Full Text Journal Articles by
Author Frank W Ohl

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TetrODrive: an open-source microdrive for combined electrophysiology and optophysiology.

Marcel Brosch, Alisa Vlasenko, Frank W Ohl, Michael T Lippert,

<i>Objective</i>. In tetrode recordings, the cell types of the recorded units are difficult to determine based on electrophysiological characteristics alone. Optotagging, the use of optogenetic stimulation to precisely identify cells, is a method to overcome this challenge. However, recording from many different cells requires advancing electrodes and light sources slowly ... Read more >>

J Neural Eng (Journal of neural engineering)
[2021, 18(4):]

Cited: 0 times

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State Transitions During Discrimination Learning in the Gerbil Auditory Cortex Analyzed by Network Causality Metrics.

Robert Kozma, Sanqing Hu, Yury Sokolov, Tim Wanger, Andreas L Schulz, Marie L Woldeit, Ana I Gonçalves, Miklós Ruszinkó, Frank W Ohl,

This work studies the evolution of cortical networks during the transition from escape strategy to avoidance strategy in auditory discrimination learning in Mongolian gerbils trained by the well-established two-way active avoidance learning paradigm. The animals were implanted with electrode arrays centered on the surface of the primary auditory cortex and ... Read more >>

Front Syst Neurosci (Frontiers in systems neuroscience)
[2021, 15:641684]

Cited: 0 times

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Task rule and choice are reflected by layer-specific processing in rodent auditory cortical microcircuits.

Marina M Zempeltzi, Martin Kisse, Michael G K Brunk, Claudia Glemser, Sümeyra Aksit, Katrina E Deane, Shivam Maurya, Lina Schneider, Frank W Ohl, Matthias Deliano, Max F K Happel,

The primary auditory cortex (A1) is an essential, integrative node that encodes the behavioral relevance of acoustic stimuli, predictions, and auditory-guided decision-making. However, the realization of this integration with respect to the cortical microcircuitry is not well understood. Here, we characterize layer-specific, spatiotemporal synaptic population activity with chronic, laminar current ... Read more >>

Commun Biol (Communications biology)
[2020, 3(1):345]

Cited: 3 times

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Self-regulated critical brain dynamics originate from high frequency-band activity in the MEG.

Stefan Dürschmid, Christoph Reichert, Nike Walter, Hermann Hinrichs, Hans-Jochen Heinze, Frank W Ohl, Giulio Tononi, Matthias Deliano,

Brain function requires the flexible coordination of billions of neurons across multiple scales. This could be achieved by scale-free, critical dynamics balanced at the edge of order and disorder. Criticality has been demonstrated in several, often reduced neurophysiological model systems. In the intact human brain criticality has yet been only ... Read more >>

PLoS One (PloS one)
[2020, 15(6):e0233589]

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An optically transparent multi-electrode array for combined electrophysiology and optophysiology at the mesoscopic scale.

Marcel Brosch, Martin Deckert, Sanchit Rathi, Kentaroh Takagaki, Theresa Weidner, Frank W Ohl, Bertram Schmidt, Michael T Lippert,

<h4>Objective</h4>A number of tissue penetrating opto-electrodes to simultaneously record and optogenetically influence brain activity have been developed. For experiments at the surface of the brain, such as electrocorticogram (ECoG) recordings and surface optogenetics, fewer devices have been described and no device has found widespread adoption for neuroscientific experiments. One issue ... Read more >>

J Neural Eng (Journal of neural engineering)
[2020, 17(4):046014]

Cited: 0 times

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Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex.

Katrina E Deane, Michael G K Brunk, Andrew W Curran, Marina M Zempeltzi, Jing Ma, Xiao Lin, Francesca Abela, Sümeyra Aksit, Matthias Deliano, Frank W Ohl, Max F K Happel,

<h4>Key points</h4>Ketamine is a common anaesthetic agent used in research and more recently as medication in treatment of depression. It has known effects on inhibition of interneurons and cortical stimulus-locked responses, but the underlying functional network mechanisms are still elusive. Analysing population activity across all layers within the auditory cortex, ... Read more >>

J Physiol (The Journal of physiology)
[2020, 598(13):2741-2755]

Cited: 5 times

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Representation of Auditory Task Components and of Their Relationships in Primate Auditory Cortex.

Stanislava Knyazeva, Elena Selezneva, Alexander Gorkin, Frank W Ohl, Michael Brosch,

The current study aimed to resolve some of the inconsistencies in the literature on which mental processes affect auditory cortical activity. To this end, we studied auditory cortical firing in four monkeys with different experience while they were involved in six conditions with different arrangements of the task components sound, ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:306]

Cited: 2 times

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Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma.

Marcus Jeschke, Max F K Happel, Konstantin Tziridis, Patrick Krauss, Achim Schilling, Holger Schulze, Frank W Ohl,

Harmful environmental sounds are a prevailing source of chronic hearing impairments, including noise induced hearing loss, hyperacusis, or tinnitus. How these symptoms are related to pathophysiological damage to the sensory receptor epithelia and its effects along the auditory pathway, have been documented in numerous studies. An open question concerns the ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:598406]

Cited: 1 time

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Matching stimulation paradigms resolve apparent differences between optogenetic and electrical VTA stimulation.

