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Author G De Rosa

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SAT-175 Trial in Progress Interim Report: A Phase II Clinical Trial Using Single Agent Cabozantinib in Advanced Adrenocortical Carcinoma.

Sara Shokry Daniel Bedrose, Lina Altameemi, Marilyne Daher, Gina Tamsen De Rosa, Jeena Mary Varghese, Camilo Jimenez, Matthew Campbell, Mouhammed Amir Habra,

Abstract BACKGROUND: Adrenocortical carcinoma (ACC) in an aggressive malignancy with suboptimal response to frontline chemotherapy and without established second line treatment. cMET activation is associated with ACC resistance to chemotherapy. Cabozantinib is a multi-kinase inhibitor that targets the VEGFR, c-MET, AXL, and RET receptors. We report interim data about using ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Resolution of Giant Coronary Aneurisms in a Child With Refractory Kawasaki Disease Treated With Anakinra.

Alessandro Gambacorta, Danilo Buonsenso, Gabriella De Rosa, Ilaria Lazzareschi, Antonio Gatto, Federica Brancato, Davide Pata, Piero Valentini,

Kawasaki disease (KD) is an acute, febrile illness of unknown etiology that mainly affects children under 5 years of age. intravenous immunoglobulin (IVIG), the standard treatment, has reduced coronary involvement to <5%. Patients who do not improve after an initial IVIG have a higher risk of developing coronary arteries aneurysms, ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:]

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Resolution of Giant Coronary Aneurisms in a Child With Refractory Kawasaki Disease Treated With Anakinra.

Alessandro Gambacorta, Danilo Buonsenso, Gabriella De Rosa, Ilaria Lazzareschi, Antonio Gatto, Federica Brancato, Davide Pata, Piero Valentini,

Kawasaki disease (KD) is an acute, febrile illness of unknown etiology that mainly affects children under 5 years of age. intravenous immunoglobulin (IVIG), the standard treatment, has reduced coronary involvement to <5%. Patients who do not improve after an initial IVIG have a higher risk of developing coronary arteries aneurysms, ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:195]

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ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma.

Dimas Carolina Belisario, Muhlis Akman, Martina Godel, Virginia Campani, Maria Pia Patrizio, Lorena Scotti, Claudia Maria Hattinger, Giuseppe De De Rosa, Massimo Donadelli, Massimo Serra, Joanna Kopecka, Chiara Riganti,

The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by the drug. The ATP Binding Cassette transporter A1 (ABCA1) effluxes isopentenyl pyrophosphate (IPP), a strong activator of anti-tumor Vγ9Vδ2 T-cells. Recruiting this population may ... Read more >>

Cells (Cells)
[2020, 9(3):]

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DOAC plasma levels measured by chromogenic anti-Xa assays and HPLC-UV in apixaban- and rivaroxaban-treated patients from the START-Register.

Michela Cini, Cristina Legnani, Roberto Padrini, Benilde Cosmi, Claudia Dellanoce, Giovanni De Rosa, Rossella Marcucci, Vittorio Pengo, Daniela Poli, Sophie Testa, Gualtiero Palareti,

INTRODUCTION:To measure direct factor Xa inhibitor (apixaban, edoxaban, rivaroxaban) concentrations, dedicated chromogenic anti-Xa assays are recommended as suitable methods to provide rapid drug quantification. Moreover, the high-performance liquid chromatography with ultraviolet detection (HPLC-UV) is reported as a reliable quantitative technique. We investigated seven anti-Xa assays and an HPLC-UV method for ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2020, 42(2):214-222]

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Skin permeation and thermodynamic features of curcumin-loaded liposomes.

Virginia Campani, Lorena Scotti, Teresa Silvestri, Marco Biondi, Giuseppe De Rosa,

This work describes the development of liposomes encapsulating curcumin (CURC) aiming to provide insights on the influence of CURC on the thermodynamic and skin permeation/penetration features of the vesicles. CURC-loaded liposomes were prepared by hydration of lipid film, in the 0.1-15% CURC:DPPC w/w ratio range. The obtained formulations were characterized ... Read more >>

J Mater Sci Mater Med (Journal of materials science. Materials in medicine)
[2020, 31(2):18]

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Patient Centric Pharmaceutical Drug Product Design-The Impact on Medication Adherence.

