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Author G Zeiler

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Investigation of biomarkers for impending fluid overload in a feline acute haemorrhage-resuscitation model.

Gareth E Zeiler, Brighton T Dzikiti, Peter Kamerman, Friederike Pohlin, Roxanne K Buck, Andrea Fuller,

<h4>Objective</h4>To determine biomarkers for impending fluid overload during intravenous fluid administration in a feline haemorrhage-resuscitation model.<h4>Study design</h4>Randomized crossover study.<h4>Animals</h4>A group of six domestic cats (mean age and weight: 21 months; 4.9 kg, respectively).<h4>Methods</h4>The cats underwent three treatments, 2 months apart. They were anaesthetized and instrumented to measure a range of ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2021, 48(6):871-881]

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Use of blood colour for assessment of arterial oxygen saturation in immobilized impala (Aepyceros melampus).

Etienne P Basson, Gareth E Zeiler, Peter R Kamerman, Leith C R Meyer,

<h4>Objective</h4>To determine the relationship between arterial blood colour [as defined by the International Commission on Illumination (CIE) L∗a∗b∗ colour space] and haemoglobin oxygen saturation [functional saturation (SaO<sub>2</sub>) and fractional saturation (FO<sub>2</sub>Hb)], and if arterial blood colour can be used to predict arterial haemoglobin oxygen saturation.<h4>Study design</h4>Descriptive study as an adjunct ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2021, 48(5):725-733]

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Immobilization of African buffaloes (Syncerus caffer) using etorphine-midazolam compared with etorphine-azaperone.

Justin F Grace, Michele A Miller, Jacobus P Raath, Liesel L Laubscher, Peter E Buss, Gareth E Zeiler,

<h4>Objective</h4>To compare induction times and physiological effects of etorphine-azaperone with etorphine-midazolam immobilization in African buffaloes.<h4>Study design</h4>Randomized crossover study.<h4>Animals</h4>A group of 10 adult buffalo bulls (mean body weight 353 kg).<h4>Methods</h4>Etorphine-azaperone (treatment EA; 0.015 and 0.15 mg kg<sup>-1</sup>, respectively) and etorphine-midazolam (treatment EM; 0.015 and 0.15 mg kg<sup>-1</sup>, respectively) were administered once ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2021, 48(5):734-744]

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Immobilization, cardiopulmonary and blood gas effects of ketamine-butorphanol-medetomidine versus butorphanol-midazolam-medetomidine in free-ranging serval (Leptailurus serval).

Christiaan J Blignaut, Gerhard Steenkamp, Daan Loock, Roxanne Emslie, Gareth E Zeiler,

<h4>Objective</h4>To compare ketamine-butorphanol-medetomidine (KBM) with butorphanol-midazolam-medetomidine (BMM) immobilization of serval.<h4>Study design</h4>Blinded, randomized trial.<h4>Animals</h4>A total of 23 captures [KBM: five females, six males; 10.7 kg (mean); BMM: 10 females, two males; 9.6 kg].<h4>Methods</h4>Serval were cage trapped and immobilized using the assigned drug combination delivered via a blow dart into gluteal muscles. ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2021, 48(5):707-715]

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Short-term clinical outcomes of 220 dogs with thoraco-lumbar disc disease treated by mini-hemilaminectomy.

Ross C Elliott, Chantel Moon, Gareth Zeiler, Remo Lobetti,

Thoraco-lumbar intervertebral disc extrusion is a common condition seen in veterinary practice. Although there are different surgical techniques described for decompression, most of these techniques are based on the surgeon's preference or experience rather than clinical research. Our objective was to determine the clinical outcomes, using return to ambulation and ... Read more >>

J S Afr Vet Assoc (Journal of the South African Veterinary Association)
[2020, 91(0):e1-e8]

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What hinders pulmonary gas exchange and changes distribution of ventilation in immobilized white rhinoceroses (Ceratotherium simum) in lateral recumbency?

Martina Mosing, Andreas D Waldmann, Muriel Sacks, Peter Buss, Jordyn M Boesch, Gareth E Zeiler, Giselle Hosgood, Robin D Gleed, Michele Miller, Leith C R Meyer, Stephan H Böhm,

This study used electrical impedance tomography (EIT) measurements of regional ventilation and perfusion to elucidate the reasons for severe gas exchange impairment reported in rhinoceroses during opioid-induced immobilization. EIT values were compared with standard monitoring parameters to establish a new monitoring tool for conservational immobilization and future treatment options. Six ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2020, 129(5):1140-1149]

Cited: 1 time

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Dental Pathology in a Wild Serval (Leptailurus serval) Population.

