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Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain

Daniela Torres-Campana, Béatrice Horard, Sandrine Denaud, Gérard Benoit, Benjamin Loppin, Guillermo Orsi,

<h4>ABSTRACT</h4> The formation of a diploid zygote is a highly complex cellular process that is entirely controlled by maternal gene products stored in the egg cytoplasm. This highly specialized transcriptional program is tightly controlled at the chromatin level in the female germline. As an extreme case in point, the massive ... Read more >>

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Severe Acute Respiratory Infections (SARI) surveillance in over-65-years-old patients: the experience of a University hospital (seasons 2017-2018 and 2018-2019).

E Bertamino, A Zerbetto, C Capalbo, V Alfonsi, A Petrucca, I Santino, R Bonfini, M Aromatario, L M Pomes, R Mancini, S Ferracuti, C Rizzo, A Bella, G B Orsi, C Napoli,

<h4>Background</h4>Influenza is a relevant public health problem, also due to the risk of complications. The most effective measure to prevent influenza is vaccination; therefore, at present, there is consensus among European countries, regarding the need for routine seasonal influenza vaccination of elderly and individuals at increased risk of severe influenza. ... Read more >>

Ann Ig (Annali di igiene : medicina preventiva e di comunita)
[2021, 33(3):278-288]

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Awareness and Behaviors Regarding COVID-19 among Albanian Undergraduates.

Francesca Gallè, Arjeta Veshi, Elita Anna Sabella, Morena Çitozi, Giovanna Da Molin, Stefano Ferracuti, Giorgio Liguori, Giovanni Battista Orsi, Christian Napoli, Christian Napoli,

The coronavirus disease 2019 (COVID-19) pandemic has led to the adoption of restriction measures that have had notable consequences on the health and wellbeing of individuals. This survey was carried out on a sample of 905 Albanian undergraduates to assess their knowledge about COVID-19 and their health-related behaviors and communication ... Read more >>

Behav Sci (Basel) (Behavioral sciences (Basel, Switzerland))
[2021, 11(4):]

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Microstructural and functional brain abnormalities in multiple sclerosis predicted by osteopontin and neurofilament light.

Gergely Orsi, Tamas Cseh, Zsofia Hayden, Gabor Perlaki, Szilvia Anett Nagy, Omar Giyab, Dorte Aalund Olsen, Jonna Skov Madsen, Timea Berki, Zsolt Illes,

<h4>Background</h4>Osteopontin (OPN) is a proinflammatory biomarker, and neurofilament light chain (NFL) levels reflect axonal damage. Resting-state functional MRI (rs-fMRI) defines brain networks during wakeful rest.<h4>Objective</h4>To examine, if levels of OPN and NFL are associated on the long term with (i) lesion evolution, (ii) changes in normal-appearing white matter (NAWM) microstructure ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2021, 51:102923]

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Clinical Characteristics and Outcome of Neuronal Surface Antibody-Mediated Autoimmune Encephalitis Patients in a National Cohort.

Zsófia Hayden, Beáta Bóné, Gergely Orsi, Monika Szots, Ferenc Nagy, Tünde Csépány, Zsolt Mezei, Cecília Rajda, Diána Simon, József Najbauer, Zsolt Illes, Timea Berki,

<b>Background:</b> In our previous single-center study of autoimmune encephalitis (AE) related autoantibody test results we found positivity in 60 patients out of 1,034 with suspected AE from 2012 through 2018 as part of a Hungarian nationwide program. In our current multicenter retrospective study, we analyzed the clinical characteristics and outcome ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:611597]

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Muscle damage in response to a single bout of high intensity concentric exercise in patients with Pompe disease.

