Full Text Journal Articles by
Author G Giagnoni

Advertisement

Find full text journal articles






Effect of protein concentrate mixtures and dietary addition of exogenous phytase on major milk minerals and proteins, including casein phosphorylation.

N A Poulsen, G Giagnoni, M Johansen, P Lund, L B Larsen,

Variations in major milk minerals, proteins, and their posttranslational modifications are largely under genetic influence, whereas the effect of nongenetic factors is less studied. Through a controlled feeding experiment (incomplete balanced Latin square design), the effect of concentrate mixtures, based on fava beans, rapeseed meal, or soybean meal as main ... Read more >>

J Dairy Sci (Journal of dairy science)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Effect of exogenous dietary phytase and concentrate mixtures based on faba beans, rapeseed meal or soybean meal as main protein source on phytate and total phosphorus excretion in dairy cows

G Giagnoni, P Lund, J Sehested, M Johansen,

The aim of this study was to test the effect of exogenous dietary phytase on in vivo phytate P and total P excretion in dairy cows fed three different concentrate mixtures. Excretion and apparent total tract digestibility (ATTD) of phytate P and total P were measured in 24 Danish Holstein ... Read more >>

Anim Feed Sci Technol (Animal feed science and technology.)
[2021, 276:Not Available]

Cited: 0 times

View full text PDF listing >>



Advertisement

Rimonabant, a cannabinoid CB1 receptor antagonist, attenuates mechanical allodynia and counteracts oxidative stress and nerve growth factor deficit in diabetic mice.

Francesca Comelli, Isabella Bettoni, Anita Colombo, Pietro Fumagalli, Gabriella Giagnoni, Barbara Costa,

Diabetes is one of the leading causes of painful neuropathy and to date, besides a tight glycemic control, a viable treatment for this complication is not available. Rimonabant is a selective cannabinoid CB(1) receptor antagonist that produces a significant increase in insulin sensitivity and a reduction of HbA(1c) in diabetic ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2010, 637(1-3):62-69]

Cited: 18 times

View full text PDF listing >>



Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress.

Francesca Comelli, Isabella Bettoni, Mariapia Colleoni, Gabriella Giagnoni, Barbara Costa,

Neuropathy is the most common complication of diabetes and it is still considered to be relatively refractory to most of the analgesics. The aim of the present study was to explore the antinociceptive effect of a controlled cannabis extract (eCBD) in attenuating diabetic neuropathic pain. Repeated treatment with cannabis extract ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2009, 23(12):1678-1684]

Cited: 20 times

View full text PDF listing >>



The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice.

Barbara Costa, Isabella Bettoni, Stefania Petrosino, Francesca Comelli, Gabriella Giagnoni, Vincenzo Di Marzo,

Given that the pharmacological or genetic inactivation of fatty acid amide hydrolase (FAAH) counteracts pain and inflammation, and on the basis of the established involvement of transient receptor potential vanilloid type-1 (TRPV1) channels in inflammatory pain, we tested the capability of a dual FAAH/TRPV1 blocker, N-arachidonoyl-serotonin (AA-5-HT), to relieve oedema ... Read more >>

Pharmacol Res (Pharmacological research)
[2010, 61(6):537-546]

Cited: 36 times

View full text PDF listing >>



Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice.

Isabella Bettoni, Francesca Comelli, Clara Rossini, Francesca Granucci, Gabriella Giagnoni, Francesco Peri, Barbara Costa,

Neuropathic pain remains a prevalent clinical problem because it is often poorly responsive to the currently used analgesics, thus it is crucial the identification of new potential targets and drugs. Recent evidence indicated that microglial cells in the spinal cord are critically involved in the development and maintenance of neuropathic ... Read more >>

Glia (Glia)
[2008, 56(12):1312-1319]

Cited: 108 times

View full text PDF listing >>



The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors.

