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Author G Shan

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Targeted delivery and stimulus-responsive release of anticancer drugs for efficient chemotherapy.

Lei Qiao, Xue Yuan, Hui Peng, Guisong Shan, Min Gao, Xiaoqing Yi, Xiaoyan He,

Chemotherapy is currently an irreplaceable strategy for cancer treatment. Doxorubicin hydrochloride (DOX) is a clinical first-line drug for cancer chemotherapy. While its efficacy for cancer treatment is greatly compromised due to invalid enrichment or serious side effects. To increase the content of intracellular targets and boost the antitumor effect of ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):2218-2228]

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The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

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Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation.

Dejun Zeng, Zhengyang Hu, Yanjun Yi, Besskaya Valeria, Guangyao Shan, Zhencong Chen, Cheng Zhan, Miao Lin, Zongwu Lin, Qun Wang,

<h4>Background</h4>Differences in genetics and microenvironment of LUAD patients with or without TP53 mutation were analyzed to illustrate the role of TP53 mutation within the carcinogenesis of LUAD, which will provide new concepts for the treatment of LUAD.<h4>Methods</h4>In this study, we used genetics and clinical info from the TCGA database, including ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2021, 21(1):316]

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Estimating the accumulative dose uncertainty for intracavitary and interstitial brachytherapy.

Binbing Wang, Weibiao Hu, Guoping Shan, Xiaoxian Xu,

Image-guided adaptive brachytherapy shows the ability to deliver high doses to tumors while sparing normal tissues. However, interfraction dose delivery introduces uncertainties to high dose estimation, which relates to normal tissue toxicity. The purpose of this study was to investigate the high-dose regions of two applicator approaches in brachytherapy. For ... Read more >>

Biomed Eng Online (Biomedical engineering online)
[2021, 20(1):106]

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Testing the efficacy of camera-trap sampling designs for monitoring giant pandas in a heterogeneous landscape.

Zhenxia Cui, Wenai Zhao, Yashuai Zhang, Naxun Zhao, Guoyu Shan, Xiaoping Yu, Xinping Ye,

The use of camera traps is prevalent in the ecological study of giant pandas (Ailuropoda melanoleuca). The reliability of camera-trap surveying results greatly depends on sampling designs that significantly influence the detection probability of the target species. Few studies have tested the efficacy of sampling designs on camera-trap surveys for ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma.

Huan Zhang, Guangyao Shan, Benjie Cai, Guoshu Bi, Zhencong Chen, Jiaqi Liang, Valeria Besskaya, Yuansheng Zheng, Weigang Guo, Lin Wang, Songtao Xu, Cheng Zhan,

<h4>Background</h4>The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy.<h4>Methods</h4>This was a retrospective cohort study of 80 ALK-rearranged lung adenocarcinoma patients who had undergone radical ... Read more >>

Thorac Cancer (Thoracic cancer)
[2021, :]

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Inpatient palliative care utilisation among patients with gallbladder cancer in the United States: A 10-year perspective.

Zahra Mojtahedi, Guogen Shan, Katayoon Ghodsi, Karen Callahan, Ji W Yoo, Jennifer Vanderlaan, Jerry Reeves, Jay J Shen,

<h4>Objectives</h4>Gallbladder cancer (GBC) is a rare, poor-prognosis cancer with unique demographics, comorbidities and a paucity of research. This study investigated inpatient palliative care and its associations with demographics, comorbidities (e.g., obesity), length of stay and hospital charges in GBC in US hospitals (2007-2016).<h4>Methods</h4>Data were extracted from the National Inpatient Sample ... Read more >>

Eur J Cancer Care (Engl) (European journal of cancer care)
[2021, :e13520]

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Melioidosis-related mycotic aneurysm: Three cases.

Tan Kok Tong, Giri Shan, Feona Joseph Sibangun, Benjamin Leong Dak Keung,

<h4>Background</h4>Melioidosis-related mycotic aneurysm (MA) is rare but a potentially life-threatening disease with high morbidity and mortality rate.<h4>Case presentation</h4>We report a case series of mycotic aneurysm caused by <i>Burkholderia pseudomallei</i> and the subsequent outcomes. Here, we illustrate their clinical characteristics, laboratory results, radiological findings, mode of therapies and clinical outcomes.<h4>Conclusion</h4>Melioidosis-associated MA ... Read more >>

IDCases (IDCases)
[2021, 26:e01295]

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Transcriptional profiling reveals changes in gene regulation and signaling transduction pathways during temperature stress in wucai (Brassica campestris L.).

