Full Text Journal Articles by
Author Frederick W Lombard

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Perioperative thrombocytopenia.

Frederick W Lombard, Wanda M Popescu, Adriana D Oprea, Miklos D Kertai,

<h4>Purpose of review</h4>In this review, we discuss recent developments and trends in the perioperative management of thrombocytopenia.<h4>Recent findings</h4>Large contemporary data base studies show that preoperative thrombocytopenia is present in about 8% of asymptomatic patients, and is associated with increased risks for bleeding and 30-day mortality. Traditionally specific threshold platelet counts ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):335-344]

Cited: 0 times

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Effect of Regional Analgesia Techniques on Opioid Consumption and Length of Stay After Thoracic Surgery.

Wills C Dunham, Frederick W Lombard, David A Edwards, Yaping Shi, Matthew S Shotwell, Kara Siegrist, Susan S Eagle, Mias Pretorius, Matthew D McEvoy, Erin A Gillaspie, Jonathan C Nesbitt, Jonathan P Wanderer, Miklos D Kertai,

<h4>Background</h4>We examined how intercostal nerve block (ICNB) with standard bupivacaine and ICNB with extended-release liposomal bupivacaine, compared with thoracic epidural analgesia (TEA), were associated with postoperative opioid pain medication consumption and hospital length of stay (LOS) after thoracic surgery.<h4>Methods</h4>We studied 1935 patients who underwent thoracic surgery between January 1, 2010, ... Read more >>

Semin Cardiothorac Vasc Anesth (Seminars in cardiothoracic and vascular anesthesia)
[2020, :1089253220949434]

Cited: 0 times

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Risk Factors for Mitral Valve Surgery: Atrial Fibrillation and Pulmonary Hypertension.

Frederick W Lombard, Yafen Liang,

Semin Cardiothorac Vasc Anesth (Seminars in cardiothoracic and vascular anesthesia)
[2019, 23(1):57-69]

Cited: 1 time

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Outcomes in Patients Undergoing Cardiac Surgery Who Decline Transfusion and Received Erythropoietin Compared to Patients Who Did Not: A Matched Cohort Study.

Lorent Duce, Mary L Cooter, Sharon L McCartney, Frederick W Lombard, Nicole R Guinn,

<h4>Background</h4>Erythropoiesis-stimulating agents, such as erythropoietin (EPO), can be used to treat preoperative anemia. Some studies suggest an increased risk of mortality and thrombotic events, and use in cardiovascular surgery remains off-label. This study compares outcomes in cardiac surgery patients declining blood transfusion who received EPO with a matched cohort who ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2018, 127(2):490-495]

Cited: 2 times

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Perioperative β-Adrenergic Blockade in Noncardiac and Cardiac Surgery: A Clinical Update.

Adriana D Oprea, Frederick W Lombard, Miklos D Kertai,

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2019, 33(3):817-832]

Cited: 4 times

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Elective Venovenous Extracorporeal Membrane Oxygenation for Resection of Endotracheal Tumor: A Case Report.

W Jonathan Dunkman, Alina Nicoara, Jacob Schroder, Momen M Wahidi, Aimen El Manafi, Desiree Bonadonna, Coral X Giovacchini, Frederick W Lombard,

We present a case in which we electively used venovenous extracorporeal membrane oxygenation (VV-ECMO) to facilitate safe resection of a nearly obstructing airway tumor near the carina in a 37-year-old male. The patient was brought to the operating room and underwent bifemoral cannulation for VV-ECMO under light sedation while maintaining ... Read more >>

A A Case Rep (A & A case reports)
[2017, 9(4):97-100]

Cited: 2 times

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Perioperative Venous Thromboembolism: A Review.

