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Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways.

Wei Zhang, Bello Babatunde Kazeem, Haitao Yang, Gang Liu, Guanglu Wang, Zhixing Li, Tao Guo, Panpan Zhao, Jingquan Dong,

Aeromonas sobria, a Gram-negative bacterium that can colonize both humans and animals, is found in a variety of environments, including water, seafood, meat, and vegetables (Cahill, 1990; Galindo et al., 2004; Song et al., 2019). Aeromonas spp. are conditionally pathogenic bacteria in aquaculture, which can rapidly proliferate, causing disease and ... Read more >>

J Zhejiang Univ Sci B (Journal of Zhejiang University. Science. B)
[2021, 22(9):782-790]

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Layer-dependent ferroelectricity in 2H-stacked few-layer α-In2Se3.

Baohua Lv, Zhi Yan, Wuhong Xue, Ruilong Yang, Jiayi Li, Wenjuan Ci, Ruixue Pang, Peng Zhou, Gang Liu, Zhongyuan Liu, Wenguang Zhu, Xiaohong Xu,

Atomically thin two-dimensional (2D) van der Waals materials have exhibited many exotic layer-dependent physical properties including electronic structure, magnetic order, etc. Here, we report a striking even-odd layer dependent oscillation in the ferroelectric polarization of 2H-stacked few-layer α-In<sub>2</sub>Se<sub>3</sub> nanoflakes. As characterized by piezoresponse force microscopy (PFM), when the in-plane (IP) ... Read more >>

Mater Horiz (Materials horizons)
[2021, 8(5):1472-1480]

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Magnetism modulation and conductance quantization in a gadolinium oxide memristor.

Zhuolin Xie, Shuang Gao, Xiaoyu Ye, Huali Yang, Guodong Gong, Ying Lu, Junya Ye, Gang Liu, Run-Wei Li,

The requests for higher information storage density, greater data processing power, and memory-centric computing capability in the current big data era are motivating global research interests in novel solid-state electronic devices that can unite the electron charge and spin degrees of freedom. Herein, the simultaneous realization of magnetism modulation and ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(45):26322-26329]

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Regulating the synthesis rate and yield of bio-assembled FeS nanoparticles for efficient cancer therapy.

Zheng Dang, Yong Guan, Zhao Wu, Xia-Yu Tao, Ying Xiong, Hao-Bo Bai, Chang-Sheng Shao, Gang Liu, Qing Huang, Li-Jiao Tian, Yang-Chao Tian,

Biosynthesis has gained growing interest due to its energy efficiency and environmentally benign nature. Recently, biogenic iron sulfide nanoparticles (FeS NPs) have exhibited excellent performance in environmental remediation and energy recovery applications. However, their biosynthesis regulation strategy and application prospects in the biomedical field remain to be explored. Herein, biogenic ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(45):18977-18986]

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TULP3 Silencing Suppresses Cell Proliferation, Migration and Invasion in Gastric Cancer Via the PTEN/Akt/Snail Signaling Pathway

Rui Liu, Jun Song, Qingsheng Fu, Gang Liu, Chengxiong Zhang, Bing Wang, Zhi Li,

<h4>Purpose: </h4> Tubby-like protein 3 (TULP3), a member of the tubby family, has been related to the development of nervous system by gene knockout researches. Nevertheless, the regulatory mechanism and role of TULP3 in the gastric cancer are not clear. Current research is the first probe into the regulatory effect ... Read more >>

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A new biomechanical classification system for split fractures of the humeral greater tuberosity: guidelines for surgical treatment.

Gang Liu, Xiaoguang Guo, Qian Zhao, Bo Qin, Junjie Lu, Dingsu Bao, Shijie Fu,

<h4>Background</h4>Split fractures of the humeral greater tuberosity (HGT) are common injuries. Although there are numerous surgical treatments for these fractures, no classification system combining clinical and biomechanical characteristics has been presented to guide the choice of fixation method.<h4>Methods</h4>We created a standardised fracture of the HGT in 24 formalin-fixed cadavers. Six ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):692]

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Effects of hydroxychloroquine on proteinuria in membranous nephropathy.