Roxanne S Emslie, Gareth Zeiler, Daan Loock, Sonja C Boy, Gerhard Steenkamp,

Members of the family Felidae suffer from a wide range of dental, oral and maxillofacial conditions that can cause significant morbidity and mortality. Although many dental, oral and maxillofacial anomalies of the domestic cat (Felis catus) also occur in wild felines, we could find no investigations of these conditions in ... Read more >>

J Comp Pathol (Journal of comparative pathology)
[2020, 180:16-28]

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Blood acid-base, haematological and haemostatic effects of hydroxyethyl starch (130/0.4) compared to succinylated gelatin colloid infusions in normovolaemic dogs.

Roxanne K Buck, Lynette Bester, Keagan J Boustead, Abdur R Kadwa, Gareth E Zeiler,

Synthetic colloids are commonly administered to dogs to treat absolute or relative hypovolaemia. Voluven® (tetrastarch 130/0.4) and Gelofusine® (succinylated gelatin) are available to veterinarians in South Africa. In humans, use of these products has caused acid-base derangements, changes in haematology and impaired haemostasis. We aimed to investigate these effects in ... Read more >>

J S Afr Vet Assoc (Journal of the South African Veterinary Association)
[2020, 91(0):e1-e9]

Cited: 2 times

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Development of a severity scoring system for acute haemorrhage in anaesthetized domestic cats: the CABSS score.

Gareth E Zeiler, Andrea Fuller, Eva Rioja, Peter Kamerman, Roxanne K Buck, Friederike Pohlin, Brighton T Dzikiti,

<h4>Objective</h4>To determine whether physiological, haematological, biochemical or electrolyte variables can predict severe haemorrhage in cats.<h4>Study design</h4>Randomized crossover study whereby each cat underwent mild and severe haemorrhage, with a 2 month period between events.<h4>Animals</h4>A group of six domestic cats aged 21 ± 1 months and weighing 4.9 ± 1.2 kg, mean ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2020, 47(4):499-508]

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Evaluation of the reliability of pulse oximetry, at different attachment sites, to detect hypoxaemia in immobilized impala (Aepyceros melampus).

Thembeka K Mtetwa, Gareth E Zeiler, Liesel Laubscher, Silke Pfitzer, Leith C R Meyer,

<h4>Objective</h4>Evaluation of the reliability of pulse oximetry at four different attachment sites compared to haemoglobin oxygen saturation measured by a co-oximeter and calculated by a blood gas analyser in immobilized impala.<h4>Study design</h4>Randomized crossover study.<h4>Animals</h4>A total of 16 female impala.<h4>Methods</h4>Impala were immobilized with etorphine or thiafentanil alone, or etorphine in combination ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2020, 47(3):323-333]

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Effects of chemical and mechanical stimulation on laryngeal motion during alfaxalone, thiopentone or propofol anaesthesia in healthy dogs.

Sandra Labuscagne, Gareth E Zeiler, Brighton T Dzikiti,

<h4>Objective</h4>To compare the effect of chemical and mechanical stimulation on arytenoid cartilage motion during anaesthetic induction with alfaxalone, thiopentone or propofol.<h4>Study design</h4>Masked, randomized, crossover study.<h4>Animals</h4>A group of eight adult Beagle dogs.<h4>Methods</h4>Anaesthesia was induced with thiopentone (7.5 mg kg<sup>-1</sup>), propofol (3 mg kg<sup>-1</sup>) or alfaxalone (1.5 mg kg<sup>-1</sup>) intravenously (IV), which ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2019, 46(4):435-442]

Cited: 1 time

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Etorphine-Ketamine Constant Rate Infusion for Maintenance of Anaesthesia in a Compromised White Rhinoceros (Ceratotherium simum).

Friederike Pohlin, Peter Buss, Michele Miller, Gerhard Steenkamp, Robin Gleed, Luke Poore, Jordyn Boesch, Gareth Zeiler,

A subadult white rhinoceros bull presented for oesophageal endoscopic evaluation and foreign body removal under general anaesthesia. The animal had a history of nasal and oral regurgitation of water and ingesta with weight-loss for 6 days prior to the procedure and had been diagnosed with oesophageal obstruction caused by a ... Read more >>

Case Rep Vet Med (Case reports in veterinary medicine)
[2019, 2019:4309043]

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Compared to etorphine-azaperone, the ketamine-butorphanol-medetomidine combination is also effective at immobilizing zebra (Equus zebra).

