Full Text Journal Articles by
Author Frank M Ruemmele

Advertisement

Find full text journal articles






Corona Virus Disease 2019 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology, and Nutrition.

Dan Turner, Ying Huang, Javier Martín-de-Carpi, Marina Aloi, Gili Focht, Ben Kang, Ying Zhou, Cesar Sanchez, Michael D Kappelman, Holm H Uhlig, Gemma Pujol-Muncunill, Oren Ledder, Paolo Lionetti, Jorge Amil Dias, Frank M Ruemmele, Richard K Russell, ,

INTRODUCTION:With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about the risk to children with inflammatory bowel diseases (IBD). We aimed to collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in the era of COVID-19. METHODS:An electronic reporting system of children with IBD ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, 70(6):727-733]

Cited: 0 times

View full text PDF listing >>



Neurological Adverse Effects Associated With Anti-tumor Necrosis Factor Alpha Antibodies in Pediatric Inflammatory Bowel Diseases.

Valérie Bertrand, Nathalie Massy, Bénédicte Pigneur, Stéphanie Coopman, Geneviève Durrieu, Louise Gaboriau, Vincent Langlois, Corinne Gower-Rousseau, Jean-Pierre Hugot, Frank M Ruemmele, ,

OBJECTIVES:Neurological adverse effects (NAEs) induced by biotherapies have been reported in the literature mainly in adult patients with inflammatory bowel disease (IBD), rheumatic diseases, or psoriasis. There are scant data in children. Aims of this study are to report and describe noninfective NAE associated with anti-TNFα antibodies in pediatric IBD, ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, 70(6):841-848]

Cited: 0 times

View full text PDF listing >>



Advertisement

Corticosteroids, but not TNF Antagonists, are Associated with Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results from an International Registry.

Erica J Brenner, Ryan C Ungaro, Richard B Gearry, Gilaad G Kaplan, Michele Kissous-Hunt, James D Lewis, Siew C Ng, Jean-Francois Rahier, Walter Reinisch, Frank M Ruemmele, Flavio Steinwurz, Fox E Underwood, Xian Zhang, Jean-Frederic Colombel, Michael D Kappelman,

Background and Aims:The impact of Coronavirus disease 2019 (COVID-19) on patients with inflammatory bowel disease (IBD) is unknown. We sought to characterize the clinical course of COVID-19 among IBD patients and evaluate the association between demographics, clinical characteristics, and immunosuppressant treatments on COVID-19 outcomes. Methods:Surveillance Epidemiology of Coronavirus Under Research ... Read more >>

Gastroenterology (Gastroenterology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Infectious and digestive complications in glycogen storage disease type Ib: Study of a French cohort.

Camille Wicker, Célina Roda, Ariane Perry, Jean Baptiste Arnoux, Anais Brassier, Martin Castelle, Aude Servais, Jean Donadieu, Juliette Bouchereau, Bénédicte Pigneur, Philippe Labrune, Frank M Ruemmele, Pascale de Lonlay,

Glycogenosis type Ib (GSD1B) causes not only hypoglycemia but also infections and "Crohn's disease like" inflammatory bowel disease (IBD) that can significantly impair patient's quality of life. We retrospectively evaluated infectious and digestive complications in 9 French patients (3 girls, 6 boys) diagnosed at 0.8 years on average, with a mean ... Read more >>

Mol Genet Metab Rep (Molecular genetics and metabolism reports)
[2020, 23:100581]

Cited: 0 times

View full text PDF listing >>



COVID-19 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto group of ESPGHAN.

Dan Turner, Ying Huang, Javier Martín-de-Carpi, Marina Aloi, Gili Focht, Ben Kang, Ying Zhou, Cesar Sanchez, Michael D Kappelman, Holm H Uhlig, Gemma Pujol-Muncunill, Oren Ledder, Paolo Lionetti, Jorge Amil Dias, Frank M Ruemmele, Richard K Russell, ,

INTRODUCTION:With the current COVID-19 pandemic, concerns have been raised about the risk to children with inflammatory bowel diseases (IBD). We aimed to collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in the era of COVID-19. METHODS:An electronic reporting system of children with IBD infected with SARS-CoV-2 ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Neurological Adverse Effects Associated with anti-TNF Alpha Antibodies in Pediatric Inflammatory Bowel Diseases.

