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Author Franck Monnien

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Treatment algorithm and prognostic factors for patients with stage I-III carcinoma of the anal canal: a 20-year multicenter study.

Diane Bruyere, Franck Monnien, Prudence Colpart, Patrick Roncarati, Lucine Vuitton, Elodie Hendrick, Alexis Lepinoy, Alexandra Luquain, Charlotte Pilard, Thomas Lerho, Chloé Molimard, Philippe Maingon, Laurent Arnould, Marie-Christine Bone-Lepinoy, Laurence Dusserre, Laurent Martin, Celia Reynders, Marie Ancion, Didier Peiffert, Agnès Leroux, Pascale Hubert, Jean-Baptiste Delhorme, Jean-Pierre Ghnassia, Anne-Sophie Woronoff, Philippe Delvenne, Jean-Luc Prétet, Jean-François Bosset, Olivier Peulen, Christiane Mougin, Séverine Valmary-Degano, Michael Herfs,

Despite a growing incidence in developed countries and a recent improved understanding of its pathogenesis, anal cancer management has not evolved over the past decades and drug combination used as first-line regimen still largely depends on clinician preferences. Aiming at paving the way for precision medicine, a large cohort of ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, :]

Cited: 0 times

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Comparison of Molecular and Histologic Ultrastaging Methods in Sentinel Lymph Node Analysis from Clinical Stage II Colon Cancers.

Olivier Deroo, Zaher Lakkis, Brice Paquette, David Grand, Franck Monnien, Sophie Felix, Christophe Borg, Bruno Heyd, Stefano Kim, Séverine Valmary-Degano,

Various studies have demonstrated that occult metastases may be present in patients with clinical stage II colon cancer. The objective of this prospective investigation was to compare the performance of molecular analysis and histologic ultrastaging in detecting occult metastases in sentinel lymph nodes (SLNs). SLNs were collected ex vivo during ... Read more >>

Appl. Immunohistochem. Mol. Morphol. (Applied immunohistochemistry & molecular morphology : AIMM)
[2019, 27(7):e65-e70]

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["Discovering Pathology", a serious game dedicated to the discovery of pathology for medical students].

Anthony Jacquier, Marc Briot, Gilles Barillot, Olivier Deroo, Franck Monnien, Quentin Hurlot, François-Xavier Frenois, François Aubin, Bruno Degano, Christophe Reffay, Séverine Valmary-Degano,

The serious game is a digital concept whose intention is to combine serious aspects with the playful springs of video games. Educational, learning and communication tool's, their production has been growing steadily since the 2000s. France has become the world's second largest producer of serious games, behind the United States ... Read more >>

Ann Pathol (Annales de pathologie)
[2019, 39(2):151-157]

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ATG9A Is Overexpressed in Triple Negative Breast Cancer and Its In Vitro Extinction Leads to the Inhibition of Pro-Cancer Phenotypes.

Aurore Claude-Taupin, Leïla Fonderflick, Thierry Gauthier, Laura Mansi, Jean-René Pallandre, Christophe Borg, Valérie Perez, Franck Monnien, Marie-Paule Algros, Marc Vigneron, Pascale Adami, Régis Delage-Mourroux, Paul Peixoto, Michael Herfs, Michaël Boyer-Guittaut, Eric Hervouet,

Early detection and targeted treatments have led to a significant decrease in mortality linked to breast cancer (BC), however, important issues need to be addressed in the future. One of them will be to find new triple negative breast cancer (TNBC) therapeutic strategies, since none are currently efficiently targeting this ... Read more >>

Cells (Cells)
[2018, 7(12):]

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Down-regulation of A-FABP predicts non-muscle invasive bladder cancer progression: investigation with a long term clinical follow-up.

Christel Mathis, Isabelle Lascombe, Franck Monnien, Hugues Bittard, François Kleinclauss, Isabelle Bedgedjian, Sylvie Fauconnet, Séverine Valmary-Degano,

BACKGROUND:Non-muscle invasive bladder cancers (NMIBC: pTa, pT1) are characterised by a high risk of recurrence and/or progression. Identification of prognostic markers is needed to improve both diagnosis and management of the disease. The aim of this study was to analyse the expression of A-FABP (adipocyte-fatty acid binding protein) and to ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):1239]

Cited: 1 time

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A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Michael Herfs, Patrick Roncarati, Benjamin Koopmansch, Olivier Peulen, Diane Bruyere, Alizee Lebeau, Elodie Hendrick, Pascale Hubert, Aurelie Poncin, William Penny, Nathalie Piazzon, Franck Monnien, David Guenat, Christiane Mougin, Jean-Luc Prétet, Lucine Vuitton, Karin Segers, Frederic Lambert, Vincent Bours, Laurence de Leval, Severine Valmary-Degano, Charles M Quick, Christopher P Crum, Philippe Delvenne,

BACKGROUND:Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be developed. The present article aimed at addressing this information gap by in-depth characterising ... Read more >>

Br. J. Cancer (British journal of cancer)
[2018, 118(10):1302-1312]

Cited: 3 times

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Pediatric Chordomas: Results of a Multicentric Study of 40 Children and Proposal for a Histopathological Prognostic Grading System and New Therapeutic Strategies.

