Full Text Journal Articles by
Author Francisco Campos

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Mild systemic inflammation enhances response to OnabotulinumtoxinA in chronic migraineurs.

Yago Leira, Clara Domínguez, Pablo Ameijeira, Esteban López-Arias, Paulo Ávila-Gómez, María Pérez-Mato, Tomás Sobrino, Francisco Campos, Juan Blanco, Rogelio Leira,

The anti-inflammatory effect of OnabotulinumtoxinA (OnabotA) has been a matter of discussion for many years. In chronic migraine, however, increased pro-inflammatory state is associated with good response to OnabotA. We aimed to investigate whether a mild systemic inflammatory state elicited by a common oral infection (periodontitis) could enhance treatment response ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):1092]

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COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children: A Multinational Study.

Omar Yassef Antúnez-Montes, Maria Isabel Escamilla, Augusto Flavio Figueroa-Uribe, Erick Arteaga-Menchaca, Manuel Lavariega-Saráchaga, Perla Salcedo-Lozada, Priscilla Melchior, Rodrigo Beréa de Oliveira, Juan Carlos Tirado Caballero, Hernando Pinzon Redondo, Laura Vanessa Montes Fontalvo, Roger Hernandez, Carolina Chavez, Francisco Campos, Fadia Uribe, Olguita Del Aguila, Jorge Alberto Rios Aida, Andrea Parra Buitrago, Lina Maria Betancur Londoño, León Felipe Mendoza Vega, Carolina Almeida Hernández, Michela Sali, Julian Esteban Higuita Palacio, Jessica Gomez-Vargas, Adriana Yock-Corrales, Danilo Buonsenso,

<h4>Background</h4>To date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, to appropriately plan and allocate resources to face the pandemic on a local and international level.<h4>Methods</h4>Ambispective multicenter cohort study from 5 Latin ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e1-e6]

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Early Neurological Change After Ischemic Stroke Is Associated With 90-Day Outcome.

Laura Heitsch, Laura Ibanez, Caty Carrera, Michael M Binkley, Daniel Strbian, Turgut Tatlisumak, Alejandro Bustamante, Marc Ribó, Carlos Molina, Antoni Dávalos, Elena López-Cancio, Lucia Muñoz-Narbona, Carol Soriano-Tárraga, Eva Giralt-Steinhauer, Victor Obach, Agnieszka Slowik, Joanna Pera, Katarzyna Lapicka-Bodzioch, Justyna Derbisz, Tomás Sobrino, José Castillo, Francisco Campos, Emilio Rodríguez-Castro, Susana Arias-Rivas, Tomas Segura, Gemma Serrano-Heras, Cristófol Vives-Bauza, Rosa Díaz-Navarro, Silva Tur, Carmen Jimenez, Joan Martí-Fàbregas, Raquel Delgado-Mederos, Juan Arenillas, Jerzy Krupinski, Natalia Cullell, Nuria P Torres-Aguila, Elena Muiño, Jara Cárcel-Márquez, Francisco Moniche, Juan A Cabezas, Andria L Ford, Rajat Dhar, Jaume Roquer, Pooja Khatri, Jordi Jiménez-Conde, Israel Fernandez-Cadenas, Joan Montaner, Jonathan Rosand, Carlos Cruchaga, Jin-Moo Lee, ,

<h4>Background and purpose</h4>Large-scale observational studies of acute ischemic stroke (AIS) promise to reveal mechanisms underlying cerebral ischemia. However, meaningful quantitative phenotypes attainable in large patient populations are needed. We characterize a dynamic metric of AIS instability, defined by change in National Institutes of Health Stroke Scale score (NIHSS) from baseline ... Read more >>

Stroke (Stroke)
[2021, 52(1):132-141]

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Patient Perspective on the Management of Cancer Pain in Spain.

