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Author Fumiaki Takahashi

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The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee.

Masae Ikeda, Masako Shida, Shogo Shigeta, Satoru Nagase, Fumiaki Takahashi, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007. The aim of this research was to evaluate the influence of the introduction of the first guideline on clinical trends and outcomes of patients with early-stage cervical cancer who underwent surgery.<h4>Methods</h4>This analysis ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e44]

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Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2017 and annual treatment report for 2012.

Satoru Nagase, Tsuyoshi Ohta, Fumiaki Takahashi, Nobuo Yaegashi, ,

<h4>Aim</h4>To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2017 and the Annual Treatment Report for 2012, on the outcomes of patients who started treatment in 2012.<h4>Methods</h4>The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, :]

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Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer

Ryosuke Fujisawa, Takeshi Iwaya, Fumitaka Endo, Masashi Idogawa, Noriyuki Sasaki, Hayato Hiraki, Shoichiro Tange, Tomomi Hirano, Yuka Koizumi, Masakazu Abe, Tomoko Takahashi, Mizunori Yaegashi, Yuji Akiyama, Mari Masuda, Akira Sasaki, Fumiaki Takahashi, Yasushi Sasaki, Takashi Tokino, Satoshi Nishizuka,

<h4>Purpose</h4> We investigated whether early circulating tumor DNA (ctDNA) changes, measured using digital PCR (dPCR), can predict later chemotherapy responses in esophageal squamous cell cancer (ESCC). <h4>Design</h4> We compared the dynamics of ctDNA and tumor volumes during chemotherapy in 42 ESCC. The accuracy of predictions of later chemotherapy responses were ... Read more >>

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Rationale and Design of BeatNF2 Trial: A Clinical Trial to Assess the Efficacy and Safety of Bevacizumab in Patients with Neurofibromatosis Type 2 Related Vestibular Schwannoma.

Masazumi Fujii, Masao Kobayakawa, Kiyoshi Saito, Akihiro Inano, Akio Morita, Mitsuhiro Hasegawa, Akitake Mukasa, Takafumi Mitsuhara, Takeo Goto, Shigeru Yamaguchi, Takashi Tamiya, Hirofumi Nakatomi, Soichi Oya, Fumiaki Takahashi, Taku Sato, Mudathir Bakhit, On Behalf Of The BeatNF Trial Investigators,

Neurofibromatosis type 2 (NF2) causes bilateral vestibular schwannomas (VSs), leading to deafness. VS is treated by surgery or radiation, but neither treatments prevent hearing loss. Bevacizumab was found to be effective in suppressing the tumor's growth and may help to improve hearing. We are conducting a randomized, double-blind, multicenter clinical ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2021, 28(1):726-739]

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Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy.

Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa, Takafumi Toita, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi,

<h4>Background: </h4> The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definitive radiotherapy (RT)/ concurrent chemoradiotherapy (CCRT). <h4>Methods: </h4> Patients with persistent cervical cancer treated with definitive RT/CCRT at ... Read more >>

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Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy.

Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa, Takafumi Toita, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi,

<h4>Background</h4>The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definitive radiotherapy (RT)/ concurrent chemoradiotherapy (CCRT).<h4>Methods</h4>Patients with persistent cervical cancer treated with definitive RT/CCRT at 35 institutions from 2005 to ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1169]

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Implementing an Intervention to Improve Adverse Incident Reporting in the Hospital Setting: A Pilot Study

Naomi Akiyama, Keisuke Koeda, Ryuji Uozumi, Fumiaki Takahashi, Kuniaki Ogasawara,

<h4>Background: </h4> To improve patient safety, it is needed to collect information related to adverse events and near-miss reports. This practice constitutes one of the strategies hospital managers use to understand the kinds of errors that occur at their hospitals. This pilot study aimed to evaluate an intervention designed to ... Read more >>

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Predicting the consistency of intracranial meningiomas using apparent diffusion coefficient maps derived from preoperative diffusion-weighted imaging.

Kenya Miyoshi, Tsukasa Wada, Ikuko Uwano, Makoto Sasaki, Hiroaki Saura, Shunrou Fujiwara, Fumiaki Takahashi, Eiki Tsushima, Kuniaki Ogasawara,

<h4>Objective</h4>The consistency of meningiomas is a critical factor affecting the difficulty of resection, operative complications, and operative time. The apparent diffusion coefficient (ADC) is derived from diffusion-weighted imaging (DWI) and is calculated using two optimized b values. While the results of comparisons between the standard ADC and the consistency of ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2020, :1-8]

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Vascular Response Occurring at 3 Months After Everolimus-Eluting Cobalt-Chromium Stent Implantation in Patients With ST-Segment Elevation Myocardial Infarction vs. Stable Coronary Artery Disease.

