Full Text Journal Articles by
Author Garret A FitzGerald

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Sexual dimorphism in body clocks.

Seán T Anderson, Garret A FitzGerald,

Science (Science (New York, N.Y.))
[2020, 369(6508):1164-1165]

Cited: 0 times

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Accounting for Time: Circadian Rhythms in the Time of COVID-19.

Shaon Sengupta, Thomas G Brooks, Gregory R Grant, Garret A FitzGerald,

The COVID-19 pandemic has necessitated novel approaches and collaborative efforts across multiple disciplines. It is known that various aspects of our physiology and response to pathogens are under tight clock control. However, the assimilation of circadian biology into our clinical and research practices is still evolving. Using a focused review ... Read more >>

J. Biol. Rhythms (Journal of biological rhythms)
[2020, :748730420953335]

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Reopening schools during COVID-19.

Ronan Lordan, Garret A FitzGerald, Tilo Grosser,

Science (Science (New York, N.Y.))
[2020, 369(6508):1146]

Cited: 0 times

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COVID-19, microangiopathy, hemostatic activation, and complement.

Wen-Chao Song, Garret A FitzGerald,

J. Clin. Invest. (The Journal of clinical investigation)
[2020, 130(8):3950-3953]

Cited: 1 time

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Academia Europaea Position Paper on Translational Medicine: The Cycle Model for Translating Scientific Results into Community Benefits.

Péter Hegyi, Ole H Petersen, Stephen Holgate, Bálint Erőss, András Garami, Zsolt Szakács, Dalma Dobszai, Márta Balaskó, Lajos Kemény, Shuang Peng, Joao Monteiro, András Varró, Tara Lamont, Jeffrey Laurence, Zoe Gray, Andrew Pickles, Garret A FitzGerald, Christopher E M Griffiths, Jacek Jassem, Dmitri A Rusakov, Alexei Verkhratsky, Andrea Szentesi,

INTRODUCTION:Translational science has gained prominence in medicine, but there is still much work to be done before scientific results are used optimally and incorporated into everyday health practice. As the main focus is still on generating new scientific data with financial resources primarily available for that purpose, other activities that ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(5):]

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Bmal1 Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice.

Guangrui Yang, Jiayang Zhang, Tingting Jiang, James Monslow, Soon Yew Tang, Leslie Todd, Ellen Puré, Lihong Chen, Garret A FitzGerald,

OBJECTIVE:Although the molecular components of circadian rhythms oscillate in discrete cellular components of the vasculature and many aspects of vascular function display diurnal variation, the cellular connections between the molecular clock and inflammatory cardiovascular diseases remain to be elucidated. Previously we have shown that pre- versus postnatal deletion of Bmal1 ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2020, 40(6):1523-1532]

Cited: 0 times

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Misguided drug advice for COVID-19.

Garret A FitzGerald,

Science (Science (New York, N.Y.))
[2020, 367(6485):1434]

Cited: 21 times

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Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo.

Luigia Di Francesco, Annalisa Bruno, Emanuela Ricciotti, Stefania Tacconelli, Melania Dovizio, Paloma Guillem-Llobat, Maria Alessandra Alisi, Beatrice Garrone, Isabella Coletta, Giorgina Mangano, Claudio Milanese, Garret A FitzGerald, Paola Patrignani,

Rationale:The development of inhibitors of microsomal prostaglandin (PG)E2 synthase-1 (mPGES-1) was driven by the promise of attaining antiinflammatory agents with a safe cardiovascular profile because of the possible diversion of the accumulated substrate, PGH2, towards prostacyclin (PGI2). Objectives:We studied the effect of the human mPGES-1 inhibitor, AF3485 (a benzamide derivative) ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:374]

Cited: 0 times

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The promise and reality of therapeutic discovery from large cohorts.

Eugene Melamud, D Leland Taylor, Anurag Sethi, Madeleine Cule, Anastasia Baryshnikova, Danish Saleheen, Nick van Bruggen, Garret A FitzGerald,

Technological advances in rapid data acquisition have transformed medical biology into a data mining field, where new data sets are routinely dissected and analyzed by statistical models of ever-increasing complexity. Many hypotheses can be generated and tested within a single large data set, and even small effects can be statistically ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, 130(2):575-581]

Cited: 1 time

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Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input.