Gideon P Stemmet, Leith Cr Meyer, Angela Bruns, Peter Buss, David Zimmerman, Katja Koeppel, Gareth E Zeiler,

<h4>Objective</h4>To compare immobilization efficacy of a nonpotent opioid drug combination, ketamine-butorphanol-medetomidine (KBM) to the preferred etorphine-azaperone (EA) combination in zebras.<h4>Study design</h4>Randomized crossover trial.<h4>Animals</h4>A group of ten adult zebra (six females and four male).<h4>Methods</h4>KBM and EA were administered once to the zebras in random order by dart, 3 weeks apart. Once ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2019, 46(4):466-475]

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EFFECTS OF A SUPPLEMENTAL ETORPHINE DOSE ON PULMONARY ARTERY PRESSURE AND CARDIAC OUTPUT IN IMMOBILIZED, BOMA-HABITUATED WHITE RHINOCEROS ( CERATOTHERIUM SIMUM): A PRELIMINARY STUDY.

Jordyn M Boesch, R D Gleed, Peter Buss, Markus Hofmeyr, Adrian Tordiffe, Gareth Zeiler, Leith Meyer,

The effects of etorphine on the pulmonary vascular system of white rhinoceros ( Ceratotherium simum) have not been described and could play a role in the severe hypoxemia that develops after immobilization with etorphine-based drug combinations. Characterization of these effects requires measurement of pulmonary vascular pressures and cardiac output (CO). ... Read more >>

J Zoo Wildl Med (Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians)
[2018, 49(4):849-855]

Cited: 1 time

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Xenotransfusion with packed bovine red blood cells to a wildebeest calf (Connochaetes taurinus).

Roxanne K Buck, George F Stegmann, Luke A Poore, Tahiyya Shaik, Travis Gray, Gareth E Zeiler,

A 4-month-old female blue wildebeest (Connochaetes taurinus) was presented for bilateral pelvic limb fracture repair. Clinical examination under anaesthesia revealed a water-hammer pulse and a haematocrit of 0.13. A xenotransfusion was performed using bovine (Bos taurus) erythrocytes because of inability to acquire a wildebeest donor. Clinical parameters improved following transfusion ... Read more >>

J S Afr Vet Assoc (Journal of the South African Veterinary Association)
[2018, 89(0):e1-e6]

Cited: 1 time

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Effects of hyaluronidase on ropivacaine or bupivacaine regional anaesthesia of the canine pelvic limb.

Travis R Gray, Brighton T Dzikiti, Gareth E Zeiler,

OBJECTIVE:To determine the effect of hyaluronidase on time to onset and offset of anaesthesia in ropivacaine or bupivacaine femoral-ischiatic nerve blocks. STUDY DESIGN:Blinded randomized crossover trial. ANIMALS:Eight dogs. METHODS:Each dog underwent four treatments separated into two blocks - initially, the ropivacaine treatment block: RS (ropivacaine 0.5% plus saline 0.9%) and ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2019, 46(2):214-225]

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Aortic Arch Baroreceptor Stimulation in an Experimental Goat Model: A Novel Method to Lower Blood Pressure.

Jacobus F Benson, Johan P Schoeman, Frans J Venter, James A Ker, Gareth E Zeiler, Lynette Bester, Janet van Niekerk, Gregory R Tintinger,

The effect of aortic baroreceptor stimulation on blood pressure manipulation was assessed using the goat species Capra aegagrus hircus. The aim of this study was to manipulate blood pressure with future intention to treat high blood pressure in humans. The ages of the animals ranged from 6 months to 2 ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2018, 5:193]

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CAPTIVE MANAGEMENT OF WILD IMPALA ( AEPYCEROS MELAMPUS) DURING INTENSIVE IMMOBILIZATION AND GENERAL ANESTHESIA STUDY TRIALS.

Gareth E Zeiler, Leith C R Meyer,

Immobilization and anesthesia of impala ( Aepyceros melampus) has become a popular research theme. This demand is brought about by the increased need to immobilize and anesthetize impala and other medium-sized wild ungulates because of their increased value in game ranching and zoological collections. To improve our understanding of immobilization ... Read more >>

J Zoo Wildl Med (Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians)
[2017, 48(4):1058-1071]

Cited: 1 time

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Blood acid-base status in impala (Aepyceros melampus) immobilised and maintained under total intravenous anaesthesia using two different drug protocols.

Gareth E Zeiler, Leith C R Meyer,

<h4>Background</h4>In mammals, homeostasis and survival are dependent on effective trans-membrane movement of ions and enzyme function, which are labile to extreme acid-base changes, but operate efficiently within a narrow regulated pH range. Research in patients demonstrating a pH shifts outside the narrow regulated range decreased the cardiac output and systemic ... Read more >>

BMC Vet Res (BMC veterinary research)
[2017, 13(1):246]

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Comparison of thiafentanil-medetomidine to etorphine-medetomidine immobilisation of impalas (Aepyceros melampus).

