Full Text Journal Articles by
Author Galen Hostetter

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Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.

Mike R Wilson, Jeanne Holladay, Rachael Sheridan, Galen Hostetter, Bree Berghuis, Carrie Graveel, Curt Essenburg, Anderson Peck, Thai H Ho, Melissa Stanton, Ronald L Chandler,

The Wnt pathway co-receptor, Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5), labels tumor-prone stem cell populations in certain types of tissue. In this study, we show that ARID1A and PIK3CA mutations in LGR5+ cells result in renal angiosarcomas in adult mice. The tumors originate in the renal medulla. ... Read more >>

Stem Cell Res (Stem Cell Research)
[2020, 46:101849]

Cited: 0 times

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Loss of microRNA-21 leads to profound stromal remodeling and short survival in K-Ras-driven mouse models of pancreatic cancer.

Josh Schipper, Jennifer J Westerhuis, Ian Beddows, Zach Madaj, David Monsma, Galen Hostetter, Matti Kiupel, Jose R Conejo-Garcia, Lorenzo F Sempere,

The microenvironment of pancreatic cancer adenocarcinoma (PDAC) is highly desmoplastic with distinct tumor-restraining and tumor-promoting fibroblast subpopulations. Re-education rather than indiscriminate elimination of these fibroblasts has emerged as a new strategy for combination therapy. Here, we studied the effects of global loss of profibrotic noncoding regulatory microRNA-21 (miR-21) in K-Ras-driven ... Read more >>

Int. J. Cancer (International journal of cancer)
[2020, :]

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Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

David J Clark, Saravana M Dhanasekaran, Francesca Petralia, Jianbo Pan, Xiaoyu Song, Yingwei Hu, Felipe da Veiga Leprevost, Boris Reva, Tung-Shing M Lih, Hui-Yin Chang, Weiping Ma, Chen Huang, Christopher J Ricketts, Lijun Chen, Azra Krek, Yize Li, Dmitry Rykunov, Qing Kay Li, Lin S Chen, Umut Ozbek, Suhas Vasaikar, Yige Wu, Seungyeul Yoo, Shrabanti Chowdhury, Matthew A Wyczalkowski, Jiayi Ji, Michael Schnaubelt, Andy Kong, Sunantha Sethuraman, Dmitry M Avtonomov, Minghui Ao, Antonio Colaprico, Song Cao, Kyung-Cho Cho, Selim Kalayci, Shiyong Ma, Wenke Liu, Kelly Ruggles, Anna Calinawan, Zeynep H Gümüş, Daniel Geiszler, Emily Kawaler, Guo Ci Teo, Bo Wen, Yuping Zhang, Sarah Keegan, Kai Li, Feng Chen, Nathan Edwards, Phillip M Pierorazio, Xi Steven Chen, Christian P Pavlovich, A Ari Hakimi, Gabriel Brominski, James J Hsieh, Andrzej Antczak, Tatiana Omelchenko, Jan Lubinski, Maciej Wiznerowicz, W Marston Linehan, Christopher R Kinsinger, Mathangi Thiagarajan, Emily S Boja, Mehdi Mesri, Tara Hiltke, Ana I Robles, Henry Rodriguez, Jiang Qian, David Fenyö, Bing Zhang, Li Ding, Eric Schadt, Arul M Chinnaiyan, Zhen Zhang, Gilbert S Omenn, Marcin Cieslik, Daniel W Chan, Alexey I Nesvizhskii, Pei Wang, Hui Zhang, ,

Cell (Cell)
[2020, 180(1):207]

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Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