Yan-Jiao Cheng, Xu-Yang Cheng, Yi-Miao Zhang, Fang Wang, Xin Wang, Li-Qiang Meng, Gang Liu, Zhao Cui, Ming-Hui Zhao,

<h4>Background</h4>Many patients with primary membranous nephropathy have severe proteinuria unresponsive to optimized renin-angiotensin-aldosterone system inhibitors (RAASi). We evaluated the efficacy and safety of hydroxychloroquine as an adjunctive agent in membranous nephropathy (MN) treatments.<h4>Methods</h4>We prospectively recruited 126 patients with biopsy-proven primary membranous nephropathy and urinary protein 1-8 g/day while receiving optimized RAASi ... Read more >>

J Nephrol (Journal of nephrology)
[2021, :]

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Treatment of cyanide-bearing wastewater by the N263-TBP synergistic extraction system.

Yonghui Song, Yifan Li, Xihong He, Xinhui Zeng, Min Zhou, Gang Liu, Jiameng Zhou,

In this study, a trioctylmethylammonium chloride (N263)- tributyl phosphate (TBP)-n-octanol-sulfonated kerosene (N263-T) synergistic extraction system and an N263-n-octanol-sulfonated kerosene (N263-O) system were used to treat cyanide (CN)-bearing wastewater. The extraction saturation capacity of the two systems was measured. The influences of the initial pH and phase ratio (O/A) of the ... Read more >>

Chemosphere (Chemosphere)
[2021, :133052]

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Detecting Mycobacterium Tuberculosis using a nitrofuranyl calanolide-trehalose probe based on nitroreductase Rv2466c.

Xueyuan Li, Pengfei Geng, Xiaoqiao Hong, Zhaogang Sun, Gang Liu,

A new Mtb fluorescent probe, NFC-Tre-5, was reported that could label single cells of Mtb under various stress conditions <i>via</i> a unique fluorescence off-on feature by a Rv2466c-mediated reductive mechanism. This probe effectively facilitates the rapid and specific detection of Mtb in the host cell during infection and the detection ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, :]

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Multiplying the heterologous production of spinosad through tandem amplification of its biosynthetic gene cluster in Streptomyces coelicolor.

Hong Li, Yuanyuan Pan, Gang Liu,

Heterologous expression of the biosynthetic gene cluster (BGC) is important for studying the microbial natural products (NPs), especially for those kept in silent or poorly expressed in their original strains. Here, we cloned the spinosad BGC through the Cas9-Assisted Targeting of Chromosome segments and amplified it to five copies through ... Read more >>

Microb Biotechnol (Microbial biotechnology)
[2021, :]

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A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis.

Richard Y Kim, Krishna P Sunkara, Ken R Bracke, Andrew G Jarnicki, Chantal Donovan, Alan C Hsu, Antonio Ieni, Emma L Beckett, Izabela Galvão, Sara Wijnant, Fabio Lm Ricciardolo, Antonino Di Stefano, Tatt Jhong Haw, Gang Liu, Angela L Ferguson, Umamainthan Palendira, Peter A Wark, Griet Conickx, Pieter Mestdagh, Guy G Brusselle, Gaetano Caramori, Paul S Foster, Jay C Horvat, Philip M Hansbro,

[Figure: see text]. ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(621):eaav7223]

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Novel high-performance anodic materials for lithium ion batteries: two-dimensional Sn-X (X = C, Si, and Ge) alloy monolayers.

