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A risk-group classification model in patients with bladder cancer under neoadjuvant cisplatin-based combination chemotherapy.

Matteo Ferro, Giuseppe Lucarelli, Ottavio de Cobelli, Pasquale Dolce, Daniela Terracciano, Gennaro Musi, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Fabio Crocerossa, Abdal Rahman Abu Farhan, Riccardo Autorino, Mihai Dorin Vartolomei, Michele Marchioni, Andrea Mari, Andrea Minervini, Nicola Longo, Giuseppe Celentano, Francesco Chiancone, Sisto Perdonà, Paola Del Prete, Pasquale Ditonno, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Dario Ribera, Pietro De Placido, Sergio Facchini, Luca Scafuri, Antonio Verde, Giuseppe Di Lorenzo, Vincenzo Cosimato, Angelo Luciano, Vincenzo Francesco Caputo, Felice Crocetto, Carlo Buonerba,

The objective of the current research was to explore the potential prognostic value of readily available clinical and pathologic variables in bladder cancer. The novel association found between cholesterol levels and prognosis may provide the rationale for exploring novel treatments. Patients included had histologically confirmed urothelial bladder cancer and were treated with ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, :]

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Incidence, risk factors and outcomes of urethral recurrence after radical cystectomy for bladder cancer: A systematic review and meta-analysis.

Ekaterina Laukhtina, Keiichiro Mori, David D Andrea, Marco Moschini, Mohammad Abufaraj, Francesco Soria, Andrea Mari, Wojciech Krajewski, Simone Albisinni, Jeremy Yuen-Chun Teoh, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Satoshi Katayama, Nico С Grossmann, Pawel Rajwa, Dmitry Enikeev, Kristin Zimmermann, Harun Fajkovic, Petr Glybochko, Shahrokh F Shariat, Benjamin Pradere, ,

We aimed to conduct a systematic review and meta-analysis assessing the incidence and risk factors of urethral recurrence (UR) as well as summarizing data on survival outcomes in patients with UR after radical cystectomy (RC) for bladder cancer. The MEDLINE and EMBASE databases were searched in February 2021 for studies ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Accuracy of Frozen Section Analysis of Urethral and Ureteral Margins During Radical Cystectomy for Bladder Cancer: A Systematic Review and Diagnostic Meta-Analysis.

Ekaterina Laukhtina, Pawel Rajwa, Keiichiro Mori, Marco Moschini, David D'Andrea, Mohammad Abufaraj, Francesco Soria, Andrea Mari, Wojciech Krajewski, Simone Albisinni, Jeremy Yuen-Chun Teoh, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Satoshi Katayama, Nico C Grossmann, Dmitry Enikeev, Kristin Zimmermann, Harun Fajkovic, Petr Glybochko, Shahrokh F Shariat, Benjamin Pradere, ,

<h4>Context</h4>The question of the ability of frozen section analysis (FSA) to accurately detect malignant pathology intraoperatively has been discussed for many decades.<h4>Objective</h4>We aimed to conduct a systematic review and meta-analysis assessing the diagnostic estimates of FSA of the urethral and ureteral margins in patients treated with radical cystectomy (RC) for ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Current application of the enhanced recovery after surgery protocol for patients undergoing radical cystectomy: lessons learned from European excellence centers.

Simone Albisinni, Marco Moschini, Ettore Di Trapani, Francesco Soria, Andrea Mari, Atiqullah Aziz, Jeremy Teoh, Ekaterina Laukhtina, Keiichiro Mori, David D'Andrea, Diego M Carrion, Wojciech Krajewski, Mohammad Abufaraj, Alessia Cimadamore, Wei Shen Tan, Ronan Flippot, Jonathan Khalifa, Kimberly Gonsette, Benjamin Pradere, ,

<h4>Purpose</h4>There is no consensus on which items of Enhanced Recovery After Surgery (ERAS) should and should not be implemented in radical cystectomy (RC). The aim of this study is to report current practices across European high-volume RC centers involved in ERAS.<h4>Methods</h4>Based on the recommendations of the ERAS society, we developed ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, :]

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Flexible fibre optic vs digital ureteroscopy and enhanced vs unenhanced imaging for diagnosis and treatment of upper tract urothelial carcinoma (UTUC): results from the Clinical Research Office of the Endourology Society (CROES)-UTUC registry.

