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Do high-dose corticosteroids improve outcomes in hospitalized COVID-19 patients?

Gagan Kumar, Dhaval Patel, Martin Hererra, David Jefferies, Ankit Sakhuja, Mark Meersman, Drew Dalton, Rahul Nanchal, Achuta Kumar Guddati,

Coronavirus disease 2019 (COVID-19) is characterized by dysregulated hyperimmune response and steroids have been shown to decrease mortality. However, whether higher dosing of steroids results in better outcomes has been debated. This was a retrospective observation of COVID-19 admissions between March 1, 2020, and March 10, 2021. Adult patients (≥18 ... Read more >>

J Med Virol (Journal of medical virology)
[2022, 94(1):372-379]

Cited: 1 time

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Outcomes of Covid 19 patients-Are Hispanics at greater risk?

Rahul Nanchal, Dhaval Patel, Achuta Kumar Guddati, Ankit Sakhuja, Mark Meersman, Drew Dalton, Gagan Kumar,

Disparities in outcomes exist in outcomes of coronavirus disease-19 (COVID-19). Little is known about other ethnic minorities in United States. We included all COVID-19 positive adult patients (≥18 years) hospitalized between March 1, 2020 and February 5th 2021. We compared in hospital mortality, use of intensive care unit services and ... Read more >>

J Med Virol (Journal of medical virology)
[2021, :]

Cited: 1 time

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Multiband transparency effect induced by toroidal excitation in a strongly coupled planar terahertz metamaterial.

Angana Bhattacharya, Rakesh Sarkar, Naval K Sharma, Bhairov K Bhowmik, Amir Ahmad, Gagan Kumar,

The multiband transparency effect in terahertz (THz) domain has intrigued the scientific community due to its significance in developing THz multiband devices. In this article, we have proposed a planar metamaterial geometry comprised of a toroidal split ring resonator (TSRR) flanked by two asymmetric C resonators. The proposed geometry results ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):19186]

Cited: 0 times

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Does ABO Blood Groups Affect Outcomes in Hospitalized COVID-19 Patients?

Gagan Kumar, Rahul Nanchal, Martin Hererra, Ankit Sakhuja, Dhaval Patel, Mark Meersman, Drew Dalton, Achuta Kumar Guddati,

<h4>Background</h4>Blood group type A has been associated with increased susceptibility for coronavirus disease 2019 (COVID-19) infection when compared to group O. The aim of our study was to examine outcomes in hospitalized COVID-19 patients among blood groups A and O.<h4>Methods</h4>This is an observational study. Kruskal-Wallis and Chi-square tests were used ... Read more >>

J Hematol (Journal of hematology)
[2021, 10(3):98-105]

Cited: 2 times

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 104 times

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Characterization of sucrose non-fermenting-1 (SNF1) homologue gene in Fusarium udum WSP-V2 and its regulation by the biocontrol agent Pseudomonas fluorescens OKC.

Gagan Kumar, Sudheer K Yadav, Birinchi Kumar Sarma,

<i>Sucrose non-fermenting 1</i> (<i>SNF1</i>) is a protein kinase and plays an important role in the energy homeostasis of glucose repressible gene transcription. It derepresses glucose repressed genes and associated with pathogenesis and production of cell wall degrading enzymes in fungal species. In the present study, we identified and characterized <i>SNF1</i> ... Read more >>

3 Biotech (3 Biotech)
[2021, 11(1):19]

Cited: 0 times

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Outcomes of adult critically ill patients with hemophagocytic lymphohistiocytosis in united states-analysis from an administrative database from 2007 to 2015.

Gagan Kumar, Martin Hererra, Dhaval Patel, Rahul Nanchal, Achuta K Guddati,

<h4>Background</h4>Severe infections caused by the novel coronavirus 2 display similarities to secondary hemophagocytic lymphohistiocytosis (HLH). However, HLH is a rare disease and has not been well described in critically ill patients.<h4>Methods</h4>We used the Nationwide Inpatient Sample (NIS), the largest all-payer inpatient care database publicly available in the United States to ... Read more >>

Am J Blood Res (American journal of blood research)
[2020, 10(6):330-338]

Cited: 0 times

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Predictors and outcomes of healthcare-associated infections in COVID-19 patients.

