Full Text Journal Articles by
Author Friedrich Hahn

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High accuracy gene expression profiling of sorted cell subpopulations from breast cancer PDX model tissue.

Warren Porter, Eileen Snowden, Friedrich Hahn, Mitchell Ferguson, Frances Tong, W Shannon Dillmore, Rainer Blaesius,

Intratumor Heterogeneity (ITH) is a functionally important property of tumor tissue and may be involved in drug resistance mechanisms. Although descriptions of ITH can be traced back to very early reports about cancer tissue, mechanistic investigations are still limited by the precision of analysis methods and access to relevant tissue ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238594]

Cited: 0 times

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Target verification of artesunate-related antiviral drugs: Assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling.

Friedrich Hahn, Aischa Niesar, Christina Wangen, Markus Wild, Benedikt Grau, Lars Herrmann, Aysun Capci, Annie Adrait, Yohann Couté, Svetlana B Tsogoeva, Manfred Marschall,

Human cytomegalovirus (HCMV) infection is associated with serious pathology such as transplant rejection or embryonic developmental defects. Antiviral treatment with currently available drugs targeting viral enzymes is often accompanied with severe side effects and the occurrence of drug-resistant viruses. For this reason, novel ways of anti-HCMV therapy focusing on so ... Read more >>

Antiviral Res (Antiviral research)
[2020, 180:104861]

Cited: 1 time

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The trimeric artesunate derivative TF27 exerts strong anti-cytomegaloviral efficacy: Focus on prophylactic efficacy and oral treatment of immunocompetent mice.

Markus Wild, Luca D Bertzbach, Pierre Tannig, Christina Wangen, Regina Müller, Lars Herrmann, Tony Fröhlich, Svetlana B Tsogoeva, Benedikt B Kaufer, Manfred Marschall, Friedrich Hahn,

Human cytomegalovirus (HCMV) causes serious and even life-threatening diseases, particularly upon congenital or post-transplant infection. Treatment of HCMV infections with currently available drugs targeting viral enzymes is often limited by severe side effects and the emergence of drug-resistant viruses. To avoid this problem, novel therapeutic options directed to host proteins ... Read more >>

Antiviral Res (Antiviral research)
[2020, 178:104788]

Cited: 1 time

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Artesunate derivative TF27 inhibits replication and pathogenesis of an oncogenic avian alphaherpesvirus.

Luca D Bertzbach, Andelé M Conradie, Friedrich Hahn, Markus Wild, Manfred Marschall, Benedikt B Kaufer,

Nucleoside analogues have been the cornerstone of clinical treatment of herpesvirus infections since the 1970s. However, severe side effects and emergence of drug resistant viruses raise the need for alternative treatment options. We recently investigated the broad and strong antiherpesviral activity of the optimized artesunate derivative TF27 in vitro. TF27 ... Read more >>

Antiviral Res (Antiviral research)
[2019, 171:104606]

Cited: 2 times

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Correction: Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

[This corrects the article DOI: 10.18632/oncotarget.26911.]. ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(49):5119]

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Flow based single cell analysis of the immune landscape distinguishes Barrett's esophagus from adjacent normal tissue.

Moen Sen, Friedrich Hahn, Taylor A Black, Maureen DeMarshall, Warren Porter, Eileen Snowden, Stephanie S Yee, Frances Tong, Mitchell Ferguson, Emylee N Fleshman, Hiroshi Nakagawa, Gary W Falk, Gregory G Ginsberg, Michael L Kochman, Rainer Blaesius, Anil K Rustgi, Erica L Carpenter,

Barrett's esophagus (BE) is metaplasia of the squamous epithelium to a specialized columnar epithelium. BE progresses through low- and high-grade dysplasia before developing into esophageal adenocarcinoma. The BE microenvironment is not well defined. We compare 12 human clinical BE and adjacent normal squamous epithelium biopsies using single cell immunophenotyping by ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(38):3592-3604]

Cited: 3 times

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Chemically sulfated polysaccharides from natural sources: Assessment of extraction-sulfation efficiencies, structural features and antiviral activities.

Shuvam Mukherjee, Kanika Ghosh, Friedrich Hahn, Christina Wangen, Hanife Strojan, Regina Müller, Namrata Anand, Imran Ali, Kaushik Bera, Bimalendu Ray, Corina Hutterer, Manfred Marschall, Sayani Ray,

The provisioning of compound libraries with a high degree of diversity and attractive pharmacological properties is a limiting step in drug development. This study reports the production of highly bioactive sulfated polysaccharides, originally present in a nonsulfated, dormant state in natural sources, and demonstrates their antiviral activity (human cytomegalovirus EC50 ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2019, 136:521-530]

Cited: 0 times

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Visible-Light-Driven C-H Oxidation of Cyclic Tertiary Amines: Access to Synthetic Strychnos Alkaloids with Antiviral Activity.