Kévin Beccaria, Arnault Tauziède-Espariat, Franck Monnien, Homa Adle-Biassette, Julien Masliah-Planchon, Gaëlle Pierron, Laetitia Maillot, Marc Polivka, Annie Laquerrière, Sandrine Bouillot-Eimer, Edouard Gimbert, Guillaume Gauchotte, Laurent Coffinet, Henri Sevestre, Claire Alapetite, Stéphanie Bolle, Dominic Thompson, Schahrazed Bouazza, Bernard George, Michel Zérah, Christian Sainte-Rose, Stéphanie Puget, Pascale Varlet,

Pediatric chordomas are rare malignant neoplasms, and few data are available for optimizing therapeutic strategies and outcome. This study aimed at evaluating how best to manage them and to identify prognostic factors. This multicentric retrospective study included 40 children diagnosed with chordomas between 1966 and 2012. Clinical, radiological, and histopathological ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2018, 77(3):207-215]

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Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis.

Arnault Tauziede-Espariat, Béatrice Parfait, Aurore Besnard, Joëlle Lacombe, Johan Pallud, Sanaa Tazi, Stéphanie Puget, Guillaume Lot, Benoît Terris, Joëlle Cohen, Michel Vidaud, Dominique Figarella-Branger, Franck Monnien, Marc Polivka, Homa Adle-Biassette, Pascale Varlet,

Clear cell meningioma (CCM) is a rare grade II histopathological subtype that usually occurs in young patients and displays high recurrence rate. Germline SMARCE1 mutations have been described in hereditary forms of this disease and more recently in small syndromic and sporadic CCM series. The diagnostic value of SMARCE1 in ... Read more >>

Brain Pathol. (Brain pathology (Zurich, Switzerland))
[2018, 28(4):466-474]

Cited: 3 times

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Human papillomaviruses in colorectal cancers: A case-control study in western patients.

Lucine Vuitton, Carine Jaillet, Elise Jacquin, Franck Monnien, Marine Heberle, Maria I Mihai, Catherine Lassabe, Johnny Raffoul, Marc Puyraveau, Zaher Lakkis, Najib Lamfichekh, Alain Picard, Jean-Luc Prétet, Christiane Mougin, Séverine Valmary-Degano,

Colorectal cancer (CRC) is one of the most common cancers. As in other cancer locations, the involvement of human papillomaviruses (HPV) has been suggested but remains highly debated with wide differences among reported prevalence of HPV infection in CRCs.To determine the actual prevalence of high risk HPV16 and 18 in ... Read more >>

Dig Liver Dis (Digestive and Liver Disease)
[2017, 49(4):446-450]

Cited: 1 time

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Somatic mutational spectrum analysis in a prospective series of 104 gastrointestinal stromal tumors.

David Guenat, Olivier Deroo, Sandrine Magnin, Loïc Chaigneau, Franck Monnien, Christophe Borg, Christiane Mougin, Jean-François Emile, Jean-Luc Prétet,

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors distinguished by driver mutations in proto-oncogenes KIT or PDGFRA in 85-90% of cases. These mutations have been linked to the response to imatinib, a multikinase inhibitor, and have independent prognostic impact. Here, we describe the prospective study of the molecular characteristics of 104 GISTs ... Read more >>

Oncol. Rep. (Oncology reports)
[2017, 37(3):1671-1681]

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[Authorization of pathologists for the estimation of the tumor cell percentage on tissue sample for molecular analysis purpose].

Alexandra Luquain, Francine Arbez-Gindre, Isabelle Bedgedjian, Sophie Felix, Jean-Marie Harimenshi, Ionela-Marcela Mihai, Franck Monnien, Cristina Singeorzan, Séverine Valmary-Degano,

Before molecular analysis is performed, morphological control with an estimation of the tumour cell percentage (%TC) could have a major impact on mutation detection. Accreditation according to NF EN ISO 15189 commands an authorization through evaluation of skills. The objective of this work was to validate the empowerment of pathologists to estimate %TC ... Read more >>

Ann Pathol (Annales de pathologie)
[2016, 36(4):268-274]

Cited: 0 times

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Prognostic and Therapeutic Markers in Chordomas: A Study of 287 Tumors.

