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Author Frank Moriarty

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Cognitive decline associated with anticholinergics, benzodiazepines and Z-drugs: Findings from The Irish Longitudinal Study on Ageing (TILDA).

Frank Moriarty, George M Savva, Carlota M Grossi, Kathleen Bennett, Chris Fox, Ian Maidment, Yoon K Loke, Nicholas Steel, Rose Anne Kenny, Kathryn Richardson,

<h4>Aims</h4>To estimate the association between patterns of anticholinergic, benzodiazepine and Z-drug medication use and change in cognitive function in middle-aged and older adults.<h4>Methods</h4>This prospective cohort study used data from the first three waves of The Irish Longitudinal Study on Ageing (TILDA), including community-dwelling adults aged ≥50 years followed for up ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2020, :]

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Factors associated with initiation of bone-health medication among older adults in primary care in Ireland

Mary Walsh, Mari Nerdrum, Tom Fahey, Frank Moriarty,

<h4>ABSTRACT</h4> <h4>Background</h4> Adults at high risk of fragility fracture should be offered pharmacological treatment when not contraindicated, however under-treatment is common. <h4>Objective</h4> This study aimed to investigate factors associated with bone-health medication initiation in older patients attending primary care. <h4>Design</h4> Retrospective cohort study. <h4>Setting</h4> 44 general practices in Ireland from ... Read more >>

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Persistence with oral bisphosphonates and denosumab among older adults in primary care in Ireland

Mary Walsh, Tom Fahey, Frank Moriarty,

<h4>ABSTRACT</h4> <h4>Purpose</h4> Gaps in pharmacological treatment for osteoporosis can reduce effectiveness. This study aimed to estimate persistence rates for oral bisphosphonates and denosumab in older primary care patients and identify factors associated with discontinuation. <h4>Methods</h4> Older patients newly prescribed oral bisphosphonates or denosumab between 2012 and 2017 were identified from ... Read more >>

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Pharmacists in general practice: a qualitative process evaluation of the General Practice Pharmacist (GPP) study.

Oscar James, Karen Cardwell, Frank Moriarty, Susan M Smith, Barbara Clyne,

BACKGROUND:There is some evidence to suggest that pharmacists integrated into primary care improves patient outcomes and prescribing quality. Despite this growing evidence, there is a lack of detail about the context of the role. OBJECTIVE:To explore the implementation of The General Practice Pharmacist (GPP) intervention (pharmacists integrating into general practice ... Read more >>

Fam Pract (Family practice)
[2020, 37(5):711-718]

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Agreement between self-reported morbidity and pharmacy claims data for prescribed medications in an older community based population.

Clionadh Mannion, John Hughes, Frank Moriarty, Kathleen Bennett, Caitriona Cahir,

<h4>Background</h4>Studies have indicated variability around prevalence estimates of multimorbidity due to poor consensus regarding its definition and measurement. Medication-based measures of morbidity may be valuable resources in the primary-care setting where access to medical data can be limited. We compare the agreement between patient self-reported and medication-based morbidity; and examine ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):283]

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Assessing the Diagnostic Accuracy of Multimedia Messaging for the Diagnosis of Scaphoid Fractures.

Ciaran Stanley, Frank Moriarty, Frank McGrath,

<b><i>Introduction:</i></b> <i>Use of smartphone messaging applications, such as WhatsApp, for communication within clinical teams is widespread. Various studies have shown multiple uses for smartphones and multimedia messaging in orthopedic clinical practice for coordinating clinical duties and diagnosing various injuries but none have assessed scaphoid fractures. Our aims were to: (1) assess ... Read more >>

Telemed J E Health (Telemedicine journal and e-health : the official journal of the American Telemedicine Association)
[2020, :]

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Aspirin prescribing in cardiovascular disease in middle-aged and older adults in Ireland: findings from The Irish Longitudinal Study on Ageing