David J Clark, Saravana M Dhanasekaran, Francesca Petralia, Jianbo Pan, Xiaoyu Song, Yingwei Hu, Felipe da Veiga Leprevost, Boris Reva, Tung-Shing M Lih, Hui-Yin Chang, Weiping Ma, Chen Huang, Christopher J Ricketts, Lijun Chen, Azra Krek, Yize Li, Dmitry Rykunov, Qing Kay Li, Lin S Chen, Umut Ozbek, Suhas Vasaikar, Yige Wu, Seungyeul Yoo, Shrabanti Chowdhury, Matthew A Wyczalkowski, Jiayi Ji, Michael Schnaubelt, Andy Kong, Sunantha Sethuraman, Dmitry M Avtonomov, Minghui Ao, Antonio Colaprico, Song Cao, Kyung-Cho Cho, Selim Kalayci, Shiyong Ma, Wenke Liu, Kelly Ruggles, Anna Calinawan, Zeynep H Gümüş, Daniel Geiszler, Emily Kawaler, Guo Ci Teo, Bo Wen, Yuping Zhang, Sarah Keegan, Kai Li, Feng Chen, Nathan Edwards, Phillip M Pierorazio, Xi Steven Chen, Christian P Pavlovich, A Ari Hakimi, Gabriel Brominski, James J Hsieh, Andrzej Antczak, Tatiana Omelchenko, Jan Lubinski, Maciej Wiznerowicz, W Marston Linehan, Christopher R Kinsinger, Mathangi Thiagarajan, Emily S Boja, Mehdi Mesri, Tara Hiltke, Ana I Robles, Henry Rodriguez, Jiang Qian, David Fenyö, Bing Zhang, Li Ding, Eric Schadt, Arul M Chinnaiyan, Zhen Zhang, Gilbert S Omenn, Marcin Cieslik, Daniel W Chan, Alexey I Nesvizhskii, Pei Wang, Hui Zhang, ,

To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC and paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration of proteogenomic measurements uniquely identified ... Read more >>

Cell (Cell)
[2019, 179(4):964-983.e31]

Cited: 9 times

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Notch3 promotes prostate cancer-induced bone lesion development via MMP-3.

Sourik S Ganguly, Galen Hostetter, Lin Tang, Sander B Frank, Kathylynn Saboda, Rohit Mehra, Lisha Wang, Xiaohong Li, Evan T Keller, Cindy K Miranti,

Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenografts and monitored tumor growth, lesion phenotype, and the ... Read more >>

Oncogene (Oncogene)
[2020, 39(1):204-218]

Cited: 1 time

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Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer.

Şükrü Tüzmen, Galen Hostetter, Aprill Watanabe, Cumhur Ekmekçi, Patricia E Carrigan, Ishaiahu Shechter, Olli Kallioniemi, Laurence J Miller, Spyro Mousses,

AIM:To help characterize the FDFT1 gene and protein expression in cancer. Cholesterol represents an important structural component of lipid rafts. These specializations can be involved in pathways stimulating cell growth, survival and other processes active in cancer. This cellular compartment can be expanded by acquisition of cholesterol from the circulation or by ... Read more >>

Per Med (Personalized medicine)
[2019, 16(1):51-65]

Cited: 1 time

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Volume Retention, Metabolism, and Cellular Composition of Human Fat Xenografts.

Brittany A Merrifield, Anthony Chang, Galen Hostetter, Ewa Komorowska-Timek,

Background:To optimize the take of transferred fat, better understanding of fat graft morphology and growth properties in vivo is critical. We aim to evaluate survival, volume retention, metabolism, and cellular composition of various aliquots of human fat xenografts. Methods:Twenty athymic nude mice were injected subcutaneously in opposing flanks with 0.1 ml ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2018, 6(8):e1869]

Cited: 0 times

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Nuclear PTEN Localization Contributes to DNA Damage Response in Endometrial Adenocarcinoma and Could Have a Diagnostic Benefit for Therapeutic Management of the Disease.

