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Author Geert O Janssens

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Clinical characteristics of subsequent histologically confirmed meningiomas in long-term childhood cancer survivors: A Dutch LATER study.

Lisanne C Verbruggen, Judith L Kok, Jop C Teepen, Geert O Janssens, Charlotte M de Boer, Lukas J A Stalpers, Meike W Vernooij, Eline van Dulmen-den Broeder, Jacqueline J Loonen, Marry M van den Heuvel-Eibrink, Wim J E Tissing, Margriet van der Heiden-van der Loo, Anne Birgitta Versluys, Sebastian J C M M Neggers, Flora E van Leeuwen, Eelco W Hoving, Pieter Wesseling, Leontine C M Kremer, Cécile M Ronckers, Helena J H van der Pal, ,

<h4>Background</h4>Meningiomas are the most frequent brain tumours occurring after pediatric cranial radiotherapy (CrRT). Data on course of disease, to inform clinical management of meningiomas, are sparse. This study reports the clinical characteristics of histologically confirmed meningiomas in childhood cancer survivors (CCS) in the Netherlands.<h4>Methods</h4>In total, 6015 CCS from the Dutch ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 150:240-249]

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Nasopharyngeal carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations.

Tal Ben-Ami, Udo Kontny, Aurore Surun, Ines B Brecht, Ricardo López Almaraz, Monica Dragomir, Apostolos Pourtsidis, Michela Casanova, Brice Fresneau, Gianni Bisogno, Dominik T Schneider, Yves Reguerre, Ewa Bien, Teresa Stachowicz-Stencel, Gustaf Österlundh, Marc Wygoda, Geert O Janssens, József Zsiros, Nina Jehanno, Herve J Brisse, Lorenza Gandola, Hans Christiansen, Line Claude, Andrea Ferrari, Carlos Rodriguez-Galindo, Daniel Orbach,

Nasopharyngeal carcinoma (NPC) is a rare pediatric tumor. Collaborative studies performed over the last decades showed improved results compared to historical data, but standardized guidelines for diagnosis and management of pediatric NPC are still unavailable. This study presents a European consensus guideline for the diagnosis and treatment of pediatric NPC ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, :e29018]

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Locoregional control using highly conformal flank target volumes and volumetric-modulated arc therapy in pediatric renal tumors: Results from the Dutch national cohort.

Joeri Mul, Martine van Grotel, Enrica Seravalli, Mirjam E Bosman, Harm van Tinteren, Prakriti Roy, Raquel Dávila Fajardo, Godelieve A M Tytgat, Annelies M C Mavinkurve-Groothuis, Cornelis P van de Ven, Marc H W A Wijnen, Ronald R de Krijger, Annemieke S Littooij, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<h4>Background and purpose</h4>In pediatric renal tumors, conventional two opposing photon beams have been used to cover the postoperative flank target volume for decades. This single center study describes the locoregional outcome using highly conformal flank target volumes adjusted for postoperative changes and intra-fraction motion combined with Volumetric-Modulated Arc Therapy (VMAT).<h4>Materials ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 159:249-254]

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Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise.

Joeri Mul, Patrick Melchior, Enrica Seravalli, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Kristin Gurtner, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Henry Mandeville, Tom Boterberg, Petra S Kroon, Alexis N T J Kotte, Bianca A W Hoeben, Peter S N van Rossum, Martine van Grotel, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe, Geert O Janssens,

<h4>Background and purpose</h4>Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation of this new target volume definition in an international multicenter setting and to explore the necessity of quality assurance.<h4>Materials and methods</h4>Six ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 28:39-47]

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High Prevalence of Weight Gain in Childhood Brain Tumor Survivors and Its Association With Hypothalamic-Pituitary Dysfunction.