Theresa Cs Weidner, Daniel Vincenz, Marta Brocka, Jennifer Tegtmeier, Anja M Oelschlegel, Frank W Ohl, Jürgen Goldschmidt, Michael T Lippert,

BACKGROUND:Optogenetic stimulation has grown into a popular brain stimulation method in basic neuroscience while electrical stimulation predominates in clinical applications. In order to explain the effects of electrical stimulation on a cellular level and evaluate potential advantages of optogenetic therapies, comparisons between the two stimulation modalities are necessary. This comparison ... Read more >>

Brain Stimul (Brain stimulation)
[2020, 13(2):363-371]

Cited: 0 times

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Early Sensory Loss Alters the Dendritic Branching and Spine Density of Supragranular Pyramidal Neurons in Rodent Primary Sensory Cortices.

Tamar Macharadze, Eike Budinger, Michael Brosch, Henning Scheich, Frank W Ohl, Julia U Henschke,

Multisensory integration in primary auditory (A1), visual (V1), and somatosensory cortex (S1) is substantially mediated by their direct interconnections and by thalamic inputs across the sensory modalities. We have previously shown in rodents (Mongolian gerbils) that during postnatal development, the anatomical and functional strengths of these crossmodal and also of ... Read more >>

Front Neural Circuits (Frontiers in neural circuits)
[2019, 13:61]

Cited: 1 time

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Ultrastructure of giant thalamic terminals in the auditory cortex.

Katja Saldeitis, Karin Richter, Klaus-Dieter Fischer, Frank W Ohl, José M Mateos, Eike Budinger,

The auditory system comprises some very large axonal terminals like the endbulb and calyx of Held and "giant" corticothalamic synapses. Previously, we described a hitherto unknown population of giant thalamocortical boutons arising from the medial division of the medial geniculate body (MGm) in the Mongolian gerbil, which terminate over a ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2019, 50(9):3445-3453]

Cited: 0 times

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β-adrenergic modulation of discrimination learning and memory in the auditory cortex.

Horst Schicknick, Julia U Henschke, Eike Budinger, Frank W Ohl, Eckart D Gundelfinger, Wolfgang Tischmeyer,

Despite vast literature on catecholaminergic neuromodulation of auditory cortex functioning in general, knowledge about its role for long-term memory formation is scarce. Our previous pharmacological studies on cortex-dependent frequency-modulated tone-sweep discrimination learning of Mongolian gerbils showed that auditory-cortical D<sub>1/5</sub> -dopamine receptor activity facilitates memory consolidation and anterograde memory formation. Considering ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2019, 50(7):3141-3163]

Cited: 3 times

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CAVE: An Open-Source Tool for Combined Analysis of Head-Mounted Calcium Imaging and Behavior in MATLAB.

Jennifer Tegtmeier, Marcel Brosch, Kathrin Janitzky, Hans-Jochen Heinze, Frank W Ohl, Michael T Lippert,

Calcium imaging in freely behaving rodents using head-mounted miniature microscopes is currently becoming an increasingly popular technique in neuroscience. Due to the large amounts of complex data that the technique produces, user friendly software is needed for quick and efficient processing. Here, we present a new tool for analyzing calcium ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2018, 12:958]

Cited: 2 times

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Crossmodal Connections of Primary Sensory Cortices Largely Vanish During Normal Aging.

Julia U Henschke, Frank W Ohl, Eike Budinger,

During aging, human response times (RTs) to unisensory and crossmodal stimuli decrease. However, the elderly benefit more from crossmodal stimulus representations than younger people. The underlying short-latency multisensory integration process is mediated by direct crossmodal connections at the level of primary sensory cortices. We investigate the age-related changes of these ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2018, 10:52]

Cited: 3 times

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Dopaminergic neuromodulation of high gamma stimulus phase-locking in gerbil primary auditory cortex mediated by D1/D5-receptors.

Matthias Deliano, Michael G K Brunk, Mohamed El-Tabbal, Maria M Zempeltzi, Max F K Happel, Frank W Ohl,

Cortical release of the neurotransmitter dopamine has been implied in adapting cortical processing with respect to various functions including coding of stimulus salience, expectancy, error prediction, behavioral relevance and learning. Dopamine agonists have been shown to modulate recurrent cortico-thalamic feedback, and should therefore also affect synchronization and amplitude of thalamo-cortical ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2020, 51(5):1315-1327]

Cited: 8 times

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Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices.

Julia U Henschke, Anja M Oelschlegel, Frank Angenstein, Frank W Ohl, Jürgen Goldschmidt, Patrick O Kanold, Eike Budinger,

The nervous system integrates information from multiple senses. This multisensory integration already occurs in primary sensory cortices via direct thalamocortical and corticocortical connections across modalities. In humans, sensory loss from birth results in functional recruitment of the deprived cortical territory by the spared senses but the underlying circuit changes are ... Read more >>

Brain Struct Funct (Brain structure & function)
[2018, 223(3):1165-1190]

Cited: 13 times

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Compensating Level-Dependent Frequency Representation in Auditory Cortex by Synaptic Integration of Corticocortical Input.