Ananda Mukherjee, Amanda L Patterson, Jitu W George, Tyler J Carpenter, Zachary B Madaj, Galen Hostetter, John I Risinger, Jose M Teixeira,

Endometrial adenocarcinoma (EndoCA) is the most common gynecologic cancer type in the United States, and its incidence is increasing. The majority of patients are disease-free after surgical resection of stage I tumors, which is often followed by radiotherapy, but most patients with advanced disease recur and have a poor prognosis, ... Read more >>

Mol. Cancer Ther. (Molecular cancer therapeutics)
[2018, 17(9):1995-2003]

Cited: 0 times

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Notch3 Promotes Prostate Cancer-Induced Bone Lesion Development via MMP-3

Sourik Ganguly, Galen Hostetter, Lin Tang, Sander Frank, Kathylynn Saboda, Rohit Mehra, Lisha Wang, Xiaohong Li, Evan Keller, Cindy Miranti,

ABSTRACT Prostate cancer metastases primarily localize in the bone where they induce a unique osteoblastic response. Elevated Notch activity is associated with high-grade disease and metastasis. To address how Notch affects prostate cancer bone lesions, we manipulated Notch expression in mouse tibia xenografts and monitored tumor growth, lesion phenotype, and ... Read more >>

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Correction to: Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in luminal B breast cancer.

Benjamin A Katchman, I Tolgay Ocal, Heather E Cunliffe, Yu-Hui Chang, Galen Hostetter, Aprill Watanabe, Janine LoBello, Douglas F Lake,

After the publication of this work [1], an error was noticed in Fig. 4a. The micrograph image sh528 was accidentally duplicated. ... Read more >>

Breast Cancer Res. (Breast cancer research : BCR)
[2018, 20(1):89]

Cited: 0 times

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Inhibition of ROCK1 kinase modulates both tumor cells and stromal fibroblasts in pancreatic cancer.

Clifford J Whatcott, Serina Ng, Michael T Barrett, Galen Hostetter, Daniel D Von Hoff, Haiyong Han,

ROCK, or Rho-associated coiled coil-containing protein kinase, is a member of the AGC kinase family and has been shown to play a role in cell migration, ECM synthesis, stress-fiber assembly, and cell contraction. Increased ROCK expression has been reported in multiple pathological conditions, including cancer. Here, we report increased expression ... Read more >>

PLoS ONE (PloS one)
[2017, 12(8):e0183871]

Cited: 15 times

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The CA19-9 and Sialyl-TRA Antigens Define Separate Subpopulations of Pancreatic Cancer Cells.

Daniel Barnett, Ying Liu, Katie Partyka, Ying Huang, Huiyuan Tang, Galen Hostetter, Randall E Brand, Aatur D Singhi, Richard R Drake, Brian B Haab,

Molecular markers to detect subtypes of cancer cells could facilitate more effective treatment. We recently identified a carbohydrate antigen, named sTRA, that is as accurate a serological biomarker of pancreatic cancer as the cancer antigen CA19-9. We hypothesized that the cancer cells producing sTRA are a different subpopulation than those ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):4020]

Cited: 2 times

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A Gastric Glycoform of MUC5AC Is a Biomarker of Mucinous Cysts of the Pancreas.

Jessica Sinha, Zheng Cao, Jianliang Dai, Huiyuan Tang, Katie Partyka, Galen Hostetter, Diane M Simeone, Ziding Feng, Peter J Allen, Randall E Brand, Brian B Haab,

Molecular indicators to specify the risk posed by a pancreatic cyst would benefit patients. Previously we showed that most cancer-precursor cysts, termed mucinous cysts, produce abnormal glycoforms of the proteins MUC5AC and endorepellin. Here we sought to validate the glycoforms as a biomarker of mucinous cysts and to specify the ... Read more >>

PLoS ONE (PloS one)
[2016, 11(12):e0167070]

Cited: 7 times

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Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.

