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Multicenter evaluation of three different MALDI-TOF MS systems for identification of clinically relevant filamentous fungi.

Yue Sun, Jian Guo, Rong Chen, Liang Hu, Qihang Xia, Wenjuan Wu, Jinghua Wang, Fupin Hu,

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) holds promise as a potential tool for clinical identification of filamentous fungi. However, due to the lack of an appropriate extraction protocol and the difficulty of database building, the identification power of each system differs. In this study, we selected 126 clinical ... Read more >>

Med. Mycol. (Medical mycology)
[2020, :]

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In vitro activity of omadacycline against pathogens isolated from Mainland China during 2017-2018.

Dong Dong, Yonggui Zheng, Qingqing Chen, Yan Guo, Yang Yang, Shi Wu, Demei Zhu, Daniel Deng, Patricia A Bradford, Harald Reinhart, Fupin Hu,

Antibiotic resistance of bacterial pathogens isolated in China is a major concern. Omadacycline is a novel tetracycline derivative that has been approved for use in skin infections and community-acquired pneumonia. This study was conducted to determine the in vitro activity of omadacycline against a large collection of patient isolate medical ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2020, :]

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Microbiological Characteristics of Carbapenem-Resistant Enterobacteriaceae Clinical Isolates Collected from County Hospitals.

Shujin Xie, Shiming Fu, Mengwei Li, Zhusheng Guo, Xuehai Zhu, Jianmin Ren, Fupin Hu,

Objective:To investigate the molecular characteristics of carbapenem-resistant Enterobacteriaceae (CRE) from county hospitals in China. Materials and Methods:Forty-three sequential non-duplicate CRE strains (including 33 Klebsiella pneumoniae isolates, 4 Enterobacter cloacae isolates, 3 Escherichia coli isolates, 1 Serratia marcescens, 1 Morganella morganii and 1 Citrobacter freundii) were collected from 4 county hospitals and 2 ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2020, 13:1163-1169]

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CHINET efforts to control antimicrobial resistance in China.

Fupin Hu, Minggui Wang, Demei Zhu, Fu Wang,

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2020, 21:76-77]

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FTIR-assisted MALDI-TOF MS for the identification and typing of bacteria.

Bin Feng, Haimei Shi, Fuxing Xu, Fupin Hu, Jian He, Huayan Yang, Chuanfan Ding, Wenxiang Chen, Shaoning Yu,

MALDI-TOF MS is well-recognized for microbial identification and widely used in research and clinical fields due to its specificity, speed of analysis, and low cost of consumables. However, the classification or identification accuracy is poor for E. coli and Shigella. In addition, FTIR is a promising tool for bacterial typing. In ... Read more >>

Anal. Chim. Acta (Analytica chimica acta)
[2020, 1111:75-82]

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Corrigendum: Gold Nanoclusters for Targeting Methicillin-Resistant Staphylococcus aureus In Vivo.

Yangzhouyun Xie, Yong Liu, Junchuan Yang, Yuan Liu, Fupin Hu, Kui Zhu, Xingyu Jiang,

Angew. Chem. Int. Ed. Engl. (Angewandte Chemie (International ed. in English))
[2020, 59(15):5873]

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Anti-staphylococcus Antibiotics Interfere With the Transcription of Leucocidin ED Gene in Staphylococcus aureus Strain Newman.

Han Yang, Su Xu, Kaifeng Huang, Xiaogang Xu, Fupin Hu, Chunyan He, Wen Shu, Zhiyan Wang, Fang Gong, Chuanling Zhang, Qingzhong Liu,

Antibiotics have been described to modulate bacterial virulence gene expression. This study aimed to assess the changes caused by anti-Staphylococcus agents in the transcription of leucocidin ED (lukED) gene of Staphylococcus aureus strain Newman in vitro and in vivo and to determine whether the altered expression is agr dependent. The ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:265]

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The Colonization of Carbapenem-Resistant Klebsiella pneumoniae: Epidemiology, Resistance Mechanisms, and Risk Factors in Patients Admitted to Intensive Care Units in China.

