Full Text Journal Articles by
Author Frank S Walsh

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Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro.

Aziz Gauhar, Cyril V Privezentzev, Mykhaylo Demydchuk, Tanja Gerlza, Julia Rieger, Andreas J Kungl, Frank S Walsh, J Lynn Rutkowski, Pawel Stocki,

Single domain shark variable domain of new antigen receptor (VNAR) antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodies selected against the severe acute respiratory syndrome coronavirus 2 spike ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21970]

Cited: 0 times

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Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1.

Pawel Stocki, Jaroslaw Szary, Charlotte L M Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank S Walsh, J Lynn Rutkowski,

Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high affinity single domain antibodies to the transferrin receptor 1 (TfR1) with efficient biotherapeutic delivery across the BBB. A ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21172]

Cited: 6 times

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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Dag Sehlin, Pawel Stocki, Tobias Gustavsson, Greta Hultqvist, Frank S Walsh, J Lynn Rutkowski, Stina Syvänen,

Transferrin receptor 1 (TfR1) mediated transcytosis is an attractive strategy to enhance brain uptake of protein drugs, but translation remains a challenge. Here, a single domain shark antibody VNAR fragment (TXB2) with similar affinity to murine and human TfR1 was used to shuttle protein cargo into the brain. TXB2 was ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2020, 34(10):13272-13283]

Cited: 4 times

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Marshall Nirenberg: after the genetic code and into neurobiology.

Frank S Walsh,

Neurochem Int (Neurochemistry international)
[2012, 61(6):819-820]

Cited: 0 times

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Myostatin as a therapeutic target in Amyotrophic lateral sclerosis.

Frank S Walsh, Julia Lynn Rutkowski,

Amyotrophic Lateral Sclerosis is a devastating neurological disease that is inevitably fatal after 3-5years duration. Treatment options are minimal and as such new therapeutic modalities are required. In this review, we discuss the role of the myostatin pathway as a modulator of skeletal muscle mass and therapeutic approaches using biological ... Read more >>

Neurochem Int (Neurochemistry international)
[2012, 61(6):931-935]

Cited: 3 times

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Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

J Barney Bryson, Carl Hobbs, Michael J Parsons, Karen D Bosch, Amelie Pandraud, Frank S Walsh, Patrick Doherty, Linda Greensmith,

In amyotrophic lateral sclerosis (ALS), the progressive loss of motor neurons is accompanied by extensive muscle denervation, resulting in paralysis and ultimately death. Upregulation of amyloid beta (A4) precursor protein (APP) in muscle fibres coincides with symptom onset in both sporadic ALS patients and the SOD1(G93A) mouse model of familial ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2012, 21(17):3871-3882]

Cited: 32 times

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Honoring nobel laureate Dr. Marshall Nirenberg on decoding brain memory. Preface.

Haruhiro Higashida, David Trisler, Frank S Walsh,

Neurochem Int (Neurochemistry international)
[2012, 61(6):815-816]

Cited: 0 times

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Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons.

Ying Gao, Kangwen Deng, Zixuan Cao, Edmund I Graziani, Adam M Gilbert, Frank E Koehn, Andrew Wood, Patrick Doherty, Frank S Walsh,

One of the major barriers to successful axon regeneration in the adult CNS is the presence of inhibitory molecules that originate from the myelin sheath and glial scar. So far, only a small number of pharmacological compounds have exhibited functional activity against CNS inhibitors in promoting axon regeneration after injury. ... Read more >>

J Neurochem (Journal of neurochemistry)
[2010, 113(5):1331-1342]

Cited: 10 times

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Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.

