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Author Gavin Y Oudit

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Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility.

Anissa Viveiros, Mahmoud Gheblawi, Preetinder K Aujla, Deanna K Sosnowski, John M Seubert, Zamaneh Kassiri, Gavin Y Oudit,

Aged males disproportionately succumb to increased COVID-19 severity, hospitalization, and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2) facilitate SARS-CoV-2 viral entry and may have sexually dimorphic regulation. As viral load dictates disease severity, we investigated the expression, protein levels, and activity of ACE2 ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2021, 164:13-16]

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Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries.

Kaiming Wang, Mahmoud Gheblawi, Anish Nikhanj, Matt Munan, Erika MacIntyre, Conar O'Neil, Marko Poglitsch, Daniele Colombo, Franca Del Nonno, Zamaneh Kassiri, Wendy Sligl, Gavin Y Oudit,

ACE (angiotensin-converting enzyme)-2 as the target for SARS-CoV-2 also negatively regulates the renin-angiotensin system. Pathological activation of ADAM17 (A disintegrin and metalloproteinase-17) may potentiate inflammation and diminish ACE2-mediated tissue protection through proteolytic shedding, contributing to SARS-CoV-2 pathogenesis. We aim to examine plasma soluble ACE2 and angiotensin profiles in relation to ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, :HYPERTENSIONAHA12118295]

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Cardiac Complications of Common Drugs of Abuse: Pharmacology, Toxicology and Management.

Luke R Gagnon, Chandu Sadasivan, Kevin Perera, Gavin Y Oudit,

Cardiovascular complications from drugs of abuse are becoming more apparent due to increased usage worldwide. Substance abuse can cause both acute and chronic cardiovascular complications and is increasing in prevalence especially in young adults. These substances contribute to the development of acute coronary syndrome, type II myocardial injury, arrhythmias, cardiomyopathies ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, :]

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Apelin Pathway in Cardiovascular, Kidney, and Metabolic Diseases: Therapeutic role of Apelin Analogs and Apelin Receptor Agonists.

Amanda A de Oliveira, Ander Vergara, Xiaopu Wang, John C Vederas, Gavin Y Oudit,

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are linked to vascular, heart, kidney, and metabolic disorders. Therefore, the apelinergic system has surfaced as a critical therapeutic strategy for cardiovascular diseases (including pulmonary arterial hypertension), kidney disease, ... Read more >>

Peptides (Peptides)
[2021, :170697]

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Gelsolin is an important mediator of Angiotensin II-induced activation of cardiac fibroblasts and fibrosis.

Sayantan Jana, Preetinder Aujla, Mei Hu, Tolga Kilic, Pavel Zhabyeyev, Christopher A McCulloch, Gavin Y Oudit, Zamaneh Kassiri,

Myocardial fibrosis is a characteristic of various cardiomyopathies, and myocardial fibroblasts play a central role in this process. Gelsolin (GSN) is an actin severing and capping protein that regulates actin assembly and may be involved in fibroblast activation. While the role of GSN in mechanical stress-mediated cardiac fibrosis has been ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21932]

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Evaluating the diagnostic and prognostic value of biomarkers for heart disease and major adverse cardiac events in patients with muscular dystrophy.

Anish Nikhanj, Bailey Miskew Nichols, Kaiming Wang, Zaeem A Siddiqi, Gavin Y Oudit,

<h4>Aims</h4>Heart disease is recognized as the leading cause of morbidity and mortality in patients with muscular dystrophy (MD). Our study demonstrates the clinical utility of cardiac biomarkers to improve the diagnosis of cardiomyopathy and prognostication of major adverse cardiac events (MACE) in these vulnerable patients.<h4>Methods and results</h4>We prospectively followed 117 ... Read more >>

Eur Heart J Qual Care Clin Outcomes (European heart journal. Quality of care & clinical outcomes)
[2021, 7(6):564-573]

Cited: 2 times

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Burden of Valvular Heart Disease in Patients with Fabry Disease.

Haran Yogasundaram, Anish Nikhanj, Safia Chatur, Arthur Qi, Leanne Hagen, Laurie Bailey, Aneal Khan, Robert J Hopkin, Nowell M Fine, John L Jefferies, Gavin Y Oudit,

J Am Soc Echocardiogr (Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography)
[2021, :]

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Cardiac remodelling predicts outcome in patients with chronic heart failure.