Dimitra Sarantopoulou, Soon Yew Tang, Emanuela Ricciotti, Nicholas F Lahens, Damien Lekkas, Jonathan Schug, Xiaofeng S Guo, Georgios K Paschos, Garret A FitzGerald, Allan I Pack, Gregory R Grant,

Library preparation is a key step in sequencing. For RNA sequencing there are advantages to both strand specificity and working with minute starting material, yet until recently there was no kit available enabling both. The Illumina TruSeq stranded mRNA Sample Preparation kit (TruSeq) requires abundant starting material while the Takara Bio SMART-Seq ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13477]

Cited: 0 times

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Dosing time matters.

Marc D Ruben, David F Smith, Garret A FitzGerald, John B Hogenesch,

Science (Science (New York, N.Y.))
[2019, 365(6453):547-549]

Cited: 9 times

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Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.

Angela Sacco, Annalisa Bruno, Annalisa Contursi, Melania Dovizio, Stefania Tacconelli, Emanuela Ricciotti, Paloma Guillem-Llobat, Tania Salvatore, Luigia Di Francesco, Rosa Fullone, Patrizia Ballerini, Vincenzo Arena, Sara Alberti, Guizhu Liu, Yanjun Gong, Alessandro Sgambato, Carlo Patrono, Garret A FitzGerald, Ying Yu, Paola Patrignani,

Inflammatory bowel disease (IBD) is associated with an increased risk for thromboembolism, platelet activation, and abnormalities in platelet number and size. In colitis, platelets can extravasate into the colonic interstitium. We generated a mouse with a specific deletion of cyclooxygenase (COX)-1 in megakaryocytes/platelets [(COX-1 conditional knockout (cKO)] to clarify the ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2019, 370(3):416-426]

Cited: 0 times

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Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain.

Katherine N Theken, Elliot V Hersh, Nicholas F Lahens, Hyo Min Lee, Xuanwen Li, Eric J Granquist, Helen E Giannakopoulos, Lawrence M Levin, Stacey A Secreto, Gregory R Grant, John A Detre, Garret A FitzGerald, Tilo Grosser, John T Farrar,

The mechanisms underlying interindividual variability in analgesic efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) are not well understood. Therefore, we performed pain phenotyping, functional neuroimaging, pharmacokinetic/pharmacodynamic assessments, inflammation biomarkers, and gene expression profiling in healthy subjects who underwent surgical extraction of bony impacted third molars and were treated with ibuprofen (400 mg; ... Read more >>

Clin. Pharmacol. Ther. (Clinical pharmacology and therapeutics)
[2019, 106(3):632-641]

Cited: 0 times

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Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions.

Guangrui Yang, Lihong Chen, Jiayang Zhang, Baoyin Ren, Garret A FitzGerald,

Recently, by utilizing conventional and tamoxifen inducible Bmal1 (Brain and muscle Arnt-like protein 1) knockout mice, we found that delaying the loss of circadian rhythms to adulthood attenuates the impact on general integrity and survival at least under 12h light/12h dark conditions (LD). To understand further the contribution of Bmal1 ... Read more >>

JCI Insight (JCI insight)
[2019, 5:]

Cited: 1 time

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A decade of Science Translational Medicine.

Elazer R Edelman, Garret A FitzGerald,

In this Editorial, co-Chief Scientific Advisors of Science Translational Medicine, Elazer Edelman and Garret FitzGerald, discuss challenges and opportunities for the next decade of translational research. ... Read more >>

Sci Transl Med (Science translational medicine)
[2019, 11(489):]

Cited: 0 times

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Time-Dependent Hypotensive Effect of Aspirin in Mice.

Lihong Chen, Guangrui Yang, Jiayang Zhang, Baoyin Ren, Soonyew Tang, Xuanwen Li, Garret A FitzGerald,

Objective- Evening but not morning administration of low-dose aspirin has been reported to lower blood pressure in hypertensive patients. The present study was designed to determine whether this phenomenon could be replicated in mice, and if so, whether a time-dependent effect of aspirin on blood pressure was because of alteration ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2018, 38(12):2819-2826]

Cited: 0 times

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Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.

Nan Lin, Jessica E S Shay, Hong Xie, David S M Lee, Nicolas Skuli, Qiaosi Tang, Zilu Zhou, Andrew Azzam, Hu Meng, Haichao Wang, Garret A FitzGerald, M Celeste Simon,

Colonic tissues in Inflammatory Bowel Disease (IBD) patients exhibit oxygen deprivation and activation of hypoxia-inducible factor 1α and 2α (HIF-1α and HIF-2α), which mediate cellular adaptation to hypoxic stress. Notably, macrophages and neutrophils accumulate preferentially in hypoxic regions of the inflamed colon, suggesting that myeloid cell functions in colitis are ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:2565]

Cited: 1 time

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Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice.