Enrica Menditto, Valentina Orlando, Giuseppe De Rosa, Paola Minghetti, Umberto Maria Musazzi, Caitriona Cahir, Marta Kurczewska-Michalak, Przemysław Kardas, Elísio Costa, José Manuel Sousa Lobo, Isabel F Almeida,

Medication adherence is a growing concern for public health and poor adherence to therapy has been associated with poor health outcomes and higher costs for patients. Interventions for improving adherence need to consider the characteristics of the individual therapeutic regimens according to the needs of the patients. In particular, geriatric ... Read more >>

Pharmaceutics (Pharmaceutics)
[2020, 12(1):]

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[Bartonella endocarditis associated with glomerulonephritis and neuroretinitis].

Hernán C Chavin, Mariela Sierra, Lucía Vicente, Verónica I Chiaradia, Graciela De Rosa, Ana A Pisarevsky,

Blood-culture negative endocarditis is a diagnostic challenge. Both Bartonella and Coxiella can cause it with similar clinical presentations mimicking a systemic vasculitis. The identification of the etiologic agent is essential because they differ in treatment type and duration. We present a case of blood-culture negative endocarditis caused by Bartonella henselae, ... Read more >>

Medicina (B Aires) (Medicina)
[2020, 80(2):177-180]

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Gain-of-function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway.

Immacolata Andolfo, Barbara Eleni Rosato, Francesco Manna, Gianluca De Rosa, Roberta Marra, Antonella Gambale, Domenico Girelli, Roberta Russo, Achille Iolascon,

Dehydrated hereditary stomatocytosis (DHS), or xerocytosis, is an autosomal dominant hemolytic anemia. Most patients with DHS carry mutations in the PIEZO1 gene encoding a mechanosensitive cation channel. We here demonstrate that patients with DHS have low levels of hepcidin and only a slight increase of ERFE, the erythroid negative regulator ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2020, 95(2):188-197]

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Two case reports of fetal alcohol syndrome: broadening into the spectrum of cardiac disease to personalize and to improve clinical assessment.

R Onesimo, C De Rose, A B Delogu, A Battista, C Leoni, S Veltri, G De Rosa, G Zampino,

BACKGROUND:Fetal alcohol spectrum disorder (FASD) refers to a broad spectrum of disabilities, in infants and children, resulting from moderate to excessive prenatal alcohol exposure. Significant associations with alcohol exposure were already reported with congenital structural heart defects: i.e. ventricular septal defects, atrial septal defects, conotruncal defects. CASES PRESENTATION:We describe two ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):167]

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How Can We Assess Positive Welfare in Ruminants?

Silvana Mattiello, Monica Battini, Giuseppe De Rosa, Fabio Napolitano, Cathy Dwyer,

Until now, most research has focused on the development of indicators of negative welfare, and relatively few studies provide information on valid, reliable, and feasible indicators addressing positive aspects of animal welfare. However, a lack of suffering does not guarantee that animals are experiencing a positive welfare state. The aim ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2019, 9(10):]

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Pulseless ventricular tachycardia and ventricular fibrillation complicating severe traumatic brain injury in pediatrics.

Marco Piastra, Luca Tortorolo, Orazio Genovese, Tony C Morena, Enzo Picconi, Gabriella De Rosa, Giorgio Conti,

Minerva Anestesiol (Minerva anestesiologica)
[2019, 85(12):1366-1367]

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The BMP-SMAD pathway mediates the impaired hepatic iron metabolism associated with the ERFE-A260S variant.

Immacolata Andolfo, Barbara Eleni Rosato, Roberta Marra, Gianluca De Rosa, Francesco Manna, Antonella Gambale, Achille Iolascon, Roberta Russo,

The erythroferrone (ERFE) is the erythroid regulator of hepatic iron metabolism by suppressing the expression of hepcidin. Congenital dyserythropoietic anemia type II (CDAII) is an inherited hyporegenerative anemia due to biallelic mutations in the SEC23B gene. Patients with CDAII exhibit marked clinical variability, even among individuals sharing the same pathogenic ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2019, 94(11):1227-1235]

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Metastatic Bilateral Strumal Carcinoid: A Case Report and Review of the Literature.