Lingyu Xu, Joseph Pagano, Kelvin Chow, Gavin Y Oudit, Mark J Haykowsky, Yoko Mikami, Andrew G Howarth, James A White, Jonathan G Howlett, Jason R B Dyck, Todd J Anderson, Justin A Ezekowitz, Richard B Thompson, D Ian Paterson,

<h4>Aims</h4>Surveillance imaging is often used to detect remodelling, a change in cardiac geometry, and/or function; however, there are limited data in patients with chronic heart failure (HF). We sought to characterize cardiac remodelling in patients with chronic HF and evaluate its association with outcome.<h4>Methods and results</h4>A prospective cohort of patients ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, :]

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Clinical utility of 12-lead electrocardiogram in evaluating heart disease in patients with muscular dystrophy: Assessment of left ventricular hypertrophy, conduction disease, and cardiomyopathy.

Anish Nikhanj, Haran Yogasundaram, Shane Kimber, Zaeem A Siddiqi, Gavin Y Oudit,

<h4>Introduction</h4>Heart disease remains a leading cause of mortality in patients with muscular dystrophy (MD), and cardiac assessment by standard imaging modalities is challenging due to the prominence of physical limitations.<h4>Methods</h4>In this prospective cohort study of 169 MD patients and 34 negative control patients, we demonstrate the clinical utility of a 12-lead ... Read more >>

Ann Noninvasive Electrocardiol (Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc)
[2021, 26(6):e12876]

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Looking at the Right Side: Amenability of the Right Ventricle to Therapy in Patients With Titin-Related Dilated Cardiomyopathy.

Kenji Rowel Q Lim, Chandu Sadasivan, Gavin Y Oudit,

Can J Cardiol (The Canadian journal of cardiology)
[2021, :]

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Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activators.

Kleinberg X Fernandez, Conrad Fischer, Jennie Vu, Mahmoud Gheblawi, Wang Wang, Samantha Gottschalk, Xavier Iturrioz, Catherine Llorens-Cortés, Gavin Y Oudit, John C Vederas,

High blood pressure and consequential cardiovascular diseases are among the top causes of death worldwide. The apelinergic (APJ) system has emerged as a promising target for the treatment of cardiovascular issues, especially prevention of ischemia reperfusion (IR) injury after a heart attack or stroke. However, rapid degradation of the endogenous ... Read more >>

RSC Med Chem (RSC medicinal chemistry)
[2021, 12(8):1402-1413]

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Cardiac reverse remodelling and health status in patients with chronic heart failure.

Kaiming Wang, Erik Youngson, Jeffrey A Bakal, Jissy Thomas, Finlay A McAlister, Gavin Y Oudit,

<h4>Aims</h4>This study aims to assess long-term changes in left ventricular ejection fraction (LVEF) together with echocardiographic markers of cardiac remodelling and their association with prognosis and patient-reported quality of life (QoL).<h4>Methods and results</h4>We conducted a retrospective analysis of serial echocardiograms performed between January 2009 and December 2019 in 1089 patients ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(4):3106-3118]

Cited: 1 time

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Barth syndrome-related cardiomyopathy is associated with a reduction in myocardial glucose oxidation.

Amanda A Greenwell, Keshav Gopal, Tariq R Altamimi, Christina T Saed, Faqi Wang, Seyed Amirhossein Tabatabaei Dakhili, Kim L Ho, Liyan Zhang, Farah Eaton, Jennifer Kruger, Rami Al Batran, Gary D Lopaschuk, Gavin Y Oudit, John R Ussher,

Heart failure presents as the leading cause of infant mortality in individuals with Barth syndrome (BTHS), a rare genetic disorder due to mutations in the tafazzin (<i>TAZ</i>) gene affecting mitochondrial structure and function. Investigations into the perturbed bioenergetics in the BTHS heart remain limited. Hence, our objective was to identify ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2021, 320(6):H2255-H2269]

Cited: 1 time

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Effect of Active Cancer on the Cardiac Phenotype: A Cardiac Magnetic Resonance Imaging-Based Study of Myocardial Tissue Health and Deformation in Patients With Chemotherapy-Naïve Cancer.

Dina Labib, Alessandro Satriano, Steven Dykstra, Reis Hansen, Yoko Mikami, David G Guzzardi, Zdenka Slavikova, Patricia Feuchter, Jacqueline Flewitt, Sandra Rivest, Rosa Sandonato, Carmen P Lydell, Andrew G Howarth, Louis Kolman, Brian Clarke, D Ian Paterson, Gavin Y Oudit, Edith Pituskin, Winson Y Cheung, Joon Lee, James A White,

Background The overlap between cancer and cardiovascular care continues to expand, with intersections emerging before, during, and following cancer therapies. To date, emphasis has been placed on how cancer therapeutics influence downstream cardiac health. However, whether active malignancy itself influences chamber volumes, function, or overall myocardial tissue health remains uncertain. ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(9):e019811]

Cited: 4 times

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Loss of TIMP4 (Tissue Inhibitor of Metalloproteinase 4) Promotes Atherosclerotic Plaque Deposition in the Abdominal Aorta Despite Suppressed Plasma Cholesterol Levels.