Francesco Soria, M Pilar Laguna, Morgan Roupret, Patricio Garcia-Marchinena, Mariano Sebastián Gonzalez, Tomonori Habuchi, Erkan Erkan, Anthony Ng, Paolo Gontero, Jean de la Rosette,

<h4>Objectives</h4>To compare the oncological outcomes of patients with upper tract urothelial carcinoma (UTUC) undergoing kidney-sparing surgery (KSS) with fibre-optic (FO) vs digital (D) ureteroscopy (URS). To evaluate the oncological impact of image-enhancement technologies such as narrow-band imaging (NBI) and Image1-S in patients with UTUC.<h4>Patients and methods</h4>The Clinical Research Office of ... Read more >>

BJU Int (BJU international)
[2021, :]

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First-line immune-checkpoint inhibitor combination therapy for chemotherapy-eligible patients with metastatic urothelial carcinoma: A systematic review and meta-analysis.

Keiichiro Mori, Benjamin Pradere, Marco Moschini, Hadi Mostafaei, Ekaterina Laukhtina, Victor M Schuettfort, Reza Sari Motlagh, Francesco Soria, Jeremy Y C Teoh, Shin Egawa, Thomas Powles, Shahrokh F Shariat, ,

<h4>Introduction</h4>Platinum-based combination chemotherapy is the standard treatment for patients with chemotherapy-eligible metastatic urothelial carcinoma (mUC). Immune-checkpoint inhibitors (ICIs) are currently assessed in this setting. This review aimed to assess the role of ICIs alone or in combination as first-line treatment in chemotherapy-eligible patients with mUC.<h4>Methods</h4>Multiple databases were searched for articles ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 151:35-48]

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Deep Learning-based Recalibration of the CUETO and EORTC Prediction Tools for Recurrence and Progression of Non-muscle-invasive Bladder Cancer.

Mateusz Jobczyk, Konrad Stawiski, Marcin Kaszkowiak, Paweł Rajwa, Waldemar Różański, Francesco Soria, Shahrokh F Shariat, Wojciech Fendler,

Despite being standard tools for decision-making, the European Organisation for Research and Treatment of Cancer (EORTC), European Association of Urology (EAU), and Club Urologico Espanol de Tratamiento Oncologico (CUETO) risk groups provide moderate performance in predicting recurrence-free survival (RFS) and progression-free survival (PFS) in non-muscle-invasive bladder cancer (NMIBC). In this ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Three vs. Four Cycles of Neoadjuvant Chemotherapy for Localized Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy: A Retrospective Multi-Institutional Analysis.

Matteo Ferro, Ottavio de Cobelli, Gennaro Musi, Giuseppe Lucarelli, Daniela Terracciano, Daniela Pacella, Tommaso Muto, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Fabio Crocerossa, Abdal Rahman Abu Farhan, Riccardo Autorino, Mihai Dorin Vartolomei, Matteo Muto, Michele Marchioni, Andrea Mari, Luca Scafuri, Andrea Minervini, Nicola Longo, Francesco Chiancone, Sisto Perdona, Pietro De Placido, Antonio Verde, Michele Catellani, Stefano Luzzago, Francesco Alessandro Mistretta, Pasquale Ditonno, Vincenzo Francesco Caputo, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Giuseppe Di Lorenzo, Felice Crocetto, Carlo Buonerba,

<h4>Background</h4>Three or four cycles of cisplatin-based chemotherapy is the standard neoadjuvant treatment prior to cystectomy in patients with muscle-invasive bladder cancer. Although NCCN guidelines recommend 4 cycles of cisplatin-gemcitabine, three cycles are also commonly administered in clinical practice. In this multicenter retrospective study, we assessed a large and homogenous cohort ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:651745]

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Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy.

Matteo Ferro, Dragoş-Florin Babă, Ottavio de Cobelli, Gennaro Musi, Giuseppe Lucarelli, Daniela Terracciano, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Papalia Rocco, Roberto Mario Scarpa, Abdal Rahman Abu Farhan, Riccardo Autorino, Antonio Brescia, Michele Marchioni, Andrea Mari, Andrea Minervini, Nicola Longo, Francesco Chiancone, Sisto Perdona', Biagio Barone, Pietro De Placido, Michele Catellani, Danilo Bottero, Pasquale Ditonno, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Salvatore Smelzo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Felice Crocetto, Carlo Buonerba, Alina Danilesco, Mihai Dorin Vartolomei,