Barbara Costa, Francesca Comelli, Isabella Bettoni, Mariapia Colleoni, Gabriella Giagnoni,

Palmitoylethanolamide (PEA) is an endogenous lipid that is thought to be involved in endogenous protective mechanisms activated as a result of stimulation of inflammatory response. In spite of the well demonstrated anti-inflammatory properties of PEA, its involvement in controlling pain pathways still remains poorly characterized. On this basis, we tested ... Read more >>

Pain (Pain)
[2008, 139(3):541-550]

Cited: 162 times

View full text PDF listing >>



Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved.

Francesca Comelli, Gabriella Giagnoni, Isabella Bettoni, Mariapia Colleoni, Barbara Costa,

This study aimed to give a rationale for the employment of phytocannabinoid formulations to treat neuropathic pain. It was found that a controlled cannabis extract, containing multiple cannabinoids, in a defined ratio, and other non-cannabinoid fractions (terpenes and flavonoids) provided better antinociceptive efficacy than the single cannabinoid given alone, when ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2008, 22(8):1017-1024]

Cited: 35 times

View full text PDF listing >>



Fructose-fused gamma-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands.

Ana C Araújo, Francesco Nicotra, Barbara Costa, Gabriella Giagnoni, Laura Cipolla,

We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABA(A) receptors. ... Read more >>

Carbohydr Res (Carbohydrate research)
[2008, 343(10-11):1840-1848]

Cited: 7 times

View full text PDF listing >>



The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation.

F Comelli, G Giagnoni, I Bettoni, M Colleoni, B Costa,

<h4>Background and purpose</h4>2-arachidonoylglycerol (2-AG) is an endocannabinoid whose hydrolysis is predominantly catalysed by the enzyme monoacylglycerol lipase (MAGL). The development of MAGL inhibitors could offer an opportunity to investigate the anti-inflammatory and anti-nociceptive role of 2-AG, which have not yet been elucidated. On these bases, URB602, a MAGL inhibitor, was ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2007, 152(5):787-794]

Cited: 52 times

View full text PDF listing >>



AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain.

Barbara Costa, Dario Siniscalco, Anna Elisa Trovato, Francesca Comelli, Maria Luisa Sotgiu, Mariapia Colleoni, Sabatino Maione, Francesco Rossi, Gabriella Giagnoni,

An attractive alternative to the use of direct agonists at the cannabinoid receptor type 1 (CB1) in the control of neuropathic pain may be to potentiate the actions of endogenous cannabinoids. Thus, the effects of AM404, an inhibitor of anandamide uptake, were assessed in an experimental model of neuropathic pain ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2006, 148(7):1022-1032]

Cited: 62 times

View full text PDF listing >>



The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.

Barbara Costa, Anna Elisa Trovato, Francesca Comelli, Gabriella Giagnoni, Mariapia Colleoni,

Cannabidiol, the major psycho-inactive component of cannabis, has substantial anti-inflammatory and immunomodulatory effects. This study investigated its therapeutic potential on neuropathic (sciatic nerve chronic constriction) and inflammatory pain (complete Freund's adjuvant intraplantar injection) in rats. In both models, daily oral treatment with cannabidiol (2.5-20 mg/kg to neuropathic and 20 mg/kg ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2007, 556(1-3):75-83]

Cited: 114 times

View full text PDF listing >>



Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.

Barbara Costa, Anna Elisa Trovato, Mariapia Colleoni, Gabriella Giagnoni, Elena Zarini, Tiziano Croci,

Many reports have shown the efficacy of cannabinoid agonists in chronic pain, whereas no report exists concerning the potential effect of cannabinoid antagonists following prolonged treatment. We tested the effects of repeated administration of the selective cannabinoid receptor type 1 (CB1) antagonist, SR141716 (rimonabant), in rats with chronic constriction injury ... Read more >>

Pain (Pain)
[2005, 116(1-2):52-61]

Cited: 57 times

View full text PDF listing >>



Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation.

