Full Text Journal Articles by
Author Gennaro Clemente

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Effects of a multifactorial ecosustainable isocaloric diet on liver fat in patients with type 2 diabetes: randomized clinical trial.

Giuseppe Della Pepa, Claudia Vetrani, Valentina Brancato, Marilena Vitale, Serena Monti, Giovanni Annuzzi, Gianluca Lombardi, Anna Izzo, Marianna Tommasone, Paola Cipriano, Gennaro Clemente, Peppino Mirabelli, Marcello Mancini, Marco Salvatore, Gabriele Riccardi, Angela Albarosa Rivellese, Lutgarda Bozzetto,

INTRODUCTION:Treatment options for non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2D) are still a matter of debate. We compared the effects of a diet including different components versus a proven beneficial diet rich in monounsaturated fatty acids (MUFAs) on liver fat in T2D. RESEARCH DESIGN AND ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

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Pasta Consumption and Connected Dietary Habits: Associations with Glucose Control, Adiposity Measures, and Cardiovascular Risk Factors in People with Type 2 Diabetes-TOSCA.IT Study.

Marilena Vitale, Maria Masulli, Angela Albarosa Rivellese, Enzo Bonora, Anna Carla Babini, Giovanni Sartore, Laura Corsi, Raffaella Buzzetti, Giuseppe Citro, Maria Pompea Antonia Baldassarre, Antonio Carlo Bossi, Carla Giordano, Stefania Auciello, Elisabetta Dall'Aglio, Rossella Iannarelli, Laura Tonutti, Michele Sacco, Graziano Di Cianni, Gennaro Clemente, Giovanna Gregori, Sara Grioni, Vittorio Krogh, Gabriele Riccardi, Olga Vaccaro,

BACKGROUND:Pasta is a refined carbohydrate with a low glycemic index. Whether pasta shares the metabolic advantages of other low glycemic index foods has not really been investigated. The aim of this study is to document, in people with type-2 diabetes, the consumption of pasta, the connected dietary habits, and the ... Read more >>

Nutrients (Nutrients)
[2019, 12(1):]

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An integrated care pathway for cancer patients with diabetes: A proposal from the Italian experience.

Marco Gallo, Gennaro Clemente, Domenico Cristiano Corsi, Massimo Michelini, Concetta Suraci, Daniele Farci, Maria Chantal Ponziani, Riccardo Candido, Antonio Russo, Nicoletta Musacchio, Carmine Pinto, Domenico Mannino, Stefania Gori,

Diabetes and cancer frequently coexist in the same subject, often with relevant clinical effects on the management and prognosis of the comorbid patient. The existing guidelines, however, do not appropriately address many clinical issues in this setting. Although collaboration between diabetologists and oncologists should play an important role in achieving ... Read more >>

Diabetes Res. Clin. Pract. (Diabetes research and clinical practice)
[2020, 159:107721]

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Gastrointestinal effects of extra-virgin olive oil associated with lower postprandial glycemia in type 1 diabetes.

Lutgarda Bozzetto, Antonio Alderisio, Gennaro Clemente, Marisa Giorgini, Francesca Barone, Ettore Griffo, Giuseppina Costabile, Claudia Vetrani, Paola Cipriano, Angela Giacco, Gabriele Riccardi, Angela Albarosa Rivellese, Giovanni Annuzzi,

OBJECTIVE:To explore the possible mechanisms behind the lower glycemic response observed when extra-virgin olive oil (EVOO) is added to a high-glycemic index meal in patients with type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS:According to a randomized cross-over design, eleven T1D patients (6 women, 5 men) on insulin pump consumed ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2019, 38(6):2645-2651]

Cited: 1 time

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Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents.