Márk Váczi, Szilvia Anett Nagy, Tamás Kőszegi, Bernadette Misovics, Edina Szabó, Éva Müller, Gábor Perlaki, Gergely Orsi, József Pál, Péter Bogner, Zsolt Illes,

<h4>Background</h4>In Pompe disease, resistance exercise could be an effective treatment to delay motor function impairment, however, the acute effects of this exercise modality are unclear.<h4>Methods</h4>In a prospective cohort study, we compared responses to a single bout of resistance exercise by serum markers of muscle damage and quantitative muscle magnetic resonance ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2021, 9(5):389]

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Muscle damage in response to a single bout of high intensity concentric exercise in patients with Pompe disease

Márk Váczi, Szilvia Anett Nagy, Tamás Kőszegi, Bernadette Misovics, Edina Szabó, Éva Müller, Gábor Perlaki, Gergely Orsi, József Pál, Péter Bogner, Zsolt Illes,

<h4>Background</h4> In Pompe disease, resistance exercise could be an effective treatment to delay motor function impairment, however, the acute effects of this exercise modality are unclear. <h4>Methods</h4> In a prospective cohort study, we compared responses to a single bout of resistance exercise by serum markers of muscle damage and quantitative ... Read more >>

(Annals of Translational Medicine)
[2021, 9(5):]

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Prognostic Role of a New Index Tested in European and Korean Advanced Biliary Tract Cancer Patients: the PECS Index.

Giulia Rovesti, Francesco Leone, Giovanni Brandi, Lorenzo Fornaro, Mario Scartozzi, Monica Niger, Changhoon Yoo, Francesco Caputo, Roberto Filippi, Mariaelena Casagrande, Nicola Silvestris, Daniele Santini, Luca Faloppi, Andrea Palloni, Massimo Aglietta, Caterina Vivaldi, Hyungwoo Cho, Eleonora Lai, Elisabetta Fenocchio, Federico Nichetti, Nicoletta Pella, Stefania De Lorenzo, Massimo Di Maio, Enrico Vasile, Filippo de Braud, Jae Ho Jeong, Giuseppe Aprile, Giulia Orsi, Stefano Cascinu, Andrea Casadei-Gardini,

<h4>Background and aim</h4>The aim of the present study is to evaluate a new index (PECS (PsECogSii)index) influenced by PS ECOG and systemic immune-inflammation index (SII) in unresectable locally advanced or metastatic BTC patients treated with first-line chemotherapy.<h4>Methods</h4>This multicenter, international, study was conducted on a training cohort of 130 patients and ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2021, :]

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Extensive molecular reclassification: new perspectives in small bowel adenocarcinoma?

Andrea Casadei-Gardini, Sara Lonardi, Valeria Smiroldo, Matteo Canale, Alessandro Passardi, Nicola Silvestris, Giulia Orsi, Floriana Nappo, Lorenza Rimassa, Matteo Fassan, Paola Spaggiari, Oronzo Brunetti, Kalliopi Andrikou, Stefano Cascinu,

SBA classification is still based on the location of the primary tumor, without genetic information. in the current study, an extensive genetic profile of SBA, was performed in order to identify and quantify targetable alterations for a future precision medicine in SBA. Clinical-pathological information for 24 patients affected by SBA ... Read more >>

Med Oncol (Medical oncology (Northwood, London, England))
[2021, 38(2):17]

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Fast 3 T nigral hyperintensity magnetic resonance imaging in Parkinson's disease.

Gabriella Hernadi, David Pinter, Szilvia Anett Nagy, Gergely Orsi, Samuel Komoly, Jozsef Janszky, Norbert Kovacs, Gabor Perlaki,

The absence of nigral hyperintensity is a promising MR marker for Parkinson's disease (PD), but its small size imposes limitations on its routine use. Our aim was to compare Multi Echo Data Image Combination (MEDIC), segmented echo-planar imaging (EPISEG) and fluid-attenuated inversion recovery (FLAIR) sequences, as well as both magnitude ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):1179]

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Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort.

U Peretti, A Cavaliere, M Niger, G Tortora, M C Di Marco, M G Rodriquenz, F Centonze, I G Rapposelli, G Giordano, F De Vita, L Stuppia, A Avallone, M Ratti, C Paratore, L G Forti, G Orsi, M M Valente, M Gaule, M Macchini, P Carrera, S Calzavara, M Simbolo, D Melisi, F De Braud, L Salvatore, S De Lorenzo, C Chiarazzo, M Falconi, S Cascinu, M Milella, M Reni,

<h4>Objective</h4>Germline BRCA1-2 pathogenic variants (gBRCApv) increase the risk of pancreatic cancer and predict for response to platinating agents and poly(ADP-ribose) polymerase inhibitors. Data on worldwide gBRCApv incidence among pancreatic ductal adenocarcinoma (PDAC) patients are sparse and describe a remarkable geographic heterogeneity. The aim of this study is to analyze the ... Read more >>

ESMO Open (ESMO open)
[2021, 6(1):100032]

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Correction to: Prognostic Role of Blood Eosinophil Count in Patients with Sorafenib-Treated Hepatocellular Carcinoma.