Jiska van Schaik, Ichelle M A A van Roessel, Netteke A Y N Schouten-van Meeteren, Laura van Iersel, Sarah C Clement, Annemieke M Boot, Hedi L Claahsen-van der Grinten, Marta Fiocco, Geert O Janssens, Dannis G van Vuurden, Erna M Michiels, Sen K S Han, Paul A S P van Trotsenburg, Peter W P Vandertop, Leontien C M Kremer, Hanneke M van Santen,

<h4>Purpose</h4>Childhood brain tumor survivors (CBTS) are at risk for developing obesity, which negatively influences cardiometabolic health. The prevalence of obesity in CBTS may have been overestimated in previous cohorts because of inclusion of children with craniopharyngioma. On the contrary, the degree of weight gain may have been underestimated because of ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, 39(11):1264-1273]

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Outcome of Stage IV Completely Necrotic Wilms Tumour and Local Stage III Treated According to the SIOP 2001 Protocol.

Raquel Dávila Fajardo, Rhoikos Furtwängler, Martine van Grotel, Harm van Tinteren, Claudia Pasqualini, Kathy Pritchard-Jones, Reem Al-Saadi, Beatriz de Camargo, Gema L Ramírez Villar, Norbert Graf, Xavier Muracciole, Patrick Melchior, Daniel Saunders, Christian Rübe, Marry M van den Heuvel-Eibrink, Geert O Janssens, Arnauld C Verschuur,

<h4>Objective</h4>Wilms tumour (WT) patients with a localised completely necrotic nephroblastoma after preoperative chemotherapy are a favourable outcome group. Since the introduction of the SIOP 2001 protocol, the SIOP- Renal Tumour Study Group (SIOP-RTSG) has omitted radiotherapy for such patients with low-risk, local stage III in an attempt to reduce treatment ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(5):]

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Metabolic Syndrome Parameters, Determinants, and Biomarkers in Adult Survivors of Childhood Cancer: Protocol for the Dutch Childhood Cancer Survivor Study on Metabolic Syndrome (Dutch LATER METS).

Vincent Pluimakers, Marta Fiocco, Jenneke van Atteveld, Monique Hobbelink, Dorine Bresters, Eline Van Dulmen-den Broeder, Margriet Van der Heiden-van der Loo, Geert O Janssens, Leontien Kremer, Jacqueline Loonen, Marloes Louwerens, Helena Van der Pal, Cécile Ronckers, Hanneke Van Santen, Birgitta Versluys, Andrica De Vries, Marry Van den Heuvel-Eibrink, Sebastian Neggers,

<h4>Background</h4>Potential late effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia, and hypertension. These risk factors cluster together as metabolic syndrome and increase the risk for development of diabetes mellitus and cardio- and cerebrovascular disease. Knowledge on risk factors, timely diagnosis, and preventive strategies is of importance to ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2021, 10(1):e21256]

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The spleen as an organ at risk in paediatric radiotherapy: A SIOP-Europe Radiation Oncology Working Group report.

Niruthiga Arunagiri, Sarah M Kelly, Cathy Dunlea, Olivia Dixon, Jessica Cantwell, Pravesh Bhudia, Tom Boterberg, Geert O Janssens, Jennifer E Gains, Yen-Ch'ing Chang, Mark N Gaze, ,

<h4>Background</h4>Radiation may cause long-term splenic dysfunction, risking potentially fatal late sepsis. We aimed to review this complication's magnitude in paediatric radiotherapy and gauge the level of awareness of the spleen as an organ at risk.<h4>Methods</h4>Clinical trial protocols and radiotherapy guidelines, patient/parent information sheets, and professional guidance documents were reviewed to assess ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 143:1-10]

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The contribution of surgical clips for optimizing highly-conformal image-guided flank irradiation in pediatric renal tumors: A single center experience.

Joeri Mul, Cornelis P van de Ven, Enrica Seravalli, Annemieke S Littooij, Marc H W A Wijnen, Martine van Grotel, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<h4>Background and aims</h4>Two-opposing photon beams are considered standard of care for flank irradiation in pediatric patients with renal tumors. Nowadays, Image-Guided Radiotherapy (IGRT) techniques allow high-precision dose delivery to complex flank target volumes taking into account postoperative organ shifts and tumor bed motion. This study examines the contribution of a ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 156:62-68]

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A Role of brachytherapy in bilateral Wilms tumors: A long-term follow-up of three highly selected cases and literature review.