Riccardo Ricci, Maurizio Martini, Gloria Ravegnini, Tonia Cenci, Massimo Milione, Paola Lanza, Francesco Pierconti, Donatella Santini, Sabrina Angelini, Alberto Biondi, Fausto Rosa, Sergio Alfieri, Gennaro Clemente, Roberto Persiani, Alessandra Cassano, Maria A Pantaleo, Luigi M Larocca,

BACKGROUND:Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA methylation which, although pervasive, appears nevertheless not randomly distributed. Although often indolent, these tumors are mostly chemorefractory in aggressive cases. Promoter methylation-induced O6-methylguanine DNA methyltransferase (MGMT) inactivation improves the efficacy of alkylating agents in gliomas, ... Read more >>

Clin Epigenetics (Clinical epigenetics)
[2019, 11(1):2]

Cited: 1 time

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Mirizzi Syndrome: Diagnosis and Management of a Challenging Biliary Disease.

Gennaro Clemente, Andrea Tringali, Agostino M De Rose, Elena Panettieri, Marino Murazio, Gennaro Nuzzo, Felice Giuliante,

Background:Mirizzi syndrome is a condition difficult to diagnose and treat, representing a particular "challenge" for the biliary surgeon. The disease can mimic cancer of the gallbladder, causing considerable diagnostic difficulties. Furthermore, it increases the risk of intraoperative biliary injury during cholecystectomy. The aim of this study is to point out ... Read more >>

Can J Gastroenterol Hepatol (Canadian journal of gastroenterology & hepatology)
[2018, 2018:6962090]

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Impact of a Mediterranean Dietary Pattern and Its Components on Cardiovascular Risk Factors, Glucose Control, and Body Weight in People with Type 2 Diabetes: A Real-Life Study.

Marilena Vitale, Maria Masulli, Ilaria Calabrese, Angela Albarosa Rivellese, Enzo Bonora, Stefano Signorini, Gabriele Perriello, Sebastiano Squatrito, Raffaella Buzzetti, Giovanni Sartore, Anna Carla Babini, Giovanna Gregori, Carla Giordano, Gennaro Clemente, Sara Grioni, Pasquale Dolce, Gabriele Riccardi, Olga Vaccaro, ,

This study evaluates the relation of a Mediterranean dietary pattern and its individual components with the cardiovascular risk factors profile, plasma glucose and body mass index (BMI) in people with type 2 diabetes. We studied 2568 participants at 57 diabetes clinics. Diet was assessed with the EPIC (European Prospective Investigation ... Read more >>

Nutrients (Nutrients)
[2018, 10(8):]

Cited: 3 times

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Diabetologists and Oncologists attitudes towards treating diabetes in the oncologic patient: Insights from an exploratory survey.

Gennaro Clemente, Marisa Giorgini, Marcello Mancini, Marco Gallo, ,

AIMS:Diabetes and cancer frequently coexist in the same subject, often having relevant effects on the management and prognosis of the oncologic patient. However, existing guidelines do not deal with many clinical issues in this setting appropriately. In evaluating the opinions of Diabetologists and Oncologists dealing with diabetes care in people ... Read more >>

Diabetes Res. Clin. Pract. (Diabetes research and clinical practice)
[2018, 143:420-427]

Cited: 1 time

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Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial.

Olga Vaccaro, Maria Masulli, Antonio Nicolucci, Enzo Bonora, Stefano Del Prato, Aldo P Maggioni, Angela A Rivellese, Sebastiano Squatrito, Carlo B Giorda, Giorgio Sesti, Paolo Mocarelli, Giuseppe Lucisano, Michele Sacco, Stefano Signorini, Fabrizio Cappellini, Gabriele Perriello, Anna Carla Babini, Annunziata Lapolla, Giovanna Gregori, Carla Giordano, Laura Corsi, Raffaella Buzzetti, Gennaro Clemente, Graziano Di Cianni, Rossella Iannarelli, Renzo Cordera, Olga La Macchia, Chiara Zamboni, Cristiana Scaranna, Massimo Boemi, Ciro Iovine, Davide Lauro, Sergio Leotta, Elisabetta Dall'Aglio, Emanuela Cannarsa, Laura Tonutti, Giuseppe Pugliese, Antonio C Bossi, Roberto Anichini, Francesco Dotta, Antonino Di Benedetto, Giuseppe Citro, Daniela Antenucci, Lucia Ricci, Francesco Giorgino, Costanza Santini, Agostino Gnasso, Salvatore De Cosmo, Donatella Zavaroni, Monica Vedovato, Agostino Consoli, Maria Calabrese, Paolo di Bartolo, Paolo Fornengo, Gabriele Riccardi, , ,

BACKGROUND:The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. METHODS:TOSCA.IT ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2017, 5(11):887-897]

Cited: 40 times

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The Mucocele of the Gallbladder.