Valérie Bertrand, Nathalie Massy, Bénédicte Pigneur, Stéphanie Coopman, Geneviève Durrieu, Louise Gaboriau, Vincent Langlois, Corinne Gower-Rousseau, Jean-Pierre Hugot, Frank M Ruemmele, ,

OBJECTIVES:neurologic adverse effects (NAE) induced by biotherapies have been reported in the literature mainly in adult patients with inflammatory bowel disease (IBD), rheumatic diseases or psoriasis. There are scant data in children. Aims of this study are to report and describe non-infective NAE associated with anti-TNFα antibodies in pediatric IBD, ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Nutritional interventions for the treatment of IBD: current evidence and controversies.

Bénédicte Pigneur, Frank M Ruemmele,

Environmental factors, particularly diet, are the focus of current research as potential triggers of inflammatory bowel disease (IBD). Epidemiological cohort data showing a rapid increase of IBD in western countries and the emergence of IBD in developing countries paralleling the introduction of a western diet are indirect arguments linking food ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2019, 12:1756284819890534]

Cited: 0 times

View full text PDF listing >>



Safety of anti-TNF biologics in paediatric inflammatory bowel disease.

Frank M Ruemmele,

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2019, 4(11):813-815]

Cited: 0 times

View full text PDF listing >>



Mucosal Healing and Bacterial Composition in Response to Enteral Nutrition Vs Steroid-based Induction Therapy-A Randomised Prospective Clinical Trial in Children With Crohn's Disease.

Bénédicte Pigneur, Patricia Lepage, Stanislas Mondot, Jacques Schmitz, Olivier Goulet, Joël Doré, Frank M Ruemmele,

AIMS:Exclusive enteral nutrition [EEN] is as efficacious as corticosteroids [CS] to induce remission in Crohn's disease [CD], without their adverse effects. EEN seems to be more efficient than steroids to induce mucosal healing, but the underlying molecular mechanisms are only sparsely understood. We aimed in the present work to study ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2019, 13(7):846-855]

Cited: 2 times

View full text PDF listing >>



Diagnostic and Therapeutic Approach in Paediatric Inflammatory Bowel Diseases: Results from a Clinical Practice Survey.

Jiri Bronsky, Lissy de Ridder, Frank M Ruemmele, Anne Griffiths, Stephan Buderus, Ondrej Hradsky, Almuthe Christina Hauer,

OBJECTIVES:Despite existence of international guidelines for diagnosis and management of inflammatory bowel diseases (IBD) in children, there might be differences in the clinical approach. METHODS:A survey on clinical practice in paediatric IBD was performed among members of the ESPGHAN Porto IBD working group and interest group, PIBD-NET, and IBD networks ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2019, 68(5):676-683]

Cited: 0 times

View full text PDF listing >>



Development and Validation of the Mucosal Inflammation Noninvasive Index For Pediatric Crohn's Disease.

Martinus A Cozijnsen, Assaf Ben Shoham, Ben Kang, Byung-Ho Choe, Yon Ho Choe, Maria M E Jongsma, Richard K Russell, Frank M Ruemmele, Johanna C Escher, Lissy de Ridder, Sibylle Koletzko, Javier Martín-de-Carpi, Jeffrey Hyams, Thomas Walters, Anne Griffiths, Dan Turner,

BACKGROUND & AIMS:Mucosal healing (MH) has become a goal of therapy for Crohn's disease (CD), but frequent endoscopies are not feasible. We aimed to develop and validate a non-invasive index to assess mucosal inflammation in children with CD. METHODS:We collected data from the multi-center prospective ImageKids study, in which children ... Read more >>

Clin. Gastroenterol. Hepatol. (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2019, :]

Cited: 0 times

View full text PDF listing >>



Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary.

Dan Turner, Anne M Griffiths, David Wilson, Diane R Mould, Robert N Baldassano, Richard K Russell, Marla Dubinsky, Melvin B Heyman, Lissy de Ridder, Jeffrey Hyams, Javier Martin de Carpi, Laurie Conklin, William A Faubion, Sibylle Koletzko, Athos Bousvaros, Frank M Ruemmele,

INTRODUCTION:The optimal trial design for assessing novel therapies in paediatric IBD (PIBD) is a subject of intense ongoing global discussions and debate among the different stakeholders. However, there is a consensus that the current situation in which most medications used in children with IBD are prescribed as off-label without sufficient ... Read more >>

Gut (Gut)
[2020, 69(1):32-41]

Cited: 0 times

View full text PDF listing >>



The effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in paediatric patients with Crohn's disease: a post hoc analysis.