Pengfei Zhu, Yunxiao Zu, Yue Kuai, Shuli Gao, Ge Wu, Wen Chen, Liyuan Wu, Changcheng Chen, Gang Liu,

Lithium-ion batteries (LIBs) have always been the focus of researchers for energy storage applications. Here, the first-principles density functional theory method was used to explore the possibility of using stanene derived structures as LIB anodes. And such two-dimensional structures are similar to graphene or stanene, but half of the Sn ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2021, :]

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Dendrite Net: A White-Box Module for Classification, Regression, and System Identification.

Gang Liu, Jing Wang,

The simulation of biological dendrite computations is vital for the development of artificial intelligence (AI). This article presents a basic machine-learning (ML) algorithm, called Dendrite Net or DD, just like the support vector machine (SVM) or multilayer perceptron (MLP). DD's main concept is that the algorithm can recognize this class ... Read more >>

IEEE Trans Cybern (IEEE transactions on cybernetics)
[2021, PP:]

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Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair.

Xianyun Wang, Shiqi Hu, Junlang Li, Dashuai Zhu, Zhenzhen Wang, Jhon Cores, Ke Cheng, Gang Liu, Ke Huang,

Mesenchymal stem cells (MSCs) repair injured tissues mainly through their paracrine actions. One of the important paracrine components of MSC secretomes is the extracellular vesicle (EV). The therapeutic potential of MSC-EVs has been established in various cardiac injury preclinical models. However, the large-scale production of EVs remains a challenge. We ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(47):55767-55779]

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Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs.

Shi-Yue Pan, Gang Liu, Jia-Hao Lin, Yi-Peng Jin,

Dexmedetomidine is commonly used in small animal anesthesia for its potent sedative and analgesic properties; however, concerns regarding its cardiovascular effects prevent its full adoption into veterinary clinical practice. This meta-analysis was to determine the effects of dexmedetomidine on sedation, analgesia, cardiovascular and adverse reactions in dogs compared to other ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2021, 11(11):]

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Electrophysiological Evaluation of an Anticancer Drug Gemcitabine on Cardiotoxicity Revealing Down-regulation and Modification of the Activation Gating Properties in the Human Rapid Delayed Rectifier Potassium Channel

Mengyan Wei, Pu Wang, Xiufang Zhu, Yangong Liu, Mingqi Zheng, Gang Liu, Hiroki Osanai, Kenshi Yoshimura, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono,

Gemcitabine is an antineoplastic drug commonly used in the treatment of several types of cancers including pancreatic cancer and non–small cell lung cancer. Although gemcitabine-induced cardiotoxicity is widely recognized, the exact mechanism of cardiac dysfunction causing arrhythmias remains unclear. The objective of this study was to electrophysiologically evaluate the proarrhythmic ... Read more >>

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Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.

Yue Cui, Yongqiang Wang, Gang Liu,

<h4>Context</h4>Epigallocatechin gallate (EGCG) is the most abundant catechin from tea. Previous studies have indicated EGCG has a cardioprotective effect.<h4>Objective</h4>This manuscript mainly explores the role of EGCG in pressure-overload cardiac hypertrophy and its mechanism related to the Akt/mTOR pathway.<h4>Methods and methods</h4>Transverse aortic constriction (TAC) was utilized to establish the cardiac hypertrophy ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1305-1313]

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Absorption of SO2 by triethylenetetramine in ether (alcohol)/H2O system

Bin Zhao, Lulu Xu, yanxia niu, Fei Gao, Qingtao Sheng, Yugao Wang, Gang Liu, Jun Shen,

The use of organic solvents to remove SO2 from flue gas has the advantages of low investment cost, convenient operation, high efficiency, and reusability. We prepared three absorbents in this paper, namely tetraethylenetetramine (TETA), triethylenetetramine /triethylene glycol dimethyl ether (TriEDGME), and triethylenetetramine/triethylene glycol dimethyl ether/H2O. The atmospheric bubbling method absorbs ... Read more >>

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Solitary multicystic lesion lung cancer: two case reports and review of the literature.