Barbara Costa, Gabriella Giagnoni, Chiara Franke, Anna Elisa Trovato, Mariapia Colleoni,

Cannabidiol (CBD), a nonpsychoactive marijuana constituent, was recently shown as an oral antihyperalgesic compound in a rat model of acute inflammation. We examined whether the CBD antihyperalgesic effect could be mediated by cannabinoid receptor type 1 (CB1) or cannabinoid receptor type 2 (CB2) and/or by transient receptor potential vanilloid type ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2004, 143(2):247-250]

Cited: 100 times

View full text PDF listing >>



Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw.

Barbara Costa, Mariapia Colleoni, Silvia Conti, Daniela Parolaro, Chiara Franke, Anna Elisa Trovato, Gabriella Giagnoni,

Cannabidiol, the major non-psychoactive component of marijuana, has various pharmacological actions of clinical interest. It is reportedly effective as an anti-inflammatory and anti-arthritic in murine collagen-induced arthritis. The present study examined the anti-inflammatory and anti-hyperalgesic effects of cannabidiol, administered orally (5-40 mg/kg) once a day for 3 days after the ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2004, 369(3):294-299]

Cited: 84 times

View full text PDF listing >>



Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain.

B Costa, M Colleoni, S Conti, A E Trovato, M Bianchi, M L Sotgiu, G Giagnoni,

The antinociceptive properties of cannabinoids in persistent pain are not fully elucidated. We investigated the effect of repeated treatment with the synthetic cannabinoid receptor agonist WIN 55,212-2 on the neuropathic pain induced in rats by chronic constriction of the sciatic nerve. WIN 55,212-2 administered daily throughout the development of neuropathy ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2004, 141(1):4-8]

Cited: 56 times

View full text PDF listing >>



Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems.

Barbara Costa, Silvia Conti, Gabriella Giagnoni, Mariapia Colleoni,

1. The anti-inflammatory activity of the endogenous fatty acid amide palmitoylethanolamide and its relationship to cyclo-oxygenase (COX) activity, nitric oxide (NO) and oxygen free radical production were investigated in the rat model of carrageenan-induced acute paw inflammation and compared with the nonsteroidal anti-inflammatory drug (NSAID) indomethacin. 2. Palmitoylethanolamide (1, 3, ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2002, 137(4):413-420]

Cited: 74 times

View full text PDF listing >>



Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat.

Silvia Conti, Barbara Costa, Mariapia Colleoni, Daniela Parolaro, Gabriella Giagnoni,

1. The antiinflammatory activity of synthetic cannabinoid nabilone in the rat model of carrageenan-induced acute hindpaw inflammation was compared with that of the endocannabinoid palmitoylethanolamide and the nonsteroidal antiinflammatory drug indomethacin. 2. Preliminary experiments in rats used a tetrad of behavioural tests, specific for tetrahydrocannabinol-type activity in the CNS. These ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2002, 135(1):181-187]

Cited: 122 times

View full text PDF listing >>



Chronic delta-9-tetrahydrocannabinol treatment increases cAMP levels and cAMP-dependent protein kinase activity in some rat brain regions.

T Rubino, D Vigano', P Massi, M Spinello, E Zagato, G Giagnoni, D Parolaro,

When Delta(9)-tetrahydrocannabinol (Delta(9)-THC,15 mg/kg) was injected intraperitoneally twice a day for 6 days, tolerance to its analgesic effect appeared to be complete. Chronic exposure to Delta(9)-THC caused a significant reduction in CB1 receptor binding in all brain areas that contain this receptor. Cannabinoid receptor density was markedly reduced in the ... Read more >>

Neuropharmacology (Neuropharmacology)
[2000, 39(7):1331-1336]

Cited: 48 times

View full text PDF listing >>



Precipitated and spontaneous withdrawal in rats tolerant to anandamide.