<h4>Aim</h4>To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC).<h4>Patients & methods</h4>213 patients were included.<h4>Inclusion criteria</h4>Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC.<h4>Results</h4>Five-years overall survival ... Read more >>

Future Sci OA (Future science OA)
[2021, 7(7):FSO709]

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Reply to Francesco Montorsi, Marco Bandini, and Andrea Necchi's Letter to the Editor re: Francesco Soria, Marco Moschini, David D'Andrea, et al. Comparative Effectiveness in Perioperative Outcomes of Robotic versus Open Radical Cystectomy: Results from a Multicenter Contemporary Retrospective Cohort Study. Eur Urol Focus 2020;6:1233-9.

Francesco Soria, David D'Andrea, Paolo Gontero, Shahrokh F Shariat,

Eur Urol Focus (European urology focus)
[2021, :]

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Association of patients' sex with treatment outcomes after intravesical bacillus Calmette-Guérin immunotherapy for T1G3/HG bladder cancer.

David D'Andrea, Francesco Soria, Anne J Grotenhuis, Eugene K Cha, Nuria Malats, Savino Di Stasi, Steven Joniau, Tommaso Cai, Bas W G van Rhijn, Jaques Irani, Jeffrey Karnes, John Varkarakis, Jack Baniel, Joan Palou, Marek Babjuk, Martin Spahn, Peter Ardelt, Renzo Colombo, Vincenzo Serretta, Guido Dalbagni, Paolo Gontero, Riccardo Bartoletti, Stephane Larré, Per-Uno Malmstrom, Richard Sylvester, Shahrokh F Shariat,

<h4>Purpose</h4>To investigate the association of patients' sex with recurrence and disease progression in patients treated with intravesical bacillus Calmette-Guérin (BCG) for T1G3/HG urinary bladder cancer (UBC).<h4>Materials and methods</h4>We analyzed the data of 2635 patients treated with adjuvant intravesical BCG for T1 UBC between 1984 and 2019. We accounted for missing ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Intravesical Therapy in Patients with Intermediate-risk Non-muscle-invasive Bladder Cancer: A Systematic Review and Network Meta-analysis of Disease Recurrence.

Ekaterina Laukhtina, Mohammad Abufaraj, Abdallah Al-Ani, Mustafa Rami Ali, Keiichiro Mori, Marco Moschini, Fahad Quhal, Reza Sari Motlagh, Benjamin Pradere, Victor M Schuettfort, Hadi Mostafaei, Satoshi Katayama, Nico C Grossmann, Harun Fajkovic, Francesco Soria, Dmitry Enikeev, Shahrokh F Shariat, ,

<h4>Context</h4>Patients with intermediate-risk non-muscle-invasive bladder cancer (NMIBC) may pose a clinical dilemma without an agreed evidence-based decision tree for personalized treatment.<h4>Objective</h4>To perform a systematic review and network meta-analysis (NMA) to summarize available evidence on the oncologic outcomes of intravesical therapy in patients with intermediate-risk NMIBC.<h4>Evidence acquisition</h4>The MEDLINE, EMBASE, and ClinicalTrials.gov ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Prevalence and trends in urinary incontinence among women in the United States, 2005-2018.

Mohammad Abufaraj, Tianlin Xu, Chao Cao, Abdelmuez Siyam, Ula Isleem, Abdulla Massad, Francesco Soria, Shahrokh F Shariat, Siobhan Sutcliffe, Lin Yang,

<h4>Background</h4>Women are disproportionately affected by urinary incontinence compared with men. Urinary incontinence results in physical and psychological adverse consequences and impaired quality of life and contributes to significant societal and economic burden. Previous studies reported high urinary incontinence burden in the United States. However, the current prevalence and recent trends ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, 225(2):166.e1-166.e12]

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Re: Intravesical Nadofaragene Firadenovec Gene Therapy for BCG-unresponsive Non-muscle-invasive Bladder Cancer: A Single-arm, Open-label, Repeat-dose Clinical Trial.

Francesco Soria, Paolo Gontero,

Eur Urol (European urology)
[2021, 79(6):891-892]

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Impact of Adjuvant Chemotherapy on Survival of Patients with Advanced Residual Disease at Radical Cystectomy following Neoadjuvant Chemotherapy: Systematic Review and Meta-Analysis.