Lingyun Yuan, Yushan Zheng, Libing Nie, Liting Zhang, Ying Wu, Shidong Zhu, Jinfeng Hou, Guo Lei Shan, Tong Kun Liu, Guohu Chen, Xiaoyan Tang, Chenggang Wang,

<h4>Background</h4>Wucai (Brassica campestris L. ssp. chinensis var. rosularis Tsen) is a cold-tolerant plant that is vulnerable to high temperature. This study explored the response mechanism of wucai to low temperature. In this study, wucai seedlings were treated with different temperatures, including low temperature (LT), high temperature (HT), and a control.<h4>Results</h4>According ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):687]

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Accelerating drug repurposing for COVID-19 via modeling drug mechanism of action with large scale gene-expression profiles

Lu Han, Shan, Chu, Wang, Wang, Gao, Zhou,

The novel coronavirus disease, named COVID-19, emerged in China in December 2019, and has rapidly spread around the world. It is clearly urgent to fight COVID-19 at global scale. The development of methods for identifying drug uses based on phenotypic data can improve the efficiency of drug development. However, there ... Read more >>

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An Anisotropic Equivalent Thermal Model for Shield Differential Through-Silicon Vias

Guangbao Shan, Guoliang Li, Dongdong Chen, Zifeng Yang, Di Li, Yintang Yang,

An accurate equivalent thermal model is proposed to calculate the equivalent thermal conductivity (ETC) of shield differential through-silicon via (SDTSV). The mathematical expressions of ETC in both horizontal and vertical directions are deduced by considering the anisotropy of SDTSV. The accuracy of the proposed model is verified by the finite ... Read more >>

Micromachines (Basel) (Micromachines)
[2021, 12(10):]

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Computed tomography angiography for aerodigestive injuries in penetrating neck trauma: A systematic review.

Lorenzo Paladino, Bonny J Baron, Gururaj Shan, Richard Sinert,

<h4>Objectives</h4>Management of hemodynamically stable patients with penetrating neck trauma (PNT) has evolved in recent years with improvements in imaging technology. Computed tomography angiography (CTA) encompassing all zones of the neck has become part of the standard diagnostic algorithm for PNT patients who do not require immediate surgical intervention for vascular ... Read more >>

Acad Emerg Med (Academic emergency medicine : official journal of the Society for Academic Emergency Medicine)
[2021, 28(10):1160-1172]

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Establishment of a Lung Cancer Discriminative Model Based on an Optimized Support Vector Machine Algorithm and Study of Key Targets of Wogonin in Lung Cancer.

Lin Wang, Jianhua Zhang, Guoyong Shan, Junting Liang, Wenwen Jin, Yingyue Li, Fangchu Su, Yanhua Ba, Xifeng Tian, Xiaoyan Sun, Dayong Zhang, Weihua Zhang, Chuan Liang Chen,

An optimized support vector machine model was used to construct a lung cancer diagnosis model based on serological indicators, and a molecular regulation model of Wogonin, a component of <i>Scutellaria baicalensis</i>, was established. Serological indexes of patients were collected, the grid search method was used to identify the optimal penalty ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:728937]

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Association between Serum Uric Acid and Hypertension in Han and Yugur of Gansu Province: The China National Health Survey.

Chengdong Yu, Xiaolan Ren, Li Pan, Hongjun Zhao, Ye Wang, Lijun Chang, Huijing He, Jin'en Xi, Guangliang Shan,

<h4>Introduction</h4>Serum uric acid (SUA) has been found correlated with an increased risk of hypertension, but evidence is sparse regarding the association in Gansu Province, especially in Yugur people. This study aimed to explore the nonlinear relationship between SUA levels and hypertension in Han and Yugur people in China.<h4>Methods</h4>The cross-sectional study ... Read more >>

Kidney Blood Press Res (Kidney & blood pressure research)
[2021, :1-11]

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Some Thoughts Concerning the Mutational Background of Cell Lines and Heterogeneity of Bulk Tumor.

Guoshu Bi, Jiaqi Liang, Guangyao Shan, Cheng Zhan, Qun Wang,

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2021, 16(9):e67-e68]

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Wrist Internal Loading and Tempo-Dependent, Effort-Reducing Motor Behaviour Strategies for Two Elite Pianists.

Craig Turner, Peter Visentin, Gongbing Shan,

One of the greatest challenges in reducing high rates of performance injuries among musicians is in providing them usable tools to address playing-related musculoskeletal problems (PRMP) before they become disorders. Studies in biomechanics have the potential to provide such tools. In order to better understand the mechanisms through which PRMP ... Read more >>

Med Probl Perform Art (Medical problems of performing artists)
[2021, 36(3):141-149]

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Author Correction: Advances in sperm analysis: techniques, discoveries and applications.