Ronald J Gordon, Frederick W Lombard,

Venous thromboembolism (VTE) is a significant problem in the perioperative period, increasing patient morbidity, mortality, and health care costs. It is also considered the most preventable of the major postoperative complications. Despite widespread adoption of prophylaxis guidelines, it appears that morbidity from the disease has not substantially changed within the ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2017, 125(2):403-412]

Cited: 7 times

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The Risk of Oxygen during Cardiac Surgery (ROCS) trial: study protocol for a randomized clinical trial.

Marcos G Lopez, Mias Pretorius, Matthew S Shotwell, Robert Deegan, Susan S Eagle, Jeremy M Bennett, Bantayehu Sileshi, Yafen Liang, Brian J Gelfand, Adam J Kingeter, Kara K Siegrist, Frederick W Lombard, Tiffany M Richburg, Dane A Fornero, Andrew D Shaw, Antonio Hernandez, Frederic T Billings,

<h4>Background</h4>Anesthesiologists administer excess supplemental oxygen (hyper-oxygenation) to patients during surgery to avoid hypoxia. Hyper-oxygenation, however, may increase the generation of reactive oxygen species and cause oxidative damage. In cardiac surgery, increased oxidative damage has been associated with postoperative kidney and brain injury. We hypothesize that maintenance of normoxia during cardiac ... Read more >>

Trials (Trials)
[2017, 18(1):295]

Cited: 4 times

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Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery.

Adriana D Oprea, Frederick W Lombard, Wen-Wei Liu, William D White, Jörn A Karhausen, Yi-Ju Li, Timothy E Miller, Solomon Aronson, Tong J Gan, Manuel L Fontes, Miklos D Kertai,

<h4>Background</h4>Increased pulse pressure (PP) is an important independent predictor of cardiovascular outcome and acute kidney injury (AKI) after cardiac surgery. The objective of this study was to determine whether elevated baseline PP is associated with postoperative AKI and 30-day mortality after noncardiac surgery.<h4>Methods</h4>We evaluated 9125 adult patients who underwent noncardiac ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2016, 123(6):1480-1489]

Cited: 3 times

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Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats.

Toshihiro Sasaki, Ulrike Hoffmann, Motomu Kobayashi, Huaxin Sheng, Abdelkader Ennaceur, Frederick W Lombard, David S Warner,

<h4>Background</h4>Cognitive dysfunction can be a long-term complication following subarachnoid hemorrhage (SAH). Preclinical models have been variously characterized to emulate this disorder. This study was designed to directly compare long-term cognitive deficits in the context of similar levels of insult severity in the cisterna magna double-blood (DB) injection versus prechiasmatic blood ... Read more >>

Neurocrit Care (Neurocritical care)
[2016, 25(2):293-305]

Cited: 3 times

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Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers.

Miklos D Kertai, Miklos D Kertai, Wenjing Qi, Yi-Ju Li, Frederick W Lombard, Yutao Liu, Michael P Smith, Mark Stafford-Smith, Mark F Newman, Carmelo A Milano, Joseph P Mathew, Mihai V Podgoreanu, ,

Atrial tissue gene expression profiling may help to determine how differentially expressed genes in the human atrium before cardiopulmonary bypass (CPB) are related to subsequent biologic pathway activation patterns, and whether specific expression profiles are associated with an increased risk for postoperative atrial fibrillation (AF) or altered response to β-blocker ... Read more >>

J Mol Cell Cardiol (Journal of molecular and cellular cardiology)
[2016, 92:109-115]

Cited: 5 times

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Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest.

Jennifer M Hanna, Jeffrey E Keenan, Hanghang Wang, Nicholas D Andersen, Jeffrey G Gaca, Frederick W Lombard, Ian J Welsby, G Chad Hughes,

<h4>Objective</h4>Human fibrinogen concentrate (HFC) is approved by the Food and Drug Administration for use at 70 mg/kg to treat congenital afibrinogenemia. We sought to determine whether this dose of HFC increases fibrinogen levels in the setting of high-risk bleeding associated with aortic reconstruction and deep hypothermic circulatory arrest (DHCA).<h4>Methods</h4>This was ... Read more >>

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2016, 151(2):376-382]

Cited: 8 times

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Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.