Gennaro Clemente, Valeria Fico, Davide De Sio, Agostino Maria De Rose,

The gallbladder polyps are a common finding during ultrasonography but only in rare cases they may be a cancer. When a polyp is greater than 1 cm, the cholecystectomy is usually performed. In these images, a polyp of 4 cm corresponding to a collection of mucus (mucocele) is reported. This unusual polyp ... Read more >>

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2017, 21(8):1366-1367]

Cited: 0 times

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Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study.

M Vitale, M Masulli, A A Rivellese, E Bonora, F Cappellini, A Nicolucci, S Squatrito, D Antenucci, A Barrea, C Bianchi, F Bianchini, L Fontana, P Fornengo, F Giorgino, A Gnasso, E Mannucci, A Mazzotti, R Nappo, A P Palena, P Pata, G Perriello, S Potenziani, R Radin, L Ricci, F Romeo, C Santini, M Scarponi, R Serra, A Timi, A A Turco, M Vedovato, D Zavaroni, S Grioni, G Riccardi, O Vaccaro, ,

Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols ... Read more >>

Eur J Nutr (European journal of nutrition)
[2018, 57(2):679-688]

Cited: 8 times

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Polyphenol intake and cardiovascular risk factors in a population with type 2 diabetes: The TOSCA.IT study.

Marilena Vitale, Olga Vaccaro, Maria Masulli, Enzo Bonora, Stefano Del Prato, Carlo B Giorda, Antonio Nicolucci, Sebastiano Squatrito, Stefania Auciello, Anna C Babini, Laura Bani, Raffaella Buzzetti, Emanuela Cannarsa, Mauro Cignarelli, Massimo Cigolini, Gennaro Clemente, Sara Cocozza, Laura Corsi, Federica D'Angelo, Elisabetta Dall'Aglio, Graziano Di Cianni, Lucia Fontana, Giovanna Gregori, Sara Grioni, Carla Giordano, Rossella Iannarelli, Ciro Iovine, Annunziata Lapolla, Davide Lauro, Luigi Laviola, Chiara Mazzucchelli, Stefano Signorini, Laura Tonutti, Roberto Trevisan, Chiara Zamboni, Gabriele Riccardi, Angela A Rivellese, ,

The role of polyphenol intake on cardiovascular risk factors is little explored, particularly in people with diabetes.To evaluate the association between the intake of total polyphenols and polyphenol classes with the major cardiovascular risk factors in a population with type 2 diabetes.Dietary habits were investigated in 2573 males and females ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2017, 36(6):1686-1692]

Cited: 8 times

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Unexpected gallbladder cancer: Surgical strategies and prognostic factors.

Gennaro Clemente,

Gallbladder cancer is the most common tumor of the biliary tract and it is associated with a poor prognosis. Unexpected gallbladder cancer is a cancer incidentally discovered, as a surprise, at the histological examination after cholecystectomy for gallstones or other indications. It is a potentially curable disease, with an intermediate ... Read more >>

World J Gastrointest Surg (World journal of gastrointestinal surgery)
[2016, 8(8):541-544]

Cited: 1 time

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Diabetology and oncology meet in a network model: union is strength.

Marco Gallo, Luigi Gentile, Emanuela Arvat, Oscar Bertetto, Gennaro Clemente,

Diabetes and cancer are increasingly common conditions, and the management of cancer patients with diabetes is often challenging. Diabetes in cancer patients poses several complex clinical issues, including which treatment is suitable to control hyperglycemia, how to better counteract glucocorticoid-induced hyperglycemia, and how to manage nutritional problems of cachectic patients ... Read more >>

Acta Diabetol (Acta diabetologica)
[2016, 53(4):515-524]

Cited: 5 times

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Liver Resection for Primary Intrahepatic Stones: Focus on Postoperative Infectious Complications.