Gagan Kumar, Alex Adams, Martin Hererra, Erine Raybon Rojas, Vartika Singh, Ankit Sakhuja, Mark Meersman, Drew Dalton, Shravan Kethireddy, Rahul Nanchal, Achuta Kumar Guddati,

<h4>Introduction</h4>Healthcare-associated infections (HAI) after viral illnesses are important sources of morbidity and mortality. This has not been extensively studied in hospitalized COVID-19 patients.<h4>Methods</h4>This study included all COVID-19-positive adult patients (≥18 years) hospitalized between 01 March and 05 August 2020 at the current institution. The Centers for Disease Control and Prevention ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 104:287-292]

Cited: 15 times

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The Number of Confirmed Cases of Covid-19 by using Machine Learning: Methods and Challenges.

Amir Ahmad, Sunita Garhwal, Santosh Kumar Ray, Gagan Kumar, Sharaf Jameel Malebary, Omar Mohammed Barukab,

Covid-19 is one of the biggest health challenges that the world has ever faced. Public health policy makers need the reliable prediction of the confirmed cases in future to plan medical facilities. Machine learning methods learn from the historical data and make predictions about the events. Machine learning methods have ... Read more >>

Arch Comput Methods Eng (Archives of computational methods in engineering : state of the art reviews)
[2020, :1-9]

Cited: 16 times

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Incidence of Venous Thromboembolism and Effect of Anticoagulant Dosing in Hospitalized COVID-19 Patients.

Gagan Kumar, Dhaval Patel, Tariq Odeh, Erine Rojas, Ankit Sakhuja, Mark Meersman, Drew Dalton, Rahul Nanchal, Achuta Kumar Guddati,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) is characterized by coagulopathy and thrombotic events. We examined factors associated with development of venous thromboembolism (VTE) in COVID-19 and to discern if higher dose of anticoagulation was beneficial in these patients.<h4>Methods</h4>This study involves an observational study of prospectively collected data in the setting of a ... Read more >>

J Hematol (Journal of hematology)
[2020, 10(4):162-170]

Cited: 0 times

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The Number of Confirmed Cases of Covid-19 by using Machine Learning: Methods and Challenges

Amir Ahmada, Sunita Garhwal, Santosh Kumar Ray, Gagan Kumar, Sharaf Malebary, Omar Mohammed Omar Barukab,

Covid-19 is one of the biggest health challenges that the world has ever faced. Public health policy makers need the reliable prediction of the confirmed cases in future to plan medical facilities. Machine learning methods learn from the historical data and make a prediction about the event. Machine learning methods ... Read more >>

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Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary and Renal Considerations: Executive Summary.

Rahul Nanchal, Ram Subramanian, Constantine J Karvellas, Steven M Hollenberg, William J Peppard, Kai Singbartl, Jonathon Truwit, Ali H Al-Khafaji, Alley J Killian, Mustafa Alquraini, Khalil Alshammari, Fayez Alshamsi, Emilie Belley-Cote, Rodrigo Cartin-Ceba, Joanna C Dionne, Dragos M Galusca, David T Huang, Robert C Hyzy, Mats Junek, Prem Kandiah, Gagan Kumar, Rebecca L Morgan, Peter E Morris, Jody C Olson, Rita Sieracki, Randolph Steadman, Beth Taylor, Waleed Alhazzani,

Crit Care Med (Critical care medicine)
[2020, 48(3):415-419]

Cited: 0 times

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Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations.