Giulia Orsi, Francesco Tovoli, Vincenzo Dadduzio, Caterina Vivaldi, Oronzo Brunetti, Luca Ielasi, Fabio Conti, Giulia Rovesti, Laura Gramantieri, Mario Domenico Rizzato, Irene Pecora, Antonella Argentiero, Federica Teglia, Sara Lonardi, Francesca Salani, Alessandro Granito, Vittorina Zagonel, Giorgia Marisi, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Francesca Benevento, Alessandro Cucchetti, Fabio Piscaglia, Stefano Cascinu, Mario Scartozzi, Andrea Casadei-Gardini,

An Online First version of this article was made available online at https://link.springer.com/article/10.1007/s11523-020-00757-3 on 12 October 2020. Errors were subsequently identified in the article, and the following corrections should be noted. ... Read more >>

Target Oncol (Targeted oncology)
[2020, 15(6):809-810]

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Prognostic Role of Blood Eosinophil Count in Patients with Sorafenib-Treated Hepatocellular Carcinoma.

Giulia Orsi, Francesco Tovoli, Vincenzo Dadduzio, Caterina Vivaldi, Oronzo Brunetti, Luca Ielasi, Fabio Conti, Giulia Rovesti, Laura Gramantieri, Mario Domenico Rizzato, Irene Pecora, Antonella Argentiero, Federica Teglia, Sara Lonardi, Francesca Salani, Alessandro Granito, Vittorina Zagonel, Giorgia Marisi, Giuseppe Cabibbo, Francesco Giuseppe Foschi, Francesca Benevento, Alessandro Cucchetti, Fabio Piscaglia, Stefano Cascinu, Mario Scartozzi, Andrea Casadei-Gardini,

<h4>Background</h4>Inflammation is a long-established hallmark of liver fibrosis and carcinogenesis. Eosinophils are emerging as crucial components of the inflammatory process influencing cancer development. The role of blood eosinophils in patients with hepatocellular carcinoma receiving systemic treatment is an unexplored field.<h4>Objective</h4>The objective of this study was to analyse the prognostic role ... Read more >>

Target Oncol (Targeted oncology)
[2020, 15(6):773-785]

Cited: 2 times

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Retrospective survival analysis in patients with metastatic pancreatic ductal adenocarcinoma with insulin-treated type 2 diabetes mellitus.

Andrea Pretta, Pina Ziranu, Marco Puzzoni, Eleonora Lai, Giulia Orsi, Nicole Liscia, Eleonora Molinaro, Stefano Mariani, Laura Riggi, Giulia Rovesti, Marco Dubois, Marco Migliari, Mara Persano, Giorgio Saba, Valentino Impera, Francesca Musio, Erich Batzella, Laura Demurtas, Valeria Pusceddu, Giorgio Astara, Luca Faloppi, Andrea Casadei Gardini, Kalliopi Andrikou, Stefano Cascinu, Mario Scartozzi,

<h4>Introduction</h4>The association between pancreatic ductal adenocarcinoma (PDAC) and type 2 diabetes mellitus (DM2) has long been evaluated and the role of antidiabetic medications such as metformin has also been investigated. The objective of this study was to examine the association between insulin use and overall survival (OS) in patients with ... Read more >>

Tumori (Tumori)
[2020, :300891620976945]

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No Evidence of SARS-CoV-2 Circulation in Rome (Italy) during the Pre-Pandemic Period: Results of a Retrospective Surveillance.

Carlo Capalbo, Enrico Bertamino, Alessandro Zerbetto, Iolanda Santino, Andrea Petrucca, Rita Mancini, Rita Bonfini, Valeria Alfonsi, Stefano Ferracuti, Paolo Marchetti, Maurizio Simmaco, Giovanni Battista Orsi, Christian Napoli,

In March 2020, the World Health Organization (WHO) declared that the COVID-19 outbreak recorded over the previous months could be characterized as a pandemic. The first known Italian SARS-CoV-2 positive case was reported on 21 February. In some countries, cases of suspected "COVID-19-like pneumonia" had been reported earlier than those ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(22):]

Cited: 2 times

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Exploring chemotherapy holiday and drugs re-challenge in advanced pancreatic cancer patients.