Mei Hu, Sayantan Jana, Tolga Kilic, Faqi Wang, Mengcheng Shen, Gerrit Winkelaar, Gavin Y Oudit, Katey Rayner, Da-Wei Zhang, Zamaneh Kassiri,

[Figure: see text]. ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2021, 41(6):1874-1889]

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Pharmacological and cell-specific genetic PI3Kα inhibition worsens cardiac remodeling after myocardial infarction.

Xueyi Chen, Pavel Zhabyeyev, Abul K Azad, Bart Vanhaesebroeck, Chad E Grueter, Allan G Murray, Zamaneh Kassiri, Gavin Y Oudit,

<h4>Background</h4>PI3Kα (Phosphoinositide 3-kinase α) regulates multiple downstream signaling pathways controlling cell survival, growth, and proliferation and is an attractive therapeutic target in cancer and obesity. The clinically-approved PI3Kα inhibitor, BYL719, is in further clinical trials for cancer and overgrowth syndrome. However, the potential impact of PI3Kα inhibition on the heart ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2021, 157:17-30]

Cited: 0 times

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Sickle cell disease, interleukin-18, and arrhythmias.

Pavel Zhabyeyev, Gavin Y Oudit,

Blood (Blood)
[2021, 137(9):1138-1139]

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Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.

Christoph Muus, Malte D Luecken, Gökcen Eraslan, Lisa Sikkema, Avinash Waghray, Graham Heimberg, Yoshihiko Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya Subramanian, Christopher Smillie, Karthik A Jagadeesh, Elizabeth Thu Duong, Evgenij Fiskin, Elena Torlai Triglia, Meshal Ansari, Peiwen Cai, Brian Lin, Justin Buchanan, Sijia Chen, Jian Shu, Adam L Haber, Hattie Chung, Daniel T Montoro, Taylor Adams, Hananeh Aliee, Samuel J Allon, Zaneta Andrusivova, Ilias Angelidis, Orr Ashenberg, Kevin Bassler, Christophe Bécavin, Inbal Benhar, Joseph Bergenstråhle, Ludvig Bergenstråhle, Liam Bolt, Emelie Braun, Linh T Bui, Steven Callori, Mark Chaffin, Evgeny Chichelnitskiy, Joshua Chiou, Thomas M Conlon, Michael S Cuoco, Anna S E Cuomo, Marie Deprez, Grant Duclos, Denise Fine, David S Fischer, Shila Ghazanfar, Astrid Gillich, Bruno Giotti, Joshua Gould, Minzhe Guo, Austin J Gutierrez, Arun C Habermann, Tyler Harvey, Peng He, Xiaomeng Hou, Lijuan Hu, Yan Hu, Alok Jaiswal, Lu Ji, Peiyong Jiang, Theodoros S Kapellos, Christin S Kuo, Ludvig Larsson, Michael A Leney-Greene, Kyungtae Lim, Monika Litviňuková, Leif S Ludwig, Soeren Lukassen, Wendy Luo, Henrike Maatz, Elo Madissoon, Lira Mamanova, Kasidet Manakongtreecheep, Sylvie Leroy, Christoph H Mayr, Ian M Mbano, Alexi M McAdams, Ahmad N Nabhan, Sarah K Nyquist, Lolita Penland, Olivier B Poirion, Sergio Poli, CanCan Qi, Rachel Queen, Daniel Reichart, Ivan Rosas, Jonas C Schupp, Conor V Shea, Xingyi Shi, Rahul Sinha, Rene V Sit, Kamil Slowikowski, Michal Slyper, Neal P Smith, Alex Sountoulidis, Maximilian Strunz, Travis B Sullivan, Dawei Sun, Carlos Talavera-López, Peng Tan, Jessica Tantivit, Kyle J Travaglini, Nathan R Tucker, Katherine A Vernon, Marc H Wadsworth, Julia Waldman, Xiuting Wang, Ke Xu, Wenjun Yan, William Zhao, Carly G K Ziegler, , ,

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the body. We assessed the cell-type-specific expression of ACE2, TMPRSS2 and CTSL across 107 single-cell RNA-sequencing ... Read more >>

Nat Med (Nature medicine)
[2021, 27(3):546-559]

Cited: 37 times

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Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury.

K Lockhart Jamieson, Ahmed M Darwesh, Deanna K Sosnowski, Hao Zhang, Saumya Shah, Pavel Zhabyeyev, Jun Yang, Bruce D Hammock, Matthew L Edin, Darryl C Zeldin, Gavin Y Oudit, Zamaneh Kassiri, John M Seubert,

Myocardial infarction (MI) accounts for a significant proportion of death and morbidity in aged individuals. The risk for MI in females increases as they enter the peri-menopausal period, generally occurring in middle-age. Cytochrome (CYP) 450 metabolizes N-3 and N-6 polyunsaturated fatty acids (PUFA) into numerous lipid mediators, oxylipids, which are ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(4):]

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Cardiac and Cardiometabolic Phenotyping of Trastuzumab-Mediated Cardiotoxicity: a Secondary Analysis of the MANTICORE trial.