Wen-Liang Song, Emanuela Ricciotti, Xue Liang, Tilo Grosser, Gregory R Grant, Garret A FitzGerald,

Prostaglandin (PG) D2 is formed by two distinct PGD synthases (PGDS): lipocalin-type PGDS (L-PGDS), which acts as a PGD2-producing enzyme and as extracellular lipophilic transporter, and hematopoietic PGDS (H-PGDS), a σ glutathione-S-transferase. PGD2 plays an important role in the maintenance of vascular function; however, the relative contribution of L-PGDS- and ... Read more >>

J. Pharmacol. Exp. Ther. (The Journal of pharmacology and experimental therapeutics)
[2018, 367(3):425-432]

Cited: 2 times

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Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Xinzhi Li, Liudmila L Mazaleuskaya, Chong Yuan, Laurel L Ballantyne, Hu Meng, William L Smith, Garret A FitzGerald, Colin D Funk,

J. Lipid Res. (Journal of lipid research)
[2018, 59(10):2035]

Cited: 0 times

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The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond.

Pallavi R Devchand, Tianyun Liu, Russ B Altman, Garret A FitzGerald, Eric E Schadt,

For almost two decades, pioglitazone has been prescribed primarily to prevent and treat insulin resistance in some type 2 diabetic patients. In this review, we trace the path to discovery of pioglitazone as a thiazolidinedione compound, the glitazone tracks through the regulatory agencies, the trek to molecular agonism in the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1093]

Cited: 4 times

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Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy.

Xinzhi Li, Laurel L Ballantyne, Mackenzie C Crawford, Garret A FitzGerald, Colin D Funk,

The participation of cyclooxygenase (COX) in embryo implantation and parturition has been studied extensively. However, the distinct role of the two COX isoforms in these processes still remains unclear. Using three characterized mouse lines where the Ptgs1 and Ptgs2 genes substitute for one another, this study focused on the reproductive ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):12097]

Cited: 1 time

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Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2.

Georgios K Paschos, Soon Yew Tang, Katherine N Theken, Xuanwen Li, Ioannis Verginadis, Damien Lekkas, Lindsay Herman, Weili Yan, John Lawson, Garret A FitzGerald,

Previous studies using genetic mouse models have implicated COX-2 in the browning of white adipose tissues (WATs) in mice during cold exposure. However, COX-2 is important during development, and conventional knockouts (KOs) exhibit many defects, conditioned by genetic background. Similarly, the physiological relevance of transgenic overexpression of COX-2 is questionable. ... Read more >>

Cell Rep (Cell reports)
[2018, 24(4):809-814]

Cited: 7 times

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Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.

Xinzhi Li, Liudmila L Mazaleuskaya, Laurel L Ballantyne, Hu Meng, Garret A FitzGerald, Colin D Funk,

The distinct functions of each cyclooxygenase (COX) isoform in renal homeostasis have been the subject of intense investigation for many years. We took the novel approach of using 3 characterized mouse lines, where the prostaglandin (PG)-endoperoxide synthase genes 1 and 2 ( Ptgs1 and Ptgs2) substitute for one another to ... Read more >>

FASEB J. (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2018, 32(10):5326-5337]

Cited: 2 times

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Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.

Huifeng Hao, Sheng Hu, Qing Wan, Chuansheng Xu, Hong Chen, Liyuan Zhu, Zhenyu Xu, Jian Meng, Richard M Breyer, Nailin Li, De-Pei Liu, Garret A FitzGerald, Miao Wang,

OBJECTIVE:Deletion of mPGES-1 (microsomal prostaglandin E synthase-1)-an anti-inflammatory target alternative to COX (cyclooxygenase)-2-attenuates injury-induced neointima formation in mice. This is attributable to the augmented levels of PGI2 (prostacyclin)-a known restraint of the vascular response to injury, acting via IP (I prostanoid receptor). To examine the role of mPGES-1-derived PGE2 (prostaglandin ... Read more >>

Arterioscler. Thromb. Vasc. Biol. (Arteriosclerosis, thrombosis, and vascular biology)
[2018, 38(5):1115-1124]

Cited: 5 times

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Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment.

Tilo Grosser, Ali Naji, Garret A FitzGerald,

Circ. Res. (Circulation research)
[2018, 122(4):537-539]

Cited: 4 times

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