Marina Macchini, Umberto Peretti, Giulia Orsi, Silvia Zanon, Elena Mazza, Maria Maddalena Valente, Domenico Tamburrino, Giulio Belfiori, Gemma Rossi, Sabrina Gloria Giulia Testoni, Paolo Passoni, Claudio Doglioni, Stefano Cascinu, Michele Reni,

<h4>Purpose</h4>We aimed to explore the role of drugs re-challenge at the disease progression after a chemotherapy-free interval for pancreatic adenocarcinoma (PDAC) patients.<h4>Methods</h4>We retrospectively analyzed the outcome of re-treatments at the progression in two cohorts of advanced PDAC patients who had disease control (DC) and a treatment holiday ≥ 3 months after upfront chemotherapy.<h4>Results</h4>Between 2015 ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2021, 87(1):95-101]

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Cluster analysis identifies patients at risk of catheter-associated urinary tract infections in intensive care units: findings from the SPIN-UTI Network.

M Barchitta, A Maugeri, G Favara, P M Riela, C La Mastra, M C La Rosa, R Magnano San Lio, G Gallo, I Mura, A Agodi, ,

<h4>Background</h4>Although preventive strategies have been proposed against catheter-associated urinary tract infections (CAUTIs) in intensive care units (ICUs), more efforts are needed to control the incidence rate.<h4>Aim</h4>To distinguish patients according to their characteristics at ICU admission, and to identify clusters of patients at higher risk for CAUTIs.<h4>Methods</h4>A two-step cluster analysis was ... Read more >>

J Hosp Infect (The Journal of hospital infection)
[2021, 107:57-63]

Cited: 3 times

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Are Health Literacy and Lifestyle of Undergraduates Related to the Educational Field? An Italian Survey.

Francesca Gallè, Patrizia Calella, Christian Napoli, Fabrizio Liguori, Eduardo Alfonso Parisi, Giovanni Battista Orsi, Giorgio Liguori, Giuliana Valerio,

<i>Background</i>: Health literacy (HL) is a fundamental ability to successfully deal with health and illness issues. This study aimed to assess HL among undergraduates from healthcare and non-healthcare degree courses of two Italian universities and the association between their HL, lifestyles, and BMI assumed as health outcome. <i>Methods</i>: The Health ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(18):]

Cited: 1 time

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Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription.

Júlia Torné, Dominique Ray-Gallet, Ekaterina Boyarchuk, Mickaël Garnier, Patricia Le Baccon, Antoine Coulon, Guillermo A Orsi, Geneviève Almouzni,

Nucleosomes represent a challenge in regard to transcription. Histone eviction enables RNA polymerase II (RNAPII) progression through DNA, but compromises chromatin integrity. Here, we used the SNAP-tag system to distinguish new and old histones and monitor chromatin reassembly coupled to transcription in human cells. We uncovered a transcription-dependent loss of old ... Read more >>

Nat Struct Mol Biol (Nature structural & molecular biology)
[2020, 27(11):1057-1068]

Cited: 3 times

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Sedentary Behaviors and Physical Activity of Italian Undergraduate Students during Lockdown at the Time of CoViD-19 Pandemic.

Francesca Gallè, Elita Anna Sabella, Stefano Ferracuti, Osvalda De Giglio, Giuseppina Caggiano, Carmela Protano, Federica Valeriani, Eduardo Alfonso Parisi, Giuliana Valerio, Giorgio Liguori, Maria Teresa Montagna, Vincenzo Romano Spica, Giovanna Da Molin, Giovanni Battista Orsi, Christian Napoli,

<i>Background</i>: From March to May 2020, lockdown measures were adopted in Italy to contain the epidemic of the novel Coronavirus. People were forced to restrict their movement and social contacts, therefore having a higher risk of inactivity. This study, carried out among Italian undergraduates, explored their sedentary and physical activities ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(17):]

Cited: 19 times

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Moderate Vaccine Effectiveness against Severe Acute Respiratory Infection Caused by A(H1N1)pdm09 Influenza Virus and No Effectiveness against A(H3N2) Influenza Virus in the 2018/2019 Season in Italy.

