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Author Frank Lammert

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Vulnerability to alcohol-associated liver disease: A tale of two systems.

Ersin Karatayli, Frank Lammert,

Hepatology (Hepatology (Baltimore, Md.))
[2022, 75(2):246-247]

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Neglected geriatric assessment and overtreatment of older patients with pancreatic cancer - Results from a prospective phase IV clinical trial.

Johannes Betge, Nadine Schulte, Sebastian Belle, Tianzuo Zhan, Beate Krammer-Steiner, Jean-Charles Moulin, Matthias Kleiß, Frank Lammert, Ulrich Wedding, Sebastian Räth, Martin Maenz, Lisa Hegele, Julian Larcher-Senn, Ralf Jesenofsky, Matthias P Ebert, Nicolai Härtel,

<h4>Background</h4>Older patients with metastatic pancreatic cancer may suffer increased toxicity from intensive chemotherapy. Treatment individualization by geriatric assessment (GA) might improve functional outcome.<h4>Methods</h4>We performed a multicenter, phase IV, open label trial in patients ≥70 years with metastatic pancreatic adenocarcinoma. Patients underwent GA and were assigned to one of three categories based ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2022, :]

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Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population.

Isabel Graupera, Maja Thiele, Miquel Serra-Burriel, Llorenç Caballeria, Dominique Roulot, Grace Lai-Hung Wong, Núria Fabrellas, Indra Neil Guha, Anita Arslanow, Carmen Expósito, Rosario Hernández, Guruprasad Padur Aithal, Peter R Galle, Guillem Pera, Vincent Wai-Sun Wong, Frank Lammert, Pere Ginès, Laurent Castera, Aleksander Krag, ,

<h4>Background & aims</h4>Fibrosis-4 (FIB-4) and the nonalcoholic fatty liver disease fibrosis score (NFS) are the 2 most popular noninvasive blood-based serum tests proposed for widespread fibrosis screening. We therefore aimed to describe the accuracy of FIB-4 and NFS to detect elevated liver stiffness as an indicator of hepatic fibrosis in ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis.

Hamish Innes, Hans Dieter Nischalke, Indra Neil Guha, Karl Heinz Weiss, Will Irving, Daniel Gotthardt, Eleanor Barnes, Janett Fischer, M Azim Ansari, Jonas Rosendahl, Shang-Kuan Lin, Astrid Marot, Vincent Pedergnana, Markus Casper, Jennifer Benselin, Frank Lammert, John McLauchlan, Philip L Lutz, Victoria Hamill, Sebastian Mueller, Joanne R Morling, Georg Semmler, Florian Eyer, Johann von Felden, Alexander Link, Arndt Vogel, Jens U Marquardt, Stefan Sulk, Jonel Trebicka, Luca Valenti, Christian Datz, Thomas Reiberger, Clemens Schafmayer, Thomas Berg, Pierre Deltenre, Jochen Hampe, Felix Stickel, Stephan Buch,

The host genetic background for hepatocellular carcinoma (HCC) is incompletely understood. We aimed to determine if four germline genetic polymorphisms, rs429358 in apolipoprotein E (APOE), rs2642438 in mitochondrial amidoxime reducing component 1 (MARC1), rs2792751 in glycerol-3-phosphate acyltransferase (GPAM), and rs187429064 in transmembrane 6 superfamily member 2 (TM6SF2), previously associated with ... Read more >>

Hepatol Commun (Hepatology communications)
[2021, :]

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MARC1 p.A165T variant is associated with decreased markers of liver injury and enhanced antioxidant capacity in autoimmune hepatitis.

Maciej K Janik, Wiktor Smyk, Beata Kruk, Benedykt Szczepankiewicz, Barbara Górnicka, Magdalena Lebiedzińska-Arciszewska, Yaiza Potes, Inês C M Simões, Susanne N Weber, Frank Lammert, Mariusz R Więckowski, Piotr Milkiewicz, Marcin Krawczyk,

The clinical picture of autoimmune hepatitis (AIH) varies markedly between patients, potentially due to genetic modifiers. The aim of this study was to evaluate genetic variants previously associated with fatty liver as potential modulators of the AIH phenotype. The study cohort comprised 313 non-transplanted adults with AIH. In all patients, ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):24407]

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Population screening for liver fibrosis: Toward early diagnosis and intervention for chronic liver diseases.