Frank Moriarty, Alan Barry, Rose Anne Kenny, Tom Fahey,

<h4>Background</h4> Aspirin use for cardiovascular indications is widespread despite evidence not supporting use in patients without cardiovascular disease (CVD). This study characterises aspirin prescribing among people aged ≥50 years in Ireland for primary and secondary prevention, and factors associated with prescription. <h4>Methods</h4> This cross-sectional study includes participants from wave 3 ... Read more >>

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Hospital initiation of benzodiazepines and Z-drugs in older adults and discontinuation in primary care

Seán Coll, Mary Walsh, Tom Fahey, Frank Moriarty,

<h4>Objective</h4> To examine factors associated with continuation of hospital-initiated benzodiazepine receptor agonists (BZRAs) among adults aged ≥65 years, specifically instructions on hospital discharge summaries. <h4>Methods</h4> This retrospective cohort study involved anonymised electronic record data on prescribing and hospitalisations for 38,229 patients aged ≥65 from forty-four GP practices in Ireland 2011-2016. ... Read more >>

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A comparison of contemporary versus older studies of aspirin for primary prevention.

Frank Moriarty, Mark H Ebell,

<h4>Background</h4>Recent aspirin trials have not shown similar benefits for primary prevention as older studies.<h4>Objective</h4>To compare benefits and harms of aspirin for primary prevention before and after widespread use of statins and colorectal cancer screening.<h4>Methods</h4>We compared studies of aspirin for primary prevention that recruited patients from 2005 onward with previous individual ... Read more >>

Fam Pract (Family practice)
[2020, 37(3):290-296]

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Evaluation of the General Practice Pharmacist (GPP) intervention to optimise prescribing in Irish primary care: a non-randomised pilot study.

Karen Cardwell, Susan M Smith, Barbara Clyne, Laura McCullagh, Emma Wallace, Ciara Kirke, Tom Fahey, Frank Moriarty, ,

<h4>Objective</h4>Limited evidence suggests integration of pharmacists into the general practice team could improve medicines management for patients, particularly those with multimorbidity and polypharmacy. This study aimed to develop and assess the feasibility of an intervention involving pharmacists, working within general practices, to optimise prescribing in Ireland.<h4>Design</h4>Non-randomised pilot study.<h4>Setting</h4>Primary care in ... Read more >>

BMJ Open (BMJ open)
[2020, 10(6):e035087]

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Local NO2 concentrations and asthma among over-50s in Ireland: A microdata analysis.

Philip Carthy, Aonghus Ó Domhnaill, Margaret O'Mahony, Anne Nolan, Frank Moriarty, Brian Broderick, Martina Hennessy, Aoife Donnelly, Owen Naughton, Sean Lyons,

BACKGROUND:Links between air pollution and asthma are less well established for older adults than some younger groups. Nitrogen dioxide (NO2) concentrations are widely used as an indicator of transport-related air pollution, and some literature suggests NO2 may directly affect asthma. METHODS:This study used data on 8162 adults >50 years old in ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2020, :]

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How many medications do doctors in primary care use? An observational study of the DU90% indicator in primary care in England.

Chiamaka Chiedozie, Mark Murphy, Tom Fahey, Frank Moriarty,

Aim: To apply the DU90% indicator (the number of unique drugs which make up 90% of a doctor's prescribing) to GP practices prescribing in England to examine time trends, practice-level variation, and relationships with practice characteristics Method: This is an observational cohort study of all general practices in England. ... Read more >>

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Cognitive decline associated with anticholinergics, benzodiazepines, and Z-drugs: findings from The Irish Longitudinal Study on Ageing (TILDA)

Frank Moriarty, George Savva, Carlota Grossi, Kathleen Bennett, Chris Fox, Ian Maidment, Yoon Loke, Nicholas Steel, Rose Anne Kenny, Kathryn Richardson,

<h4>Aim</h4> To estimate the association between patterns of anticholinergic, benzodiazepine, and Z-drug medication use and change in cognitive function in middle-aged and older adults. <h4>Method</h4> This prospective cohort study used data from the first three waves of The Irish Longitudinal Study on Ageing (TILDA), including community-dwelling adults aged ≥50 years ... Read more >>

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Quality, scope and reporting standards of randomised controlled trials in Irish Health Research: an observational study.

