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Author Geert O Janssens

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

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Towards homogenization of total body irradiation practices in pediatric patients across SIOPE affiliated centers. A survey by the SIOPE radiation oncology working group.

Bianca A W Hoeben, Montserrat Pazos, Michael H Albert, Enrica Seravalli, Mirjam E Bosman, Christoph Losert, Tom Boterberg, Farkhad Manapov, Inna Ospovat, Soraya Mico Milla, Candan Demiroz Abakay, Jacob Engellau, Gregor Kos, Stéphane Supiot, Marc Bierings, Geert O Janssens,

BACKGROUND AND PURPOSE:To reduce relapse risk, Total Body Irradiation (TBI) is part of conditioning regimens for hematopoietic stem cell transplantation (HSCT) in pediatric acute leukemia. The study purpose was to evaluate clinical practices regarding TBI, such as fractionation, organ shielding and delivery techniques, among SIOPE affiliated radiotherapy centers. METHODS:An electronic ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 155:113-119]

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Introduction to the COG/SIOP/PROS supplement on radiation oncology.

John A Kalapurakal, John C Breneman, Geert O Janssens, Karen Marcus,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28768]

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Deep learning-enabled MRI-only photon and proton therapy treatment planning for paediatric abdominal tumours.

Mateusz C Florkow, Filipa Guerreiro, Frank Zijlstra, Enrica Seravalli, Geert O Janssens, John H Maduro, Antje C Knopf, René M Castelein, Marijn van Stralen, Bas W Raaymakers, Peter R Seevinck,

PURPOSE:To assess the feasibility of magnetic resonance imaging (MRI)-only treatment planning for photon and proton radiotherapy in children with abdominal tumours. MATERIALS AND METHODS:The study was conducted on 66 paediatric patients with Wilms' tumour or neuroblastoma (age 4 ± 2 years) who underwent MR and computed tomography (CT) acquisition on the same day ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, :]

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Deep learning-based synthetic CT generation for paediatric brain MR-only photon and proton radiotherapy.

Matteo Maspero, Laura G Bentvelzen, Mark H F Savenije, Filipa Guerreiro, Enrica Seravalli, Geert O Janssens, Cornelis A T van den Berg, Marielle E P Philippens,

BACKGROUND AND PURPOSE:To enable accurate magnetic resonance imaging (MRI)-based dose calculations, synthetic computed tomography (sCT) images need to be generated. We aim at assessing the feasibility of dose calculations from MRI acquired with a heterogeneous set of imaging protocol for paediatric patients affected by brain tumours. MATERIALS AND METHODS:Sixty paediatric ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, :]

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Gliomas, germ cell tumors, and craniopharyngioma.

Paul Aridgides, Geert O Janssens, Steve Braunstein, Shauna Campbell, Matthew Poppe, Erin Murphy, Shannon MacDonald, Matthew Ladra, Claire Alapetite, Daphne Haas-Kogan,

This report summarizes the current multimodality treatment approaches for children with low- and high-grade gliomas, germinoma, and nongerminomatous germ cell tumors, and craniopharyngiomas used in the Children's Oncology Group (COG) and the International Society of Pediatric Oncology (SIOP). Treatment recommendations are provided in the context of historical approaches regarding the ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28401]

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Global pediatric radiation therapy in resource-limited settings.

Clayton B Hess, Jeannette Parkes, Geert O Janssens, Chi Lin, Kenneth Wong, Mohamed S Zaghloul, Daniel G Marconi, Tom Boterberg, Natia Esiashvili,

This report provides a summary of the global burden of childhood cancer morbidity and mortality, which disproportionately affects low- and middle-income countries as well as low- and middle-income communities within high-income countries. We review past successes and current challenges to improving clinical pediatric radiotherapy, education, and research in these regions. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28299]

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Surrogate-free machine learning-based organ dose reconstruction for pediatric abdominal radiotherapy.