Pere Ginès, Laurent Castera, Frank Lammert, Isabel Graupera, Miquel Serra-Burriel, Alina M Allen, Vincent Wai-Sun Wong, Phillipp Hartmann, Maja Thiele, Llorenç Caballeria, Robert J de Knegt, Ivica Grgurevic, Salvador Augustin, Emmanuel A Tsochatzis, Jörn M Schattenberg, Indra Neil Guha, Andrea Martini, Rosa M Morillas, Montserrat Garcia-Retortillo, Harry J de Koning, Núria Fabrellas, Judit Pich, Ann T Ma, M Alba Diaz, Dominique Roulot, Philip N Newsome, Michael Manns, Patrick S Kamath, Aleksander Krag, ,

Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non-alcoholic fatty liver disease and alcohol-related liver disease, although chronic hepatitis B and C infections are still major etiological factors in some areas of the world. Recent studies have shown ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2022, 75(1):219-228]

Cited: 2 times

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Acute cholestatic liver injury following carbimazole treatment in a patient with VPS33B haploinsufficiency.

Thomas Adams, Roman Liebe, Johannes Lehmann, Marcin Krawczyk, Frank Lammert,

Clin Res Hepatol Gastroenterol (Clinics and research in hepatology and gastroenterology)
[2021, 46(3):101803]

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Prognostic performance of the 'DICA' endoscopic classification and the 'CODA' score in predicting clinical outcomes of diverticular disease: an international, multicentre, prospective cohort study.

Antonio Tursi, Giovanni Brandimarte, Francesco Di Mario, Walter Elisei, Marcello Picchio, Leonardo Allegretta, Maria Laura Annunziata, Mauro Bafutto, Gabrio Bassotti, Maria Antonietta Bianco, Raffaele Colucci, Rita Conigliaro, Dan Dumitrascu, Ricardo Escalante, Luciano Ferrini, Giacomo Forti, Marilisa Franceschi, Maria Giovanna Graziani, Frank Lammert, Giovanni Latella, Giovanni Maconi, Gerardo Nardone, Lucia Camara de Castro Oliveira, Enio Chaves Oliveira, Alfredo Papa, Savvas Papagrigoriadis, Anna Pietrzak, Stefano Pontone, Tomas Poskus, Giuseppe Pranzo, Matthias Christian Reichert, Stefano Rodinò, Jaroslaw Regula, Giuseppe Scaccianoce, Franco Scaldaferri, Roberto Vassallo, Costantino Zampaletta, Angelo Zullo, Daniele Piovani, Stefanos Bonovas, Silvio Danese, ,

<h4>Objective</h4>To investigate the predictive value of the Diverticular Inflammation and Complication Assessment (DICA) classification and to develop and validate a combined endoscopic-clinical score predicting clinical outcomes of diverticulosis, named Combined Overview on Diverticular Assessment (CODA).<h4>Design</h4>A multicentre, prospective, international cohort study.<h4>Setting</h4>43 gastroenterology and endoscopy centres located in Europe and South America.<h4>Participants</h4>2215 ... Read more >>

Gut (Gut)
[2021, :]

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[Impact of Covid 19 on endoscopy in Germany].