Barbara Clyne, Fiona Boland, Norah Murphy, Edel Murphy, Frank Moriarty, Alan Barry, Emma Wallace, Tatyana Devine, Susan M Smith, Declan Devane, Andrew Murphy, Tom Fahey,

<h4>Background</h4>Despite efforts to improve the accuracy and transparency of the design, conduct, and reporting of randomised controlled trials (RCTs), deficiencies remain. Such deficiencies contribute to significant, avoidable waste of health research investment and impede reproducibility. This study aimed to synthesise and critically analyse changes over time in the conduct and ... Read more >>

Trials (Trials)
[2020, 21(1):494]

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The Development of an Accreditation Framework for Continuing Education Activities for Pharmacists.

Sarah Drumm, Frank Moriarty, Michael J Rouse, David Croke, Catriona Bradley,

Accreditation is the recognition that an educational activity meets certain standards. The processes for accreditation vary considerably depending on the type of activity, and currently there are differing accreditation systems in place for pharmacy continuing education (CE) across different countries. Research was carried out on a selection of these systems ... Read more >>

Pharmacy (Basel) (Pharmacy (Basel, Switzerland))
[2020, 8(2):]

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More than coffee - a World Café to explore enablers of pharmacy practice research.

Oisín N Kavanagh, Frank Moriarty, Catriona Bradley, James O'Hagan, Gary Stack, Dervla Kelly,

BACKGROUND:Pharmacists are in demand now more than ever to provide high-quality expertise about the effectiveness, safety and use of medications. Amidst an increasingly complex and costly healthcare system, policy makers need robust evidence to justify public spending on pharmacy services. Research on the impact of existing and emerging pharmacy practices ... Read more >>

Int J Pharm Pract (The International journal of pharmacy practice)
[2020, 28(5):512-521]

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The effectiveness of integrating clinical pharmacists within general practice to optimise prescribing and health outcomes in primary care patients with polypharmacy: A protocol for a systematic review

Aisling Croke, Oscar James, Barbara Clyne, Frank Moriarty, Karen Cardwell, Susan Smith,

Introduction: Coordinating prescribing for patients with polypharmacy is a challenge for general practitioners. Pharmacists may improve management and outcomes for patients with polypharmacy. This systematic review aims to examine the clinical and cost-effectiveness of pharmacist interventions to optimise prescribing and improve health outcomes in patients with polypharmacy in primary care ... Read more >>

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Efficacy and safety of sacubitril/valsartan in the treatment of heart failure: protocol for a systematic review incorporating unpublished clinical study reports.

David Byrne, Tom Fahey, Frank Moriarty,

Background: Sacubitril/valsartan is a first-in-class angiotensin-receptor neprilysin inhibitor used to treat heart failure with reduced ejection fraction. The evidence base for this novel medication is largely based on one pivotal phase III trial which was stopped early due to significant clinical benefits being shown. However potential limitations in the trial ... Read more >>

HRB Open Res (HRB open research)
[2020, 3:5]

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Efficacy and safety of sacubitril/valsartan in the treatment of heart failure: protocol for a systematic review incorporating unpublished clinical study reports

David Byrne, Tom Fahey, Frank Moriarty,

Background: Sacubitril/valsartan is a first-in-class angiotensin-receptor neprilysin inhibitor used to treat heart failure with reduced ejection fraction. The evidence base for this novel medication is largely based on one pivotal phase III trial which was stopped early due to significant clinical benefits being shown. However potential limitations in the trial ... Read more >>

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The evolution of an evidence based intervention designed to improve prescribing and reduce polypharmacy in older people with multimorbidity and significant polypharmacy in primary care (SPPiRE).