Xiaohua Qin, Shi Wu, Min Hao, Jing Zhu, Baixing Ding, Yang Yang, Xiaogang Xu, Minggui Wang, Fan Yang, Fupin Hu,

BACKGROUND:Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a threat to public health, most notably as a superbug causing nosocomial infections. Patients in the intensive care unit (ICU) are at increased risk of hospital-acquired K pneumoniae infection, especially CRKP. This study was conducted to investigate the frequency of gastrointestinal and nasopharyngeal K ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, 221(Supplement_2):S206-S214]

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The Predominance of Strain Replacement Among Enterobacteriaceae Pairs With Emerging Carbapenem Resistance During Hospitalization.

Baixing Ding, Zhen Shen, Xiaohua Qin, Yang Yang, Xiaogang Xu, Qinglan Guo, Fupin Hu, Minggui Wang,

Isolates of Enterobacteriaceae collected from the same patient can lose carbapenem susceptibility during antimicrobial therapy, but little attention has been given to how this conversion takes place. In the current study, we retrospectively analyzed microbiological and clinical data from patients with enterobacterial infections at a tertiary hospital in Shanghai, China. ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, 221(Supplement_2):S215-S219]

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Molecular Characteristics and Antimicrobial Susceptibility Profiles of Elizabethkingia Clinical Isolates in Shanghai, China.

Leilei Wang, Xuefei Zhang, Dan Li, Fupin Hu, Minggui Wang, Qinglan Guo, Fan Yang,

Purpose:To investigate molecular characteristics and antimicrobial susceptibility profiles of clinical isolates of Elizabethkingia in Shanghai, China. Methods:Elizabethkingia isolates were collected in a university-affiliated hospital in 2012-2015 and 2017-2018. They were re-identified to species level by 16S rRNA gene and species-specific gene sequencing. Antimicrobial susceptibility testing, screening for metallo-beta-lactamase production, identification ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2020, 13:247-256]

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Chronic Staphylococcus aureus Superantigen Toxic Shock Syndrome Toxin-1 Exposure Accelerates the Progression of Atherosclerosis in Rabbits.

Huanqiang Zhao, Lei Chen, Chunyan He, Shaobo Li, Han Yang, Xiaogang Xu, Fupin Hu, Zelin Cui, Qingzhong Liu,

Background:It has been reported that infectious agents contribute to the atherosclerotic process. However, it is unclear whether Staphylococcus aureus superantigen (SAg) toxic shock syndrome toxin-1 (TSST-1) has an effect on atherosclerosis progression. The present study was designed to investigate the pathogenic role of TSST-1 exposure in the atherosclerotic process in ... Read more >>

Acta Cardiol Sin (Acta Cardiologica Sinica)
[2020, 36(1):24-32]

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697. Evaluation of Contezolid Activity to Anaerobic and Gram-positive-cocci Isolates from a Phase 3 Acute Bacterial Skin and Skin Structure Infection Clinical Trial (MRX-I-06).

Yang Yang, Fupin Hu, Demei Zhu,

AbstractBackgroundContezolid (MRX-I) is an oxazolidinone in development for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). In this study, in vitro susceptibility (S) for Contezolid and comparator agents for Gram-positive (GP) and anaerobic isolates from Phase 3 ABSSSI clinical trials were determined.Methods313 isolates were collected from 65 ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S315-S315]

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576. A Multicenter Epidemiology Study on Risk Factors of Vancomycin-Resistant Enterococcus Infections in China: Results from the China Antimicrobial Surveillance Network (CHINET) in 2016.

Dongfang Lin, Yan Guo, Yang Yang, Demei Zhu, Fupin Hu,

AbstractBackgroundBacterial resistance in China had been increasing in prevalence. Vancomycin-resistant enterococcus (VRE) different from other bacteria had lower isolated rate and apparent regional variations. In this study, we identified the characteristics of VRE infections in Chinese patients based on the China Antimicrobial Surveillance Network (CHINET) in 2016.MethodsThis case–control study was ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S271-S272]

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2478. Surveillance of antibacterial resistance among clinical isolates from hospitals in Shanghai: results of 2018.