Jesús García-Foncillas, Antonio Antón-Torres, Fernando Caballero-Martínez, Francisco J Campos, Margarita Feyjoo, Alfonso Gómez de Liaño, Diana Monge, Carlos Camps,

Pain in cancer is often underdiagnosed and undertreated. Breakthrough pain, in particular, severely impacts the quality of life of patients. In this study, we evaluated management and care of pain in Spain from the patient perspective by assessing the experience of 275 patients who had suffered breakthrough pain. Although most ... Read more >>

J Patient Exp (Journal of patient experience)
[2020, 7(6):1417-1424]

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Antibiotic prescriptions in children with COVID-19 and Multisystem Inflammatory Syndrome: a multinational experience in 990 cases from Latin America

Adriana Yock-Corrales, Jacopo Lenzi, Rolando Ulloa-Gutiérrez, Jessica Gómez-Vargas, Antúnez-Montes Omar Yassef, Jorge Alberto Rios Aida, Olguita del Aguila, Erick Arteaga-Menchaca, Francisco Campos, Fadia Uribe, Andrea Parra Buitrago, Lina Maria Betancur Londoño, Martin Brizuela, Danilo Buonsenso,

<h4>Background</h4> To date, there are no comprehensive data on antibiotic use in children with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C). <h4>Methods</h4> Multicenter cohort study from 5 Latin American countries. Children 17 years of age or younger with microbiologically confirmed SARS-CoV-2 infection or fulfilling MIS-C definition were included. Antibiotic prescriptions were ... Read more >>

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PET/CT Integrated With CT Colonography in Preoperative Obstructive Colorectal Cancer by Incomplete Optical Colonoscopy: A Prospective Study.

Nuria Sánchez-Izquierdo, Mario Pagès, Maria Mayoral, Domenico Rubello, Patrick M Colletti, Francisco Campos, Inmaculada Romero, Sebastián Casanueva, Andrea Fritsch, David Fuster,

<h4>Aim</h4>The aim of this study was to evaluate if integrating whole-body PET/CT with CT colonography (PET/CTC) improves the preoperative diagnosis of obstructive colorectal cancer (CRC).<h4>Methods</h4>We prospectively included 47 consecutive patients (18 women and 29 men; mean age, 71 ± 14 years) suspected of having CRC by optical colonoscopy, which was ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, 45(12):943-947]

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Editorial: Ion Homeostasis in Plant Stress and Development.

José M Mulet, Francisco Campos, Lynne Yenush,

Front Plant Sci (Frontiers in plant science)
[2020, 11:618273]

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Multi-ancestry genetic study in 5,876 patients identifies an association between excitotoxic genes and early outcomes after acute ischemic stroke

Laura Ibanez, Laura Heitsch, Caty Carrera, Fabiana H.G. Farias, Rajat Dhar, John Budde, Kristy Bergmann, Joseph Bradley, Oscar Harari, Chia-Ling Phuah, Robin Lemmens, Alessandro Viana Oliveira Souza, Francisco Moniche, Antonio Cabezas-Juan, Juan Francisco Arenillas, Jerzy Krupinksi, Natalia Cullell, Nuria Torres-Aguila, Elena Muiño, Jara Cárcel-Márquez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Rebeca Marin-Bueno, Alejandro Hornick, Cristofol Vives-Bauza, Rosa Diaz Navarro, Silvia Tur, Carmen Jimenez, Victor Obach, Tomas Segura, Gemma Serrano-Heras, Jong-Won Chung, Jaume Roquer, Carol Soriano-Tarraga, Eva Giralt-Steinhauer, Marina Mola-Caminal, Joanna Pera, Katarzyna Lapicka-Bodzioch, Justyna Derbisz, Antoni Davalos, Elena Lopez-Cancio, Lucia Muñoz, Turgut Tatlisumak, Carlos Molina, Marc Ribo, Alejandro Bustamante, Tomas Sobrino, Jose Castillo-Sanchez, Francisco Campos, Emilio Rodriguez-Castro, Susana Arias-Rivas, Manuel Rodríguez-Yáñez, Christina Herbosa, Andria Ford, Antonio Arauz, Iscia Lopes-Cendes, Theodore Lowenkopf, Miguel Barboza, Hajar Amini, Boryana Stamova, Bradley Ander, Frank Sharp, Gyeong Moon Kim, Oh Young Bang, Jordi Jimenez-Conde, Agnieszka Slowik, Daniel Stribian, Ellen Tsai, Linda Burkly, Joan Montaner, Israel Fernandez-Cadenas, Jin-Moo Lee, Carlos Cruchaga,

<h4>ABSTRACT</h4> During the first hours after stroke onset neurological deficits can be highly unstable: some patients rapidly improve, while others deteriorate. This early neurological instability has a major impact on long-term outcome. Here, we aimed to determine the genetic architecture of early neurological instability measured by the difference between NIH ... Read more >>

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Inhibition of endogenous blood glutamate oxaloacetate transaminase enhances the ischemic damage.