Caroline McCarthy, Frank Moriarty, Emma Wallace, Susan M Smith, ,

<h4>Introduction</h4>By the time an intervention is ready for evaluation in a definitive RCT the context of the evidence base may have evolved. To avoid research waste, it is imperative that intervention design and evaluation is an adaptive process incorporating emerging evidence and novel concepts. The aim of this study is ... Read more >>

J Comorb (Journal of comorbidity)
[2020, 10:2235042X20946243]

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Comparing Potentially Inappropriate Prescribing Tools and Their Association With Patient Outcomes.

Frank Moriarty, Kathleen Bennett, Rose Anne Kenny, Tom Fahey, Caitriona Cahir,

<h4>Objective</h4>To assess the agreement of several different measures of potentially inappropriate prescribing (PIP) in older people and compare their relationship with patient-reported outcomes.<h4>Design</h4>Prospective cohort study including participants in The Irish Longitudinal Study on Ageing (TILDA).<h4>Setting</h4>Waves 1 and 2 of TILDA, a nationally representative aging cohort study.<h4>Participants</h4>A total of 1753 community-dwelling ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2020, 68(3):526-534]

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Potentially serious alcohol-medication interactions and falls in community-dwelling older adults: a prospective cohort study.

Alice Holton, Fiona Boland, Paul Gallagher, Tom Fahey, Frank Moriarty, Rose Anne Kenny, Gráinne Cousins,

OBJECTIVE:To investigate the association between potentially serious alcohol-medication interactions (POSAMINO criteria), hypothesised to increase the risk of falls in older adults, and falls in community-dwelling older adults at two and 4 years follow-up. DESIGN:A prospective cohort study. SETTING:The Irish Longitudinal Study on Ageing. SUBJECTS:A total of 1,457 community-dwelling older adults ... Read more >>

Age Ageing (Age and ageing)
[2019, 48(6):824-831]

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Evaluation of the General Practice Pharmacist (GPP) intervention to optimise prescribing in Irish primary care: a non-randomised pilot study

Karen Cardwell, Susan Smith, Barbara Clyne, Laura McCullagh, Emma Wallace, Ciara Kirke, Tom Fahey, Frank Moriarty,

<h4>Objective</h4> Limited evidence suggests integration of pharmacists into the general practice team could improve medicines management for patients, particularly those with multimorbidity and polypharmacy. This study aimed to develop and assess the feasibility of an intervention involving pharmacists, working within general practices, to optimise prescribing in Ireland. <h4>Design</h4> Non-randomised pilot ... Read more >>

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Association of Antidepressants With Recurrent, Injurious and Unexplained Falls is Not Explained by Reduced Gait Speed.

Orna A Donoghue, Robert Briggs, Frank Moriarty, Rose Anne Kenny,

<h4>Objective</h4>To examine if antidepressants at baseline are associated with falls and syncope over 4 years follow-up and if any observed associations are explained by baseline gait speed.<h4>Design</h4>Longitudinal study (three waves).<h4>Setting</h4>The Irish Longitudinal Study on Ageing (TILDA), a nationally representative cohort study.<h4>Participants</h4>Two thousand ninety-three community-dwelling adults aged ≥60 years.<h4>Measurements</h4>Antidepressants (ATC code ... Read more >>

Am J Geriatr Psychiatry (The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry)
[2020, 28(3):274-284]

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A Comparison of Contemporary versus Older Studies of Aspirin for Primary Prevention

Frank Moriarty, Mark Ebell,

<h4>Objective</h4> This study compares the benefits and harms of aspirin for primary prevention before and after widespread use of statins and colorectal cancer screening. <h4>Methods</h4> We compared studies of aspirin for primary prevention that recruited patients from 2005 onward with previous individual patient meta-analyses that recruited patients from 1978 to ... Read more >>

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