Masaru Ishida, Daisuke Terashita, Tomonori Itoh, Hiromasa Otake, Yoshiro Tsukiyama, Tatsuo Kikuchi, Takatoshi Hayashi, Takahide Suzuki, Yoshiaki Ito, Takashi Morita, Kiyoshi Hibi, Takahiro Sawada, Takayuki Okamura, Junya Shite, Fumiaki Takahashi, Toshiro Shinke, Yoshihiro Morino,

<h4>Background</h4>Second-generation drug-eluting stents (DES) reduce the incidence of stent thrombosis, even in patients with ST-segment elevated myocardial infarction (STEMI). However, the early local vascular healing after DES implantation in STEMI lesions, which mainly concerns stent thrombosis, is still unclear.Methods and Results:We attempted to determine early local vascular healing 3 months after cobalt-chromium ... Read more >>

Circ J (Circulation journal : official journal of the Japanese Circulation Society)
[2020, 84(11):1941-1948]

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Frequent Tumor Burden Monitoring of Esophageal Squamous Cell Carcinoma With Circulating Tumor DNA Using Individually Designed Digital Polymerase Chain Reaction.

Takeshi Iwaya, Fumitaka Endo, Fumiaki Takahashi, Takashi Tokino, Yasushi Sasaki, Satoshi S Nishizuka,

Gastroenterology (Gastroenterology)
[2021, 160(1):463-465.e4]

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Human Papillomavirus (HPV) Genotyping Assay Suitable for Monitoring the Impact of the 9-Valent HPV Vaccine.

Iwao Kukimoto, Koji Matsumoto, Fumiaki Takahashi, Takashi Iwata, Kohsei Tanaka, Mayuko Yamaguchi-Naka, Kasumi Yamamoto, Hideaki Yahata, Makoto Nakabayashi, Hisamori Kato, Naotake Tsuda, Mamiko Onuki, Nobuo Yaegashi, ,

In Japan, a bivalent human papillomavirus (HPV) vaccine against carcinogenic HPV16/18 was licensed in 2009, and a quadrivalent vaccines against HPV16/18 and non-carcinogenic HPV6/11 was licensed in 2011. Recently, the next-generation 9-valent vaccine targeting HPV6/11/16/18/31/33/45/52/58 has been approved. Accurate HPV genotyping is essential for HPV vaccine research and surveillance. The ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2020, 251(4):287-294]

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Multi-institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan.

Kiyoto Shiga, Ken-Ichi Nibu, Yasushi Fujimoto, Takahiro Asakage, Akihiro Homma, Hiroki Mitani, Takenori Ogawa, Kenji Okami, Shigeyuki Murono, Shigeru Hirano, Tsutomu Ueda, Nobuhiro Hanai, Kiyoaki Tsukahara, Ichiro Ota, Seiichi Yoshimoto, Takeshi Shinozaki, Shigemichi Iwae, Katsunori Katagiri, Daisuke Saito, Naomi Kiyota, Makoto Tahara, Fumiaki Takahashi, Ryuichi Hayashi,

<h4>Objectives</h4>This study aimed to evaluate the efficacy of chemoradiotherapy (CRT) for patients with advanced cancer of the external auditory canal (EAC) by analyzing the outcome of the patients.<h4>Methods</h4>This is a multi-institutional retrospective survey, and we reviewed the medical records of the subjects. A total of 181 patients with tumor (T)3 ... Read more >>

Laryngoscope (The Laryngoscope)
[2021, 131(3):E870-E874]

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Implementing an intervention to improve adverse incident reporting in the hospital setting: A pilot study

Naomi Akiyama, Keisuke Koeda, Ryuji Uozumi, Fumiaki Takahashi, Kuniaki Ogasawara,

<h4>Objective: </h4> This pilot study evaluated an intervention designed to increase error reporting among physicians. Research was conducted at University Hospital A, where data were collected from April 2017 to March 2019. The intervention began in April 2018 and consisted of the four following steps: define reporting standards, improve the ... Read more >>

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Clinical outcomes of patients treated using very short duration dual antiplatelet therapy after implantation of biodegradable-polymer drug-eluting stents: rationale and design of a prospective multicenter REIWA registry.

Masaru Ishida, Fumiaki Takahashi, Iwao Goto, Masanobu Niiyama, Hidenori Saitoh, Tsubasa Sakamoto, Yuko Maegawa, Takuya Osaki, Osamu Nishiyama, Hiroshi Endo, Ryohei Sakamoto, Tsuyoshi Kojima, Yorihiko Koeda, Takumi Kimura, Tomonori Itoh, Yoshihiro Morino, ,

Several studies have demonstrated the safety and feasibility of short (3-6 months) and very short duration (< 2 months) dual antiplatelet therapy (DAPT) in patients with a durable-polymer drug-eluting stent (DP-DES). However, the clinical importance of using very short duration DAPT has yet to be established in patients with a biodegradable polymer drug-eluting ... Read more >>

Cardiovasc Interv Ther (Cardiovascular intervention and therapeutics)
[2020, 35(4):398-404]

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Japanese population dose from natural radiation.