Raquel Dávila Fajardo, Bradley R Pieters, Jim C H Wilde, Hugo A Heij, Rafal Chrzan, Godelieve Tytgat, Annelies M C Mavinkurve-Groothuis, Anne Smets, Petra S Kroon, An Van Damme, Kees P van de Ven, Ronald R de Krijger, Marc R Lilien, Marc H Wijnen, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<h4>Purpose</h4>To describe experience with partial nephrectomy combined with brachytherapy as part of the local management of bilateral Wilms tumor (WT) including a review of the available literature.<h4>Results (methods and case description)</h4>Between 2011 and 2014, three highly selected patients (age nine months, 16 months, and 4 years) with bilateral WT (two synchronous and ... Read more >>

Brachytherapy (Brachytherapy)
[2021, 20(2):478-484]

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Towards homogenization of total body irradiation practices in pediatric patients across SIOPE affiliated centers. A survey by the SIOPE radiation oncology working group.

Bianca A W Hoeben, Montserrat Pazos, Michael H Albert, Enrica Seravalli, Mirjam E Bosman, Christoph Losert, Tom Boterberg, Farkhad Manapov, Inna Ospovat, Soraya Mico Milla, Candan Demiroz Abakay, Jacob Engellau, Gregor Kos, Stéphane Supiot, Marc Bierings, Geert O Janssens,

<h4>Background and purpose</h4>To reduce relapse risk, Total Body Irradiation (TBI) is part of conditioning regimens for hematopoietic stem cell transplantation (HSCT) in pediatric acute leukemia. The study purpose was to evaluate clinical practices regarding TBI, such as fractionation, organ shielding and delivery techniques, among SIOPE affiliated radiotherapy centers.<h4>Methods</h4>An electronic survey ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2021, 155:113-119]

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Introduction to the COG/SIOP/PROS supplement on radiation oncology.

John A Kalapurakal, John C Breneman, Geert O Janssens, Karen Marcus,

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28768]

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

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Deep learning-enabled MRI-only photon and proton therapy treatment planning for paediatric abdominal tumours.

Mateusz C Florkow, Filipa Guerreiro, Frank Zijlstra, Enrica Seravalli, Geert O Janssens, John H Maduro, Antje C Knopf, René M Castelein, Marijn van Stralen, Bas W Raaymakers, Peter R Seevinck,

<h4>Purpose</h4>To assess the feasibility of magnetic resonance imaging (MRI)-only treatment planning for photon and proton radiotherapy in children with abdominal tumours.<h4>Materials and methods</h4>The study was conducted on 66 paediatric patients with Wilms' tumour or neuroblastoma (age 4 ± 2 years) who underwent MR and computed tomography (CT) acquisition on the same day as ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 153:220-227]

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Deep learning-based synthetic CT generation for paediatric brain MR-only photon and proton radiotherapy.

Matteo Maspero, Laura G Bentvelzen, Mark H F Savenije, Filipa Guerreiro, Enrica Seravalli, Geert O Janssens, Cornelis A T van den Berg, Marielle E P Philippens,

<h4>Background and purpose</h4>To enable accurate magnetic resonance imaging (MRI)-based dose calculations, synthetic computed tomography (sCT) images need to be generated. We aim at assessing the feasibility of dose calculations from MRI acquired with a heterogeneous set of imaging protocol for paediatric patients affected by brain tumours.<h4>Materials and methods</h4>Sixty paediatric patients ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 153:197-204]

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Gliomas, germ cell tumors, and craniopharyngioma.

Paul Aridgides, Geert O Janssens, Steve Braunstein, Shauna Campbell, Matthew Poppe, Erin Murphy, Shannon MacDonald, Matthew Ladra, Claire Alapetite, Daphne Haas-Kogan,

This report summarizes the current multimodality treatment approaches for children with low- and high-grade gliomas, germinoma, and nongerminomatous germ cell tumors, and craniopharyngiomas used in the Children's Oncology Group (COG) and the International Society of Pediatric Oncology (SIOP). Treatment recommendations are provided in the context of historical approaches regarding the ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28401]

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Global pediatric radiation therapy in resource-limited settings.