Antonio Dopico-López, María Pérez-Mato, Andrés da Silva-Candal, Ramón Iglesias-Rey, Aharon Rabinkov, Ana Bugallo-Casal, Tomás Sobrino, David Mirelman, José Castillo, Francisco Campos,

Glutamate oxaloacetate transaminase 1 (GOT1) enzyme plays a critical role in the cell metabolism by participating in the carbohydrate and amino acid metabolism. In ischemic stroke, we have demonstrated that recombinant GOT1 acts as a novel neuroprotective treatment against the excess of extracellular glutamate that accumulates in the brain following ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2020, :]

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Sentinel Lymph Node Biopsy in breast cancer with 99mTc-Tilmanocept: A novel tracer in the real life. A multicenter study.

Sergi Vidal-Sicart, María Eugenia Rioja, Andrea Prieto, Elena Goñi, Isabel Gómez, María Dolores Albala, Luis Lumbreras, Luisa Fernanda León, José Ramón Gómez, Francisco Campos,

<b>Purpose:</b> <sup>99m</sup>Tc-Tilmanocept is a novel radiopharmaceutical for SLN biopsy in breast cancer. The aim was to describe the results with <sup>99m</sup>Tc-Tilmanocept in a heterogeneous group of breast cancer patients scheduled for SLN biopsy. <b>Methods:</b> Radiotracer preparation followed the manufacturer's indications. Local protocols for SLN detection within 9 participant centers were ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2020, :]

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The presence of leukoaraiosis enhances the association between sTWEAK and hemorrhagic transformation.

Andrés da Silva-Candal, María Pérez-Mato, Manuel Rodríguez-Yáñez, Iria López-Dequidt, José M Pumar, Paulo Ávila-Gómez, Tomás Sobrino, Francisco Campos, José Castillo, Pablo Hervella, Ramón Iglesias-Rey,

<h4>Objective</h4>To investigate whether elevated serum levels of sTWEAK (soluble tumor necrosis factor-like inducer of apoptosis) might be involved in a higher frequency of symptomatic hemorrhagic transformation (HT) through the presence of leukoaraiosis (LA) in patients with acute ischemic stroke (IS) undergoing reperfusion therapies.<h4>Methods</h4>This is a retrospective observational study. The primary ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(11):2103-2114]

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Renal sinus lipomatosis of the kidney.

Joana Alfarelos, Gustavo Gomes, Francisco Campos, Mário Matias, António Canelas,

A 62 year old man with a history of weight loss and left flank pain did a renal ultrasound that showed a heterogeneous formation involving the left kidney compatible with a solid lesion... ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2020, 73(9):862-863]

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Subtle executive deficits are associated with higher brain amyloid burden and lower cortical volume in subjective cognitive decline: the FACEHBI cohort.

Alba Pérez-Cordón, Gemma Monté-Rubio, Angela Sanabria, Octavio Rodriguez-Gomez, Sergi Valero, Carla Abdelnour, Marta Marquié, Ana Espinosa, Gemma Ortega, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Ana Mauleón, Silvia Gil, Juan Pablo Tartari, Francisco Lomeña, Francisco Campos, Assumpta Vivas, Marta Gomez-Chiari, Alba Benaque, Agustin Ruiz, Luis Tárraga, Mercè Boada, Montserrat Alegret, ,

To determine whether lower performance on executive function tests in subjective cognitive decline (SCD) individuals are associated with higher levels of brain amyloid beta (Aβ) deposition and regional volumetric reduction in areas of interest for Alzheimer's disease (AD). 195 individuals with SCD from the FACEHBI study were assessed with a ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):17721]

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Toll-like receptors as diagnostic targets in pellucid marginal degeneration.