Martina Borghese, Paola Razzore, Annamaria Ferrero, Lorenzo Daniele, Luca Liban Mariani, Luca Giuseppe Sgro, Giovanni DE Rosa, Nicoletta Biglia,

Primary ovarian carcinoids are very rare tumors that belong to the germ cell family of ovarian malignancies. They account for less than 1% of all carcinoid tumors and for less than 0.1% of all ovarian neoplasms. Recurrences are even rarer, with only few cases reported in the literature. Strumal carcinoid ... Read more >>

Anticancer Res. (Anticancer research)
[2019, 39(9):5053-5056]

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Germline mutations and new copy number variants among 40 pediatric cancer patients suspected for genetic predisposition.

Antonella Gambale, Roberta Russo, Immacolata Andolfo, Lucia Quaglietta, Gianluca De Rosa, Valentina Contestabile, Lucia De Martino, Rita Genesio, Piero Pignataro, Sabrina Giglio, Mario Capasso, Rosanna Parasole, Barbara Pasini, Achille Iolascon,

Cancer predisposition syndromes (CPS) result from germline pathogenic variants, and they are increasingly recognized in the etiology of many pediatric cancers. Herein, we report the genetic/genomic analysis of 40 pediatric patients enrolled from 2016 to 2018. Our diagnostic workflow was successful in 50% of screened cases. Overall, the proportion of ... Read more >>

Clin. Genet. (Clinical genetics)
[2019, 96(4):359-365]

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Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis.

D J Manzella, L Vicente, A A Pérez de la Hoz, R J Zamora, G De Rosa, A A Pisarevsky,

A 62-year-old man with a history of systemic sclerosis was admitted with diffuse alveolar hemorrhage and acute kidney injury without clinical data suggestive of glomerulonephritis. Laboratory tests showed anemia, leukocytosis with neutrophilia, thrombocytopenia, elevated serum creatinine and metabolic acidosis. Antinuclear antibodies were positive at a titer of 1/640 (speckled, 1/160; ... Read more >>

Reumatismo (Reumatismo)
[2019, 71(2):92-98]

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PAX8-GLIS3 gene fusion is a pathognomonic genetic alteration of hyalinizing trabecular tumors of the thyroid.

Caterina Marchiò, Arnaud Da Cruz Paula, Rodrigo Gularte-Merida, Thais Basili, Alissa Brandes, Edaise M da Silva, Catarina Silveira, Lorenzo Ferrando, Jasna Metovic, Francesca Maletta, Laura Annaratone, Fresia Pareja, Brian P Rubin, Aaron P Hoschar, Giovanni De Rosa, Stefano La Rosa, Massimo Bongiovanni, Bibianna Purgina, Simonetta Piana, Marco Volante, Britta Weigelt, Jorge S Reis-Filho, Mauro Papotti,

The hyalinizing trabecular adenoma/tumor is a rare and poorly characterized follicular-derived thyroid neoplasm recently shown to harbor recurrent PAX8-GLIS1 or PAX8-GLIS3 gene fusions. Here we sought to define the repertoire of genetic alterations of hyalinizing trabecular tumors, and whether PAX8-GLIS3 fusions are pathognomonic for hyalinizing trabecular tumors. A discovery series ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2019, 32(12):1734-1743]

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Characterization of Two Cases of Congenital Dyserythropoietic Anemia Type I Shed Light on the Uncharacterized C15orf41 Protein.

Roberta Russo, Roberta Marra, Immacolata Andolfo, Gianluca De Rosa, Barbara Eleni Rosato, Francesco Manna, Antonella Gambale, Maddalena Raia, Sule Unal, Susanna Barella, Achille Iolascon,

CDA type I is a rare hereditary anemia, characterized by relative reticulocytopenia, and congenital anomalies. It is caused by biallelic mutations in one of the two genes: (i) CDAN1, encoding Codanin-1, which is implicated in nucleosome assembly and disassembly; (ii) C15orf41, which is predicted to encode a divalent metal ion-dependent ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:621]

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Human-Animal Interactions in Dairy Buffalo Farms.

Fabio Napolitano, Francesco Serrapica, Ada Braghieri, Felicia Masucci, Emilio Sabia, Giuseppe De Rosa,

This study aimed to assess the relationship between stockperson behavior and buffalo behavior. The research was carried out in 27 buffalo farms. The behavior of stockpeople and animals during milking and the avoidance distance at the feeding place were recorded. Recordings were repeated within one month to assess test-retest reliability. ... Read more >>

Animals (Basel) (Animals : an open access journal from MDPI)
[2019, 9(5):]

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Carbonic anhydrase inhibitors in patients with X-linked retinoschisis: effects on macular morphology and function.

