Skwarski, Bartlomiej W Papiez, Ruth E Macpherson, Fergus V Gleeson, Julia A Schnabel, Geoff S Higgins, John D Fenwick,

<h4>Background</h4>To determine the relative abilities of compartment models to describe time-courses of 18F-fluoromisonidazole (FMISO) tumor uptake in patients with advanced stage non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography (dPET), and study correlations between values of the blood flow-related parameter K<sub>1</sub> obtained from fits of the models ... Read more >>

EJNMMI Res (EJNMMI research)
[2018, 8(1):73]

Cited: 0 times

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T-LAK cell-originated protein kinase (TOPK): an emerging target for cancer-specific therapeutics.

Katharine J Herbert, Thomas M Ashton, Remko Prevo, Giacomo Pirovano, Geoff S Higgins,

'Targeted' or 'biological' cancer treatments rely on differential gene expression between normal tissue and cancer, and genetic changes that render tumour cells especially sensitive to the agent being applied. Problems exist with the application of many agents as a result of damage to local tissues, tumour evolution and treatment resistance, ... Read more >>

Cell Death Dis (Cell death & disease)
[2018, 9(11):1089]

Cited: 17 times

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The new screening program to prevent cervical cancer using HPV DNA: getting the balance right in maintaining quality.

Suzanne M Garland, Wayne Dimech, Peter Collignon, , Louise Cooley, Graeme R Nimmo, David W Smith, Rob Baird, William Rawlinson, Anna-Maria Costa, Geoff Higgins,

Along with the reduction in human papillomavirus (HPV) infection and cervical abnormalities as a result of the successful HPV vaccination program, Australia is adopting a new screening strategy. This involves a new paradigm moving from cervical cytological screening to molecular nucleic acid technology (NAT), using HPV DNA assays as primary ... Read more >>

J Pathol Clin Res (The journal of pathology. Clinical research)
[2018, 4(4):207-212]

Cited: 1 time

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The evolutionary landscape of colorectal tumorigenesis.

William Cross, Michal Kovac, Ville Mustonen, Daniel Temko, Hayley Davis, Ann-Marie Baker, Sujata Biswas, Roland Arnold, Laura Chegwidden, Chandler Gatenbee, Alexander R Anderson, Viktor H Koelzer, Pierre Martinez, Xiaowei Jiang, Enric Domingo, Dan J Woodcock, Yun Feng, Monika Kovacova, Tim Maughan, , Marnix Jansen, Manuel Rodriguez-Justo, Shazad Ashraf, Richard Guy, Christopher Cunningham, James E East, David C Wedge, Lai Mun Wang, Claire Palles, Karl Heinimann, Andrea Sottoriva, Simon J Leedham, Trevor A Graham, Ian P M Tomlinson,

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, we investigate the evolutionary fitness landscape occupied by these neoplasms. Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations-considered to be ... Read more >>

Nat Ecol Evol (Nature ecology & evolution)
[2018, 2(10):1661-1672]

Cited: 27 times

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4D-PET reconstruction using a spline-residue model with spatial and temporal roughness penalties.

George P Ralli, Michael A Chappell, Daniel R McGowan, Ricky A Sharma, Geoff S Higgins, John D Fenwick,

4D reconstruction of dynamic positron emission tomography (dPET) data can improve the signal-to-noise ratio in reconstructed image sequences by fitting smooth temporal functions to the voxel time-activity-curves (TACs) during the reconstruction, though the optimal choice of function remains an open question. We propose a spline-residue model, which describes TACs as ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2018, 63(9):095013]

Cited: 0 times

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CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner.

Remko Prevo, Giacomo Pirovano, Rathi Puliyadi, Katharine J Herbert, Gonzalo Rodriguez-Berriguete, Alice O'Docherty, William Greaves, W Gillies McKenna, Geoff S Higgins,

Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has been proposed as a tumor specific anti-cancer target. Here we show that the effects of CDK1 inhibition are not restricted to tumor cells but can also ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2018, 17(12):1513-1523]

Cited: 12 times

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The Future of Radiobiology.