Uxía Regueiro, María Pérez-Mato, Pablo Hervella, Francisco Campos, Tomás Sobrino, Isabel Lema,

The main purpose of this study is to evaluate the diagnostic role of Toll-like receptors 2 (TLR2) and 4 (TLR4) expression in corneal and conjunctival epithelial cells of eyes with pellucid marginal degeneration (PMD) compared to keratoconus patients (KC) and control subjects. A prospective case-control study in 29 PMD eyes, ... Read more >>

Exp Eye Res (Experimental eye research)
[2020, 200:108211]

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COVID-19 and Multisystem Inflammatory Syndrome in Latin American children: a multinational study

Omar Yassef Antunez-Montes, Maria Isabel Escamilla, Augusto Flavio Figueroa-Uribe, Erick Arteaga-Menchaca, Manuel Lavariega-Sarachaga, Perla Salcedo-Lozada, Priscilla Melchior, Rodrigo Berea de Oliveira, Juan Carlos Tirado Caballero, Hernando Pinzon Redondo, Laura Vanessa Montes Fontalvo, Roger Hernandez, Carolin Chavez, Francisco Eduardo Campos, Fadia Uribe, Olguita del Aguila, JORGE ALBERTO RIOS AIDA, Andrea Parra Buitrago, Lina Maria Betancur Londono, Leon Felipe Mendoza Vega, Carolina Almeida Hernandez, Michela Sali, JULIAN HIGUITA PALACIO, Jessica Gomez-Vargas, Adriana Yock Corrales, Danilo Buonsenso,

<h4>Background: </h4> To date, there are no comprehensive data on pediatric COVID19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS C) in Latin American children, in order to appropriately plan and allocate resources to face the pandemic on a local and International lever ... Read more >>

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Point-of-care quantification of serum cellular fibronectin levels for stratification of ischemic stroke patients.

Elisabete Fernandes, Tomás Sobrino, Verónica C Martins, Ignacio Lopez-Loureiro, Francisco Campos, José Germano, Manuel Rodríguez-Pérez, Susana Cardoso, Dmitri Y Petrovykh, José Castillo, Paulo P Freitas,

The abundance of cellular fibronectin (c-Fn) for ischemic stroke patients and the narrow time-window (<4.5 h) for the decision to administer the thrombolytic treatment with recombinant tissue plasminogen activator (rtPA) are challenging for the development of a point-of-care (PoC) diagnostic platform. We report a case of stratification of ischemic stroke patients ... Read more >>

Nanomedicine (Nanomedicine : nanotechnology, biology, and medicine)
[2020, 30:102287]

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Survival and metabolism of hydroxycinnamic acids by Dekkera bruxellensis in monovarietal wines.

Adriana Nunes de Lima, Rui Magalhães, Francisco Manuel Campos, José António Couto,

Volatile phenols in wines are responsible for unpleasant aromas, which negatively affect the quality of the wine. These compounds are produced from the metabolism of hydroxycinnamic acids, mainly by the yeasts Brettanomyces/Dekkera. Relevant data, potentially useful to support decisions on how to manage the risk of contamination of wines by ... Read more >>

Food Microbiol (Food microbiology)
[2021, 93:103617]

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[Potential biomarkers predictors of mortality in COVID-19 patients in the Emergency Department].

N F Pascual Gómez, I Monge Lobo, I Granero Cremades, A Figuerola Tejerina, F Ramasco Rueda, A von Wernitz Teleki, F M Arrabal Campos, M A Sanz de Benito,

<h4>Objective</h4>Identify which biomarkers performed in the first emergency analysis help to stratify COVID-19 patients according to mortality risk.<h4>Methods</h4>Observational, descriptive and cross-sectional study performed with data collected from patients with suspected COVID-19 in the Emergency Department from February 24 to March 16, 2020. The univariate and multivariate study was performed to ... Read more >>

Rev Esp Quimioter (Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia)
[2020, 33(4):267-273]

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Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers.