Anton A Guryev, Friedrich Hahn, Manfred Marschall, Svetlana B Tsogoeva,

Air and visible light have been used in facile direct C-H oxidation of cyclic tertiary amines at ambient conditions, employing organic dyes as photocatalysts and LED. Tolerance of this new environmentally compatible protocol to various side-chain derivatizations of tryptoline and tetrahydroisoquinoline substrates was demonstrated. The developed method provides a straightforward ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2019, 25(16):4062-4066]

Cited: 0 times

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In vivo proof-of-concept for two experimental antiviral drugs, both directed to cellular targets, using a murine cytomegalovirus model.

Eric Sonntag, Friedrich Hahn, Luca D Bertzbach, Lisa Seyler, Christina Wangen, Regina Müller, Pierre Tannig, Benedikt Grau, Matthias Baumann, Eldar Zent, Gunther Zischinsky, Jan Eickhoff, Benedikt B Kaufer, Tobias Bäuerle, Svetlana B Tsogoeva, Manfred Marschall,

Infections with the human cytomegalovirus (HCMV) cause serious medical problems including organ rejection and congenital infection. Treatment of HCMV infections with currently available medication targeting viral enzymes is often accompanied with severe side effects and the occurrence of drug-resistant viruses. This demands novel therapeutical approaches like targeting genetically stable host ... Read more >>

Antiviral Res (Antiviral research)
[2019, 161:63-69]

Cited: 2 times

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Synthesis of new betulinic acid/betulin-derived dimers and hybrids with potent antimalarial and antiviral activities.

Aysun Çapcı Karagöz, Maria Leidenberger, Friedrich Hahn, Frank Hampel, Oliver Friedrich, Manfred Marschall, Barbara Kappes, Svetlana B Tsogoeva,

Severe malaria and viral infections cause life-threatening diseases in millions of people worldwide every year. In search for effective bioactive hybrid molecules, which may possess improved properties compared to their parent compounds, a series of betulinic acid/betulin based dimer and hybrid compounds carrying ferrocene and/or artesunic acid moieties, was designed ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2019, 27(1):110-115]

Cited: 2 times

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Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity.

Friedrich Hahn, Corina Hutterer, Christophe Henry, Stuart T Hamilton, Hanife Strojan, Alexandra Kraut, Ulrike Schulte, Martin Schütz, Stephan Kohrt, Christina Wangen, José Pfizer, Yohann Couté, William D Rawlinson, Stefan Strobl, Manfred Marschall,

Human cytomegalovirus (HCMV) is a major human pathogen with seropositivity rates in the adult population ranging between 40% and 95%. HCMV infection is associated with severe pathology, such as life-threatening courses of infection in immunocompromised individuals and neonates. Current standard therapy with valganciclovir has the disadvantage of adverse side effects ... Read more >>

Antiviral Res. (Antiviral research)
[2018, 159:84-94]

Cited: 2 times

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Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer.

Tony Fröhlich, Anita Kiss, János Wölfling, Erzsébet Mernyák, Ágnes E Kulmány, Renáta Minorics, István Zupkó, Maria Leidenberger, Oliver Friedrich, Barbara Kappes, Friedrich Hahn, Manfred Marschall, Gyula Schneider, Svetlana B Tsogoeva,

Artemisinin-estrogen hybrids were for the first time both synthesized and investigated for their in vitro biological activity against malaria parasites (Plasmodium falciparum 3D7), human cytomegalovirus (HCMV), and a panel of human malignant cells of gynecological origin containing breast (MCF7, MDA-MB-231, MDA-MB-361, T47D) and cervical tumor cell lines (HeLa, SiHa, C33A). ... Read more >>

(ACS medicinal chemistry letters)
[2018, 9(11):1128-1133]

Cited: 2 times

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Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action.

Tony Fröhlich, Friedrich Hahn, Lucid Belmudes, Maria Leidenberger, Oliver Friedrich, Barbara Kappes, Yohann Couté, Manfred Marschall, Svetlana B Tsogoeva,

Generation of dimers, trimers and dendrimers of bioactive compounds is an approach that has recently been developed for the discovery of new potent drug candidates. Herein, we present the synthesis of new artemisinin-derived dimers and dendrimers and investigate their action against malaria parasite Plasmodium falciparum 3D7 strain and human cytomegalovirus ... Read more >>

Chemistry (Chemistry (Weinheim an der Bergstrasse, Germany))
[2018, 24(32):8103-8113]

Cited: 5 times

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Artesunate-derived monomeric, dimeric and trimeric experimental drugs - Their unique mechanistic basis and pronounced antiherpesviral activity.