Jeffrey S Hyams, Marla Dubinsky, Joel Rosh, Frank M Ruemmele, Samantha F Eichner, Jen-Fue Maa, Andreas Lazar, Gabriela Alperovich, Nael M Mostafa, Anne M Robinson,

BACKGROUND:In the IMAgINE 1 study, adalimumab induced and maintained remission of moderate-to-severe Crohn's disease in children. AIM:To assess the efficacy, pharmacokinetics, immunogenicity and safety of immunomodulator and adalimumab combination therapy vs adalimumab monotherapy in paediatric patients with Crohn's disease. METHODS:Patients 6-17 years old with moderate-to-severe Crohn's disease (n = 192) received weight-based adalimumab ... Read more >>

Aliment. Pharmacol. Ther. (Alimentary pharmacology & therapeutics)
[2019, 49(2):155-164]

Cited: 1 time

View full text PDF listing >>



Efficacy of Adalimumab for Treatment of Perianal Fistula in Children with Moderately to Severely Active Crohn's Disease: Results from IMAgINE 1 and IMAgINE 2.

Frank M Ruemmele, Joel Rosh, William A Faubion, Marla C Dubinsky, Dan Turner, Andreas Lazar, Samantha Eichner, Jen-Fue Maa, Gabriela Alperovich, Anne M Robinson, Jeffrey S Hyams,

Background and Aims:Adalimumab has been shown to be more effective than placebo in healing fistulae in adults with moderately to severely active Crohn's disease. The efficacy and safety of adalimumab in healing fistulae in children/adolescents with Crohn's disease from the 52-week IMAgINE 1 clinical trial, and its open-label extension IMAgINE ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2018, 12(10):1249-1254]

Cited: 2 times

View full text PDF listing >>



Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds.

Fabienne Charbit-Henrion, Bernadette Bègue, Anaïs Sierra, Sylvain Hanein, Marie-Claude Stolzenberg, Zhi Li, Sandra Pellegrini, Nicolas Garcelon, Marc Jeanpierre, Bénédicte Neven, Isabelle Loge, Capucine Picard, Jérémie Rosain, Jacinta Bustamante, Marc Le Lorc'h, Bénédicte Pigneur, Alicia Fernandes, , Frédéric Rieux-Laucat, Jorge Amil Dias, Frank M Ruemmele, Nadine Cerf-Bensussan,

Mutations in interleukin-10 receptor (IL-10R) genes are one cause of very early-onset inflammatory bowel disease with perianal lesions, which can be cured by hematopoietic stem cell transplantation. Using a functional test, which assesses responsiveness of peripheral monocytes to IL-10, we identified three unrelated Portuguese patients carrying two novel IL-10RB mutations. ... Read more >>

PLoS ONE (PloS one)
[2018, 13(10):e0205826]

Cited: 0 times

View full text PDF listing >>



Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Evidence-based Consensus Guideline From the European Crohn's and Colitis Organization and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition.

Dan Turner, Frank M Ruemmele, Esther Orlanski-Meyer, Anne M Griffiths, Javier Martin de Carpi, Jiri Bronsky, Gabor Veres, Marina Aloi, Caterina Strisciuglio, Christian P Braegger, Amit Assa, Claudio Romano, Séamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy de Ridder, Konstantinos H Katsanos, Nick Croft, Víctor Manuel Navas-López, David C Wilson, Sally Lawrence, Richard K Russell,

BACKGROUND AND AIM:Acute severe colitis (ASC) is one of the few emergencies in pediatric gastroenterology. Tight monitoring and timely medical and surgical interventions may improve outcomes and minimize morbidity and mortality. We aimed to standardize daily treatment of ASC in children through detailed recommendations and practice points which are based ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2018, 67(2):292-310]

Cited: 5 times

View full text PDF listing >>



Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition.