B Costa, G Giagnoni, M Colleoni,

<h4>Rationale</h4>There is evidence that cannabinoids cause tolerance and physical dependence in humans and animals.<h4>Objectives</h4>The aim of this work was to study whether the endogenous ligand for the cannabinoid receptor, arachidonylethanolamide (anandamide), induced behavioral tolerance and physical dependence in rats.<h4>Methods</h4>Rats were injected with anandamide (20 mg/kg i.p.) daily for 2 weeks. ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2000, 149(2):121-128]

Cited: 28 times

View full text PDF listing >>



Cross-tolerance and convergent dependence between morphine and cannabimimetic agent WIN 55,212-2 in the guinea-pig ileum myenteric plexus.

L Basilico, D Parolaro, M Colleoni, B Costa, G Giagnoni,

The cross-tolerance and convergent dependence between morphine and the cannabimimetic agent R(+)-[2,3-dihydro-5-methyl-3[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-+ ++benzoxazin-yl]-(1-naphthalenyl) methanone mesylate (WIN 55,212-2) were assessed in vitro on guinea-pig ileum. To induce tolerance and dependence the myenteric plexus-longitudinal muscle was incubated at 37 degrees C for 5 h with a fixed concentration representing the IC50 for ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[1999, 376(3):265-271]

Cited: 17 times

View full text PDF listing >>



Cannabinoid-precipitated withdrawal: a time-course study of the behavioral aspect and its correlation with cannabinoid receptors and G protein expression.

T Rubino, G Patrini, P Massi, D Fuzio, D Viganò, G Giagnoni, D Parolaro,

To characterize the time course of the behavioral and biochemical aspects of the cannabinoid withdrawal syndrome, we injected the cannabinoid antagonist SR141716A (5 mg/kg i.p.) in rats made tolerant to CP-55,940 (0.4 mg/kg i.p., twice daily for 6.5 days), 1, 24 and 96 h after the last CP-55,940 injection. Because ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[1998, 285(2):813-819]

Cited: 52 times

View full text PDF listing >>



A role of nitric oxide in WIN 55,212-2 tolerance in mice.

E Spina, A Trovati, D Parolaro, G Giagnoni,

The role of nitric oxide (NO) in the development of cannabinoid tolerance was examined by using N(omega)-nitro-L-arginine methyl ester (L-NAME) as an inhibitor of NO synthase. R(+)-[2,3-Dihydro-5-methyl-3 [(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-napht halenyl)methanone mesylate (WIN 55,212-2), a cannabinoid receptor agonist, or L-NAME plus WIN 55,212-2 was acutely or chronically injected i.p. to mice and ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[1998, 343(2-3):157-163]

Cited: 25 times

View full text PDF listing >>



Cholera toxin effects on body temperature changes induced by morphine.

L Basilico, M Parenti, A Fumagalli, D Parolaro, G Giagnoni,

The present study evaluates the influence of cholera toxin and its B-subunit on thermic responses to morphine in the rats. The holotoxin (1 microg/rat) and the B-subunit (5 microg) were administered ICV and three days later rats were challenged ICV with morphine and tested for changes of body temperature. Cholera ... Read more >>

Pharmacol Biochem Behav (Pharmacology, biochemistry, and behavior)
[1997, 56(3):499-505]

Cited: 0 times

View full text PDF listing >>



Effect of chronic exposure to naltrexone and opioid selective agonists on G protein mRNA levels in the rat nervous system.

T Rubino, P Massi, G Patrini, I Venier, G Giagnoni, D Parolaro,

The in situ hybridization technique was used to investigate the effect on G protein alpha subunit expression throughout the brain of rats chronically infused with naltrexone (70 micrograms/microliters, 1 microliter/h), DAGO (0.5 micrograms/microliter, 1 microliter/h), DADLE (11.4 micrograms/microliters, 1 microliter/h), DPDPE (3.4 micrograms/microliters, 1 microliter/h) and U-50,488H (4 micrograms/microliters, 1 ... Read more >>

Brain Res Mol Brain Res (Brain research. Molecular brain research)
[1994, 23(4):333-337]

Cited: 8 times

View full text PDF listing >>



Advertisement

Disclaimer
1.1525 s