Paulo Ávila-Gómez, Pablo Hervella, Andrés Da Silva-Candal, María Pérez-Mato, Manuel Rodríguez-Yáñez, Iria López-Dequidt, José M Pumar, José Castillo, Tomás Sobrino, Ramón Iglesias-Rey, Francisco Campos,

Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(7):]

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Quantitative Proteome Analysis of Jatropha curcas L. Genotypes with Contrasting Levels of Phorbol Esters.

Andreza Raquel Barbosa de Farias, Natália P Almeida, Gilberto B Domont, Fábio C S Nogueira, Francisco A P Campos,

The phorbol esters in the seeds of Jatropha curcas are a major hindrance to the full exploitation of the potential of this oil crop as a source of raw material for the production of biodiesel. Here, various quantitative proteomic strategies are used to establish the proteomes of roots, leaves, and ... Read more >>

Proteomics (Proteomics)
[2020, 20(14):e1900273]

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Proteome dynamics of the cotyledonary haustorium and endosperm in the course of germination of Euterpe oleracea seeds.

José R S Nascimento, Domingos F Neto, Ítalo C Coutinho, Gilberto B Domont, Fábio C S Nogueira, Francisco A P Campos,

The role of the cotyledonary haustorium (CH) in the mobilization of nutrient reserves in the endosperm of species of the palm family Arecaceae is a moot question. To shed light on this matter, we present here an analysis of the quantitative proteome changes associated with four developmental stages of CH ... Read more >>

Plant Sci (Plant science : an international journal of experimental plant biology)
[2020, 298:110569]

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Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine.

Clara Domínguez-Vivero, Yago Leira, Ana López-Ferreiro, Marta Saavedra, Xiana Rodríguez-Osorio, Tomás Sobrino, Francisco Campos, José Castillo, Rogelio Leira,

Even though endothelial dysfunction is known to play a role in migraine pathophysiology, studies regarding levels of endothelial biomarkers in migraine have controversial results. Our aim was to evaluate the role of pentraxin 3 (PTX3) and soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) as potential biomarkers of endothelial ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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Antihyperthermic treatment decreases perihematomal hypodensity.

Pablo Hervella, Manuel Rodríguez-Yáñez, José Manuel Pumar, Paulo Ávila-Gómez, Andrés da Silva-Candal, Ignacio López-Loureiro, Elena Rodríguez-Maqueda, Clara Correa-Paz, José Castillo, Tomás Sobrino, Francisco Campos, Ramón Iglesias-Rey,

<h4>Objective</h4>To investigate the effect on perihematomal hypodensity and outcome of a decrease in body temperature in the first 24 hours in patients with intracerebral hemorrhage (ICH).<h4>Methods</h4>In this retrospective study on a prospectively registered database, among the 1,100 patients, 795 met all the inclusion criteria. Temperature variations in the first 24 ... Read more >>

Neurology (Neurology)
[2020, 94(16):e1738-e1748]

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Regulatory T cells participate in the recovery of ischemic stroke patients

María Santamaría-Cadavid, Emilio Rodríguez-Castro, Manuel Rodríguez-Yáñez, Susana Arias-Rivas, Iria López-Dequidt, María Pérez-Mato, Manuel Rodríguez-Pérez, Ignacio López-Loureiro, Pablo Hervella, Francisco Campos, José Castillo, Ramón Iglesias-Rey, Tomás Sobrino,

<h4>Background: </h4> Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, the role of Treg in human acute IS has been poorly investigated. Our aim was to study the relationship between circulating Treg and outcome in ... Read more >>

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Intra- and extra-hospital improvement in ischemic stroke patients: influence of reperfusion therapy and molecular mechanisms.

Pablo Hervella, Emilio Rodríguez-Castro, Manuel Rodríguez-Yáñez, Susana Arias, María Santamaría-Cadavid, Iria López-Dequidt, Ana Estany-Gestal, Elena Maqueda, Ignacio López-Loureiro, Tomás Sobrino, Francisco Campos, José Castillo, Ramón Iglesias-Rey,

Neuroprotective treatments in ischemic stroke are focused to reduce the pernicious effect of excitotoxicity, oxidative stress and inflammation. However, those cellular and molecular mechanisms may also have beneficial effects, especially during the late stages of the ischemic stroke. The objective of this study was to investigate the relationship between the ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3513]

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