Rahul Nanchal, Ram Subramanian, Constantine J Karvellas, Steven M Hollenberg, William J Peppard, Kai Singbartl, Jonathon Truwit, Ali H Al-Khafaji, Alley J Killian, Mustafa Alquraini, Khalil Alshammari, Fayez Alshamsi, Emilie Belley-Cote, Rodrigo Cartin-Ceba, Joanna C Dionne, Dragos M Galusca, David T Huang, Robert C Hyzy, Mats Junek, Prem Kandiah, Gagan Kumar, Rebecca L Morgan, Peter E Morris, Jody C Olson, Rita Sieracki, Randolph Steadman, Beth Taylor, Waleed Alhazzani,

<h4>Objectives</h4>To develop evidence-based recommendations for clinicians caring for adults with acute or acute on chronic liver failure in the ICU.<h4>Design</h4>The guideline panel comprised 29 members with expertise in aspects of care of the critically ill patient with liver failure and/or methodology. The Society of Critical Care Medicine standard operating procedures ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(3):e173-e191]

Cited: 2 times

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Independently tunable electromagnetically induced transparency effect and dispersion in a multi-band terahertz metamaterial.

Rakesh Sarkar, Dipa Ghindani, Koijam Monika Devi, S S Prabhu, Amir Ahmad, Gagan Kumar,

In this article, we experimentally and numerically investigate a planar terahertz metamaterial (MM) geometry capable of exhibiting independently tunable multi-band electromagnetically induced transparency effect (EIT). The MM structure exhibits multi-band EIT effect due to the strong near field coupling between the bright mode of the cut-wire (CW) and dark modes ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18068]

Cited: 2 times

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Identification, characterization and expression profiles of Fusarium udum stress-responsive WRKY transcription factors in Cajanus cajan under the influence of NaCl stress and Pseudomonas fluorescens OKC.

Gagan Kumar, Raina Bajpai, Ankita Sarkar, Raj Kumar Mishra, Vijai Kumar Gupta, Harikesh B Singh, Birinchi K Sarma,

The WRKY gene family has never been identified in pigeonpea (Cajanus cajan). Therefore, objective of the present study was to identify the WRKY gene family in pigeonpea and characterize the Fusarium udum stress-responsive WRKY genes under normal, NaCl-stressed and Pseudomonas fluorescens OKC (a plant growth-promoting bacterial strain) treated conditions. The ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14344]

Cited: 4 times

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Trichoderma mediate early and enhanced lignifications in chickpea during Fusarium oxysporum f. sp. ciceris infection.

Shweta Meshram, Jai Singh Patel, Sudheer K Yadav, Gagan Kumar, Dhananjaya P Singh, Harikesh B Singh, Birinchi K Sarma,

Lignifications in secondary cell walls play a significant role in defense mechanisms of plants against the invading pathogens. In the present study, we investigated Trichoderma strain specific lignifications in chickpea plants pre-treated with 10 potential Trichoderma strains and subsequently challenged with the wilt pathogen Fusarium oxysporum f. sp. ciceris (Foc). ... Read more >>

J Basic Microbiol (Journal of basic microbiology)
[2019, 59(1):74-86]

Cited: 2 times

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Association of methacholine challenge test with diagnosis of chronic lung allograft dysfunction in lung transplant patients.

Atif S Siddiqui, Gagan Kumar, Tilottama Majumdar, Edward A Graviss, Duc T Nguyen, Ahmad Goodarzi, Thomas Kaleekal,

<h4>Background</h4>Chronic lung allograft dysfunction (CLAD) is a complication of lung transplantation. We sought to determine whether bronchial hyperresponsiveness detected by the methacholine challenge test (MCT) at 3 months after lung transplant (LT) predicts the development of CLAD.<h4>Methods</h4>We performed a retrospective cohort study of 140 LT patients between 1/2008 and 6/2014 who ... Read more >>

Clin Transplant (Clinical transplantation)
[2018, 32(10):e13397]

Cited: 1 time

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Modulating Fundamental Resonance in Capacitive Coupled Asymmetric Terahertz Metamaterials.

S Jagan Mohan Rao, Yogesh Kumar Srivastava, Gagan Kumar, Dibakar Roy Chowdhury,

In this work, we experimentally investigate near-field capacitive coupling between a pair of single-gap split ring resonators (SRRs) in a terahertz metamaterial. The unit cell of our design comprises of two coupled SRRs with the split gaps facing each other. The coupling between two SRRs is examined by changing the ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):16773]

Cited: 1 time

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Controlled trial to improve resident sign-out in a medical intensive care unit.