Yang Yang, Yan Guo, Demei Zhu, Fupin Hu,

AbstractBackgroundTo investigate the current state of antibacterial resistance of clinical isolates from hospitals in Shanghai, China.MethodsAntimicrobial susceptibility testing (AST) was carried out for the clinical isolates from 50 hospitals (including 30 grade A tertiary hospitals and 20 grade B tertiary hospitals/grade A secondary hospitals, and there were 3 children hospitals ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S858-S858]

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Outbreak Of Klebsiella pneumoniae Carbapenemase-Producing Klebsiella aerogenes Strains In A Tertiary Hospital In China.

Min Hao, Zhen Shen, Meiping Ye, Fupin Hu, Xiaogang Xu, Yang Yang, Shi Wu, Dongfang Lin, Xiaohua Qin, Minggui Wang,

Purpose:This study aimed to evaluate the molecular characteristics and prevalence of clinical carbapenem-resistant Klebsiella aerogenes (CRKA), collected during an outbreak in a Chinese tertiary hospital. Methods:Antimicrobial susceptibility test, using 17 antibiotics, was performed on 14 CRKA isolates. The strains were examined for the presence of β-lactamase genes by PCR, and ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2019, 12:3283-3290]

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2037. A Novel Strategy of Antimicrobial Stewardship in Shanghai: Preliminary Practice with Integration of Three Surveillance Networks.

Minggui Wang, Fupin Hu, Bijie Hu, Qianzhou Lv, Wenhui Wu,

AbstractBackgroundThe bacterial resistance surveillance networks, antimicrobial clinical use surveillance networks and provincial hospital-acquired infection (HAI) surveillance have been well established in China. They aim to inform the current situation of bacterial resistance, antimicrobial use and HAI, and to guide the rational use of antimicrobials. However, these three networks presently are ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S685-S685]

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The strategy for correcting interference from water in Fourier transform infrared spectrum based bacterial typing.

Haimei Shi, Jiaojiao Sun, Renru Han, Chuanfan Ding, Fupin Hu, Shaoning Yu,

Accurate and effective identification and typing of microorganisms is important in epidemiological surveillance. Fourier transform infrared (FTIR) spectroscopy is a promising bacterial typing method based on extracting the infrared spectrum signal-related biochemical features of intact microbiological cells. Unfortunately, the FTIR signals of bacteria are disturbed by many factors, especially the ... Read more >>

Talanta (Talanta)
[2020, 208:120347]

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Evaluation study of using ampicillin susceptibility to predict imipenem susceptibility of E. faecalis and E. faecium

lanfang guo, Dandan Yin, Yan Guo, Yonggui Zheng, Qingyu Shi, Yang Yang, Demei Zhu, Fupin Hu,

Abstract Objective: To evaluate ampicillin to predict activity of Enterococcus faecalis and Enterococcus faecium to imipenem. Methods: A total of 127 non-duplicated strains of Enterococcus faecalis and 124 strains of Enterococcus faecium were collected from 23 hospitals in China. The antimicrobial susceptibility testing was determinated using broth microdilution and disk ... Read more >>

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Resistance reported from China antimicrobial surveillance network (CHINET) in 2018.

Fupin Hu, Yan Guo, Yang Yang, Yonggui Zheng, Shi Wu, Xiaofei Jiang, Demei Zhu, Fu Wang, ,

The aim of this study is to investigate the antimicrobial susceptibility of strains isolated from the major hospitals in China. A total of 44 teaching hospitals were involved. Antimicrobial susceptibility testing was conducted by Kirby-Bauer automated systems, and results were interpreted using CLSI criteria. Totally 244,843 strains were isolated in ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[2019, 38(12):2275-2281]

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Study of In Vitro Synergistic Bactericidal Activity of Dual β-Lactam Antibiotics Against KPC-2-Producing Klebsiella pneumoniae.