Ying Gao, Dmitry V Vasilyev, Maria Beatriz Goncalves, Fiona V Howell, Carl Hobbs, Melina Reisenberg, Ru Shen, Mei-Yi Zhang, Brian W Strassle, Peimin Lu, Lilly Mark, Michael J Piesla, Kangwen Deng, Evguenia V Kouranova, Robert H Ring, Garth T Whiteside, Brian Bates, Frank S Walsh, Gareth Williams, Menelas N Pangalos, Tarek A Samad, Patrick Doherty,

Endocannabinoids (eCBs) function as retrograde signaling molecules at synapses throughout the brain, regulate axonal growth and guidance during development, and drive adult neurogenesis. There remains a lack of genetic evidence as to the identity of the enzyme(s) responsible for the synthesis of eCBs in the brain. Diacylglycerol lipase-alpha (DAGLalpha) and ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2010, 30(6):2017-2024]

Cited: 253 times

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Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.

Kangwen Deng, Ying Gao, Zixuan Cao, Edmund I Graziani, Andrew Wood, Patrick Doherty, Frank S Walsh,

The N-terminal domain of NogoA, called amino-Nogo, inhibits axonal outgrowth and cell spreading via a largely unknown mechanism. In the present study, we show that amino-Nogo decreases Rac1 activity and inhibits fibroblast spreading. 12-O-Tetradecanoylphorbol-13-acetate-type tumor promoters, such as phorbol 12-myristate 13-acetate (PMA) and teleocidin, increase Rac1 activity and overcome the ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2010, 285(9):6425-6433]

Cited: 15 times

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BDNF regulates neuronal sensitivity to endocannabinoids.

Patrick Maison, Deborah J Walker, Frank S Walsh, Gareth Williams, Patrick Doherty,

The diacylglycerol lipases (DAGLalpha/beta) synthesize 2-arachidonylglycerol (2-AG), the major endocannabinoid in the developing and adult brain (eCB). This lipid acts on cannabinoid receptors to regulate axonal growth and guidance, activity-dependent synaptic plasticity and adult neurogenesis, and can also protect neurons from excitotoxicity. 2-AG action is generally terminated by monoacylglycerol lipase ... Read more >>

Neurosci Lett (Neuroscience letters)
[2009, 467(2):90-94]

Cited: 32 times

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Adeno-associated virus-8-mediated intravenous transfer of myostatin propeptide leads to systemic functional improvements of slow but not fast muscle.

Keith Foster, Ian R Graham, Anthony Otto, Helen Foster, Capucine Trollet, Paul J Yaworsky, Frank S Walsh, Dale Bickham, Nancy A Curtin, Susannah L Kawar, Ketan Patel, George Dickson,

Myostatin is a member of the transformating growth factor-beta (TGF-beta) superfamily of proteins and is produced almost exclusively in skeletal muscle tissue, where it is secreted and circulates as a serum protein. Myostatin acts as a negative regulator of muscle mass through the canonical SMAD2/3/4 signaling pathway. Naturally occurring myostatin ... Read more >>

Rejuvenation Res (Rejuvenation research)
[2009, 12(2):85-94]

Cited: 21 times

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Receptors for myelin inhibitors: Structures and therapeutic opportunities.

Zixuan Cao, Ying Gao, Kangwen Deng, Gareth Williams, Patrick Doherty, Frank S Walsh,

Many studies have indicated that the inability of adult mammalian central nervous system (CNS) to regenerate after injury is partly due to the existence of growth-inhibitory molecules associated with CNS myelin. Studies over the years have led to the identification of multiple myelin-associated inhibitors, among which Nogo, myelin-associated glycoprotein (MAG) ... Read more >>

Mol Cell Neurosci (Molecular and cellular neurosciences)
[2010, 43(1):1-14]

Cited: 33 times

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A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner.

Maria Beatriz Goncalves, Philipp Suetterlin, Ping Yip, Francisco Molina-Holgado, Deborah J Walker, Madeleine J Oudin, Marc P Zentar, Steven Pollard, Rafael J Yáñez-Muñoz, Gareth Williams, Frank S Walsh, Menelas N Pangalos, Patrick Doherty,

The subventricular zone (SVZ) is a major site of neurogenesis in the adult. We now show that ependymal and proliferating cells in the adult mouse SVZ express diacylglycerol lipases (DAGLs), enzymes that synthesise a CB1/CB2 cannabinoid receptor ligand. DAGL and CB2 antagonists inhibit the proliferation of cultured neural stem cells, ... Read more >>

Mol Cell Neurosci (Molecular and cellular neurosciences)
[2008, 38(4):526-536]

Cited: 115 times

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Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.

