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Author Frederick S vom Saal

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Sex-Biased Impact of Endocrine Disrupting Chemicals on Behavioral Development and Vulnerability to Disease: Of Mice and Children.

Paola Palanza, Silvia Paterlini, M Maddalena Brambilla, Greta Ramundo, Giada Caviola, Laura Gioiosa, Stefano Parmigiani, Frederick S Vom Saal, Davide Ponzi,

Sex is a fundamental biological characteristic that influences many aspects of an organism's phenotype, including neurobiological functions and behavior as a result of species-specific evolutionary pressures. Sex differences have strong implications for vulnerability to disease and susceptibility to environmental perturbations. Endocrine disrupting chemicals (EDCs) have the potential to interfere with ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, :]

Cited: 0 times

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Update on the health effects of bisphenol A: Overwhelming evidence of harm.

Frederick S Vom Saal, Laura N Vandenberg,

In 1997, the first in vivo bisphenol A (BPA) study by endocrinologists reported that feeding BPA to pregnant mice induced adverse reproductive effects in male offspring at the low dose of 2 µg/kg/day. Since then, thousands of studies have reported adverse effects in animals administered low doses of BPA. Despite ... Read more >>

Endocrinology (Endocrinology)
[2020, :]

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Bisphenol A and 17α-ethinylestradiol-induced Transgenerational Gene Expression Differences in the Brain-Pituitary-Testis Axis of Medaka, Oryzias latipes.

Albert J Thayil, Xuegeng Wang, Pooja Bhandari, Frederick S Vom Saal, Donald E Tillitt, Ramji K Bhandari,

Endocrine disrupting chemicals (EDCs), such as Bisphenol A (BPA) and 17α-ethinylestradiol (EE2), can have far reaching health effects, including transgenerational abnormalities in offspring that never directly contacted either chemical. We previously reported reduced fertilization rates and embryo survival at F2 and F3 generations caused by 7-day embryonic exposure (F0) to ... Read more >>

Biol Reprod (Biology of reproduction)
[2020, :]

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Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.

Jerrold J Heindel, Scott Belcher, Jodi A Flaws, Gail S Prins, Shuk-Mei Ho, Jiude Mao, Heather B Patisaul, William Ricke, Cheryl S Rosenfeld, Ana M Soto, Frederick S Vom Saal, R Thomas Zoeller,

"Consortium Linking Academic and Regulatory Insights on BPA Toxicity" (CLARITY-BPA) was a comprehensive "industry-standard" Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. The investigator-initiated studies were focused on integrating disease-associated, molecular, and physiological endpoints previously found by ... Read more >>

Reprod. Toxicol. (Reproductive toxicology (Elmsford, N.Y.))
[2020, :]

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Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol a or 17α-ethinylestradiol in medaka (Oryzias latipes).

Ramji K Bhandari, Xuegeng Wang, Frederick S Vom Saal, Donald E Tillitt,

Endocrine disrupting chemicals (EDCs) can induce abnormalities in organisms via alteration of molecular pathways and subsequent disruption of endocrine functions. Bisphenol A (BPA) and 17α-ethinylestradiol (EE2) are ubiquitous EDCs in the environment. Many aquatic organisms, including fish, are often exposed to varying concentrations of BPA and EE2 throughout their lifespan. ... Read more >>

Aquat Toxicol (Aquatic toxicology (Amsterdam, Netherlands))
[2020, 225:105553]

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Estrogen receptor 1 expression and methylation of Esr1 promoter in mouse fetal prostate mesenchymal cells induced by gestational exposure to bisphenol A or ethinylestradiol.

Ramji K Bhandari, Julia A Taylor, Jennifer Sommerfeld-Sager, Donald E Tillitt, William A Ricke, Frederick S Vom Saal,

Fetal/neonatal environmental estrogen exposures alter developmental programing of the prostate gland causing onset of diseases later in life. We have previously shown in vitro that exposures to 17β-estradiol (E2) and the endocrine disrupting chemical bisphenol A, at concentrations relevant to human exposure, cause an elevation of estrogen receptor α (Esr1) ... Read more >>

(Environmental epigenetics)
[2019, 5(3):dvz012]

Cited: 2 times

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Interactive Effects of Perinatal BPA or DES and Adult Testosterone and Estradiol Exposure on Adult Urethral Obstruction and Bladder, Kidney, and Prostate Pathology in Male Mice.