Wenxia Zhang, Yan Guo, Yang Yang, Dong Dong, Yonggui Zheng, Demei Zhu, Fupin Hu,

Objectives: To study the in vitro synergistic bactericidal activity of dual β-lactam antibiotics against KPC-2-producing Klebsiella pneumoniae and to explore the new therapeutic regimens for infections caused by carbapenem-resistant strains. Materials and Methods: The antimicrobial susceptibility testing of imipenem, meropenem, ceftazidime, and clavulanic acid on 40 clinically isolated strains of ... Read more >>

Microb. Drug Resist. (Microbial drug resistance (Larchmont, N.Y.))
[2020, 26(3):204-210]

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Molecular Typing and Variations in Amount of tst Gene Expression of TSST-1-Producing Clinical Staphylococcus aureus Isolates.

Huanqiang Zhao, Su Xu, Han Yang, Chunyan He, Xiaogang Xu, Fupin Hu, Wen Shu, Fang Gong, Chuanling Zhang, Qingzhong Liu,

The toxic shock syndrome toxin-1 (TSST-1), encoded by tst gene, has been proposed to cause staphylococcal toxic shock syndrome (TSS) in a susceptible host, which highlights the need to evaluate the level of tst gene expression and molecular genetic characteristics of the tst-positive isolates. A total of 916 S. aureus ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2019, 10:1388]

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Tolerability and Pharmacokinetics of Contezolid at Therapeutic and Supratherapeutic Doses in Healthy Chinese Subjects, and Assessment of Contezolid Dosing Regimens Based on Pharmacokinetic/Pharmacodynamic Analysis.

Junzhen Wu, Hailan Wu, Yu Wang, Yuancheng Chen, Beining Guo, Guoying Cao, Xiaojie Wu, Jicheng Yu, Jufang Wu, Demei Zhu, Yan Guo, Hong Yuan, Fupin Hu, Jing Zhang,

PURPOSE:This study assessed the tolerability and pharmacokinetic (PK) properties of a new-generation oxazolidinone, contezolid (MRX-I), and its major inactive metabolite, M2, after single oral administrations of 800, 1200, and 1600 mg in the fed state, and compared the efficacy of 3 dosing regimens in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) ... Read more >>

Clin Ther (Clinical therapeutics)
[2019, 41(6):1164-1174.e4]

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Results from the China Antimicrobial Surveillance Network (CHINET) in 2017 of the In Vitro Activities of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Clinical Isolates of Enterobacteriaceae and Pseudomonas aeruginosa.

Dandan Yin, Shi Wu, Yang Yang, Qingyu Shi, Dong Dong, Demei Zhu, Fupin Hu, ,

The in vitro activities of ceftazidime-avibactam (CZA), ceftolozane-tazobactam (C-T), and comparators were determined for 1,774 isolates of Enterobacteriaceae and 524 isolates of Pseudomonas aeruginosa collected by 30 medical centers from the China Antimicrobial Surveillance Network (CHINET) in 2017. Antimicrobial susceptibility testing was performed by the CLSI broth microdilution method, and ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2019, 63(4):]

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Novel Mercapto Propionamide Derivatives with Potent New Delhi Metallo-β-Lactamase-1 Inhibitory Activity and Low Toxicity.

Zhi Meng, Mei-Lin Tang, Liting Yu, Yongxi Liang, Jilai Han, ChenChen Zhang, Fupin Hu, Jian-Ming Yu, Xun Sun,

The emergence and worldwide prevalence of New Delhi metallo-β-lactamase 1 (NDM-1) expressing Gram-negative bacteria with resistance against most β-lactam antibiotics pose a serious threat to human health. However, no NDM-1 inhibitors are clinically approved at present. Herein, based on the lead compound captopril, a series of compounds were designed, synthesized, ... Read more >>

ACS Infect Dis (ACS infectious diseases)
[2019, 5(6):903-916]

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