Maria Kahn, Stephan Zellmer, Alanna Ebigbo, Anna Muzalyova, Johanna Classen, Vivien Grünherz, Janis Böser, Lutz P Breitling, Albert Beyer, Jonas Rosendahl, Frank Lammert, Claudia Traidl-Hoffmann, Helmut Messmann, Christoph Römmele,

<h4>Background</h4>Practices and hospitals are facing great challenges in coping with the COVID-19-pandemic. So far, data on the impact of the pandemic on gastroenterological facilities are lacking, especially on a temporal course. A database is lacking, especially for the outpatient care sector. University Hospital of Augsburg was commissioned to generate data ... Read more >>

Z Gastroenterol (Zeitschrift fur Gastroenterologie)
[2021, 59(12):1278-1287]

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Health-care workers in gastrointestinal endoscopy are at higher risk for SARS-CoV-2 infection compared to other aerosol-generating disciplines

Christoph Römmele, Alanna Ebigbo, Maria Kahn, Stephan Zellmer, Anna Muzalyova, Gertrud Hammel, Christina Bartenschlager, Albert Beyer, Jonas Rosendahl, Tilo Schlittenbauer, Johannes Zenk, Bilal Al-Nawas, Roland Frankenberger, Jürgen Hoffmann, Christoph Arens, Frank Lammert, Claudia Traidl-Hoffmann, Helmut Messmann,

<h4>ABSTRACT</h4> <h4>Objective</h4> Healthcare workers (HCW) are at high risk of SARS-CoV-2 infection due to exposure to potentially infectious material, especially during aerosol-generating procedures (AGP). We aimed to investigate the prevalence of infection among HCW in medical disciplines with AGP. <h4>Design</h4> A nationwide questionnaire-based study in in- and outpatient settings was ... Read more >>

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Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19

Lorenz Thurner, Natalie Fadle, Moritz Bewarder, Igor Kos, Evi Regitz, Bernhard Thurner, Yvan Fischer, Onur Cetin, Torben Rixecker, Marie-Christin Hoffmann, Klaus-Dieter Preuss, Claudia Schormann, Frank Neumann, Sylvia Hartmann, Theresa Bock, Dominic Kaddu-Mulindwa, Birgit Bette, Klaus Roemer, Joerg Thomas Bittenbring, Konstantinos Christofyllakis, Angelika Bick, Vadim Lesan, Zanir Abdi, Sebastian Mang, André Becker, Carlos Metz, Frederik Seiler, Johannes Lehmann, Thomas Adams, Phiilpp Agne, Andreas Link, Christian Werner, Angela Thiel-Bodenstaff, Matthias Reichert, Guy Danziger, Sophie Roth, Cihan Papan, Jan Pilch, Thorsten Pfuhl, Patrick Wächter, Christian Herr, Stefan Lohse, Hubert Schrezenmeier, Michael Boehm, Frank Langer, Gereon Gaebelein, Bettina Friesenhahn-Ochs, Christoph Kessel, Dirk Foell, Robert Bals, Frank Lammert, Sixten Körper, Jürgen Rissland, Christian Lensch, Stephan Stilgenbauer, Soeren Becker, Sigrun Smola, Marcin Krawczyk, Philipp Lepper,

Hyperinflammation is frequently observed in patients with severe COVID-19. Inadequate and defective IFN type I responses against SARS-CoV-2, associated with autoantibodies in a proportion of patients, lead to severe courses of disease. In addition, hyperactive responses of the humoral immune system have been described. In the current study we investigated ... Read more >>

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Hypophosphatasia: An Underappreciated Cause of Atraumatic Stress Fractures.

Grigorios Christidis, Thomas Martin, Franz Walter, Frank Lammert, Marcin Krawczyk,

Am J Med (The American journal of medicine)
[2022, 135(1):e18-e19]

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Intrahepatic cholestasis of pregnancy in conjunction with a frameshift deletion in FGFR4.

Syeda Saima Batool, Marc Dauer, Susanne Nicole Weber, Roman Liebe, Frank Lammert, Matthias Christian Reichert,

Intrahepatic cholestasis of pregnancy (ICP) is characterized by increased serum bile acid levels in the third trimester of pregnancy and resolves quickly after delivery. Here, we present the case of a 29-year-old woman who developed idiopathic liver damage during puberty, and subsequently ICP and severe pruritus during two pregnancies. DNA ... Read more >>

Clin Res Hepatol Gastroenterol (Clinics and research in hepatology and gastroenterology)
[2021, 46(3):101800]

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Protective Effects of Statin Therapy in Cirrhosis Are Limited by a Common SLCO1B1 Transporter Variant.