Caterina Rizzo, Francesco Gesualdo, Daniela Loconsole, Elisabetta Pandolfi, Antonino Bella, Andrea Orsi, Giulia Guarona, Donatella Panatto, Giancarlo Icardi, Christian Napoli, Giovanni Battista Orsi, Ilaria Manini, Emanuele Montomoli, Ilaria Campagna, Luisa Russo, Valeria Alfonsi, Simona Puzelli, Antonino Reale, Umberto Raucci, Livia Piccioni, Carlo Concato, Marta Luisa Ciofi Degli Atti, Alberto Villani, Maria Chironna, Alberto Eugenio Tozzi,

Every season, circulating influenza viruses change; therefore, vaccines must be reformulated each year. We aimed to estimate vaccine effectiveness (VE) against severe influenza infection for the 2018/19 season in Italy. We conducted a test-negative design case-control study at five Italian hospitals. We estimated influenza VE against severe acute respiratory infection ... Read more >>

Vaccines (Basel) (Vaccines)
[2020, 8(3):]

Cited: 1 time

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Prevalence of Sars-Cov-2 Infection in Health Workers (HWs) and Diagnostic Test Performance: The Experience of a Teaching Hospital in Central Italy.

Edith Lahner, Emanuele Dilaghi, Claudio Prestigiacomo, Giuliano Alessio, Laura Marcellini, Maurizio Simmaco, Iolanda Santino, Giovanni Battista Orsi, Paolo Anibaldi, Adriano Marcolongo, Bruno Annibale, Christian Napoli,

(1) Background: Health workers (HWs) are at high risk of acquiring SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections. Therefore, health authorities further recommend screening strategies for SARS-CoV-2 infection in exposed or high-risk HWs. Nevertheless, to date, the best/optimal method to screen HWs for SARS-CoV-2 infection is still under debate, ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(12):]

Cited: 20 times

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Enteritis and Severe Abdominal Pain as the First Presentation of Covid-19.

A Kecler-Pietrzyk, G Orsi, J Carthy, W C Torreggiani,

Presentation A male patient with no significant past medical history presented to emergency department with progressive in severity abdominal pain, associated with mild nausea and diarrhea. No other significant symptoms were reported. Diagnosis On investigation with CT, duodenojejunitis was diagnosed as the cause of abdominal pain. Lung basal changes were ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):102]

Cited: 1 time

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The Exponential Phase of the Covid-19 Pandemic in Central Italy: An Integrated Care Pathway.

Carlo Capalbo, Antonio Aceti, Maurizio Simmaco, Rita Bonfini, Monica Rocco, Alberto Ricci, Christian Napoli, Matteo Rocco, Valeria Alfonsi, Antonella Teggi, Giovanni Battista Orsi, Marina Borro, Iolanda Santino, Robert Preissner, Paolo Marchetti, Adriano Marcolongo, Paolo Anibaldi,

The Coronavirus Disease (Covid-19) pandemic is rapidly spreading across the world, representing an unparalleled challenge for health care systems. There are differences in the estimated fatality rates, which cannot be explained easily. In Italy, the estimated case fatality rate was 12.7% in mid-April, while Germany remained at 1.8%. Moreover, it ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(11):]

Cited: 4 times

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Understanding Knowledge and Behaviors Related to CoViD-19 Epidemic in Italian Undergraduate Students: The EPICO Study.

Francesca Gallè, Elita Anna Sabella, Giovanna Da Molin, Osvalda De Giglio, Giuseppina Caggiano, Valeria Di Onofrio, Stefano Ferracuti, Maria Teresa Montagna, Giorgio Liguori, Giovanni Battista Orsi, Christian Napoli,

<i>Background:</i> On February 2020, the novel coronavirus (2019-nCoV) epidemic began in Italy. In order to contain the spread of the virus, the Italian government adopted emergency measures nationwide, including closure of schools and universities, workplaces and subsequently lockdown. This survey was carried out among Italian undergraduates to explore their level ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(10):]

Cited: 29 times

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