Amy A Kirkham, Edith Pituskin, Richard B Thompson, John R Mackey, Sheri L Koshman, Davinder Jassal, Marshall Pitz, Mark J Haykowsky, Joseph J Pagano, Kelvin Chow, Albert K Tsui, Justin A Ezekowitz, Gavin Y Oudit, D Ian Paterson,

<h4>Aims</h4>An improved understanding of the pathophysiology of trastuzumab-mediated cardiotoxicity is required to improve outcomes of patients with HER2-positive breast cancer. We aimed to characterize the cardiac and cardiometabolic phenotype of trastuzumab-mediated toxicity and potential interactions with cardiac pharmacotherapy.<h4>Methods and results</h4>This study was an analysis of serial magnetic resonance imaging (MRI) ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, :]

Cited: 0 times

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Cardiomyopathies and Genetic Testing in Heart Failure: Role in Defining Phenotype-Targeted Approaches and Management.

Haran Yogasundaram, Waleed Alhumaid, Tara Dzwiniel, Susan Christian, Gavin Y Oudit,

Cardiomyopathies represent an important cause of heart failure, often affecting young individuals, and have important implications for relatives. Genetic testing for cardiomyopathies is an established care pathway in contemporary cardiology practice. The primary cardiomyopathies where genetic testing is indicated are hypertrophic, dilated, arrhythmogenic, and restrictive cardiomyopathies, with left ventricular noncompaction ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, 37(4):547-559]

Cited: 1 time

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Left atrial remodelling, mid-regional pro-atrial natriuretic peptide, and prognosis across a range of ejection fractions in heart failure.

Brendan N Putko, Anamaria Savu, Padma Kaul, Justin Ezekowitz, Jason R Dyck, Todd J Anderson, James A White, D Ian Paterson, Richard B Thompson, Gavin Y Oudit,

<h4>Aims</h4>Measures of structural and functional remodelling of the left atrium (LA) are emerging as useful biomarkers in heart failure (HF). We hypothesized that LA volume and its contribution to stroke volume (SV) would predict a composite endpoint of HF hospitalization or death in patients with HF.<h4>Methods and results</h4>We recruited 57 ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2021, 22(2):220-228]

Cited: 1 time

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Layer-specific strain in patients with heart failure using cardiovascular magnetic resonance: not all layers are the same.

Lingyu Xu, Joseph J Pagano, Mark J Haykowksy, Justin A Ezekowitz, Gavin Y Oudit, Yoko Mikami, Andrew Howarth, James A White, Jason R B Dyck, Todd Anderson, D Ian Paterson, Richard B Thompson, ,

<h4>Background</h4>Global longitudinal strain (GLS), most commonly measured at the endocardium, has been shown to be superior to left ventricular (LV) ejection fraction (LVEF) for the identification of systolic dysfunction and prediction of outcomes in heart failure (HF). We hypothesized that strains measured at different myocardial layers (endocardium = ENDO, epicardium = EPI, average = AVE) will ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2020, 22(1):81]

Cited: 1 time

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Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.

Anissa Viveiros, Jaslyn Rasmuson, Jennie Vu, Sharon L Mulvagh, Cindy Y Y Yip, Colleen M Norris, Gavin Y Oudit,

Biological sex is increasingly recognized as a critical determinant of health and disease, particularly relevant to the topical COVID-19 pandemic caused by the SARS-CoV-2 coronavirus. Epidemiological data and observational reports from both the original SARS epidemic and the most recent COVID-19 pandemic have a common feature: males are more likely ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2021, 320(1):H296-H304]

Cited: 22 times

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Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium.

Shin-Haw Lee, Sina Hadipour-Lakmehsari, Da Hye Kim, Michelle Di Paola, Uros Kuzmanov, Saumya Shah, Joseph Jong-Hwan Lee, Thomas Kislinger, Parveen Sharma, Gavin Y Oudit, Anthony O Gramolini,

In the current study we examined several proteomic- and RNA-Seq-based datasets of cardiac-enriched, cell-surface and membrane-associated proteins in human fetal and mouse neonatal ventricular cardiomyocytes. By integrating available microarray and tissue expression profiles with MGI phenotypic analysis, we identified 173 membrane-associated proteins that are cardiac-enriched, conserved amongst eukaryotic species, and ... Read more >>

Sci Data (Scientific data)
[2020, 7(1):425]

Cited: 2 times

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