Melissa Merkel, Christina Schneider, Robin Greinert, Alexander Zipprich, Cristina Ripoll, Frank Lammert, Matthias C Reichert,

Complications of cirrhosis and portal hypertension (PH) can be reduced by statin therapy. The common loss-of-function variant p.V174A in the solute carrier organic anion transporter gene 1B1 (SLCO1B1) gene encoding the organic anion transporting polypeptide 1B1 results in decreased hepatic uptake of statins. Our specific aim was to assess the ... Read more >>

Hepatol Commun (Hepatology communications)
[2021, 5(10):1755-1766]

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Management of Intrahepatic Cholestasis of Pregnancy: Recommendations of the Working Group on Obstetrics and Prenatal Medicine - Section on Maternal Disorders.

Carsten Hagenbeck, Amr Hamza, Sven Kehl, Holger Maul, Frank Lammert, Verena Keitel, Matthias C Hütten, Ulrich Pecks,

Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease specific to pregnancy. The cardinal symptom of pruritus and a concomitant elevated level of bile acids in the serum and/or alanine aminotransferase (ALT) are suggestive for the diagnosis. Overall, the maternal prognosis is good. The fetal outcome depends on ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2021, 81(8):922-939]

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Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study).

Cornelius Engelmann, Adam Herber, Annegret Franke, Tony Bruns, Philipp Reuken, Ingolf Schiefke, Alexander Zipprich, Stefan Zeuzem, Tobias Goeser, Ali Canbay, Christoph Berg, Jonel Trebicka, Frank E Uschner, Johannes Chang, Tobias Mueller, Niklas Aehling, Moritz Schmelzle, Katrin Splith, Frank Lammert, Christian M Lange, Christoph Sarrazin, Christian Trautwein, Michael Manns, Dieter Häussinger, Jan Pfeiffenberger, Peter R Galle, Anett Schmiedeknecht, Thomas Berg,

<h4>Background & aims</h4>Based on positive results from small single center studies, granulocyte-colony stimulating factor (G-CSF) is being widely used for the treatment of patients with acute-on-chronic liver failure (ACLF). Herein, we aimed to evaluate the safety and efficacy of G-CSF in patients with ACLF.<h4>Methods</h4>In this multicenter, prospective, controlled, open-label phase ... Read more >>

J Hepatol (Journal of hepatology)
[2021, 75(6):1346-1354]

Cited: 4 times

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High glucose enhances antigen-independent CTL killing via TRAIL

Wenjuan Yang, Andreas Denger, Caroline Diener, Frederic Küppers, Leticia Soriano-Baguet, Gertrud Schäfer, Archana Yanamandra, Renping Zhao, Arne Knörck, Eva Schwarz, Martin Hart, Frank Lammert, Leticia Prates Roma, Dirk Brenner, Grigorios Christidis, Volkhard Helms, Eckart Meese, Markus Hoth, Bin Qu,

Cytotoxic T lymphocytes (CTLs) are involved in development of diabetes. However, the impact of excessive glucose on CTL-mediated antigen-independent killing remains elusive. Here, we report that TNF-related apoptosis inducing ligand (TRAIL) is substantially up- regulated in CTLs in environments with high glucose (HG) both in vitro and in vivo . ... Read more >>

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Drug adherence and psychosocial characteristics of patients presenting with hypertensive urgency at the emergency department.

Lucas Lauder, Sebastian Ewen, Julius Glasmacher, Frank Lammert, Wolfgang Reith, Naemi Schreiber, Dominic Kaddu-Mulindwa, Christian Ukena, Michael Böhm, Markus R Meyer, Felix Mahfoud,

<h4>Objective</h4>To identify potentially targetable psychosocial factors associated with nonadherence to prescribed antihypertensive medications in patients presenting with hypertensive urgencies at an emergency department.<h4>Methods</h4>This prospective study included patients treated with antihypertensive drugs who presented with hypertensive urgencies (SBP ≥180 mmHg and/or DBP ≥110 mmHg) at the emergency department of a tertiary referral clinic ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(8):1697-1704]

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Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury.