Matt L Harlow, Nichole Maloney, Joseph Roland, Maria Jose Guillen Navarro, Matthew K Easton, Susan M Kitchen-Goosen, Elissa A Boguslawski, Zachary B Madaj, Ben K Johnson, Megan J Bowman, Maurizio D'Incalci, Mary E Winn, Lisa Turner, Galen Hostetter, Carlos María Galmarini, Pablo M Aviles, Patrick J Grohar,

There is a great need to develop novel approaches to target oncogenic transcription factors with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the continued activity of the EWS-FLI1 transcription factor to maintain the malignant phenotype. We have previously shown that the small molecule trabectedin ... Read more >>

Cancer Res. (Cancer research)
[2016, 76(22):6657-6668]

Cited: 13 times

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Segment and fit thresholding: a new method for image analysis applied to microarray and immunofluorescence data.

Elliot Ensink, Jessica Sinha, Arkadeep Sinha, Huiyuan Tang, Heather M Calderone, Galen Hostetter, Jordan Winter, David Cherba, Randall E Brand, Peter J Allen, Lorenzo F Sempere, Brian B Haab,

Experiments involving the high-throughput quantification of image data require algorithms for automation. A challenge in the development of such algorithms is to properly interpret signals over a broad range of image characteristics, without the need for manual adjustment of parameters. Here we present a new approach for locating signals in ... Read more >>

Anal. Chem. (Analytical chemistry)
[2015, 87(19):9715-9721]

Cited: 8 times

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Upregulation of glycans containing 3' fucose in a subset of pancreatic cancers uncovered using fusion-tagged lectins.

Sudhir Singh, Kuntal Pal, Jessica Yadav, Huiyuan Tang, Katie Partyka, Doron Kletter, Peter Hsueh, Elliot Ensink, Birendra Kc, Galen Hostetter, H Eric Xu, Marshall Bern, David F Smith, Anand S Mehta, Randall Brand, Karsten Melcher, Brian B Haab,

The fucose post-translational modification is frequently increased in pancreatic cancer, thus forming the basis for promising biomarkers, but a subset of pancreatic cancer patients does not elevate the known fucose-containing biomarkers. We hypothesized that such patients elevate glycan motifs with fucose in linkages and contexts different from the known fucose-containing ... Read more >>

J. Proteome Res. (Journal of proteome research)
[2015, 14(6):2594-2605]

Cited: 10 times

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Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.

Kenneth C Valkenburg, Galen Hostetter, Bart O Williams,

A clinical need to better categorize patients with prostate cancer exists. The Wnt/β-catenin signaling pathway plays important roles in human prostate cancer progression. Deletion of the endogenous Wnt antagonist adenomatous polyposis coli (Apc) in mice causes high grade prostate intraepithelial neoplasia, widely thought to be the precursor to prostate cancer. ... Read more >>

Prostate (The Prostate)
[2015, 75(14):1579-1585]

Cited: 6 times

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Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A.

Huiyuan Tang, Sudhir Singh, Katie Partyka, Doron Kletter, Peter Hsueh, Jessica Yadav, Elliot Ensink, Marshall Bern, Galen Hostetter, Douglas Hartman, Ying Huang, Randall E Brand, Brian B Haab,

The sialyl-Lewis A (sLeA) glycan forms the basis of the CA19-9 assay and is the current best biomarker for pancreatic cancer, but because it is not elevated in ∼25% of pancreatic cancers, it is not useful for early diagnosis. We hypothesized that sLeA-low tumors secrete glycans that are related to ... Read more >>

Mol. Cell Proteomics (Molecular & cellular proteomics : MCP)
[2015, 14(5):1323-1333]

Cited: 11 times

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Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer.

Todd A MacKenzie, Gary N Schwartz, Heather M Calderone, Carrie R Graveel, Mary E Winn, Galen Hostetter, Wendy A Wells, Lorenzo F Sempere,

Triple-negative breast cancer (TNBC) is an aggressive subtype defined by the lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. Expression of miR-21, an oncomiR, is frequently altered and may be distinctly expressed in the tumor stroma. Because tumor lesions are a complex mixture of ... Read more >>

Am. J. Pathol. (The American journal of pathology)
[2014, 184(12):3217-3225]

Cited: 21 times

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Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer.