Gareth Williams, Andrew Wood, Emma-Jane Williams, Ying Gao, Mary L Mercado, Alan Katz, Diane Joseph-McCarthy, Brian Bates, Huai-Ping Ling, Ann Aulabaugh, Joe Zaccardi, Yuhong Xie, Menelas N Pangalos, Frank S Walsh, Patrick Doherty,

Gangliosides are key players in neuronal inhibition, with antibody-mediated clustering of gangliosides blocking neurite outgrowth in cultures and axonal regeneration post injury. In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1. The interaction is shown by analytical ultracentrifugation sedimentation and is ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2008, 283(24):16641-16652]

Cited: 24 times

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The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.

Andrew G Foley, Warren D Hirst, Helen C Gallagher, Claire Barry, Jim J Hagan, Neil Upton, Frank S Walsh, A Jackie Hunter, Ciaran M Regan,

While there is now substantial evidence that 5-HT(6) antagonism leads to significantly improved cognitive ability, the mechanism(s) and/or pathway(s) involved are poorly understood. We have evaluated the consequence of chronic administration of the 5-HT(6) receptor antagonists SB-271046 and SB-399885 on neural cell adhesion molecule polysialylation state (NCAM PSA), a neuroplastic ... Read more >>

Neuropharmacology (Neuropharmacology)
[2008, 54(8):1166-1174]

Cited: 27 times

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The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.

Lidia Mosyak, Andrew Wood, Brian Dwyer, Madhavan Buddha, Mark Johnson, Ann Aulabaugh, Xiaotian Zhong, Eleonora Presman, Susan Benard, Kerry Kelleher, James Wilhelm, Mark L Stahl, Ron Kriz, Ying Gao, Zixuan Cao, Huai-Ping Ling, Menelas N Pangalos, Frank S Walsh, William S Somers,

Nogo receptor (NgR)-mediated control of axon growth relies on the central nervous system-specific type I transmembrane protein Lingo-1. Interactions between Lingo-1 and NgR, along with a complementary co-receptor, result in neurite and axonal collapse. In addition, the inhibitory role of Lingo-1 is particularly important in regulation of oligodendrocyte differentiation and ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2006, 281(47):36378-36390]

Cited: 52 times

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Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis.

Erika L F Holzbaur, David S Howland, Nicholas Weber, Karen Wallace, Yijin She, Seung Kwak, Lioudmilla A Tchistiakova, Erin Murphy, Joseph Hinson, Riyez Karim, Xiang Yang Tan, Pamela Kelley, Kevin C McGill, Gareth Williams, Carl Hobbs, Patrick Doherty, Margaret M Zaleska, Menelas N Pangalos, Frank S Walsh,

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease leading to motor neuron cell death, but recent studies suggest that non-neuronal cells may contribute to the pathological mechanisms involved. Myostatin is a negative regulator of muscle growth whose function can be inhibited using neutralizing antibodies. In this study, we used ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2006, 23(3):697-707]

Cited: 57 times

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Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke?

Elaine A Irving, Mary Vinson, Claudia Rosin, Jenny C Roberts, Debra M Chapman, Laura Facci, David J Virley, Stephen D Skaper, Stephen A Burbidge, Frank S Walsh, A Jacqueline Hunter, Andrew A Parsons,

The inhibitory activity of myelin-associated glycoprotein (MAG) on neurons is thought to contribute to the lack of regenerative capacity of the CNS after injury. The interaction of MAG and its neuronal receptors mediates bidirectional signaling between neurons and oligodendrocytes. The novel finding that an anti-MAG monoclonal antibody not only possesses ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2005, 25(1):98-107]

Cited: 28 times

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A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists.