Yasutaka Omori, Masahiro Hosoda, Fumiaki Takahashi, Tetsuya Sanada, Shigekazu Hirao, Koji Ono, Masahide Furukawa,

The radiation doses from natural radiation sources in Japan are reviewed using the latest knowledge. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) and the Nuclear Safety Research Association report the annual effective doses from cosmic rays, terrestrial radiation, inhalation, and ingestion as natural sources. In ... Read more >>

J Radiol Prot (Journal of radiological protection : official journal of the Society for Radiological Protection)
[2020, 40(3):R99-R140]

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Epidemiological guideline influence on the therapeutic trend and patient outcome of uterine cervical cancer in Japan: Japan society of gynecologic oncology guideline evaluation committee project.

Shogo Shigeta, Masako Shida, Satoru Nagase, Masae Ikeda, Fumiaki Takahashi, Takeo Shibata, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published its first clinical guidelines for uterine cervical cancer in 2007 which has been revised twice in 2011 and 2017. The aim of this study was to investigate the influence of the first guideline publication on the therapeutic trend and patient outcome by analyzing ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 159(1):248-255]

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Comparison of ThinPrep Integrated Imager-Assisted Screening versus Manual Screening of ThinPrep Liquid-Based Cytology Specimens.

Kyoko Tanaka, Daisuke Aoki, Akiko Tozawa-Ono, Nao Suzuki, Kiyoshi Takamatsu, Masaru Nakamura, Hajime Tsunoda, Shigeo Seino, Noriko Kobayashi, Takefumi Shirayama, Fumiaki Takahashi,

<h4>Objective</h4>The aim of this study was to find out whether ThinPrep Integrated Imager (Hologic Inc.) screening is non-inferior to manual screening in the detection of cervical lesion.<h4>Study design</h4>For a total of 4,011 ThinPrep Pap test specimens stained by ThinPrep staining, manual screening (Manual arm) and ThinPrep Integrated Imager screening (Imager ... Read more >>

Acta Cytol (Acta cytologica)
[2020, 64(5):486-491]

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Human papillomavirus genotype contribution to cervical cancer and precancer: Implications for screening and vaccination in Japan.

Mamiko Onuki, Koji Matsumoto, Takashi Iwata, Kasumi Yamamoto, Yoichi Aoki, Shoji Maenohara, Naotake Tsuda, Shoji Kamiura, Kazuhiro Takehara, Koji Horie, Nobutaka Tasaka, Hideaki Yahata, Yuji Takei, Yoichi Aoki, Hisamori Kato, Takeshi Motohara, Keiichiro Nakamura, Mitsuya Ishikawa, Tatsuya Kato, Hiroyuki Yoshida, Noriomi Matsumura, Hidekatsu Nakai, Shogo Shigeta, Fumiaki Takahashi, Kiichiro Noda, Nobuo Yaegashi, Hiroyuki Yoshikawa,

To obtain baseline data for cervical cancer prevention in Japan, we analyzed human papillomavirus (HPV) data from 5045 Japanese women aged less than 40 years and diagnosed with cervical abnormalities at 21 hospitals during 2012-2017. These included cervical intraepithelial neoplasia grade 1 (CIN1, n = 573), CIN2-3 (n = 3219), adenocarcinoma in situ (AIS, n = 123), ... Read more >>

Cancer Sci (Cancer science)
[2020, 111(7):2546-2557]

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A Case of Bilateral Acute Inferior Limb Ischemia in a Patient With Ulcerative Colitis.

Mimari Kanazawa, Takeshi Sugaya, Fumiaki Takahashi, Kazuhiro Takenaka, Kouhei Tsuchida, Keiichi Tominaga, Yuichi Majima, Makoto Iijima, Kenichi Goda, Atsushi Irisawa,

A patient was diagnosed with ulcerative colitis (UC) in 2010. In March 2015, she had abdominal pain, diarrhea, bloody stool, and UC has relapsed. In June 2015, pain and sensory disturbance of both lower limbs appeared. Blood flow at the distal femoral artery was not confirmed with magnetic resonance angiography, ... Read more >>

Clin Med Insights Case Rep (Clinical medicine insights. Case reports)
[2020, 13:1179547620912734]

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Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis.