Julia A Taylor, Maren Bell Jones, Cynthia L Besch-Williford, Ashley F Berendzen, William A Ricke, Frederick S Vom Saal,

Obstructive voiding disorder (OVD) occurs during aging in men and is often, but not always, associated with increased prostate size, due to benign prostatic hyperplasia (BPH), prostatitis, or prostate cancer. Estrogens are known to impact the development of both OVD and prostate diseases, either during early urogenital tract development in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(11):]

Cited: 1 time

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BPA and risk assessment - Authors' reply.

Patricia A Hunt, Frederick S Vom Saal, Richard Stahlhut, Roy Gerona,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2020, 8(4):271-272]

Cited: 0 times

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BPA: have flawed analytical techniques compromised risk assessments?

Roy Gerona, Frederick S Vom Saal, Patricia A Hunt,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2020, 8(1):11-13]

Cited: 5 times

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Fetal bisphenol A and ethinylestradiol exposure alters male rat urogenital tract morphology at birth: Confirmation of prior low-dose findings in CLARITY-BPA.

Kristen S Uchtmann, Julia A Taylor, Barry G Timms, Richard W Stahlhut, Emily A Ricke, Mark R Ellersieck, Frederick S Vom Saal, William A Ricke,

Bisphenol A (BPA) is a contaminant in virtually all Americans. To examine BPA's adverse effects, the FDA-NCTR, NIEHS, and 14 groups of academic scientists formed a consortium: CLARITY-BPA. The purpose of our study was to investigate the effects of a wide range of doses of BPA on fetal development of ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 91:131-141]

Cited: 2 times

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Experimental BPA Exposure and Glucose-Stimulated Insulin Response in Adult Men and Women.

Richard W Stahlhut, John Peterson Myers, Julia A Taylor, Angel Nadal, Jonathan A Dyer, Frederick S Vom Saal,

Context:Human cross-sectional and animal studies have shown an association of the chemical bisphenol A (BPA) with insulin resistance, type 2 diabetes, and other metabolic diseases, but no human experimental study has investigated whether BPA alters insulin/C-peptide secretion. Design:Men and postmenopausal women (without diabetes) were orally administered either the vehicle or ... Read more >>

(Journal of the Endocrine Society)
[2018, 2(10):1173-1187]

Cited: 11 times

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Atrazine induced transgenerational reproductive effects in medaka (Oryzias latipes).

Jacob A Cleary, Donald E Tillitt, Frederick S Vom Saal, Diane K Nicks, Rachel A Claunch, Ramji K Bhandari,

Atrazine is presently one of the most abundantly used herbicides in the United States, and a common contaminant of natural water bodies and drinking waters in high-use areas. Dysregulation of reproductive processes has been demonstrated in atrazine exposed fish, including alteration of key endocrine pathways on hypothalamic-pituitary-gonadal (HPG) axis. However, ... Read more >>

Environ Pollut (Environmental pollution (Barking, Essex : 1987))
[2019, 251:639-650]

Cited: 2 times

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Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice.

Julia A Taylor, Jennifer M Sommerfeld-Sager, Chun-Xia Meng, Susan C Nagel, Toshi Shioda, Frederick S Vom Saal,

There is evidence from longitudinal studies that being light at birth and weaning is associated with subsequent rapid weight gain in infants. This is referred to as "centile crossing", which can lead to increased risk of lifetime obesity, glucose dysregulation and type 2 diabetes. Here, pregnant CD-1 mice were hemi-ovariectomized ... Read more >>

PLoS One (PloS one)
[2018, 13(12):e0208846]

Cited: 1 time

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Flaws in design, execution and interpretation limit CLARITY-BPA's value for risk assessments of bisphenol A.