Xi Tang, Gang Liu, Xianglan Tan, Chengjun Liu, Jin Xiang, Yu Jiang,

<h4>Background</h4>Lung cancer associated with cystic airspaces, especially solitary multicystic lesion lung cancer, is a rare disease (a rare imaging performance of non-small cell lung cancer). It is difficult to diagnose owing to the lack of a clear definition; therefore, diagnosis of these neoplastic lesions remains challenging.<h4>Case presentation</h4>We outlined two cases ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2021, 21(1):368]

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Identification of KIF4A as a prognostic biomarker for esophageal squamous cell carcinoma.

Lingwei Wang, Gang Liu, Enkhbat Bolor-Erdene, Qinchuan Li, Yunqing Mei, Lei Zhou,

Esophageal squamous cell carcinoma (ESCC) is the most common and aggressive tumor worldwide, and the long-term survival of these patients remains poor. Three databases (GSE17351, GSE20347, and GSE100942) were obtained from Gene Expression Omnibus, and 193 differentially expressed genes including 56 upregulated and 137 downregulated genes were identified by paired ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(21):24050-24070]

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Weight Change, Lifestyle and Mortality in Patients with Type 2 Diabetes.

Jinbo Hu, Yang Hu, Ellen Hertzmark, Chen Yuan, Gang Liu, Meir J Stampfer, Eric B Rimm, Frank B Hu, Molin Wang, Qi Sun,

<h4>Objective</h4>To examine the association between weight change and mortality among participants with incident type 2 diabetes (T2D) and evaluate the impact of adopting a healthy lifestyle on this association.<h4>Research design and methods</h4>This prospective analysis included 11,262 incident T2D patients from the Nurses' Health Study and Health Professionals Follow-up Study. We ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, :]

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Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study.

Tian-Ming Chen, Wen-Hui Li, Fang Wang, Kun Tan, Qing-Xiong Zhu, Kai Zhou, Shi-Hua Liu, Jing Liu, Jing Bi, Hui-Ling Deng, Xue-Xia Chen, Juan Li, Yu-Min Wang, Qing Zhao, Liang Zhu, Hui-Xuan Ma, Zhi Li, Ji-Kui Deng, Chun-Hui Zhu, Kang-Kang Wu, Ai-Wei Lin, Shuang-Jie Li, Dong-Meng Wang, Hui-Jun Cai, Shi-Yong Zhao, Xu-Dong Lu, Lan Ye, Fang Dong, Wen-Shuang Zhang, Yong-Hong Yang, Gang Liu,

<h4>Background</h4>Streptococcus pneumoniae (S. pneumoniae) is a major cause of bacterial meningitis, septicemia and pneumonia in children. Inappropriate choice of antibiotic can have important adverse consequences for both the individual and the community. Here, we focused on penicillin/cefotaxime non-susceptibility of S. pneumoniae and evaluated appropriateness of targeted antibiotic therapy for children ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):1156]

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Genetic testing, ultrasonography and preimplantation genetic testing of men with autosomal dominant polycystic kidney disease in Hunan, China.

Weina Li, Gang Liu, Xingguo Zhao, Yichang Lu, Huanzhu Li, Huan Zhang, Ge Lin,

The present study identified novel mutations in polycystic kidney disease (PKD) genes in China, determined the prevalence of cysts in the genital tract and accessory gonad in autosomal dominant PKD (ADPKD) patients, correlated these genes with ADPKD and male infertility and investigated whether male infertility associated with ADPKD affected the ... Read more >>

Andrologia (Andrologia)
[2021, :e14273]

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Machine Learning for Predicting Motor Improvement After Acute Subcortical Infarction Using Baseline Whole Brain Volumes.