Marco Virgolin, Ziyuan Wang, Brian Balgobind, Irma van Dijk, Jan Wiersma, Petra S Kroon, Geert O Janssens, Marcel van Herk, David C Hodgson, Lorna Zadravec Zaletel, Coen Rasch, Arjan Bel, Peter A N Bosman, Tanja Alderliesten,

To study radiotherapy-related adverse effects, detailed dose information (3D distribution) is needed for accurate dose-effect modeling. For childhood cancer survivors who underwent radiotherapy in the pre-CT era, only 2D radiographs were acquired, thus 3D dose distributions must be reconstructed from limited information. State-of-the-art methods achieve this by using 3D surrogate ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, :]

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Brain tumors: Medulloblastoma, ATRT, ependymoma.

Sujith Baliga, Lorenza Gandola, Beate Timmermann, Horan Gail, Laetitia Padovani, Geert O Janssens, Torunn I Yock,

Children with medulloblastoma, atypical teratoid rhabdoid tumor (ATRT), and ependymoma are treated with a multidisciplinary approach including surgery, radiotherapy, and chemotherapy. Lower doses of craniospinal irradiation and tumor bed boost together with chemotherapy are the current standard of care for average-risk medulloblastoma in the Children's Oncology Group (COG). The International ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, :e28395]

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Variations in screening and management practices for subsequent asymptomatic meningiomas in childhood, adolescent and young adult cancer survivors.

Lisanne C Verbruggen, Melissa M Hudson, Daniel C Bowers, Cécile M Ronckers, Gregory T Armstrong, Roderick Skinner, Eelco W Hoving, Geert O Janssens, Helena J H van der Pal, Leontine C M Kremer, Renée L Mulder,

INTRODUCTION:Childhood, adolescent and young adult (CAYA) cancer survivors treated with cranial radiotherapy are at risk for developing subsequent meningiomas. There is insufficient evidence concerning the benefits and harms of screening for subsequent meningiomas, and uncertainty about the most appropriate clinical management of asymptomatic meningiomas. Data describing current clinical decision-making is ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2020, 147(2):417-425]

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Improved survival for adolescents and young adults with Hodgkin lymphoma and continued high survival for children in the Netherlands: a population-based study during 1990-2015.

Ardine M J Reedijk, Eline A M Zijtregtop, Jan Willem W Coebergh, Friederike A G Meyer-Wentrup, Konnie M Hebeda, C Michel Zwaan, Geert O R Janssens, Rob Pieters, Wouter J Plattel, Avinash G Dinmohamed, Josée M Zijlstra, Leontien C M Kremer, Pieternella J Lugtenburg, Auke Beishuizen, Henrike E Karim-Kos,

Population-based studies that assess long-term patterns of incidence, major aspects of treatment and survival are virtually lacking for Hodgkin lymphoma (HL) at a younger age. This study assessed the progress made for young patients with HL (<25 years at diagnosis) in the Netherlands during 1990-2015. Patient and tumour characteristics were extracted ... Read more >>

Br J Haematol (British journal of haematology)
[2020, 189(6):1093-1106]

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Risk factors associated with tinnitus in 2948 Dutch survivors of childhood cancer: a Dutch LATER questionnaire study.

Annelot J M Meijer, Marta F Fiocco, Geert O Janssens, Eva Clemens, Wim J E Tissing, Jacqueline J Loonen, Eline van Dulmen-den Broeder, Andrica C H de Vries, Dorine Bresters, Birgitta Versluys, Cécile M Ronckers, Leontien C M Kremer, Helena J van der Pal, Sebastian J C M M Neggers, Margriet van der Heiden-van der Loo, Robert J Stokroos, Alex E Hoetink, Martine van Grotel, Marry M van den Heuvel-Eibrink,

Background:Tinnitus is a serious late effect of childhood cancer treatment. The aim of this study was to determine the occurrence and risk factors for tinnitus in a national cohort of childhood cancer survivors (CCS). Methods:Data were collected within the national Dutch Childhood Oncology Group - Long-Term Effects after Childhood Cancer ... Read more >>

Neurooncol Adv (Neuro-oncology advances)
[2020, 2(1):vdaa122]

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Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG.