Dan Turner, Frank M Ruemmele, Esther Orlanski-Meyer, Anne M Griffiths, Javier Martin de Carpi, Jiri Bronsky, Gabor Veres, Marina Aloi, Caterina Strisciuglio, Christian P Braegger, Amit Assa, Claudio Romano, Séamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy de Ridder, Konstantinos Katsanos, Nick Croft, Victor Navas-López, David C Wilson, Sally Lawrence, Richard K Russell,

BACKGROUND:The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% of children needing a colectomy within childhood years. We thus aimed to standardize daily treatment of pediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations and practice points. METHODS:These guidelines are a joint effort of ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2018, 67(2):257-291]

Cited: 7 times

View full text PDF listing >>



Diagnostic Yield of Next-generation Sequencing in Very Early-onset Inflammatory Bowel Diseases: A Multicentre Study.

Fabienne Charbit-Henrion, Marianna Parlato, Sylvain Hanein, Rémi Duclaux-Loras, Jan Nowak, Bernadette Begue, Sabine Rakotobe, Julie Bruneau, Cécile Fourrage, Olivier Alibeu, Frédéric Rieux-Laucat, Eva Lévy, Marie-Claude Stolzenberg, Fabienne Mazerolles, Sylvain Latour, Christelle Lenoir, Alain Fischer, Capucine Picard, Marina Aloi, Jorge Amil Dias, Mongi Ben Hariz, Anne Bourrier, Christian Breuer, Anne Breton, Jiri Bronski, Stephan Buderus, Mara Cananzi, Stéphanie Coopman, Clara Crémilleux, Alain Dabadie, Clémentine Dumant-Forest, Odul Egritas Gurkan, Alexandre Fabre, Aude Fischer, Marta German Diaz, Yago Gonzalez-Lama, Olivier Goulet, Graziella Guariso, Neslihan Gurcan, Matjaz Homan, Jean-Pierre Hugot, Eric Jeziorski, Evi Karanika, Alain Lachaux, Peter Lewindon, Rosa Lima, Fernando Magro, Janos Major, Georgia Malamut, Emmanuel Mas, Istvan Mattyus, Luisa M Mearin, Jan Melek, Victor Manuel Navas-Lopez, Anders Paerregaard, Cecile Pelatan, Bénédicte Pigneur, Isabel Pinto Pais, Julie Rebeuh, Claudio Romano, Nadia Siala, Caterina Strisciuglio, Michela Tempia-Caliera, Patrick Tounian, Dan Turner, Vaidotas Urbonas, Stéphanie Willot, Frank M Ruemmele, Nadine Cerf-Bensussan,

BACKGROUND AND AIMS:An expanding number of monogenic defects have been identified as causative of severe forms of very early-onset inflammatory bowel diseases [VEO-IBD]. The present study aimed at defining how next-generation sequencing [NGS] methods can be used to improve identification of known molecular diagnosis and to adapt treatment. METHODS:A total ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2018, 12(9):1104-1112]

Cited: 2 times

View full text PDF listing >>



Chapter 5.1.4. Paediatric Immune-related Enteropathies.

Frank M Ruemmele, John Walker-Smith, Jorge-Amil Dias, Olivier Goulet, Simon Murch,

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2018, 66 Suppl 1:S68-S70]

Cited: 0 times

View full text PDF listing >>



Focus/Summary.

Frank M Ruemmele,

Ann. Nutr. Metab. (Annals of nutrition & metabolism)
[2018, 73 Suppl 4:38]

Cited: 0 times

View full text PDF listing >>



Non-Celiac Gluten Sensitivity: A Challenging Diagnosis in Children with Abdominal Pain.

Frank M Ruemmele,

Several disorders related to the ingestion of gluten are well recognized despite overlapping clinical presentations: celiac disease, an autoimmune enteropathy triggered by gluten ingestions in susceptible individuals, allergy to wheat, and more recently non-celiac gluten sensitivity (NCGS). While celiac disease and wheat allergy are well-known disorders with a clear-cut diagnosis ... Read more >>

Ann. Nutr. Metab. (Annals of nutrition & metabolism)
[2018, 73 Suppl 4:39-46]

Cited: 0 times

View full text PDF listing >>



Editorial.

Frank M Ruemmele,

Ann. Nutr. Metab. (Annals of nutrition & metabolism)
[2018, 73 Suppl 4:5-6]

Cited: 0 times

View full text PDF listing >>



Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.