Arnault Tauziéde-Espariat, Damien Bresson, Marc Polivka, Schahrazed Bouazza, François Labrousse, Eleonora Aronica, Jean-Luc Pretet, Fabrice Projetti, Philippe Herman, Henri Salle, Franck Monnien, Séverine Valmary-Degano, Annie Laquerrière, Marc Pocard, Loïc Chaigneau, Nicolas Isambert, Marie-Hélène Aubriot-Lorton, Loïc Feuvret, Bernard George, Sébastien Froelich, Homa Adle-Biassette,

Chordomas are slow-growing malignant neoplasms. Determination of histopathologic prognostic factors using a large cohort study has been limited by their low incidence. In this retrospective study, we investigated the clinical, histopathologic, and immunohistochemical prognostic factors in 287 chordomas from 111 patients assessed by central pathologic review. Expression patterns of a ... Read more >>

J. Neuropathol. Exp. Neurol. (Journal of neuropathology and experimental neurology)
[2016, 75(2):111-120]

Cited: 19 times

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The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models.

Eric Hervouet, Aurore Claude-Taupin, Thierry Gauthier, Valérie Perez, Annick Fraichard, Pascale Adami, Gilles Despouy, Franck Monnien, Marie-Paule Algros, Michèle Jouvenot, Régis Delage-Mourroux, Michaël Boyer-Guittaut,

The GABARAP family members (GABARAP, GABARAPL1/GEC1 and GABARAPL2 /GATE-16) are involved in the intracellular transport of receptors and the autophagy pathway. We previously reported that GABARAPL1 expression was frequently downregulated in cancer cells while a high GABARAPL1 expression is a good prognosis marker for patients with lymph node-positive breast cancer.In ... Read more >>

BMC Cancer (BMC cancer)
[2015, 15:729]

Cited: 14 times

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Prognostic value of angiopoietin-2 for death risk stratification in patients with metastatic colorectal carcinoma.

Marine Jary, Dewi Vernerey, Thierry Lecomte, Erion Dobi, François Ghiringhelli, Franck Monnien, Yann Godet, Stefano Kim, Olivier Bouché, Serge Fratte, Anthony Gonçalves, Julie Leger, Lise Queiroz, Olivier Adotevi, Franck Bonnetain, Christophe Borg,

Baseline prognostic biomarkers stratifying treatment strategies in first-line metastatic colorectal cancer (mCRC) are lacking. Angiopoietin-2 (Ang-2) is proposed as a potential biomarker in several cancers. We therefore decided to establish the additional prognostic value of Ang-2 for overall survival (OS) in patients with first-line mCRC.We enrolled 177 patients treated with ... Read more >>

Cancer Epidemiol. Biomarkers Prev. (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2015, 24(3):603-612]

Cited: 5 times

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Advanced biliary tract carcinomas: a retrospective multicenter analysis of first and second-line chemotherapy.

Frédéric Fiteni, Marine Jary, Franck Monnien, Thierry Nguyen, Eric Beohou, Martin Demarchi, Erion Dobi, Francine Fein, Denis Cleau, Serge Fratté, Virginie Nerich, Franck Bonnetain, Xavier Pivot, Christophe Borg, Stefano Kim,

BACKGROUND: Gemcitabine/Cisplatin (Gem/CDDP) combination has demonstrated a clear survival advantage over gemcitabine alone and has become a new standard in advanced Biliary Tract Carcinoma (aBTC). However, Gemcitabine/Oxaliplatin (GEMOX) combination and Gemcitabine/Carboplatin (Gem/Carb) combination regimens have shown efficacy in phase II trials and there is no comparative study between different platinum ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2014, 14:143]

Cited: 9 times

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Bifractionated CPT-11 with LV5FU2 infusion (FOLFIRI-3) in combination with bevacizumab: clinical outcomes in first-line metastatic colorectal cancers according to plasma angiopoietin-2 levels.

Stefano Kim, Erion Dobi, Marine Jary, Franck Monnien, Elsa Curtit, Thierry Nguyen, Zaher Lakkis, Bruno Heyd, Serge Fratte, Denis Cléau, Najib Lamfichekh, Virginie Nerich, Boris Guiu, Martin Demarchi, Christophe Borg,

Optimization of chemotherapy effectiveness in metastatic colorectal cancers (mCRC) is a major endpoint to enhance the possibility of curative intent surgery. FOLFIRI3 has shown promising results as second-line chemotherapy for mCRC patients previously exposed to oxaliplatin. The clinical efficacy of FOLFIRI3 was never determined in association with bevacizumab in non-previously ... Read more >>

BMC Cancer (BMC cancer)
[2013, 13:611]

Cited: 11 times

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Signature patterns of human papillomavirus type 16 in invasive anal carcinoma.