Clayton B Hess, Jeannette Parkes, Geert O Janssens, Chi Lin, Kenneth Wong, Mohamed S Zaghloul, Daniel G Marconi, Tom Boterberg, Natia Esiashvili,

This report provides a summary of the global burden of childhood cancer morbidity and mortality, which disproportionately affects low- and middle-income countries as well as low- and middle-income communities within high-income countries. We review past successes and current challenges to improving clinical pediatric radiotherapy, education, and research in these regions. ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28299]

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Brain tumors: Medulloblastoma, ATRT, ependymoma.

Sujith Baliga, Lorenza Gandola, Beate Timmermann, Horan Gail, Laetitia Padovani, Geert O Janssens, Torunn I Yock,

Children with medulloblastoma, atypical teratoid rhabdoid tumor (ATRT), and ependymoma are treated with a multidisciplinary approach including surgery, radiotherapy, and chemotherapy. Lower doses of craniospinal irradiation and tumor bed boost together with chemotherapy are the current standard of care for average-risk medulloblastoma in the Children's Oncology Group (COG). The International ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28395]

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Variations in screening and management practices for subsequent asymptomatic meningiomas in childhood, adolescent and young adult cancer survivors.

Lisanne C Verbruggen, Melissa M Hudson, Daniel C Bowers, Cécile M Ronckers, Gregory T Armstrong, Roderick Skinner, Eelco W Hoving, Geert O Janssens, Helena J H van der Pal, Leontine C M Kremer, Renée L Mulder,

<h4>Introduction</h4>Childhood, adolescent and young adult (CAYA) cancer survivors treated with cranial radiotherapy are at risk for developing subsequent meningiomas. There is insufficient evidence concerning the benefits and harms of screening for subsequent meningiomas, and uncertainty about the most appropriate clinical management of asymptomatic meningiomas. Data describing current clinical decision-making is ... Read more >>

J Neurooncol (Journal of neuro-oncology)
[2020, 147(2):417-425]

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Improved survival for adolescents and young adults with Hodgkin lymphoma and continued high survival for children in the Netherlands: a population-based study during 1990-2015.

Ardine M J Reedijk, Eline A M Zijtregtop, Jan Willem W Coebergh, Friederike A G Meyer-Wentrup, Konnie M Hebeda, C Michel Zwaan, Geert O R Janssens, Rob Pieters, Wouter J Plattel, Avinash G Dinmohamed, Josée M Zijlstra, Leontien C M Kremer, Pieternella J Lugtenburg, Auke Beishuizen, Henrike E Karim-Kos,

Population-based studies that assess long-term patterns of incidence, major aspects of treatment and survival are virtually lacking for Hodgkin lymphoma (HL) at a younger age. This study assessed the progress made for young patients with HL (<25 years at diagnosis) in the Netherlands during 1990-2015. Patient and tumour characteristics were extracted ... Read more >>

Br J Haematol (British journal of haematology)
[2020, 189(6):1093-1106]

Cited: 2 times

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Risk factors associated with tinnitus in 2948 Dutch survivors of childhood cancer: a Dutch LATER questionnaire study.

Annelot J M Meijer, Marta F Fiocco, Geert O Janssens, Eva Clemens, Wim J E Tissing, Jacqueline J Loonen, Eline van Dulmen-den Broeder, Andrica C H de Vries, Dorine Bresters, Birgitta Versluys, Cécile M Ronckers, Leontien C M Kremer, Helena J van der Pal, Sebastian J C M M Neggers, Margriet van der Heiden-van der Loo, Robert J Stokroos, Alex E Hoetink, Martine van Grotel, Marry M van den Heuvel-Eibrink,

<h4>Background</h4>Tinnitus is a serious late effect of childhood cancer treatment. The aim of this study was to determine the occurrence and risk factors for tinnitus in a national cohort of childhood cancer survivors (CCS).<h4>Methods</h4>Data were collected within the national Dutch Childhood Oncology Group - Long-Term Effects after Childhood Cancer (DCOG-LATER) ... Read more >>

Neurooncol Adv (Neuro-oncology advances)
[2020, 2(1):vdaa122]

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Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG.