Miklos D Kertai, Yi-Ju Li, Yunqi Ji, Wenjing Qi, Frederick W Lombard, Svati H Shah, William E Kraus, Mark Stafford-Smith, Mark F Newman, Carmelo A Milano, Nathan Waldron, Mihai V Podgoreanu, Joseph P Mathew, ,

<h4>Background</h4>Postoperative atrial fibrillation (AF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. Genetic predisposition may predict risk for developing postoperative AF.<h4>Methods</h4>Study subjects underwent CABG surgery with cardiopulmonary bypass at Duke University Medical Center. In a discovery cohort of 877 individuals from the Perioperative Genetics and Safety ... Read more >>

Am Heart J (American heart journal)
[2015, 170(3):580-90.e28]

Cited: 8 times

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Hyperbaric oxygen therapy for treatment of neurologic sequela after atrioesophageal fistula.

Sameer A Hirji, John C Haney, Ian Welsby, Frederick W Lombard, Mark F Berry,

Atrioesophageal fistula (AEF) is a rare complication after radiofrequency ablation for atrial fibrillation but is associated with high mortality, usually due to sepsis or neurologic injury. We report the case of a patient who presented with an AEF and dense neurologic deficits who had complete neurologic recovery after management with ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2015, 99(2):681-682]

Cited: 5 times

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Reduced use of allogeneic platelets through high-yield perioperative autologous plateletpheresis and reinfusion.

Melissa Alberts, Nicholas Bandarenko, Jeffrey Gaca, Evelyn Lockhart, Carmelo Milano, Stanlin Alexander, Dean Linder, Frederick W Lombard, Ian J Welsby,

<h4>Background</h4>Intraoperative autologous platelet (PLT) collection as part of a multimodal blood conservation program carries a Class IIa recommendation from the Societies of Thoracic Surgeons and Cardiovascular Anesthesiologists, but achieving a suitable PLT yield limits its application. A novel, autologous, intraoperative, high-yield plateletpheresis collection program was established and retrospectively analyzed to ... Read more >>

Transfusion (Transfusion)
[2014, 54(5):1348-1357]

Cited: 0 times

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Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.

Joseph P Mathew, William D White, David B Schinderle, Mihai V Podgoreanu, Miles Berger, Carmelo A Milano, Daniel T Laskowitz, Mark Stafford-Smith, James A Blumenthal, Mark F Newman, ,

<h4>Background and purpose</h4>Neurocognitive decline occurs frequently after cardiac surgery and persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation of cellular energy metabolism, blockade of the N-methyl-D-aspartate receptor, diminution of the inflammatory response, and inhibition of platelet activation. We therefore hypothesized that intraoperative magnesium ... Read more >>

Stroke (Stroke)
[2013, 44(12):3407-3413]

Cited: 25 times

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Predictors of cognitive recovery after cardiac surgery.

Monique T Fontes, R Cameron Swift, Barbara Phillips-Bute, Mihai V Podgoreanu, Mark Stafford-Smith, Mark F Newman, Joseph P Mathew, ,

<h4>Background</h4>Postoperative neurocognitive decline occurs frequently. Although predictors of cognitive injury have been well examined, factors that modulate recovery have not. We sought to determine the predictors of cognitive recovery after initial injury following cardiac surgery.<h4>Methods</h4>Two hundred eighty-one patients previously enrolled in cognitive studies who experienced cognitive decline 6 weeks after ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2013, 116(2):435-442]

Cited: 17 times

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Severe tricuspid valve regurgitation: a case for laminar flow.

Frederick C Cobey, Maria Fritock, Frederick W Lombard, Donald D Glower, Madhav Swaminathan,

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2012, 26(3):522-524]

Cited: 2 times

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Update on management strategies for separation from cardiopulmonary bypass.