Friedrich Hahn, Tony Fröhlich, Theresa Frank, Luca D Bertzbach, Stephan Kohrt, Benedikt B Kaufer, Thomas Stamminger, Svetlana B Tsogoeva, Manfred Marschall,

Human cytomegalovirus (HCMV) is a major human pathogen and is associated with severe pathology, such as life-threatening courses of infection in immunocompromised individuals and neonates. Currently, antiviral therapy is still hampered by a considerable toxicity of the available drugs and induction of viral resistance. Recently, we and others reported the ... Read more >>

Antiviral Res. (Antiviral research)
[2018, 152:104-110]

Cited: 3 times

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Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin.

Aysun Çapcı Karagöz, Christoph Reiter, Ean-Jeong Seo, Lisa Gruber, Friedrich Hahn, Maria Leidenberger, Volker Klein, Frank Hampel, Oliver Friedrich, Manfred Marschall, Barbara Kappes, Thomas Efferth, Svetlana B Tsogoeva,

Hybridization of natural products has high potential to further improve their activities and may produce synergistic effects between linked pharmacophores. Here we report synthesis of nine new hybrids of natural products egonol, homoegonol, thymoquinone and artemisinin and evaluation of their activities against P. falciparum 3D7 parasites, human cytomegalovirus, sensitive and ... Read more >>

Bioorg Med Chem (Bioorganic & medicinal chemistry)
[2018, 26(12):3610-3618]

Cited: 4 times

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Synthesis of Thymoquinone-Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents.

Tony Fröhlich, Christoph Reiter, Mohamed E M Saeed, Corina Hutterer, Friedrich Hahn, Maria Leidenberger, Oliver Friedrich, Barbara Kappes, Manfred Marschall, Thomas Efferth, Svetlana B Tsogoeva,

A series of hybrid compounds based on the natural products artemisinin and thymoquinone was synthesized and investigated for their biological activity against the malaria parasite Plasmodium falciparum 3D7 strain, human cytomegalovirus (HCMV), and two leukemia cell lines (drug-sensitive CCRF-CEM and multidrug-resistant subline CEM/ADR5000). An unprecedented one-pot method of selective formation ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2018, 9(6):534-539]

Cited: 5 times

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Immunophenotyping and Transcriptomic Outcomes in PDX-Derived TNBC Tissue.

Eileen Snowden, Warren Porter, Friedrich Hahn, Mitchell Ferguson, Frances Tong, Joel S Parker, Aaron Middlebrook, Smita Ghanekar, W Shannon Dillmore, Rainer Blaesius,

Cancer tissue functions as an ecosystem of a diverse set of cells that interact in a complex tumor microenvironment. Genomic tools applied to biopsies in bulk fail to account for this tumor heterogeneity, whereas single-cell imaging methods limit the number of cells which can be assessed or are very resource ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2017, 15(4):429-438]

Cited: 4 times

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HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein.

Sara Marie Øie Solbak, Tove Ragna Reksten, Friedrich Hahn, Victor Wray, Petra Henklein, Peter Henklein, Øyvind Halskau, Ulrich Schubert, Torgils Fossen,

The human immunodeficiency virus type 1 (HIV-1) p6 protein has recently been recognized as a docking site for several cellular and viral binding partners and is important for the formation of infectious viruses. Most of its known functions are suggested to occur under hydrophobic conditions near the cytoplasmic membrane, where ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2013, 1828(2):816-823]

Cited: 14 times

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Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures.

Sara M Ø Solbak, Alok Sharma, Karsten Bruns, René Röder, David Mitzner, Friedrich Hahn, Rebekka Niebert, Anni Vedeler, Petra Henklein, Peter Henklein, Ulrich Schubert, Victor Wray, Torgils Fossen,

The proapoptotic influenza A virus PB1-F2 protein contributes to viral pathogenicity and is present in most human and avian influenza isolates. The structures of full-length PB1-F2 of the influenza strains Pandemic flu 2009 H1N1, 1918 Spanish flu H1N1, Bird flu H5N1 and H1N1 PR8, have been characterized by NMR and ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2013, 1834(2):568-582]

Cited: 8 times

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Synthesis of full length PB1-F2 influenza A virus proteins from 'Spanish flu' and 'bird flu'.

René Röder, Karsten Bruns, Alok Sharma, André Eissmann, Friedrich Hahn, Nicole Studtrucker, Torgils Fossen, Victor Wray, Peter Henklein, Ulrich Schubert,

The proapoptotic influenza A virus PB1-F2 protein contributes to viral pathogenicity and is present in most human and avian isolates. Previous synthetic protocols have been improved to provide a synthetic full length H1N1 type PB1-F2 protein that is encoded by the 'Spanish flu' isolate and an equivalent protein from an ... Read more >>

J Pept Sci (Journal of peptide science : an official publication of the European Peptide Society)
[2008, 14(8):954-962]

Cited: 4 times

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