Raquel Dávila Fajardo, Marry M van den Heuvel-Eibrink, Harm van Tinteren, Filippo Spreafico, Thomas Acha, Christophe Bergeron, Beatriz de Camargo, Foppe Oldenburger, Christian Rübe, Takaharu Oue, Christian Vokuhl, Ronald R de Krijger, Gordan Vujanic, Neil Sebire, Aurore Coulomb-L'Hermine, Paola Collini, Lorenza Gandola, Kathy Pritchard-Jones, Norbert Graf, Geert O Janssens, Martine van Grotel,

BACKGROUND:As a significant proportion of relapses occurred in the tumor bed or abdomen on patients with the fifth National Wilms Tumor Study stage I anaplastic Wilms tumor (WT), flank radiotherapy was added for stage I anaplastic WT in the subsequent study of the Children's Oncology Group (AREN0321). Preliminary results revealed ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(2):e28039]

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MRI-guided definition of cerebrospinal fluid distribution around cranial and sacral nerves: implications for brain tumors and craniospinal irradiation.

Amber M Wood, Maarten H Lequin, Marielle M Philippens, Enrica Seravalli, Sabine L Plasschaert, Marry M van den Heuvel-Eibrink, Geert O Janssens,

Background: The SIOPE-Brain Tumor Group recently published a guideline on craniospinal target volume delineation for highly conformal radiotherapy. In order to spare critical structures like e.g., the lens or cochlea, highly conformal techniques can underdose the cerebrospinal fluid (CSF) in the dural reflections around cranial and sacral nerves. The purpose ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2019, 58(12):1740-1744]

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Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand?

Fatma E El-Khouly, Sophie E M Veldhuijzen van Zanten, Vicente Santa-Maria Lopez, N Harry Hendrikse, Gertjan J L Kaspers, G Loizos, David Sumerauer, Karsten Nysom, Kaie Pruunsild, Virve Pentikainen, Halldora K Thorarinsdottir, Giedre Rutkauskiene, Victor Calvagna, Monika Drogosiewicz, Monica Dragomir, Ladislav Deak, Lidija Kitanovski, Andre O von Bueren, Rejin Kebudi, Irene Slavc, Sandra Jacobs, Filip Jadrijevic-Cvrlje, Natacha Entz-Werle, Jacques Grill, Antonis Kattamis, Peter Hauser, Jane Pears, Veronica Biassoni, Maura Massimino, Enrique Lopez Aguilar, Ingrid K Torsvik, Maria Joao Gil-da-Costa, Ella Kumirova, Ofelia Cruz-Martinez, Stefan Holm, Simon Bailey, Tim Hayden, Ulrich W Thomale, Geert O R Janssens, Christof M Kramm, Dannis G van Vuurden,

INTRODUCTION:Diffuse intrinsic pontine glioma (DIPG) is a rare clinically, neuro-radiologically, and molecularly defined malignancy of the brainstem with a median overall survival of approximately 11 months. Our aim is to evaluate the current tendency for its treatment in Europe in order to develop (inter)national consensus guidelines. METHODS:Healthcare professionals specialized in ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2019, 145(1):177-184]

Cited: 5 times

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Evaluating the benefit of PBS vs. VMAT dose distributions in terms of dosimetric sparing and robustness against inter-fraction anatomical changes for pediatric abdominal tumors.

Filipa Guerreiro, Cornel Zachiu, Enrica Seravalli, Cássia O Ribeiro, Geert O Janssens, Mario Ries, Baudouin Denis de Senneville, John H Maduro, Charlotte L Brouwer, Erik W Korevaar, Antje C Knopf, Bas W Raaymakers,

BACKGROUND AND PURPOSE:To evaluate the dosimetric sparing and robustness against inter-fraction anatomical changes between photon and proton dose distributions for children with abdominal tumors. MATERIAL AND METHODS:Volumetric modulated arc therapy (VMAT) and intensity-modulated pencil beam scanning (PBS) proton dose distributions were calculated for 20 abdominal pediatric cases (average 3, range ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 138:158-165]

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Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer.