Raquel Dávila Fajardo, Marry M van den Heuvel-Eibrink, Harm van Tinteren, Filippo Spreafico, Thomas Acha, Christophe Bergeron, Beatriz de Camargo, Foppe Oldenburger, Christian Rübe, Takaharu Oue, Christian Vokuhl, Ronald R de Krijger, Gordan Vujanic, Neil Sebire, Aurore Coulomb-L'Hermine, Paola Collini, Lorenza Gandola, Kathy Pritchard-Jones, Norbert Graf, Geert O Janssens, Martine van Grotel,

BACKGROUND:As a significant proportion of relapses occurred in the tumor bed or abdomen on patients with the fifth National Wilms Tumor Study stage I anaplastic Wilms tumor (WT), flank radiotherapy was added for stage I anaplastic WT in the subsequent study of the Children's Oncology Group (AREN0321). Preliminary results revealed ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(2):e28039]

Cited: 1 time

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MRI-guided definition of cerebrospinal fluid distribution around cranial and sacral nerves: implications for brain tumors and craniospinal irradiation.

Amber M Wood, Maarten H Lequin, Marielle M Philippens, Enrica Seravalli, Sabine L Plasschaert, Marry M van den Heuvel-Eibrink, Geert O Janssens,

<b>Background:</b> The SIOPE-Brain Tumor Group recently published a guideline on craniospinal target volume delineation for highly conformal radiotherapy. In order to spare critical structures like e.g., the lens or cochlea, highly conformal techniques can underdose the cerebrospinal fluid (CSF) in the dural reflections around cranial and sacral nerves. The purpose ... Read more >>

Acta Oncol (Acta oncologica (Stockholm, Sweden))
[2019, 58(12):1740-1744]

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Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand?

Fatma E El-Khouly, Sophie E M Veldhuijzen van Zanten, Vicente Santa-Maria Lopez, N Harry Hendrikse, Gertjan J L Kaspers, G Loizos, David Sumerauer, Karsten Nysom, Kaie Pruunsild, Virve Pentikainen, Halldora K Thorarinsdottir, Giedre Rutkauskiene, Victor Calvagna, Monika Drogosiewicz, Monica Dragomir, Ladislav Deak, Lidija Kitanovski, Andre O von Bueren, Rejin Kebudi, Irene Slavc, Sandra Jacobs, Filip Jadrijevic-Cvrlje, Natacha Entz-Werle, Jacques Grill, Antonis Kattamis, Peter Hauser, Jane Pears, Veronica Biassoni, Maura Massimino, Enrique Lopez Aguilar, Ingrid K Torsvik, Maria Joao Gil-da-Costa, Ella Kumirova, Ofelia Cruz-Martinez, Stefan Holm, Simon Bailey, Tim Hayden, Ulrich W Thomale, Geert O R Janssens, Christof M Kramm, Dannis G van Vuurden,

<h4>Introduction</h4>Diffuse intrinsic pontine glioma (DIPG) is a rare clinically, neuro-radiologically, and molecularly defined malignancy of the brainstem with a median overall survival of approximately 11 months. Our aim is to evaluate the current tendency for its treatment in Europe in order to develop (inter)national consensus guidelines.<h4>Methods</h4>Healthcare professionals specialized in DIPG ... Read more >>

J Neurooncol (Journal of neuro-oncology)
[2019, 145(1):177-184]

Cited: 6 times

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Evaluating the benefit of PBS vs. VMAT dose distributions in terms of dosimetric sparing and robustness against inter-fraction anatomical changes for pediatric abdominal tumors.

Filipa Guerreiro, Cornel Zachiu, Enrica Seravalli, Cássia O Ribeiro, Geert O Janssens, Mario Ries, Baudouin Denis de Senneville, John H Maduro, Charlotte L Brouwer, Erik W Korevaar, Antje C Knopf, Bas W Raaymakers,

<h4>Background and purpose</h4>To evaluate the dosimetric sparing and robustness against inter-fraction anatomical changes between photon and proton dose distributions for children with abdominal tumors.<h4>Material and methods</h4>Volumetric modulated arc therapy (VMAT) and intensity-modulated pencil beam scanning (PBS) proton dose distributions were calculated for 20 abdominal pediatric cases (average 3, range 1-8 years). ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2019, 138:158-165]

Cited: 1 time

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