Federica Barzaghi, Laura Cristina Amaya Hernandez, Benedicte Neven, Silvia Ricci, Zeynep Yesim Kucuk, Jack J Bleesing, Zohreh Nademi, Mary Anne Slatter, Erlinda Rose Ulloa, Anna Shcherbina, Anna Roppelt, Austen Worth, Juliana Silva, Alessandro Aiuti, Luis Murguia-Favela, Carsten Speckmann, Magda Carneiro-Sampaio, Juliana Folloni Fernandes, Safa Baris, Ahmet Ozen, Elif Karakoc-Aydiner, Ayca Kiykim, Ansgar Schulz, Sandra Steinmann, Lucia Dora Notarangelo, Eleonora Gambineri, Paolo Lionetti, William Thomas Shearer, Lisa R Forbes, Caridad Martinez, Despina Moshous, Stephane Blanche, Alain Fisher, Frank M Ruemmele, Come Tissandier, Marie Ouachee-Chardin, Frédéric Rieux-Laucat, Marina Cavazzana, Waseem Qasim, Barbarella Lucarelli, Michael H Albert, Ichiro Kobayashi, Laura Alonso, Cristina Diaz De Heredia, Hirokazu Kanegane, Anita Lawitschka, Jong Jin Seo, Marta Gonzalez-Vicent, Miguel Angel Diaz, Rakesh Kumar Goyal, Martin G Sauer, Akif Yesilipek, Minsoo Kim, Yesim Yilmaz-Demirdag, Monica Bhatia, Julie Khlevner, Erick J Richmond Padilla, Silvana Martino, Davide Montin, Olaf Neth, Agueda Molinos-Quintana, Justo Valverde-Fernandez, Arnon Broides, Vered Pinsk, Antje Ballauf, Filomeen Haerynck, Victoria Bordon, Catharina Dhooge, Maria Laura Garcia-Lloret, Robbert G Bredius, Krzysztof Kałwak, Elie Haddad, Markus Gerhard Seidel, Gregor Duckers, Sung-Yun Pai, Christopher C Dvorak, Stephan Ehl, Franco Locatelli, Frederick Goldman, Andrew Richard Gennery, Mort J Cowan, Maria-Grazia Roncarolo, Rosa Bacchetta, ,

BACKGROUND:Immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) syndrome is a monogenic autoimmune disease caused by FOXP3 mutations. Because it is a rare disease, the natural history and response to treatments, including allogeneic hematopoietic stem cell transplantation (HSCT) and immunosuppression (IS), have not been thoroughly examined. OBJECTIVE:This analysis sought to evaluate disease onset, progression, ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2018, 141(3):1036-1049.e5]

Cited: 12 times

View full text PDF listing >>



Growth Improvement with Adalimumab Treatment in Children with Moderately to Severely Active Crohn's Disease.

Thomas D Walters, William A Faubion, Anne M Griffiths, Robert N Baldassano, Johanna Escher, Frank M Ruemmele, Jeffrey S Hyams, Andreas Lazar, Samantha Eichner, Bidan Huang, Yao Li, Roopal B Thakkar,

Growth failure is common in children with Crohn's disease. The effect of adalimumab (ADA), a fully human antitumor necrosis factor antagonist, on height velocity in pediatric patients with baseline (BL) linear growth impairment in the IMAgINE 1 trial is presented.This analysis included female and male patients with growth potential (bone ... Read more >>

Inflamm. Bowel Dis. (Inflammatory bowel diseases)
[2017, 23(6):967-975]

Cited: 4 times

View full text PDF listing >>



Quality Items Required for Running a Paediatric Inflammatory Bowel Disease Centre: An ECCO Paper.

Dan Turner, Adam Carle, Steven J Steiner, Peter A Margolis, Richard B Colletti, Richard K Russell, Arie Levine, Kaija-Leena Kolho, Frank M Ruemmele, ,

The importance of a holistic approach with a comprehensive multidisciplinary team, including nutritional and psychosocial support, is becoming well recognised as a key contributor to optimal care in paediatric inflammatory bowel disease [IBD]. The Paediatric committee of ECCO [P-ECCO] aimed to determine important components that would contribute to quality of ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2017, 11(8):981-987]

Cited: 5 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0673 s