Judith L Kok, Jop C Teepen, Helena J van der Pal, Flora E van Leeuwen, Wim J E Tissing, Sebastian J C M M Neggers, Jacqueline J Loonen, Marloes Louwerens, Birgitta Versluys, Marry M van den Heuvel-Eibrink, Eline van Dulmen-den Broeder, Monique M W Jaspers, Hanneke M van Santen, Margriet van der Heiden-van der Loo, Geert O Janssens, John H Maduro, Annette H Bruggink, Marjolijn C Jongmans, Leontien C M Kremer, Cécile M Ronckers, ,

Importance:Survivors of childhood cancer (CCSs) face risk of developing subsequent tumors. Solid benign tumors may be cancer precursors; benign tumors and cancers may share etiologic factors. However, comprehensive data on the risk for solid benign tumors are lacking. Objective:To quantify the incidence of and treatment-related risk factors for histologically confirmed ... Read more >>

JAMA Oncol (JAMA oncology)
[2019, 5(5):671-680]

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Radiotherapy practice for paediatric brain tumours across Europe and quality assurance initiatives: Current situation, international survey and future perspectives.

Teresa de Rojas, Enrico Clementel, Jordi Giralt, Ofelia Cruz, Tom Boterberg, Rolf-Dieter Kortmann, Mark N Gaze, Lucas Moreno, Geert O Janssens, ,

AIM:The aim of the study is to analyse radiotherapy quality assurance (RTQA) processes in the treatment of paediatric central nervous system (CNS) tumours across Europe. METHODS:The RTQA aspects of major past and current European trials for paediatric CNS tumours were reviewed based on study protocols and publications. A survey among ... Read more >>

Eur. J. Cancer (European journal of cancer (Oxford, England : 1990))
[2019, 114:36-46]

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Feasibility of MRI-only photon and proton dose calculations for pediatric patients with abdominal tumors.

Filipa Guerreiro, Lauri Koivula, Enrica Seravalli, Geert O Janssens, John H Maduro, Charlotte L Brouwer, Erik W Korevaar, Antje C Knopf, Juha Korhonen, Bas W Raaymakers,

The purpose of this study was to develop a method enabling synthetic computed tomography (sCT) generation of the whole abdomen using magnetic resonance imaging (MRI) scans of pediatric patients with abdominal tumors. The proposed method relies on an automatic atlas-based segmentation of bone and lungs followed by an MRI intensity ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2019, 64(5):055010]

Cited: 3 times

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Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age.

Judith L Kok, Jop C Teepen, Flora E van Leeuwen, Wim J E Tissing, Sebastian J C M M Neggers, Helena J van der Pal, Jacqueline J Loonen, Dorine Bresters, Birgitta Versluys, Marry M van den Heuvel-Eibrink, Eline van Dulmen-den Broeder, Margriet van der Heiden-van der Loo, Berthe M P Aleman, Laurien A Daniels, Cornelis J A Haasbeek, Bianca Hoeben, Geert O Janssens, John H Maduro, Foppe Oldenburger, Caroline van Rij, Robbert J H A Tersteeg, Michael Hauptmann, , Leontien C M Kremer, Cécile M Ronckers,

BACKGROUND:Pediatric cranial radiotherapy (CrRT) markedly increases risk of meningiomas. We studied meningioma risk factors with emphasis on independent and joint effects of CrRT dose, exposed cranial volume, exposure age, and chemotherapy. METHODS:The Dutch Cancer Oncology Group-Long-Term Effects after Childhood Cancer (DCOG-LATER) cohort includes 5-year childhood cancer survivors (CCSs) whose cancers ... Read more >>

Neuro Oncol (Neuro-oncology)
[2019, 21(3):392-403]

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Declining free thyroxine levels over time in irradiated childhood brain tumor survivors.