Wojciech Krajewski, Łukasz Nowak, Marco Moschini, Sławomir Poletajew, Joanna Chorbińska, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Rafael Sanchez-Salas, Shahrokh F Shariat, Juan Palou, Marek Babjuk, Jeremy Yc Teoh, Francesco Soria, Benjamin Pradere, Paola Irene Ornaghi, Aleksandra Pawlak, Janusz Dembowski, Romuald Zdrojowy,

<h4>Background</h4>Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph-node dissection is the standard treatment for cT2-4a cN0 cM0 muscle-invasive bladder cancer (MIBC). Despite the significant improvement of primary-tumor downstaging with NAC, up to 50% of patients are eventually found to have advanced residual disease (pT3-T4 and/or histopathologically ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(4):]

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Systemic combining inflammatory score (SCIS): a new score for prediction of oncologic outcomes in patients with high-risk non-muscle-invasive urothelial bladder cancer.

Matteo Ferro, Marina Di Mauro, Sebastiano Cimino, Giuseppe Morgia, Giuseppe Lucarelli, Abdal Rahman Abu Farhan, Mihai Dorin Vartolomei, Angelo Porreca, Francesco Cantiello, Rocco Damiano, Gian Maria Busetto, Francesco Del Giudice, Rodolfo Hurle, Sisto Perdonà, Marco Borghesi, Pierluigi Bove, Riccardo Autorino, Nicolae Crisan, Michele Marchioni, Luigi Schips, Francesco Soria, Andrea Mari, Andrea Minervini, Alessandro Veccia, Michele Battaglia, Daniela Terracciano, Gennaro Musi, Giovanni Cordima, Matteo Muto, Vincenzo Mirone, Ottavio de Cobelli, Giorgio Ivan Russo,

<h4>Background</h4>An accurate and early diagnosis of bladder cancer (BC) is essential to offer patients the most appropriate treatment and the highest cure rate. For this reason, patients need to be best stratified by class and risk factors. We aimed to develop a score able to better predict cancer outcomes, using ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(2):626-635]

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Ejaculation-sparing versus non-ejaculation-sparing anatomic GreenLight laser enucleo-vaporization of the prostate: first comparative study.

Paolo Destefanis, Mattia Sibona, Francesco Soria, Eugenia Vercelli, Federico Vitiello, Andrea Bosio, Alessandro Bisconti, Beatrice Lillaz, Paolo Gontero,

<h4>Purpose</h4>To present the step-by-step description of an ejaculation-sparing anatomic photo-selective vaporization of the prostate (PVP) technique. To report the results of a series of ejaculation-sparing versus non-ejaculation-sparing anatomic PVPs.<h4>Methods</h4>Sexually active, benign prostatic hyperplasia (BPH) patients undergoing an anatomic PVP between 11/2018 and 2/2020 were included. Patients were divided into group ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Association of statin use and oncological outcomes in patients with first diagnosis of T1 high grade non-muscle invasive urothelial bladder cancer: results from a multicentre study.

Matteo Ferro, Michele Marchioni, Giuseppe Lucarelli, Vartolomei M Dorin, Francesco Soria, Daniela Terracciano, Francesco A Mistretta, Stefano Luzzago, Carlo Buonerba, Francesco Cantiello, Andrea Mari, Andrea Minervini, Alessandro Veccia, Alessandro Antonelli, Gennaro Musi, Rodolfo Hurle, Gian Maria Busetto, Francesco Del Giudice, Benjamin I Chung, Francesco Berardinelli, Sisto Perdonà, Paola Del Prete, Vincenzo Mirone, Marco Borghesi, Angelo Porreca, Pierluigi Bove, Riccardo Autorino, Nicolae Crisan, Abdal R Abu Farhan, Michele Battaglia, Pasquale Ditonno, Giorgio I Russo, Matteo Muto, Rocco Damiano, Matteo Manfredi, Francesco Porpiglia, Ottavio De Cobelli, Luigi Schips,

<h4>Introduction</h4>We aimed to test the hypothesis that the immune-modulatory effect of statins may improve survival outcomes in patients with non-muscle invasive bladder cancer (NMIBC). We focused on a cohort of patients diagnosed with high risk NMIBC, that were treated with intravesical BCG immunotherapy.<h4>Patients and methods</h4>We included patients at first diagnosis ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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Prognostic Value of the WHO1973 and WHO2004/2016 Classification Systems for Grade in Primary Ta/T1 Non-muscle-invasive Bladder Cancer: A Multicenter European Association of Urology Non-muscle-invasive Bladder Cancer Guidelines Panel Study.

