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No Evidence of SARS-CoV-2 Circulation in Rome (Italy) during the Pre-Pandemic Period: Results of a Retrospective Surveillance.

Carlo Capalbo, Enrico Bertamino, Alessandro Zerbetto, Iolanda Santino, Andrea Petrucca, Rita Mancini, Rita Bonfini, Valeria Alfonsi, Stefano Ferracuti, Paolo Marchetti, Maurizio Simmaco, Giovanni Battista Orsi, Christian Napoli,

In March 2020, the World Health Organization (WHO) declared that the COVID-19 outbreak recorded over the previous months could be characterized as a pandemic. The first known Italian SARS-CoV-2 positive case was reported on 21 February. In some countries, cases of suspected "COVID-19-like pneumonia" had been reported earlier than those ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(22):]

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Exploring chemotherapy holiday and drugs re-challenge in advanced pancreatic cancer patients.

Marina Macchini, Umberto Peretti, Giulia Orsi, Silvia Zanon, Elena Mazza, Maria Maddalena Valente, Domenico Tamburrino, Giulio Belfiori, Gemma Rossi, Sabrina Gloria Giulia Testoni, Paolo Passoni, Claudio Doglioni, Stefano Cascinu, Michele Reni,

PURPOSE:We aimed to explore the role of drugs re-challenge at the disease progression after a chemotherapy-free interval for pancreatic adenocarcinoma (PDAC) patients. METHODS:We retrospectively analyzed the outcome of re-treatments at the progression in two cohorts of advanced PDAC patients who had disease control (DC) and a treatment holiday ≥ 3 months after upfront chemotherapy. ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2020, :]

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Correction to: Prognostic Role of Blood Eosinophil Count in Patients with Sorafenib-Treated Hepatocellular Carcinoma.

Giulia Orsi, Francesco Tovoli, Vincenzo Dadduzio, Caterina Vivaldi, Oronzo Brunetti, Luca Ielasi, Fabio Conti, Giulia Rovesti, Laura Gramantieri, Mario Domenico Rizzato, Irene Pecora, Antonella Argentiero, Federica Teglia, Sara Lonardi, Francesca Salani, Alessandro Granito, Vittorina Zagonel, Giorgia Marisi, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Francesca Benevento, Alessandro Cucchetti, Fabio Piscaglia, Stefano Cascinu, Mario Scartozzi, Andrea Casadei-Gardini,

An Online First version of this article was made available online at https://link.springer.com/article/10.1007/s11523-020-00757-3 on 12 October 2020. Errors were subsequently identified in the article, and the following corrections should be noted. ... Read more >>

Target Oncol (Targeted oncology)
[2020, :]

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Prognostic Role of Blood Eosinophil Count in Patients with Sorafenib-Treated Hepatocellular Carcinoma.

Giulia Orsi, Francesco Tovoli, Vincenzo Dadduzio, Caterina Vivaldi, Oronzo Brunetti, Luca Ielasi, Fabio Conti, Giulia Rovesti, Laura Gramantieri, Mario Domenico Rizzato, Irene Pecora, Antonella Argentiero, Federica Teglia, Sara Lonardi, Francesca Salani, Alessandro Granito, Vittorina Zagonel, Giorgia Marisi, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Francesca Benevento, Alessandro Cucchetti, Fabio Piscaglia, Stefano Cascinu, Mario Scartozzi, Andrea Casadei-Gardini,

BACKGROUND:Inflammation is a long-established hallmark of liver fibrosis and carcinogenesis. Eosinophils are emerging as crucial components of the inflammatory process influencing cancer development. The role of blood eosinophils in patients with hepatocellular carcinoma receiving systemic treatment is an unexplored field. OBJECTIVE:The objective of this study was to analyse the prognostic ... Read more >>

Target Oncol (Targeted oncology)
[2020, :]

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Are Health Literacy and Lifestyle of Undergraduates Related to the Educational Field? An Italian Survey.

Francesca Gallè, Patrizia Calella, Christian Napoli, Fabrizio Liguori, Eduardo Alfonso Parisi, Giovanni Battista Orsi, Giorgio Liguori, Giuliana Valerio,

Background: Health literacy (HL) is a fundamental ability to successfully deal with health and illness issues. This study aimed to assess HL among undergraduates from healthcare and non-healthcare degree courses of two Italian universities and the association between their HL, lifestyles, and BMI assumed as health outcome. Methods: The Health ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(18):]

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Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription.

Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Patricia Le Baccon, Antoine Coulon, Guillermo A Orsi, Geneviève Almouzni,

Nucleosomes represent a challenge in regard to transcription. Histone eviction enables RNA polymerase II (RNAPII) progression through DNA, but compromises chromatin integrity. Here, we used the SNAP-tag system to distinguish new and old histones and monitor chromatin reassembly coupled to transcription in human cells. We uncovered a transcription-dependent loss of old ... Read more >>

Nat Struct Mol Biol (Nature structural & molecular biology)
[2020, 27(11):1057-1068]

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Sedentary Behaviors and Physical Activity of Italian Undergraduate Students during Lockdown at the Time of CoViD-19 Pandemic.

Francesca Gallè, Elita Anna Sabella, Stefano Ferracuti, Osvalda De Giglio, Giuseppina Caggiano, Carmela Protano, Federica Valeriani, Eduardo Alfonso Parisi, Giuliana Valerio, Giorgio Liguori, Maria Teresa Montagna, Vincenzo Romano Spica, Giovanna Da Molin, Giovanni Battista Orsi, Christian Napoli,

Background: From March to May 2020, lockdown measures were adopted in Italy to contain the epidemic of the novel Coronavirus. People were forced to restrict their movement and social contacts, therefore having a higher risk of inactivity. This study, carried out among Italian undergraduates, explored their sedentary and physical activities ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(17):]

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Moderate Vaccine Effectiveness against Severe Acute Respiratory Infection Caused by A(H1N1)pdm09 Influenza Virus and No Effectiveness against A(H3N2) Influenza Virus in the 2018/2019 Season in Italy.

Caterina Rizzo, Francesco Gesualdo, Daniela Loconsole, Elisabetta Pandolfi, Antonino Bella, Andrea Orsi, Giulia Guarona, Donatella Panatto, Giancarlo Icardi, Christian Napoli, Giovanni Battista Orsi, Ilaria Manini, Emanuele Montomoli, Ilaria Campagna, Luisa Russo, Valeria Alfonsi, Simona Puzelli, Antonino Reale, Umberto Raucci, Livia Piccioni, Carlo Concato, Marta Luisa Ciofi Degli Atti, Alberto Villani, Maria Chironna, Alberto Eugenio Tozzi,

Every season, circulating influenza viruses change; therefore, vaccines must be reformulated each year. We aimed to estimate vaccine effectiveness (VE) against severe influenza infection for the 2018/19 season in Italy. We conducted a test-negative design case-control study at five Italian hospitals. We estimated influenza VE against severe acute respiratory infection ... Read more >>

Vaccines (Basel) (Vaccines)
[2020, 8(3):]

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Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performance: The Experience of a Teaching Hospital in Central Italy.

Edith Lahner, Emanuele Dilaghi, Claudio Prestigiacomo, Giuliano Alessio, Laura Marcellini, Maurizio Simmaco, Iolanda Santino, Giovanni Battista Orsi, Paolo Anibaldi, Adriano Marcolongo, Bruno Annibale, Christian Napoli,

(1) Background: Health workers (HWs) are at high risk of acquiring SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections. Therefore, health authorities further recommend screening strategies for SARS-CoV-2 infection in exposed or high-risk HWs. Nevertheless, to date, the best/optimal method to screen HWs for SARS-CoV-2 infection is still under debate, ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(12):]

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Enteritis and Severe Abdominal Pain as the First Presentation of Covid-19.

A Kecler-Pietrzyk, G Orsi, J Carthy, W C Torreggiani,

Presentation A male patient with no significant past medical history presented to emergency department with progressive in severity abdominal pain, associated with mild nausea and diarrhea. No other significant symptoms were reported. Diagnosis On investigation with CT, duodenojejunitis was diagnosed as the cause of abdominal pain. Lung basal changes were ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):102]

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The Exponential Phase of the Covid-19 Pandemic in Central Italy: An Integrated Care Pathway.

Carlo Capalbo, Antonio Aceti, Maurizio Simmaco, Rita Bonfini, Monica Rocco, Alberto Ricci, Christian Napoli, Matteo Rocco, Valeria Alfonsi, Antonella Teggi, Giovanni Battista Orsi, Marina Borro, Iolanda Santino, Robert Preissner, Paolo Marchetti, Adriano Marcolongo, Paolo Anibaldi,

The Coronavirus Disease (Covid-19) pandemic is rapidly spreading across the world, representing an unparalleled challenge for health care systems. There are differences in the estimated fatality rates, which cannot be explained easily. In Italy, the estimated case fatality rate was 12.7% in mid-April, while Germany remained at 1.8%. Moreover, it ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(11):]

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Understanding Knowledge and Behaviors Related to CoViD-19 Epidemic in Italian Undergraduate Students: The EPICO Study.