Grigorios Christidis, Ersin Karatayli, Rabea A Hall, Susanne N Weber, Matthias C Reichert, Mathias Hohl, Sen Qiao, Ulrich Boehm, Dieter Lütjohann, Frank Lammert, Senem Ceren Karatayli,

<h4>Background and aims</h4>Fibroblast growth factor (FGF) 21 has recently been shown to play a potential role in bile acid metabolism. We aimed to investigate the FGF21 response in an ethanol-induced acute-on-chronic liver injury (ACLI) model in <i>Abcb4<sup>-/-</sup></i> mice with deficiency of the hepatobiliary phospholipid transporter.<h4>Methods</h4>Total RNA was extracted from wild-type ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(15):]

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[Quality management in the field of gastroenterology - Proposals of the Quality Commission of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) for Outpatient and Inpatient Quality Assurance].

Ludger Leifeld, Ulrike Denzer, Thomas Frieling, Ralf Jakobs, Herbert Koop, Pia van Leeuwen, Ahmed Madisch, Ulrich Rosien, Albrecht Stier, Britta Siegmund, Ulrich Tappe, Frank Lammert, Petra Lynen Jansen,

The quality of the medical care depends on numerous factors that can often be influenced by the doctor itself. It is a great challenge to follow the constant scientific progress in practice. Scientific standards in gastroenterology are defined in DGVS guidelines and regularly revised. The implementation of evidence-based recommendations in ... Read more >>

Z Gastroenterol (Zeitschrift fur Gastroenterologie)
[2021, 59(7):665-676]

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Effects of blocking chemokine receptor CCR1 with BX471 in two models of fibrosis prevention and rescue in mice.

Susanne N Weber, Irina Nowak, Frank Grünhage, Frank Lammert,

<h4>Background</h4>The induction, progression and resolution of liver fibrosis are influenced by multiple chemokines. The inhibition of CCR1 signalling by a specific non-peptide inhibitor (BX471) reduces kidney fibrosis after unilateral ureteral obstruction via suppression of leukocyte recruitment in mice. However, it remains unclear whether selective CCR1 inhibition also affects hepatic fibrogenesis. ... Read more >>

Biochem Biophys Rep (Biochemistry and biophysics reports)
[2021, 27:101077]

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Long-Term Colestyramine Treatment Prevents Cholestatic Attacks in Refractory Benign Recurrent Intrahepatic Cholestasis Type 1 Disease.

Eleni Koukoulioti, Athanasia Ziagaki, Susanne N Weber, Frank Lammert, Thomas Berg,

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(1):522-524]

Cited: 1 time

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Common ABCB4 and ABCB11 genotypes are associated with idiopathic chronic cholestasis in adults.

Christoph Jüngst, Christina Justinger, Janett Fischer, Thomas Berg, Frank Lammert,

Dig Dis (Digestive diseases (Basel, Switzerland))
[2021, :]

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Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD.

Vanda Marques, Marta B Afonso, Nina Bierig, Filipa Duarte-Ramos, Álvaro Santos-Laso, Raul Jimenez-Agüero, Emma Eizaguirre, Luis Bujanda, Maria J Pareja, Rita Luís, Adília Costa, Mariana V Machado, Cristina Alonso, Enara Arretxe, José M Alustiza, Marcin Krawczyk, Frank Lammert, Dina G Tiniakos, Bertram Flehmig, Helena Cortez-Pinto, Jesus M Banales, Rui E Castro, Andrea Normann, Cecília M P Rodrigues,

<b>Background:</b> Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:683250]

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Therapeutic Application of Alpha-1 Antitrypsin in COVID-19.

Felix Ritzmann, Praneeth Chitirala, Nadine Krüger, Markus Hoffmann, Wei Zuo, Frank Lammert, Sigrun Smola, Naveh Tov, Noga Alagem, Philipp M Lepper, Stefan Pöhlmann, Christoph Beisswenger, Christian Herr, Robert Bals, ,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(2):224-227]

Cited: 4 times

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