Max F K Happel, Frank W Ohl,

Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus intensity. Physiological correlates of level-constancy of auditory representations hence should ... Read more >>

PLoS One (PloS one)
[2017, 12(1):e0169461]

Cited: 4 times

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Reversal Learning in Humans and Gerbils: Dynamic Control Network Facilitates Learning.

Christian Jarvers, Tobias Brosch, André Brechmann, Marie L Woldeit, Andreas L Schulz, Frank W Ohl, Marcel Lommerzheim, Heiko Neumann,

Biologically plausible modeling of behavioral reinforcement learning tasks has seen great improvements over the past decades. Less work has been dedicated to tasks involving contingency reversals, i.e., tasks in which the original behavioral goal is reversed one or multiple times. The ability to adjust to such reversals is a key ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2016, 10:535]

Cited: 3 times

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Comodulation masking release in the inferior colliculus by combined signal enhancement and masker reduction.

Jan-Philipp Diepenbrock, Marcus Jeschke, Frank W Ohl, Jesko Verhey,

Auditory signals that contain coherent level fluctuations of a masker in different frequency regions enhance the detectability of an embedded sinusoidal target signal, an effect commonly known as comodulation masking release (CMR). Neural correlates have been proposed at different stages of the auditory system. While later stages seem to suppress ... Read more >>

J Neurophysiol (Journal of neurophysiology)
[2017, 117(2):853-867]

Cited: 1 time

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A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis.

Christina Spilker, Sven Nullmeier, Katarzyna M Grochowska, Anne Schumacher, Ioana Butnaru, Tamar Macharadze, Guilherme M Gomes, PingAn Yuanxiang, Gonca Bayraktar, Carolin Rodenstein, Carolin Geiseler, Angela Kolodziej, Jeffrey Lopez-Rojas, Dirk Montag, Frank Angenstein, Julia Bär, Wolfgang D'Hanis, Thomas Roskoden, Marina Mikhaylova, Eike Budinger, Frank W Ohl, Oliver Stork, Ana C Zenclussen, Anna Karpova, Herbert Schwegler, Michael R Kreutz,

Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (CREB). Several reports indicate that mutations in NSMF are related to Kallmann syndrome (KS), a neurodevelopmental disorder characterized by idiopathic ... Read more >>

PLoS Genet (PLoS genetics)
[2016, 12(3):e1005907]

Cited: 13 times

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Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning.

Max F K Happel, Matthias Deliano, Frank W Ohl,

Shuttle-box avoidance learning is a well-established method in behavioral neuroscience and experimental setups were traditionally custom-made; the necessary equipment is now available by several commercial companies. This protocol provides a detailed description of a two-way shuttle-box avoidance learning paradigm in rodents (here Mongolian gerbils; Meriones unguiculatus) in combination with site-specific ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2015, (105):e53002]

Cited: 3 times

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Noise Trauma Induced Neural Plasticity Throughout the Auditory System of Mongolian Gerbils: Differences between Tinnitus Developing and Non-Developing Animals.

Konstantin Tziridis, Sönke Ahlf, Marcus Jeschke, Max F K Happel, Frank W Ohl, Holger Schulze,

In this study, we describe differences between neural plasticity in auditory cortex (AC) of animals that developed subjective tinnitus (group T) after noise-induced hearing loss (NIHL) compared to those that did not [group non-tinnitus (NT)]. To this end, our analysis focuses on the input activity of cortical neurons based on ... Read more >>

Front Neurol (Frontiers in neurology)
[2015, 6:22]

Cited: 12 times

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Auditory cortex 2014 – towards a synthesis of human and animal research.

Eike Budinger, André Brechmann, Michael Brosch, Peter Heil, Reinhard König, Frank W Ohl, Henning Scheich,

Eur J Neurosci (The European journal of neuroscience)
[2015, 41(5):515-517]

Cited: 0 times

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Fast and robust estimation of spectro-temporal receptive fields using stochastic approximations.

Arne F Meyer, Jan-Philipp Diepenbrock, Frank W Ohl, Jörn Anemüller,

<h4>Background</h4>The receptive field (RF) represents the signal preferences of sensory neurons and is the primary analysis method for understanding sensory coding. While it is essential to estimate a neuron's RF, finding numerical solutions to increasingly complex RF models can become computationally intensive, in particular for high-dimensional stimuli or when many ... Read more >>

J Neurosci Methods (Journal of neuroscience methods)
[2015, 246:119-133]

Cited: 4 times

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Contribution of emotional and motivational neurocircuitry to cue-signaled active avoidance learning.

Anton Ilango, Jason Shumake, Wolfram Wetzel, Frank W Ohl,

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2014, 8:372]

Cited: 9 times

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