Tomoyuki Mutoh, Tsuyoshi Shirai, Tomonori Ishii, Yuko Shirota, Fumiyoshi Fujishima, Fumiaki Takahashi, Yoichi Kakuta, Yoshitake Kanazawa, Atsushi Masamune, Yoshikatsu Saiki, Hideo Harigae, Hiroshi Fujii,

The presence of antiendothelial cell antibodies (AECAs) has been documented in Takayasu arteritis (TAK), a chronic granulomatous vasculitis. Here, we identify cell-surface autoantigens using an expression cloning system. A cDNA library of endothelial cells is retrovirally transfected into a rat myeloma cell line from which AECA-positive clones are sorted with ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1253]

Cited: 5 times

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A nationwide, multi-center, retrospective study of symptomatic small bowel stricture in patients with Crohn's disease.

Shigeki Bamba, Ryosuke Sakemi, Toshimitsu Fujii, Teruyuki Takeda, Shin Fujioka, Kento Takenaka, Hiroki Kitamoto, Shotaro Umezawa, Hirotake Sakuraba, Toshihiro Inokuchi, Norimasa Fukata, Shinta Mizuno, Masaki Yamashita, Shinichiro Shinzaki, Hiroki Tanaka, Hidetoshi Takedatsu, Ryo Ozaki, Kei Moriya, Manabu Ishii, Tetsu Kinjo, Keiji Ozeki, Makoto Ooi, Ryohei Hayashi, Kazuki Kakimoto, Yuichi Shimodate, Kazuya Kitamura, Akihiro Yamada, Akira Sonoda, Yu Nishida, Kyouko Yoshioka, Shinya Ashizuka, Fumiaki Takahashi, Toshio Shimokawa, Taku Kobayashi, Akira Andoh, Toshifumi Hibi,

<h4>Background</h4>Small bowel stricture is one of the most common complications in patients with Crohn's disease (CD). Endoscopic balloon dilatation (EBD) is a minimally invasive treatment intended to avoid surgery; however, whether EBD prevents subsequent surgery remains unclear. We aimed to reveal the factors contributing to surgery in patients with small ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2020, 55(6):615-626]

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Severe acute pancreatitis with inflammation extending to the scrotum.

Koh Fukushi, Keiichi Tominaga, Kazuhiro Takenaka, Fumiaki Takahashi, Kouhei Tsuchida, Toshimitsu Murohisa, Makoto Iijima, Atsushi Irisawa,

Extension of inflammation into the scrotum is rare in acute pancreatitis. If inflammation spreads in the scrotum, it may become severe. Clinicians should be aware of this condition as a possible complication. Proactive imaging testing is recommended when complaining of cyst swelling or testicular pain. ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(12):2592-2593]

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A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG): disparity between serous carcinoma and clear cell carcinoma.

Wataru Yamagami, Satoru Nagase, Fumiaki Takahashi, Kazuhiko Ino, Toru Hachisuga, Mikio Mikami, Takayuki Enomoto, Hidetaka Katabuchi, Daisuke Aoki,

OBJECTIVE:International Federation of Gynecology and Obstetrics (FIGO) staging for ovarian, fallopian tube, and peritoneal cancers was revised in 2014. The aim of this study is to clarify whether the revised FIGO2014 staging reflects the prognosis of patients with ovarian cancer by histological type in Japan. METHODS:We extracted 9,747 patients who ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2020, 31(4):e45]

Cited: 2 times

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Recent trends in the incidence of latent tuberculosis infection in Japanese patients with lung cancer: A small retrospective study.

Atsuhisa Tamura, Takeshi Fukami, Akira Hebisawa, Fumiaki Takahashi,

Active tuberculosis is an important complication in Japanese lung cancer patients. We studied the generation-wise trend of latent tuberculosis infection (LTBI) among lung cancer patients. We analyzed background data including birth year, lung cancer status, and interferon-gamma release assay (IGRA) data of lung cancer patients who were admitted to National ... Read more >>

J Infect Chemother (Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy)
[2020, 26(3):315-317]

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Recurrence risk evaluation in T1N1M0/T2N0M0/T3N0M0 gastric cancer with TP53 codon 72 polymorphisms.

Yukimi Ohmori, Takashi Nomura, Norimasa Fukushima, Fumiaki Takahashi, Takeshi Iwaya, Keisuke Koeda, Satoshi S Nishizuka, ,

BACKGROUND:Postoperative adjuvant chemotherapy is not indicated for T1N1M0/T2N0M0/T3N0M0 gastric cancer. However, approximately 10% to 30% of these patients experience recurrence and metastasis. METHODS:Among 658 patients with gastric cancer who received gastrectomy with curative intent, 130 T1N1M0/T2N0M0 and 73 T3N0M0 patients were enrolled. Overall survival (OS) and relapse-free survival (RFS) were ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2019, 120(7):1154-1161]

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