Clifford J Whatcott, Caroline H Diep, Ping Jiang, Aprill Watanabe, Janine LoBello, Chao Sima, Galen Hostetter, H Michael Shepard, Daniel D Von Hoff, Haiyong Han,

Pancreatic ductal adenocarcinoma (PDAC) is characterized by high levels of fibrosis, termed desmoplasia, which is thought to hamper the efficacy of therapeutics treating PDAC. Our primary focus was to evaluate differences in the extent of desmoplasia in primary tumors and metastatic lesions. As metastatic burden is a primary cause for ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2015, 21(15):3561-3568]

Cited: 151 times

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Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer.

Vijayalakshmi Shanmugam, Ramesh K Ramanathan, Nicole A Lavender, Shripad Sinari, Manpreet Chadha, Winnie S Liang, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Hollie Benson, Lori Phillips, Angela Baker, Christopher Murray, Galen Hostetter, Daniel D Von Hoff, David W Craig, John D Carpten,

The outcome of patients with metastatic colorectal carcinoma (mCRC) following first line therapy is poor, with median survival of less than one year. The purpose of this study was to identify candidate therapeutically targetable somatic events in mCRC patient samples by whole genome sequencing (WGS), so as to obtain targeted ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2014, 7:36]

Cited: 8 times

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Establishment of genetically diverse patient-derived xenografts of colorectal cancer.

Danielle M Burgenske, David J Monsma, Dawna Dylewski, Stephanie B Scott, Aaron D Sayfie, Donald G Kim, Martin Luchtefeld, Katie R Martin, Paul Stephenson, Galen Hostetter, Nadav Dujovny, Jeffrey P MacKeigan,

Preclinical compounds tested in animal models often show limited efficacy when transitioned into human clinical trials. As a result, many patients are stratified into treatment regimens that have little impact on their disease. In order to create preclinical models that can more accurately predict tumor responses, we established patient-derived xenograft ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2014, 4(6):824-837]

Cited: 11 times

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Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.

Penny L Berger, Sander B Frank, Veronique V Schulz, Eric A Nollet, Mathew J Edick, Brittany Holly, Ting-Tung A Chang, Galen Hostetter, Suwon Kim, Cindy K Miranti,

The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation ... Read more >>

Cancer Res. (Cancer research)
[2014, 74(12):3357-3368]

Cited: 16 times

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A pilot study using next-generation sequencing in advanced cancers: feasibility and challenges.

Glen J Weiss, Winnie S Liang, Michael J Demeure, Jeff A Kiefer, Galen Hostetter, Tyler Izatt, Shripad Sinari, Alexis Christoforides, Jessica Aldrich, Ahmet Kurdoglu, Lori Phillips, Hollie Benson, Rebecca Reiman, Angela Baker, Vickie Marsh, Daniel D Von Hoff, John D Carpten, David W Craig,

New anticancer agents that target a single cell surface receptor, up-regulated or amplified gene product, or mutated gene, have met with some success in treating advanced cancers. However, patients' tumors still eventually progress on these therapies. If it were possible to identify a larger number of targetable vulnerabilities in an ... Read more >>

PLoS ONE (PloS one)
[2013, 8(10):e76438]

Cited: 20 times

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Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer.

Taly R Spivak-Kroizman, Galen Hostetter, Richard Posner, Meraj Aziz, Chengcheng Hu, Michael J Demeure, Daniel Von Hoff, Sunil R Hingorani, Timothy B Palculict, Julie Izzo, Galina M Kiriakova, Mena Abdelmelek, Geoffrey Bartholomeusz, Brian P James, Garth Powis,

Pancreatic cancer is characterized by a desmoplastic reaction that creates a dense fibroinflammatory microenvironment, promoting hypoxia and limiting cancer drug delivery due to decreased blood perfusion. Here, we describe a novel tumor-stroma interaction that may help explain the prevalence of desmoplasia in this cancer. Specifically, we found that activation of ... Read more >>

Cancer Res. (Cancer research)
[2013, 73(11):3235-3247]

Cited: 73 times

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