Francesca Gallè, Elita Anna Sabella, Giovanna Da Molin, Osvalda De Giglio, Giuseppina Caggiano, Valeria Di Onofrio, Stefano Ferracuti, Maria Teresa Montagna, Giorgio Liguori, Giovanni Battista Orsi, Christian Napoli,

Background: On February 2020, the novel coronavirus (2019-nCoV) epidemic began in Italy. In order to contain the spread of the virus, the Italian government adopted emergency measures nationwide, including closure of schools and universities, workplaces and subsequently lockdown. This survey was carried out among Italian undergraduates to explore their level ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(10):]

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Utility of neutrophil-to-lymphocyte ratio to identify long-term survivors among HCC patients treated with sorafenib.

Andrea Casadei-Gardini, Vincenzo Dadduzio, Giulia Rovesti, Giuseppe Cabibbo, Ranka Vukotic, Mario Domenico Rizzato, Giulia Orsi, Margherita Rossi, Valeria Guarneri, Sara Lonardi, Dario D'agostino, Ciro Celsa, Pietro Andreone, Vittorina Zagonel, Mario Scartozzi, Stefano Cascinu, Alessandro Cucchetti,

Sorafenib is the first multikinase inhibitor demonstrating a survival benefit for patients suffering from advanced hepatocellular carcinoma (HCC). However, 1 issue remains open: what is the factor able to predict which patients will be long survivors?In the present study, we harnessed the potential of conditional survival, aiming at estimating the ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(22):e19958]

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Association of NOS3 and ANGPT2 Gene Polymorphisms with Survival in Patients with Hepatocellular Carcinoma Receiving Sorafenib: Results of the Multicenter Prospective INNOVATE Study.

Andrea Casadei-Gardini, Giorgia Marisi, Vincenzo Dadduzio, Laura Gramantieri, Luca Faloppi, Paola Ulivi, Francesco Giuseppe Foschi, Emiliano Tamburini, Caterina Vivaldi, Mario Domenico Rizzato, Luca Ielasi, Matteo Canale, Fabio Conti, Britt Rudnas, Lorenzo Fornaro, Nicola Silvestris, Marianna Silletta, Giovanni Gerardo Cardellino, Sara Lonardi, Francesca Fornari, Giulia Orsi, Giulia Rovesti, Vittorina Zagonel, Stefano Cascinu, Mario Scartozzi,

PURPOSE:After 10 years of clinical practice and research studies, there are still no validated prognostic or predictive factors of response to sorafenib for hepatocellular carcinoma (HCC). On the basis of the results of our two retrospective studies, we designed the multicenter INNOVATE study with the aim to validate the role ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(17):4485-4493]

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Are health literacy and lifestyle of undergraduates related to the educational field? An Italian survey

Francesca Gallè, Patrizia Calella, Christian Napoli, Fabrizio Liguori, Giovanni Battista Orsi, Giorgio Liguori, Giuliana Valerio,

Abstract Background. Health literacy is a fundamental ability that allows individuals to manage their health. This study was aimed to assess health literacy and lifestyles among healthcare undergraduates in comparison to students attending other degree courses from two Italian universities. Methods. The Health Literacy Assessment Tool (HLAT-8) and the Newest ... Read more >>

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Safety in Wine Production: A Pilot Study on the Quality Evaluation of Prosecco Wine in the Framework of UE Regulation.

Vincenzo Marcotrigiano, Sandro Cinquetti, Riccardo Flamini, Mirko De Rosso, Luca Ferraro, Saverio Petrilli, Matilde Poggi, Alessandro Dettori, Anna De Polo, Osvalda De Giglio, Giovanni Battista Orsi, Maria Teresa Montagna, Christian Napoli,

In Italy, wine production is considered a sector of excellence, where the wines' appreciable sensory features are favored by environmental factors, including weather and climate conditions, which benefit territories with a specific vocation. The whole chain involves many economic and agri-food sector operators, and requires an in-depth assessment of specific ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(9):]

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Is There an Optimal Choice in Refractory Colorectal Cancer? A Network Meta-Analysis.

Andrea Casadei-Gardini, Alessandro Vagheggini, Fabio Gelsomino, Andrea Spallanzani, Paola Ulivi, Giulia Orsi, Giulia Rovesti, Kalliopi Andrikou, Emiliano Tamburini, Mario Scartozzi, Stefano Cascinu,

BACKGROUND:In the absence of head-to-head comparison studies, the present network meta-analysis evaluated and compared the efficacy of 4 therapeutic alternatives for refractory colorectal cancer. MATERIALS AND METHODS:The search focused on results from phase III randomized controlled trials. Separate (subgroup) network meta-analyses were conducted to obtain drug comparisons stratified by various ... Read more >>

Clin Colorectal Cancer (Clinical colorectal cancer)
[2020, 19(2):82-90.e9]

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Time to CA19-9 nadir: a clue for defining optimal treatment duration in patients with resectable pancreatic ductal adenocarcinoma.