Francesco Testa, Valentina Di Iorio, Beatrice Gallo, Mario Marchese, Anna Nesti, Giuseppe De Rosa, Paolo Melillo, Francesca Simonelli,

Background: Currently there is no medical treatment for X-linked retinoschisis (XLRS). In many retinal dystrophies, carbonic anhydrase inhibitors (CAIs) are effectively used to reduce cystoid macular edema. Prospective studies investigating the effect of CAIs in patients with XLRS are needed for the evaluation of their efficacy in this disease. The ... Read more >>

Ophthalmic Genet. (Ophthalmic genetics)
[2019, 40(3):207-212]

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CHM/REP1 Transcript Expression and Loss of Visual Function in Patients Affected by Choroideremia.

Valentina Di Iorio, Gabriella Esposito, Francesca De Falco, Rosa Boccia, Tiziana Fioretti, Raffaella Colucci, Giuseppe De Rosa, Paolo Melillo, Francesco Salvatore, Francesca Simonelli, Francesco Testa,

Purpose:To evaluate the disease progression in patients with clinical and genetic diagnoses of choroideremia during a long-term follow-up and to investigate the relationship between pathogenic variants in the CHM/REP1 gene and disease phenotypes. Methods:We performed a retrospective longitudinal study on 51 affected men by reviewing medical charts at baseline and ... Read more >>

Invest. Ophthalmol. Vis. Sci. (Investigative ophthalmology & visual science)
[2019, 60(5):1547-1555]

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PIEZO1 Hypomorphic Variants in Congenital Lymphatic Dysplasia Cause Shape and Hydration Alterations of Red Blood Cells.

Immacolata Andolfo, Gianluca De Rosa, Edoardo Errichiello, Francesco Manna, Barbara Eleni Rosato, Antonella Gambale, Annalisa Vetro, Valeria Calcaterra, Gloria Pelizzo, Lucia De Franceschi, Orsetta Zuffardi, Roberta Russo, Achille Iolascon,

PIEZO1 is a cation channel activated by mechanical force. It plays an important physiological role in several biological processes such as cardiovascular, renal, endothelial and hematopoietic systems. Two different diseases are associated with alteration in the DNA sequence of PIEZO1: (i) dehydrated hereditary stomatocytosis (DHS1, #194380), an autosomal dominant hemolytic ... Read more >>

Front Physiol (Frontiers in physiology)
[2019, 10:258]

Cited: 1 time

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National survey of anatomical pathology centres in Italy: the questionnaire.

G Mazzoleni, M Barbareschi, M Basciu, D Fassinato, P Vian, F Vittadello, M Truini, G De Rosa, S M Mezzopera,

To obtain a picture of the work done in Italian anatomical pathology centres in 2014, and evaluate differences between the various centres in terms of the workloads of medical and non-medical staff. A self-administered questionnaire designed by a SIAPEC working group was e-mailed to 256 centres and subsequently collected by ... Read more >>

Pathologica (Pathologica)
[2019, 111(1):4-12]

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[Laws regulating transplantation should express the contemporaneity. Questions to the constitutionalist Francesco Paolo Casavola and to the philosophers Remo Bodei and Aldo Masullo about the possibility deciding the destiny of one's own organs at the time one decides on how to die and on contacts between donor families and recipients.]

Natale G De Santo, Franco Citterio, Luca S De Santo, Guglielmo Venditti, Giusy De Rosa, Biagio Di Iorio, Giovambattista Capasso,

Transplantation represents modernity thus the laws regulating the procedure should be continuously renovated and remodeled in order to take full advantage of progress. The debate is about Law no. 219, December 22, 2017 and on Law no. 222, April 1, 1999. The quests are a) about the possibility to modify ... Read more >>

G Ital Nefrol (Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia)
[2018, 35(6):]

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Ultrasound-guided fine needle aspiration cytology in the diagnosis of hepatic and pancreatic perivascular epithelioid cell tumors: A case series.

Valentina Sangiorgio, Lorenzo Daniele, Teresa Gallo, Rodolfo Rocca, Cristina Fava, Paola Campisi, Giovanni De Rosa,

Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors that can affect any part of the body. They can be sporadic or arise in the setting of tuberous sclerosis (TSC). In this article, we report a series of three hepatic and two pancreatic PEComas diagnosed preoperatively with ultrasound-guided fine needle ... Read more >>

Diagn. Cytopathol. (Diagnostic cytopathology)
[2019, 47(4):315-319]

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