David G Kirsch, Max Diehn, Aparna H Kesarwala, Amit Maity, Meredith A Morgan, Julie K Schwarz, Robert Bristow, Sandra Demaria, Iris Eke, Robert J Griffin, Daphne Haas-Kogan, Geoff S Higgins, Alec C Kimmelman, Randall J Kimple, Isabelle M Lombaert, Li Ma, Brian Marples, Frank Pajonk, Catherine C Park, Dörthe Schaue, Phuoc T Tran, Henning Willers, Brad G Wouters, Eric J Bernhard,

Innovation and progress in radiation oncology depend on discovery and insights realized through research in radiation biology. Radiobiology research has led to fundamental scientific insights, from the discovery of stem/progenitor cells to the definition of signal transduction pathways activated by ionizing radiation that are now recognized as integral to the ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2018, 110(4):329-340]

Cited: 15 times

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Oxidative Phosphorylation as an Emerging Target in Cancer Therapy.

Thomas M Ashton, W Gillies McKenna, Leoni A Kunz-Schughart, Geoff S Higgins,

Cancer cells have upregulated glycolysis compared with normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is downregulated in all cancers. However, recent studies have shown that OXPHOS can be also upregulated in certain cancers, including leukemias, lymphomas, pancreatic ductal adenocarcinoma, high OXPHOS subtype melanoma, and ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2018, 24(11):2482-2490]

Cited: 138 times

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Beyond PARP-POLθ as an anticancer target.

Geoff S Higgins, Simon J Boulton,

Science (Science (New York, N.Y.))
[2018, 359(6381):1217-1218]

Cited: 18 times

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Targeting tumour hypoxia: shifting focus from oxygen supply to demand.

James T Coates, Michael Skwarski, Geoff S Higgins,

Tumour hypoxia is a well-recognised barrier to anti-cancer therapy and represents one of the best validated targets in oncology. Previous attempts to tackle hypoxia have focussed primarily on increasing tumour oxygen supply; however, clinical studies using this approach have yielded only modest clinical benefit, with often significant toxicity and practical ... Read more >>

Br J Radiol (The British journal of radiology)
[2019, 92(1093):20170843]

Cited: 8 times

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Low interim influenza vaccine effectiveness, Australia, 1 May to 24 September 2017.

Sheena G Sullivan, Monique B Chilver, Kylie S Carville, Yi-Mo Deng, Kristina A Grant, Geoff Higgins, Naomi Komadina, Vivian Ky Leung, Cara A Minney-Smith, Don Teng, Thomas Tran, Nigel Stocks, James E Fielding,

In 2017, influenza seasonal activity was high in the southern hemisphere. We present interim influenza vaccine effectiveness (VE) estimates from Australia. Adjusted VE was low overall at 33% (95% confidence interval (CI): 17 to 46), 50% (95% CI: 8 to 74) for A(H1)pdm09, 10% (95% CI: -16 to 31) for ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2017, 22(43):]

Cited: 26 times

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18 F-fluoromisonidazole uptake in advanced stage non-small cell lung cancer: A voxel-by-voxel PET kinetics study.

Daniel R McGowan, Ruth E Macpherson, Sara L Hackett, Dan Liu, Fergus V Gleeson, W Gillies McKenna, Geoff S Higgins, John D Fenwick,

<h4>Purpose</h4>The aim of this study was to determine the relative abilities of compartment models to describe time-courses of <sup>18</sup> F-fluoromisonidazole (FMISO) uptake in tumor voxels of patients with non-small cell lung cancer (NSCLC) imaged using dynamic positron emission tomography. Also to use fits of the best-performing model to investigate changes ... Read more >>

Med Phys (Medical physics)
[2017, 44(9):4665-4676]

Cited: 5 times

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TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy.

Giacomo Pirovano, Thomas M Ashton, Katharine J Herbert, Richard J Bryant, Clare L Verrill, Lucia Cerundolo, Francesca M Buffa, Remko Prevo, Iona Harrap, Anderson J Ryan, Valentine Macaulay, William G McKenna, Geoff S Higgins,

<h4>Background</h4>Tumour-specific radiosensitising treatments may enhance the efficacy of radiotherapy without exacerbating side effects. In this study we determined the radiation response following depletion or inhibition of TOPK, a mitogen-activated protein kinase kinase family Ser/Thr protein kinase that is upregulated in many cancers.<h4>Methods</h4>Radiation response was studied in a wide range of ... Read more >>

Br J Cancer (British journal of cancer)
[2017, 117(4):503-512]

Cited: 12 times

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