Laura van Iersel, Sarah C Clement, Antoinette Y N Schouten-van Meeteren, Annemieke M Boot, Hedi L Claahsen-van der Grinten, Bernd Granzen, K Sen Han, Geert O Janssens, Erna M Michiels, A S Paul van Trotsenburg, W Peter Vandertop, Dannis G van Vuurden, Hubert N Caron, Leontien C M Kremer, Hanneke M van Santen,

Objective:The incidence of cranial radiotherapy (cRT)-induced central hypothyroidism (TSHD) in childhood brain tumor survivors (CBTS) is reported to be low. However, TSHD may be more frequent than currently suspected, as its diagnosis is challenging due to broad reference ranges for free thyroxine (FT4) concentrations. TSHD is more likely to be ... Read more >>

Endocr Connect (Endocrine connections)
[2018, 7(12):1322-1332]

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Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial.

Daniëlle B P Eekers, Erik Roelofs, Macarena Cubillos-Mesías, Charles Niël, Robert Jan Smeenk, Ann Hoeben, Andre W H Minken, Marlies Granzier, Geert O Janssens, Johannes H A M Kaanders, Philippe Lambin, Esther G C Troost,

BACKGROUND AND PURPOSE:Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2019, 58(1):57-65]

Cited: 1 time

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Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group.

Stefan Rutkowski, Piergiorgio Modena, Daniel Williamson, Kornelius Kerl, Karsten Nysom, Barry Pizer, Ute Bartels, Stephanie Puget, François Doz, Antony Michalski, Katja von Hoff, Mathilde Chevignard, Shivaram Avula, Matthew J Murray, Stefan Schönberger, Thomas Czech, Antoinette Y N Schouten-van Meeteren, Uwe Kordes, Christof M Kramm, Dannis G van Vuurden, Esther Hulleman, Geert O Janssens, Guirish A Solanki, Marie-Luise C van Veelen, Ulrich Thomale, Martin U Schuhmann, Chris Jones, Felice Giangaspero, Dominique Figarella-Branger, Torsten Pietsch, Steve C Clifford, Stefan M Pfister, Stefaan W Van Gool,

Paediatric CNS tumours are the most common cause of childhood cancer-related morbidity and mortality, and improvements in their diagnosis and treatment are needed. New genetic and epigenetic information about paediatric CNS tumours is transforming the field dramatically. For most paediatric CNS tumour entities, subgroups with distinct biological characteristics have been ... Read more >>

Lancet Oncol. (The Lancet. Oncology)
[2018, 19(8):e419-e428]

Cited: 4 times

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Evaluation of boost irradiation in patients with intermediate-risk stage III Wilms tumour with positive lymph nodes only: Results from the SIOP-WT-2001 Registry.

Raquel Dávila Fajardo, Eva Oldenburger, Christian Rübe, Marta López-Yurda, Kathy Pritchard-Jones, Christophe Bergeron, Norbert Graf, Martine van Grotel, Harm van Tinteren, Daniel Saunders, Marry M van den Heuvel-Eibrink, Geert O Janssens, Foppe Oldenburger,

OBJECTIVE:To evaluate the value of radiotherapy boost omission in patients with intermediate-risk, stage III Wilms tumours (WT) with positive lymph nodes (LN). METHODS AND MATERIALS:All patients with intermediate-risk, stage III (LN positive) WT consecutively registered in the SIOP-WT-2001 study were included in this analysis. Endpoints were 5-year event-free survival (EFS), ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2018, 65(8):e27085]

Cited: 1 time

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Position paper: Rationale for the treatment of children with CCSK in the UMBRELLA SIOP-RTSG 2016 protocol.

Saskia L Gooskens, Norbert Graf, Rhoikos Furtwängler, Filippo Spreafico, Christophe Bergeron, Gema L Ramírez-Villar, Jan Godzinski, Christian Rübe, Geert O Janssens, Gordan M Vujanic, Ivo Leuschner, Aurore Coulomb-L'Hermine, Anne M Smets, Beatriz de Camargo, Sara Stoneham, Harm van Tinteren, Kathy Pritchard-Jones, Marry M van den Heuvel-Eibrink, ,

The International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG) has developed a new protocol for the diagnosis, treatment, and follow-up monitoring of childhood renal tumours - the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). This protocol has been designed to continue international collaboration in the treatment of childhood renal ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2018, 15(5):309-319]

Cited: 2 times

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