Frederick S Vom Saal,

The Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA) involved the Food and Drug Administration, the National Toxicology Program and 14 academic investigators funded by the National Institute of Environmental Health Sciences. Two key questions to be answered by CLARITY-BPA were as follows: (1) Would the academic investigator ... Read more >>

Basic Clin. Pharmacol. Toxicol. (Basic & clinical pharmacology & toxicology)
[2019, 125 Suppl 3:32-43]

Cited: 7 times

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Is it time to reassess current safety standards for glyphosate-based herbicides?

Laura N Vandenberg, Bruce Blumberg, Michael N Antoniou, Charles M Benbrook, Lynn Carroll, Theo Colborn, Lorne G Everett, Michael Hansen, Philip J Landrigan, Bruce P Lanphear, Robin Mesnage, Frederick S Vom Saal, Wade V Welshons, John Peterson Myers,

Use of glyphosate-based herbicides (GBHs) increased ∼100-fold from 1974 to 2014. Additional increases are expected due to widespread emergence of glyphosate-resistant weeds, increased application of GBHs, and preharvest uses of GBHs as desiccants. Current safety assessments rely heavily on studies conducted over 30 years ago. We have considered information on GBH ... Read more >>

J Epidemiol Community Health (Journal of epidemiology and community health)
[2017, 71(6):613-618]

Cited: 12 times

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Endocrine disruptor bisphenol A is implicated in urinary voiding dysfunction in male mice.

Tristan M Nicholson, Jalissa L Nguyen, Glen E Leverson, Julia A Taylor, Frederick S Vom Saal, Ronald W Wood, William A Ricke,

Estrogens, acting synergistically with androgens, are known from animal experiments to be important in lower urinary tract symptoms (LUTS) and benign prostate enlargement. Human exposure to environmental estrogens occurs throughout the life span, but the urologic health risks in men are largely unknown. Bisphenol A (BPA) is an endocrine disruptor ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(5):F1208-F1216]

Cited: 4 times

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Prenatal Exposure to Bisphenol A Disrupts Naturally Occurring Bimodal DNA Methylation at Proximal Promoter of fggy, an Obesity-Relevant Gene Encoding a Carbohydrate Kinase, in Gonadal White Adipose Tissues of CD-1 Mice.

Julia A Taylor, Keiko Shioda, Shino Mitsunaga, Shiomi Yawata, Brittany M Angle, Susan C Nagel, Frederick S Vom Saal, Toshi Shioda,

Exposure of mammalian fetuses to endocrine disruptors can increase the risk of adult-onset diseases. We previously showed that exposure of mouse fetuses to bisphenol A (BPA) caused adult-onset obesity. To examine roles of epigenetic changes in this delayed toxicity, we determined the effects of fetal mouse exposure to BPA on ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(2):779-794]

Cited: 5 times

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Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints.

Paola Palanza, Susan C Nagel, Stefano Parmigiani, Frederick S Vom Saal,

Of the approximately 85,000 chemicals in use, 1000 have been identified as having the ability to disrupt normal endocrine function. Exposure to endocrine disrupting chemicals (EDCs) during critical period in brain differentiation (prenatal and neonatal life) via the mother can alter the course of the development of sexually dimorphic behaviors. ... Read more >>

Curr Opin Behav Sci (Current opinion in behavioral sciences)
[2016, 7:69-75]

Cited: 29 times

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Erratum to: A round robin approach to the analysis of bisphenol a (BPA) in human blood samples.

Laura N Vandenberg, Roy R Gerona, Kurunthachalam Kannan, Julia A Taylor, Richard B van Breemen, Carrie A Dickenson, Chunyang Liao, Yang Yuan, Retha R Newbold, Vasantha Padmanabhan, Frederick S Vom Saal, Tracey J Woodruff,

Environ Health (Environmental health : a global access science source)
[2016, 15:43]

Cited: 0 times

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Correction to: Parma consensus statement on metabolic disruptors.