Gennaro Clemente, Agostino M De Rose, Rita Murri, Francesco Ardito, Gennaro Nuzzo, Felice Giuliante,

Primary intrahepatic lithiasis is defined by the presence of gallstones at the level of cystic dilatations of the intrahepatic biliary tree. Liver resection is considered the treatment of choice, with the purpose of removing stones and atrophic parenchyma, also reducing the risk of cholangiocarcinoma. However, in consequence of the considerable ... Read more >>

World J Surg (World journal of surgery)
[2016, 40(2):433-439]

Cited: 5 times

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Video of the Month. Laparoscopic Cholecystectomy for Left-Sided Gallbladder and Hepatic Pedicle.

Gennaro Clemente, Nicola Silvestrini, Elena Panettieri, Agostino M De Rose,

Am. J. Gastroenterol. (The American journal of gastroenterology)
[2015, 110(9):1263]

Cited: 0 times

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Visceral adiposity and subclinical atherosclerosis in healthy young men.

Gennaro Clemente, Marcello Mancini, Rosalba Giacco, Antonietta Tornatore, Monica Ragucci, Gabriele Riccardi,

Atherosclerosis begins in childhood and develops silently for decades before clinical events such as myocardial infarction or stroke occur. Only few studies have evaluated the relationship between CVD risk factors and carotid artery Intimal Media Thickness (IMT) in young asymptomatic people.The aim of this study is to investigate risk factors ... Read more >>

Int J Food Sci Nutr (International journal of food sciences and nutrition)
[2015, 66(4):466-470]

Cited: 2 times

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Metabolic consequences of the occlusion of the main pancreatic duct with acrylic glue after pancreaticoduodenectomy.

Teresa Mezza, Gennaro Clemente, Gian Pio Sorice, Caterina Conte, Agostino Maria De Rose, Vincin Alice Sun, Chiara Maria Assunta Cefalo, Alfredo Pontecorvi, Gennaro Nuzzo, Andrea Giaccari,

BACKGROUND:Pancreaticoduodenectomy represents the major treatment for pancreatic and periampullary neoplasms. Complications related to pancreaticojejunostomy are still the leading cause of morbidity and mortality. A solution proposed by some surgeons is the occlusion of main pancreatic duct by acrylic glue, avoiding pancreaticojejunostomy. Nevertheless, the consequences of this procedure on glucose metabolism ... Read more >>

Am. J. Surg. (American journal of surgery)
[2015, 210(4):783-789]

Cited: 2 times

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Investigating the synergistic interaction of diabetes, tobacco smoking, alcohol consumption, and hypercholesterolemia on the risk of pancreatic cancer: a case-control study in Italy.

Giuseppe La Torre, Antonella Sferrazza, Maria Rosaria Gualano, Chiara de Waure, Gennaro Clemente, Agostino Maria De Rose, Nicola Nicolotti, Gennaro Nuzzo, Roberta Siliquini, Antonio Boccia, Walter Ricciardi,

The aims of the present research are to investigate the possible predictors of pancreatic cancer, in particular smoking status, alcohol consumption, hypercholesterolemia, and diabetes mellitus, in patients with histologically confirmed pancreatic carcinoma and to examine the synergism between risk factors. A case-control study (80 patients and 392 controls) was conducted ... Read more >>

Biomed Res Int (BioMed research international)
[2014, 2014:481019]

Cited: 7 times

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Right and extended-right hepatectomies for unilobar colorectal metastases: impact of portal vein embolization on long-term outcome and liver recurrence.

Francesco Ardito, Maria Vellone, Brunella Barbaro, Gennaro Grande, Gennaro Clemente, Ivo Giovannini, Bruno Federico, Lorenzo Bonomo, Gennaro Nuzzo, Felice Giuliante,

BACKGROUND: Portal vein embolization (PVE) is an effective procedure to increase the future remnant liver (FRL) before major hepatectomy. A controversial issue is that PVE may stimulate tumor growth and can be associated with poor prognosis after liver resection for colorectal liver metastases (CRLM). The aim of this study was ... Read more >>

Surgery (Surgery)
[2013, 153(6):801-810]

Cited: 8 times

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Intensive structured self-monitoring of blood glucose and glycemic control in noninsulin-treated type 2 diabetes: the PRISMA randomized trial.