Séverine Valmary-Degano, Elise Jacquin, Jean-Luc Prétet, Franck Monnien, Benoit Girardo, Francine Arbez-Gindre, Marie Joly, Jean-François Bosset, Bernadette Kantelip, Christiane Mougin,

Many studies have reported that most invasive anal carcinomas contain high-risk human papillomaviruses (HPVs), HPV16 being the most prevalent type. This study aimed to investigate HPV status and cellular biomarkers in invasive anal cancers. HPV genotype distribution was determined in 76 anal cancers by the INNO-LiPA assay (Innogenetics, Gent, Belgium). ... Read more >>

Hum. Pathol. (Human pathology)
[2013, 44(6):992-1002]

Cited: 24 times

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Specific skin lesions in chronic myelomonocytic leukemia: a spectrum of myelomonocytic and dendritic cell proliferations: a study of 42 cases.

Franck Vitte, Bettina Fabiani, Claire Bénet, Sophie Dalac, Brigitte Balme, Claire Delattre, Béatrice Vergier, Marie Beylot-Barry, Dominique Vignon-Pennamen, Nicolas Ortonne, Marie Paule Algros, Agnès Carlotti, Dimitri Samaleire, Eric Frouin, Anne Levy, Liliane Laroche, Ivan Theate, Franck Monnien, Francine Mugneret, Tony Petrella,

Chronic myelomonocytic leukemia (CMML) is a rare clonal hematopoietic disorder that can also involve the skin. The histopathology of these skin lesions is not clearly defined, and few data are available in the literature. To better understand tumoral skin involvements in CMML we carried out an extensive, retrospective clinicopathologic study ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2012, 36(9):1302-1316]

Cited: 26 times

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Impact of STAT3 phosphorylation on the clinical effectiveness of anti-EGFR-based therapy in patients with metastatic colorectal cancer.

Erion Dobi, Franck Monnien, Stefano Kim, Arben Ivanaj, Thiery N'Guyen, Martin Demarchi, Olivier Adotevi, Antoine Thierry-Vuillemin, Marie Jary, Bernadette Kantelip, Xavier Pivot, Yann Godet, Severine Valmary Degano, Christophe Borg,

Half of patients with KRAS wild-type colorectal cancer do not benefit from adding anti-epithelial growth factor receptor (EGFR) to standard chemotherapy regimens. This retrospective study was performed in 94 patients with metastatic colorectal cancer (mCRC) treated in the second line with cetuximab and chemotherapy. Signal transducer and activator of transcription ... Read more >>

Clin Colorectal Cancer (Clinical colorectal cancer)
[2013, 12(1):28-36]

Cited: 14 times

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Prognostic value of phosphorylated STAT3 in advanced rectal cancer: a study from 104 French patients included in the EORTC 22921 trial.

Franck Monnien, Harouna Zaki, Christophe Borg, Christiane Mougin, Jean-François Bosset, Mariette Mercier, Francine Arbez-Gindre, Bernadette Kantelip,

BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) has been implicated as an oncogene in several neoplastic diseases. However, the biological effects of STAT3 have not been extensively studied in rectal carcinogenesis. AIMS: To evaluate STAT3 activation in advanced rectal cancers and its association with clinicopathological variables and prognosis. ... Read more >>

J. Clin. Pathol. (Journal of clinical pathology)
[2010, 63(10):873-878]

Cited: 16 times

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Expression analysis of VEGF-A and VEGF-B: relationship with clinicopathological parameters in bladder cancer.

Sylvie Fauconnet, Stephane Bernardini, Isabelle Lascombe, Guillaume Boiteux, Anne Clairotte, Franck Monnien, Eric Chabannes, Hugues Bittard,

The present investigation was conducted first to determine whether correlation exists between VEGF-A and -B mRNA levels and clinicopathological parameters and to assess their prognostic value in bladder cancer, then to clarify the expression level and biological significance of VEGF-A isoforms. Total RNA was isolated from 37 specimens of bladder ... Read more >>

Oncol. Rep. (Oncology reports)
[2009, 21(6):1495-1504]

Cited: 18 times

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The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status.

Marie E Fondrevelle, Bernadette Kantelip, Robert E Reiter, Dominique K Chopin, Jean P Thiery, Franck Monnien, Hugues Bittard, Hervé Wallerand,

Twist is considered as transcription factor that regulates epithelial mesenchymal transition (EMT) by at least inhibition of E-cadherin expression. EMT is a key event in the tumor invasion process. The purpose of this study is to investigate the expression of Twist but also those of E- and N-cadherin in human ... Read more >>

Urol. Oncol. (Urologic oncology)
[2009, 27(3):268-276]

Cited: 37 times

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