Gareth Williams, Britta J Eickholt, Patrick Maison, Rabinder Prinjha, Frank S Walsh, Patrick Doherty,

Semaphorin 3A can inhibit axonal growth and induce neuronal apoptosis following binding to neuropilin-1, with the membrane proximal MAM (meprin, A5, mu) domain in neuropilin-1 playing a key role in the formation of a higher order receptor complex. If functional motifs on semaphorin 3A and/or the MAM domain can be ... Read more >>

J Neurochem (Journal of neurochemistry)
[2005, 92(5):1180-1190]

Cited: 21 times

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Overcoming the inhibitors of myelin with a novel neurotrophin strategy.

Gareth Williams, Emma-Jane Williams, Patrick Maison, Menelas N Pangalos, Frank S Walsh, Patrick Doherty,

Myelin inhibitors activate a p75(NTR)-dependent signaling cascade in neurons that not only inhibits axonal growth but also prevents neurotrophins (NT) from stimulating growth. Most intriguingly, in addition to Trk receptors, neurotrophins also bind to p75(NTR). We have designed a "mini-neurotrophin" called B(AG) to activate TrkB in the absence of p75(NTR) ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2005, 280(7):5862-5869]

Cited: 15 times

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The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats.

Andrew G Foley, Keith J Murphy, Warren D Hirst, Helen C Gallagher, Jim J Hagan, Neil Upton, Frank S Walsh, Ciaran M Regan,

The highly potent and selective 5-HT(6) receptor antagonist SB-271046 [5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide] has previously been demonstrated to improve retention significantly in a spatial water maze paradigm in adult rats. However, SB-271046 did not have any effect on task acquisition. As these apparently contradictory findings may be reconciled by a prime influence of ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2004, 29(1):93-100]

Cited: 62 times

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A dimeric version of the short N-cadherin binding motif HAVDI promotes neuronal cell survival by activating an N-cadherin/fibroblast growth factor receptor signalling cascade.

Stephen D Skaper, Laura Facci, Gareth Williams, Emma-Jane Williams, Frank S Walsh, Patrick Doherty,

The HAVDI and INPISGQ sequences have been identified as functional binding motifs in extracellular domain 1 (ECD1) of N-cadherin. Cyclic peptides containing a tandem repeat of the individual motifs function as N-cadherin agonists and stimulate neurite outgrowth. We now show that the cyclic peptide N-Ac-CHAVDINGHAVDIC-NH2 (SW4) containing the HAVDI sequence ... Read more >>

Mol Cell Neurosci (Molecular and cellular neurosciences)
[2004, 26(1):17-23]

Cited: 19 times

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The quantification of gene expression in an animal model of brain ischaemia using TaqMan real-time RT-PCR.

Brian C Bond, David J Virley, Nigel J Cairns, A Jackie Hunter, Gary B T Moore, Stephen J Moss, Anne W Mudge, Frank S Walsh, Elena Jazin, Paul Preece,

Expression levels of mRNA are commonly measured as a ratio of test to reference gene. The assumption is that reference genes such as beta-actin or cyclophilin are unaffected by treatment and act as steady-state controls. TaqMan real-time RT-PCR was used to test these assumptions in a rat model of cerebral ... Read more >>

Brain Res Mol Brain Res (Brain research. Molecular brain research)
[2002, 106(1-2):101-116]

Cited: 64 times

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Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons.

Mary Vinson, Oliver Rausch, Peter R Maycox, Rab K Prinjha, Debra Chapman, Rachel Morrow, Alex J Harper, Colin Dingwall, Frank S Walsh, Stephen A Burbidge, David R Riddell,

The interaction between myelin-associated glycoprotein (MAG), expressed at the periaxonal membrane of myelin, and receptors on neurons initiates a bidirectional signalling system that results in inhibition of neurite outgrowth and maintenance of myelin integrity. We show that this involves a lipid-raft to lipid-raft interaction on opposing cell membranes. MAG is ... Read more >>

Mol Cell Neurosci (Molecular and cellular neurosciences)
[2003, 22(3):344-352]

Cited: 57 times

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