Gang Liu, Jiewei Wu, Chao Dang, Shuangquan Tan, Kangqiang Peng, Yaomin Guo, Shihui Xing, Chuanmiao Xie, Jinsheng Zeng, Xiaoying Tang,

<i>Background.</i> Neuroimaging biomarkers are valuable predictors of motor improvement after stroke, but there is a gap between published evidence and clinical usage. <i>Objective.</i> In this work, we aimed to investigate whether machine learning techniques, when applied to a combination of baseline whole brain volumes and clinical data, can accurately predict ... Read more >>

Neurorehabil Neural Repair (Neurorehabilitation and neural repair)
[2021, :15459683211054178]

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Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.

Joshua M Francis, Del Leistritz-Edwards, Augustine Dunn, Christina Tarr, Jesse Lehman, Conor Dempsey, Andrew Hamel, Violeta Rayon, Gang Liu, Yuntong Wang, Marcos Wille, Melissa Durkin, Kane Hadley, Aswathy Sheena, Benjamin Roscoe, Mark Ng, Graham Rockwell, Margaret Manto, Elizabeth Gienger, Joshua Nickerson, , Amir Moarefi, Michael Noble, Thomas Malia, Philip D Bardwell, William Gordon, Joanna Swain, Mojca Skoberne, Karsten Sauer, Tim Harris, Ananda W Goldrath, Alex K Shalek, Anthony J Coyle, Christophe Benoist, Daniel C Pregibon, Nikolaus Jilg, Jonathan Li, Alex Rosenthal, Colline Wong, George Daley, David Golan, Howard Heller, Arlene Sharpe, Betelihem A Abayneh, Patrick Allen, Diane Antille, Katrina Armstrong, Siobhan Boyce, Joan Braley, Karen Branch, Katherine Broderick, Julia Carney, Andrew Chan, Susan Davidson, Michael Dougan, David Drew, Ashley Elliman, Keith Flaherty, Jeanne Flannery, Pamela Forde, Elise Gettings, Amanda Griffin, Sheila Grimmel, Kathleen Grinke, Kathryn Hall, Meg Healy, Deborah Henault, Grace Holland, Chantal Kayitesi, Vlasta LaValle, Yuting Lu, Sarah Luthern, Jordan Marchewka Schneider, Brittani Martino, Roseann McNamara, Christian Nambu, Susan Nelson, Marjorie Noone, Christine Ommerborn, Lois Chris Pacheco, Nicole Phan, Falisha A Porto, Edward Ryan, Kathleen Selleck, Sue Slaughenhaupt, Kimberly Smith Sheppard, Elizabeth Suschana, Vivine Wilson, Mary Carrington, Maureen Martin, Yuko Yuki, Galit Alter, Alejandro Balazs, Julia Bals, Max Barbash, Yannic Bartsch, Julie Boucau, Mary Carrington, Josh Chevalier, Fatema Chowdhury, Edward DeMers, Kevin Einkauf, Jon Fallon, Liz Fedirko, Kelsey Finn, Pilar Garcia-Broncano, Musie S Ghebremichael, Ciputra Hartana, Chenyang Jiang, Kelly Judge, Paulina Kaplonek, Marshall Karpell, Peggy Lai, Evan C Lam, Kristina Lefteri, Xiaodong Lian, Mathias Lichterfeld, Daniel Lingwood, Hang Liu, Jinqing Liu, Natasha Ly, Zachary Manickas Hill, Ashlin Michell, Ilan Millstrom, Noah Miranda, Claire O'Callaghan, Matthew Osborn, Shiv Pillai, Yelizaveta Rassadkina, Alexandra Reissis, Francis Ruzicka, Kyra Seiger, Libera Sessa, Christianne Sharr, Sally Shin, Nishant Singh, Weiwei Sun, Xiaoming Sun, Hannah Ticheli, Alicja Trocha-Piechocka, Bruce Walker, Daniel Worrall, Xu G Yu, Alex Zhu,

[Figure: see text]. ... Read more >>

Sci Immunol (Science immunology)
[2021, :eabk3070]

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