Rahul Nanchal, Brian Aebly, Gabrielle Graves, Jonathon Truwit, Gagan Kumar, Amit Taneja, Gaurav Dagar, Jeanette Graf, Erin Hubertz, Vijaya Ramalingam, Kathlyn E Fletcher,

<h4>Objective</h4>Poor sign-out or handover of care may lead to preventable patient harm. Critically ill patients in intensive care units (ICU) are complex and prone to rapid clinical deterioration. If clinical deterioration occurs, timeliness of appropriate interventions is essential to prevent or reduce adverse outcomes. Therefore sign-outs need to efficiently transmit ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2017, 26(12):987-992]

Cited: 3 times

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Role of Resonance Modes on Terahertz Metamaterials based Thin Film Sensors.

Maidul Islam, S Jagan Mohan Rao, Gagan Kumar, Bishnu P Pal, Dibakar Roy Chowdhury,

We investigate thin film sensing capabilities of a terahertz (THz) metamaterial, which comprises of an array of single split gap ring resonators (SRRs). The top surface of the proposed metamaterial is covered with a thin layer of analyte in order to examine various sensing parameters. The sensitivity and corresponding figure ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):7355]

Cited: 5 times

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Analysis of nationwide trends and outcomes of percutaneous endoscopic gastrostomy (PEG) tube placement in hospitalized patients with cancer over a 13-year period.

Achuta Kumar Guddati, Gagan Kumar, Iuliana Shapira,

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2018, 66(1):e1-e2]

Cited: 0 times

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Brain and the Liver: Cerebral Edema, Hepatic Encephalopathy and Beyond

Gagan Kumar, Amit Taneja, Prem A. Kandiah,

Occurrence of brain dysfunction is common in both chronic liver disease as well as acute liver failure. While brain dysfunction most commonly manifests as hepatic encephalopathy is chronic liver disease; devastating complications of cerebral edema and brain herniation syndromes may occur with acute liver failure. Ammonia seems to play a ... Read more >>

(Hepatic Critical Care)
[2017, :83-103]

Cited: 0 times

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Plasmon induced transparency effect through alternately coupled resonators in terahertz metamaterial.

Koijam Monika Devi, Amarendra K Sarma, Dibakar Roy Chowdhury, Gagan Kumar,

We analyze plasmon induced transparency (PIT) in a planar terahertz metamaterial comprising of two C-shaped resonators and a cut-wire. The two C-shaped resonators are placed alternately on both sides of the cut-wire such that it exhibits a PIT effect when coupled with the cut wire. We have further shown that ... Read more >>

Opt Express (Optics express)
[2017, 25(9):10484-10493]

Cited: 7 times

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Cardiac implantable electronic device infections: Who is at greatest risk?

Parijat Saurav Joy, Gagan Kumar, Jeanne E Poole, Barry London, Brian Olshansky,

<h4>Background</h4>Cardiac implantable electronic device (CIED) infections are associated with hospitalization, mortality, increased costs, and adverse outcomes.<h4>Objective</h4>Determine the burden of infections for CIEDs based on device type, associated comorbidities, and clinical characteristics over a 12-year period.<h4>Methods</h4>Utilizing data from the National Inpatient Sample database for cases from 2000 through 2012, we identified ... Read more >>

Heart Rhythm (Heart rhythm)
[2017, 14(6):839-845]

Cited: 14 times

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Cation distribution: a key to ascertain the magnetic interactions in a cobalt substituted Mg-Mn nanoferrite matrix.

Gagan Kumar, R K Kotnala, Jyoti Shah, Vijay Kumar, Arun Kumar, Pooja Dhiman, M Singh,

The effect of Co<sup>2+</sup> substitution into nanocrystalline Mg-Mn ferrite synthesized by a solution combustion technique has been studied. The cation distribution has been inferred from X-ray diffraction, the magnetization technique, and Mössbauer spectroscopy. The X-ray analysis and cation distribution data have been used to investigate the detailed structural parameters such ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2017, 19(25):16669-16680]

Cited: 1 time

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