Changsheng Dai, Zhuoran Zhang, Guanqiao Shan, Lap-Tak Chu, Zongjie Huang, Sergey Moskovtsev, Clifford Librach, Keith Jarvi, Yu Sun,

Nat Rev Urol (Nature reviews. Urology)
[2021, 18(9):573]

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Effects of surgical treatment on 24465 patients with intestinal perforation complicated with septic shock in tertiary hospitals in China from 2017 to 2020: a systematic review

Lu Wang, Xudong Ma, Huaiwu He, Longxiang Su, Yanhong Guo, Guangliang Shan, Ye Wang, Xiang Zhou, Dawei Liu, Yun Long,

<h4>Background: </h4> Intestinal perforation often leads to abdominal infection and is one of the main causes of septic shock. Prompt surgical treatment is an important treatment for this disease. We designed this study to investigate the effects of surgical treatment on patients with intestinal perforation complicated with septic shock in ... Read more >>

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External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications.

Xuemin Feng, Xin Chen, Yi Yang, Liping Yang, Yumin Zhu, Guoqiang Shan, Lingyan Zhu, Shufeng Zhang,

Hexafluoropropylene oxide dimer and trimer acids (HFPO-DA and HFPO-TA) are used as alternatives to legacy perfluorooctanoic acid (PFOA); however, little is known about their human exposure risks. In this study, the concentrations of PFOA and HFPO were measured in major human exposure matrices and human bio-samples of local residents near ... Read more >>

Environ Int (Environment international)
[2021, 157:106824]

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The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.

Li Meihe, Gao Shan, Kang Minchao, Wu Xiaoling, An Peng, Wu Xili, Zheng Jin, Dang Huimin,

One of the hallmarks of placental dysfunction is the increase of oxidative stress. This process, along with the overexpression of the inflammasome, creates a downward spiral that can lead to a series of severe pregnancy complications. Ferroptosis is a form of iron-mediated cell death involving the accumulation of reactive oxygen ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:707959]

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CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.

Xiaolin Wang, Jingxin Li, Xing Bian, Cheng Wu, Jinghan Hua, Shuhui Chang, Tianyi Yu, Hong Li, Yongxiang Li, Shanshan Hu, Ge Shan, Wenchu Lin,

Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their modes of action in gastric cancer (GC) remain largely unknown. Here, we identified <i>circURI1</i> back-spliced from exons 3 and 4 of unconventional prefoldin RPB5 interactor 1 (URI1) from circRNA profiling of five-paired human gastric and the corresponding ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(33):]

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Correction to: Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN.

Guang Shan, Xike Zhou, Juan Gu, Daoping Zhou, Wei Cheng, Huaiguo Wu, Yueping Wang, Tian Tang, Xuedong Wang,

Cell Oncol (Dordr) (Cellular oncology (Dordrecht))
[2021, 44(4):959]

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Delirium in Older Patients after Combined Epidural-General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial.

Ya-Wei Li, Huai-Jin Li, Hui-Juan Li, Bin-Jiang Zhao, Xiang-Yang Guo, Yi Feng, Ming-Zhang Zuo, Yong-Pei Yu, Hao Kong, Yi Zhao, Da Huang, Chun-Mei Deng, Xiao-Yun Hu, Peng-Fei Liu, Yan Li, Hai-Yan An, Hong-Ye Zhang, Mei-Rong Wang, Yang-Feng Wu, Dong-Xin Wang, Daniel I Sessler, ,

<h4>Background</h4>Delirium is a common and serious postoperative complication, especially in the elderly. Epidural anesthesia may reduce delirium by improving analgesia, reducing opioid consumption, and blunting stress response to surgery. This trial therefore tested the hypothesis that combined epidural-general anesthesia reduces the incidence of postoperative delirium in elderly patients recovering from ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 135(2):218-232]

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A Multi-Sensor Mini-Bioreactor to Preselect Silage Inoculants by Tracking Metabolic Activity in situ During Fermentation.

Guilin Shan, Victoria Rosner, Andreas Milimonka, Wolfgang Buescher, André Lipski, Christian Maack, Wilfried Berchtold, Ye Wang, David A Grantz, Yurui Sun,

The microbiome in silage may vary substantially from the onset to the completion of fermentation. Improved additives and inoculants are being developed to accelerate the ensiling process, to enhance fermentation quality, and to delay spoilage during feed-out. However, current methods for preselecting and characterizing these amendments are time-consuming and costly. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2021, 12:673795]

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Modeling with Multiple Correlated Spectral Data Based on Approximating the Nonlinear Spectrum Induced by Scattering.

Yongshun Luo, Gang Li, Guosong Shan, Ling Lin,

In the spectral quantitative analysis of scattering solution, the improvement of accuracy is seriously restricted by the nonlinearity caused by scattering, and even the measurement will fail due to the influence of scattering. The important reasons are that the modeling variables are greatly affected by nonlinearity, and the information contained ... Read more >>

Appl Spectrosc (Applied spectroscopy)
[2021, :37028211036515]

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