Michele Reni, Umberto Peretti, Silvia Zanon, Marina Macchini, Gianpaolo Balzano, Elena Mazza, Domenico Tamburrino, Giulia Orsi, Paolo Giorgio Arcidiacono, Massimo Falconi, Luca Gianni,

BACKGROUND:Defining optimal treatment duration in patients with resectable pancreatic ductal adenocarcinoma (PDAC) receiving primary chemotherapy is an unmet need. The role of time to CA19-9 nadir and of nadir magnitude was explored in this study. PATIENTS AND METHODS:The databases of our institution's prospective trials were queried to speculate on the ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2020, 85(4):641-650]

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The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition.

Daniela Torres-Campana, Shuhei Kimura, Guillermo A Orsi, Béatrice Horard, Gérard Benoit, Benjamin Loppin,

Following fertilization of a mature oocyte, the formation of a diploid zygote involves a series of coordinated cellular events that ends with the first embryonic mitosis. In animals, this complex developmental transition is almost entirely controlled by maternal gene products. How such a crucial transcriptional program is established during oogenesis ... Read more >>

PLoS Genet (PLoS genetics)
[2020, 16(3):e1008543]

Cited: 2 times

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Physical Activity in Older Adults: An Investigation in a Metropolitan Area of Southern Italy.

Francesca Gallè, Elita Anna Sabella, Giovanna Da Molin, Eduardo Alfonso Parisi, Giorgio Liguori, Maria Teresa Montagna, Osvalda De Giglio, Luca Tondini, Giovanni Battista Orsi, Christian Napoli,

Physical activity (PA) and exercise are fundamental to maintaining health in older adults. World Health Organization guidelines state that older adults should practice at least 150 min/week of moderate/vigorous intensity PA to obtain health benefits. We assessed PA levels among older adults in southern Italy and evaluated possible associated determinants. ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(3):]

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Meta-analysis of early bowel resection versus initial medical therapy in patient's with ileocolonic Crohn's disease.

Éanna J Ryan, Gabriel Orsi, Michael R Boland, Adeel Zafar Syed, Ben Creavin, Michael E Kelly, Kieran Sheahan, Paul C Neary, Dara O Kavanagh, Deirdre McNamara, Des C Winter, James M O'Riordan,

BACKGROUND:Early bowel resection (EBR) in ileocolonic Crohn's disease (CD) may be associated with more durable remission compared with initial medical therapy (IMT) even when biologic therapy is included. AIM:To compare the efficacy of EBR versus IMT for ileocolonic CD METHODS: A systematic search was performed to identify studies that compared ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2020, 35(3):501-512]

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Developments in predictive biomarkers for hepatocellular carcinoma therapy.

Andrea Casadei-Gardini, Giulia Orsi, Francesco Caputo, Giorgio Ercolani,

Introduction: Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and the third largest cause of cancer-relateddeaths worldwide. Potentially curative treatments (surgical resection, radiofrequency or liver transplantation) are only available for few patients, while transarterial chemoembolization (TACE) or systemic agents are the best treatments for intermediate and ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2020, 20(1):63-74]

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Two distinct HIRA-dependent pathways handle H3.3 de novo deposition and recycling during transcription

Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Antoine Coulon, Guillermo Orsi, Geneviève Almouzni,

ABSTRACT The packaging of DNA into nucleosomes represents a challenge for transcription. Nucleosome disruption and histone eviction enables RNA Polymerase II progression through DNA, a process that compromises chromatin integrity and the maintenance of epigenetic information. Here, we used the imaging SNAP-tag system to distinguish new and old histones and ... Read more >>

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Corrigendum to "Gastric cancer: Translating novels concepts into clinical practice" [Cancer Treatm. Rev. 79C (2019) 101889].

Massimiliano Salati, Giulia Orsi, Elisabeth Smyth, Giuseppe Aprile, Giordano Beretta, Fernando De Vita, Maria Di Bartolomeo, Valentina Fanotto, Sara Lonardi, Federica Morano, Filippo Pietrantonio, Carmine Pinto, Lorenza Rimassa, Enrico Vasile, Caterina Vivaldi, Alberto Zaniboni, Pina Ziranu, Stefano Cascinu,

Cancer Treat. Rev. (Cancer treatment reviews)
[2019, 81:101932]

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Corrigendum to "Age-dependent changes at the blood-brain barrier. A comparative structural and functional study in young adult and middle aged rats" [Brain Res. Bull. 139C (2018) 269-277].

Luca Bors, Kinga Tóth, Estilla Zsófia Tóth, Ágnes Bajza, Attila Csorba, Krisztián Szigeti, Domokos Máthé, Gábor Perlaki, Gergely Orsi, Gábor K Tóth, Franciska Erdő,

Brain Res Bull (Brain research bulletin)
[2020, 155:211-212]

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