Jerrold J Heindel, Frederick S Vom Saal, Bruce Blumberg, Patrizia Bovolin, Gemma Calamandrei, Graziano Ceresini, Barbara A Cohn, Elena Fabbri, Laura Gioiosa, Christopher Kassotis, Juliette Legler, Michele La Merrill, Laura Rizzi, Ronit Machtinger, Alberto Mantovani, Michelle A Mendez, Luisa Montanini, Laura Molteni, Susan C Nagel, Stefano Parmigiani, Giancarlo Panzica, Silvia Paterlini, Valentina Pomatto, Jérôme Ruzzin, Giorgio Sartor, Thaddeus T Schug, Maria E Street, Alexander Suvorov, Riccardo Volpi, R Thomas Zoeller, Paola Palanza,

CORRECTION:After publication of the article [1], it has been brought to our attention that the thirteenth author of this article has had their name spelt incorrectly. In the original article the spelling "Laura Rizzir" was used. In fact the correct spelling should be "Laura Rizzi". ... Read more >>

Environ Health (Environmental health : a global access science source)
[2017, 16(1):130]

Cited: 1 time

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Corrigendum to "Developmental exposure to bisphenol A (BPA) alters sexual differentiation in painted turtles (Chrysemys picta)" [Gen. Comp. Endocr. 216 (2015) 77-85].

Caitlin M Jandegian, Sharon L Deem, Ramji K Bhandari, Casey M Holliday, Diane Nicks, Cheryl S Rosenfeld, Kyle W Selcer, Donald E Tillitt, Frederick S Vom Saal, Vanessa Vélez-Rivera, Ying Yang, Dawn K Holliday,

Gen Comp Endocrinol (General and comparative endocrinology)
[2017, 247:223]

Cited: 0 times

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Maternal and Fetal Pharmacokinetics of Oral Radiolabeled and Authentic Bisphenol A in the Rhesus Monkey.

Catherine A VandeVoort, Roy R Gerona, Frederick S Vom Saal, Alice F Tarantal, Patricia A Hunt, Anne Hillenweck, Daniel Zalko,

The present study was conducted in pregnant rhesus monkeys to determine the rapidity and extent to which BPA reaches the fetal compartment following oral ingestion, and the 24-hr fate of BPA. To assess metabolism changes during the course of pregnancy, we compared BPA biotransformation during the second and third trimesters ... Read more >>

PLoS One (PloS one)
[2016, 11(12):e0165410]

Cited: 1 time

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Should oral gavage be abandoned in toxicity testing of endocrine disruptors?

Laura N Vandenberg, Wade V Welshons, Frederick S Vom Saal, Pierre-Louis Toutain, John Peterson Myers,

For decades, hazard assessments for environmental chemicals have used intra-gastric gavage to assess the effects of 'oral' exposures. It is now widely used--and in some cases required--by US federal agencies to assess potential toxicity of endocrine disrupting chemicals (EDCs). In this review we enumerate several reasons why gavage is not ... Read more >>

Environ Health (Environmental health : a global access science source)
[2014, 13(1):46]

Cited: 37 times

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Minireview: Endocrine Disruptors: Past Lessons and Future Directions.

Thaddeus T Schug, Anne F Johnson, Linda S Birnbaum, Theo Colborn, Louis J Guillette, David P Crews, Terry Collins, Ana M Soto, Frederick S Vom Saal, John A McLachlan, Carlos Sonnenschein, Jerrold J Heindel,

Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue, debate, and concern among scientists, physicians, regulators, and the public. The emergence and development of this field of study has not always followed a smooth ... Read more >>

Mol. Endocrinol. (Molecular endocrinology (Baltimore, Md.))
[2016, 30(8):833-847]

Cited: 32 times

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Comment on "Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology".

Richard W Stahlhut, Richard B van Breemen, Roy R Gerona, Julia A Taylor, Wade V Welshons, Frederick S vom Saal,

Environ Health Perspect (Environmental health perspectives)
[2016, 124(4):A66]

Cited: 1 time

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