Full Text Journal Articles by
Author Frederic Harb

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Influence of intermittent fasting on prediabetes-induced neuropathy: Insights on a novel mechanistic pathway.

Maya Dannawi, Mansour E Riachi, Antony F Haddad, Mohamed El Massry, Mary Haddad, Pamela Moukarzel, Frédéric Harb, Hilda E Ghadieh, Assaad A Eid,

<h4>Aims</h4>Peripheral neuropathy (PN) is correlated with obesity and metabolic syndrome. Intermittent fasting (IF) has been described as the cornerstone in the management of obesity; however, its role in prediabetic complications is not well elucidated. Cytochromes P450 Monooxygenases (CYP450) are major sources of Reactive Oxygen Species (ROS) that orchestrate the onset ... Read more >>

Metabol Open (Metabolism open)
[2022, 14:100175]

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Activation of 20-HETE Synthase Triggers Oxidative Injury and Peripheral Nerve Damage in Type 2 Diabetic Mice.

Mary Haddad, Stéphanie Eid, Frederic Harb, Mohamed E L Massry, Sami Azar, Erik-Andre Sauleau, Assaad A Eid,

Diabetic Peripheral Neuropathy (DPN), highly prevalent among patients with diabetes, is characterized by peripheral nerve dysfunction. Reactive Oxygen Species (ROS) overproduction has been suggested to orchestrate diabetic complications including DPN. Untargeted antioxidant therapy has exhibited limited efficacy, highlighting a critical need to explore ROS sources altered in a cell-specific manner ... Read more >>

J Pain (The journal of pain)
[2022, :S1526-5900(22)00048-7]

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