Frederick W Lombard, Katherine P Grichnik,

<h4>Purpose of review</h4>To update the reader about clinical management strategies for separation from cardiopulmonary bypass. A number of new drugs are being introduced in clinical practice, with significant utility in operative patient management. Further, there is increased routine use of complex devices to achieve separation from or avoidance of cardiopulmonary ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2011, 24(1):49-57]

Cited: 3 times

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Neurocognitive dysfunction following cardiac surgery.

Frederick W Lombard, Joseph P Mathew,

Postoperative neurocognitive decline (POCD) is the most frequently reported form of brain injury in the cardiac surgery setting. Even though most patients recover over a period of several months, recovery is variable and often transient, and early decline may be a marker of neurocognitive dysfunction after several years. Recent studies, ... Read more >>

Semin Cardiothorac Vasc Anesth (Seminars in cardiothoracic and vascular anesthesia)
[2010, 14(2):102-110]

Cited: 21 times

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Development of a simplified spinal cord ischemia model in mice.

Zhengfeng Wang, Wei Yang, Gavin W Britz, Frederick W Lombard, David S Warner, Huaxin Sheng,

Use of genetically manipulated mice facilitates understanding pathological mechanisms in many diseases and contributes to therapy development. However, there is no practical and clinically relevant mouse model available for spinal cord ischemia. This report introduces a simplified long-term outcome mouse model of spinal cord ischemia. Male C57Bl/6J mice were anesthetized ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2010, 189(2):246-251]

Cited: 5 times

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Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.

Ken Takata, Huaxin Sheng, Cecil O Borel, Daniel T Laskowitz, David S Warner, Frederick W Lombard,

Cognitive dysfunction, a significant complication after subarachnoid hemorrhage (SAH), affects up to 60% of survivors. We hypothesized that oral simvastatin would improve vestibulomotor function and reduce cognitive dysfunction after experimental SAH in the rat, and explored the effects of simvastatin on vasospasm and regional cerebral blood flow (rCBF). In total ... Read more >>

J Neurosurg Anesthesiol (Journal of neurosurgical anesthesiology)
[2009, 21(4):326-333]

Cited: 16 times

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Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury.

David L McDonagh, Joseph P Mathew, Willam D White, Barbara Phillips-Bute, Daniel T Laskowitz, Mihai V Podgoreanu, Mark F Newman, ,

<h4>Background</h4>Postoperative cognitive dysfunction (POCD) is a significant cause of morbidity after noncardiac surgery. Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation.<h4>Methods</h4>Three hundred ninety-four patients older than 55 yr undergoing major ... Read more >>

Anesthesiology (Anesthesiology)
[2010, 112(4):852-859]

Cited: 66 times

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Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.

Ken Takata, Huaxin Sheng, Cecil O Borel, Daniel T Laskowitz, David S Warner, Frederick W Lombard,

Cognitive dysfunction is increasingly recognized as a significant long-term complication following subarachnoid hemorrhage (SAH), affecting up to 60% of survivors. We proposed to determine the incidence and explore potential mechanisms of cognitive dysfunction in a rat model. The effects of intracisternal blood, saline and sham injections were compared. At five ... Read more >>

Exp Neurol (Experimental neurology)
[2008, 213(2):336-344]

Cited: 31 times

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Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.

Joseph P Mathew, G Burkhard Mackensen, Barbara Phillips-Bute, Hilary P Grocott, Donald D Glower, Daniel T Laskowitz, James A Blumenthal, Mark F Newman, ,

<h4>Background and purpose</h4>Cognitive decline after cardiac surgery remains common and diminishes patients' quality of life. Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass.<h4>Methods</h4>After IRB approval, 277 patients undergoing cardiac surgery were enrolled ... Read more >>

Stroke (Stroke)
[2009, 40(3):880-887]

Cited: 76 times

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