Emanuele Bosi, Marina Scavini, Antonio Ceriello, Domenico Cucinotta, Antonio Tiengo, Raffaele Marino, Erminio Bonizzoni, Francesco Giorgino, ,

We aimed to evaluate the added value of intensive self-monitoring of blood glucose (SMBG), structured in timing and frequency, in noninsulin-treated patients with type 2 diabetes.The 12-month, randomized, clinical trial enrolled 1,024 patients with noninsulin-treated type 2 diabetes (median baseline HbA1c, 7.3% [IQR, 6.9-7.8%]) at 39 diabetes clinics in Italy. ... Read more >>

Diabetes Care (Diabetes care)
[2013, 36(10):2887-2894]

Cited: 42 times

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Insulin resistance alters islet morphology in nondiabetic humans.

Teresa Mezza, Giovanna Muscogiuri, Gian Pio Sorice, Gennaro Clemente, Jiang Hu, Alfredo Pontecorvi, Jens J Holst, Andrea Giaccari, Rohit N Kulkarni,

Type 2 diabetes is characterized by poor glucose uptake in metabolic tissues and manifests when insulin secretion fails to cope with worsening insulin resistance. In addition to its effects on skeletal muscle, liver, and adipose tissue metabolism, it is evident that insulin resistance also affects pancreatic β-cells. To directly examine ... Read more >>

Diabetes (Diabetes)
[2014, 63(3):994-1007]

Cited: 63 times

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Removal of duodenum elicits GLP-1 secretion.

Giovanna Muscogiuri, Teresa Mezza, Annamaria Prioletta, Gian Pio Sorice, Gennaro Clemente, Gerardo Sarno, Gennaro Nuzzo, Alfredo Pontecorvi, Jens J Holst, Andrea Giaccari,

OBJECTIVE:To evaluate the effect of removal of the duodenum on the complex interplay between incretins, insulin, and glucagon in nondiabetic subjects. RESEARCH DESIGN AND METHODS:For evaluation of hormonal secretion and insulin sensitivity, 10 overweight patients without type 2 diabetes (age 61 ± 19.3 years and BMI 27.9 ± 5.3 kg/m(2)) ... Read more >>

Diabetes Care (Diabetes care)
[2013, 36(6):1641-1646]

Cited: 6 times

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Prognostic significance of tumor doubling time in mass-forming type cholangiocarcinoma.

Agostino Maria De Rose, Alessandro Cucchetti, Gennaro Clemente, Francesco Ardito, Ivo Giovannini, Giorgio Ercolani, Felice Giuliante, Antonio Daniele Pinna, Gennaro Nuzzo,

The aim of this study was to determine the prognostic significance of the preoperatively assessed tumor doubling time (DT) in patients undergoing liver resection for mass-forming intrahepatic cholangiocarcinoma (IHC).We evaluated 79 patients who underwent curative resection for IHC, and in whom the same imaging technique was preoperatively available in two ... Read more >>

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2013, 17(4):739-747]

Cited: 8 times

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Addition of either pioglitazone or a sulfonylurea in type 2 diabetic patients inadequately controlled with metformin alone: impact on cardiovascular events. A randomized controlled trial.

O Vaccaro, M Masulli, E Bonora, S Del Prato, C B Giorda, A P Maggioni, P Mocarelli, A Nicolucci, A A Rivellese, S Squatrito, G Riccardi, ,

BACKGROUND AND AIMS: Metformin is the first-line therapy in type 2 diabetes. In patients inadequately controlled with metformin, the addition of a sulfonylurea or pioglitazone are equally plausible options to improve glycemic control. However, these drugs have profound differences in their mechanism of action, side effects, and impact on cardiovascular ... Read more >>

Nutr Metab Cardiovasc Dis (Nutrition, metabolism, and cardiovascular diseases : NMCD)
[2012, 22(11):997-1006]

Cited: 19 times

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