Gareth E Zeiler, Leith C R Meyer,

Impalas (Aepyceros melampus) are increasingly valuable in the South African wildlife industry, and there is a greater need to chemically immobilise them, ideally with minimal risk. This study aimed to compare the times to recumbency and physiological effects of thiafentanilmedetomidine versus etorphine-medetomidine immobilisation. A combination of thiafentanil (2 mg) + ... Read more >>

J S Afr Vet Assoc (Journal of the South African Veterinary Association)
[2017, 88(0):e1-e8]

Cited: 2 times

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Cardiopulmonary effects of anaesthesia maintained by propofol infusion versus isoflurane inhalation in cheetahs (Acinonyx jubatus).

Roxanne K Buck, Adrian Sw Tordiffe, Gareth E Zeiler,

To compare the cardiopulmonary effects of propofol total intravenous anaesthesia (TIVA) with isoflurane in cheetahs (Acinonyx jubatus) to evaluate feasibility for field use.Prospective clinical study.A group of 24 adult cheetahs, 12 per group.Cheetahs were immobilized with zolazepam/tiletamine (1.2 mg kg-1) and medetomidine [40 μg kg-1, both intramuscular (IM)] by darting. A maintenance protocol of ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2017, 44(6):1363-1372]

Cited: 2 times

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Chemical capture of impala (Aepyceros melampus): A review of factors contributing to morbidity and mortality.

Gareth E Zeiler, Leith C R Meyer,

To review the factors that contribute to morbidity and mortality of impala undergoing chemical capture, and discuss how they are potentially mitigated.PubMed, Science Direct, Google Scholar and Onderstepoort Veterinary Academic Hospital records.Impala are an important species of antelope in Africa and are often captured during management procedures, veterinary interventions and ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2017, 44(5):991-1006]

Cited: 1 time

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Effects of thiopentone, propofol and alfaxalone on laryngeal motion during oral laryngoscopy in healthy dogs.

Tesh M Smalle, Marthinus J Hartman, Lynette Bester, Roxanne K Buck, Geoffrey T Fosgate, Gareth E Zeiler,

<h4>Objective</h4>To compare the effects of thiopentone, propofol and alfaxalone on arytenoid cartilage motion and establish the dose rates to achieve a consistent oral laryngoscopy examination.<h4>Study design</h4>Randomised crossover study.<h4>Animals</h4>Six healthy adult Beagle dogs.<h4>Methods</h4>Each dog was randomly administered three induction agents with a 1-week washout period between treatments. Thiopentone (7.5 mg kg<sup>-1</sup>), propofol (3 mg kg<sup>-1</sup>) ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2017, 44(3):427-434]

Cited: 4 times

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CONTINUOUS INTRAVENOUS INFUSION ANESTHESIA WITH MEDETOMIDINE, KETAMINE, AND MIDAZOLAM AFTER INDUCTION WITH A COMBINATION OF ETORPHINE, MEDETOMIDINE, AND MIDAZOLAM OR WITH MEDETOMIDINE, KETAMINE, AND BUTORPHANOL IN IMPALA (AEPYCEROS MELAMPUS).

Christina A Gerlach, Maya S Kummrow, Leith C Meyer, Gareth E Zeiler, George F Stegmann, Roxanne K Buck, Geoffrey T Fosgate, Sabine B Kästner,

In order to develop a long-term anesthesia for flighty antelope species in field situations, two different protocols for induction and maintenance with an intravenous infusion were evaluated in wild-caught impala ( Aepyceros melampus ). Ten adult female impala were induced with two induction protocols: one consisted of 0.2 mg/kg medetomidine, ... Read more >>

J Zoo Wildl Med (Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians)
[2017, 48(1):62-71]

Cited: 1 time

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Propofol-medetomidine-ketamine total intravenous anaesthesia in thiafentanil-medetomidine-immobilized impala (Aepyceros melampus).

Roxanne K Buck, Leith R C Meyer, George F Stegmann, Sabine B R Kästner, Maya Kummrow, Christina Gerlach, Geoffrey T Fosgate, Gareth E Zeiler,

<h4>Objective</h4>To characterize a propofol-medetomidine-ketamine total intravenous anaesthetic in impala (Aepyceros melampus).<h4>Study design</h4>Prospective clinical study.<h4>Animals</h4>Ten adult female impala.<h4>Materials and methods</h4>Impala were immobilized at 1253 m above sea level with 2.0 mg thiafentanil and 2.2 mg medetomidine via projectile darts. Propofol was given to effect (0.5 mg kg<sup>-1</sup> boluses) to allow endotracheal ... Read more >>

Vet Anaesth Analg (Veterinary anaesthesia and analgesia)
[2017, 44(1):138-143]

Cited: 3 times

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