Bas W G van Rhijn, Anouk E Hentschel, Johannes Bründl, Eva M Compérat, Virginia Hernández, Otakar Čapoun, H Maxim Bruins, Daniel Cohen, Morgan Rouprêt, Shahrokh F Shariat, A Hugh Mostafid, Richard Zigeuner, Jose L Dominguez-Escrig, Maximilian Burger, Viktor Soukup, Paolo Gontero, Joan Palou, Theo H van der Kwast, Marko Babjuk, Richard J Sylvester, ,

<h4>Background</h4>In the current European Association of Urology (EAU) non-muscle-invasive bladder cancer (NMIBC) guideline, two classification systems for grade are advocated: WHO1973 and WHO2004/2016.<h4>Objective</h4>To compare the prognostic value of these WHO systems.<h4>Design, setting, and participants</h4>Individual patient data for 5145 primary Ta/T1 NMIBC patients from 17 centers were collected between 1990 and ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(2):182-191]

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Further Understanding of Urokinase Plasminogen Activator Overexpression in Urothelial Bladder Cancer Progression, Clinical Outcomes and Potential Therapeutic Targets.

Nico C Grossmann, Victor M Schuettfort, Benjamin Pradere, Marco Moschini, Fahad Quhal, Hadi Mostafaei, Francesco Soria, Satoshi Katayama, Ekaterina Laukhtina, Keiichiro Mori, Reza Sari Motlagh, Cédric Poyet, Mohammad Abufaraj, Pierre I Karakiewicz, Shahrokh F Shariat, David D'Andrea,

<h4>Purpose</h4>The Plasminogen Activation System (PAS) plays a role in tumor growth, invasion and metastasis and has been associated with oncological outcomes in urinary bladder carcinoma (UBC). The use of the different components of this system as molecular markers could improve our understanding of the heterogeneous behavior of UBC and might ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2021, 14:315-324]

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European Association of Urology (EAU) Prognostic Factor Risk Groups for Non-muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel.

Richard J Sylvester, Oscar Rodríguez, Virginia Hernández, Diana Turturica, Lenka Bauerová, Harman Max Bruins, Johannes Bründl, Theo H van der Kwast, Antonin Brisuda, José Rubio-Briones, Maximilian Seles, Anouk E Hentschel, Venkata R M Kusuma, Nicolai Huebner, Juliette Cotte, Laura S Mertens, Dimitrios Volanis, Olivier Cussenot, Jose D Subiela Henríquez, Enrique de la Peña, Francesca Pisano, Michael Pešl, Antoine G van der Heijden, Sonja Herdegen, Alexandre R Zlotta, Jaromir Hacek, Ana Calatrava, Sebastian Mannweiler, Judith Bosschieter, David Ashabere, Andrea Haitel, Jean-François Côté, Soha El Sheikh, Luca Lunelli, Ferran Algaba, Isabel Alemany, Francesco Soria, Willemien Runneboom, Johannes Breyer, Jakko A Nieuwenhuijzen, Carlos Llorente, Luca Molinaro, Christina A Hulsbergen-van de Kaa, Matthias Evert, Lambertus A L M Kiemeney, James N'Dow, Karin Plass, Otakar Čapoun, Viktor Soukup, Jose L Dominguez-Escrig, Daniel Cohen, Joan Palou, Paolo Gontero, Maximilian Burger, Richard Zigeuner, Amir Hugh Mostafid, Shahrokh F Shariat, Morgan Rouprêt, Eva M Compérat, Marko Babjuk, Bas W G van Rhijn,

<h4>Background</h4>The European Association of Urology (EAU) prognostic factor risk groups for non-muscle-invasive bladder cancer (NMIBC) are used to provide recommendations for patient treatment after transurethral resection of bladder tumor (TURBT). They do not, however, take into account the widely used World Health Organization (WHO) 2004/2016 grading classification and are based ... Read more >>

Eur Urol (European urology)
[2021, 79(4):480-488]

Cited: 3 times

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A comparison of perioperative outcomes of laparoscopic versus open nephroureterectomy for upper tract urothelial carcinoma: a propensity score matching analysis.

Luca Afferi, Mohammad Abufaraj, Francesco Soria, David D'Andrea, Evanguelos Xylinas, Thomas Seisen, Morgan Roupret, Chiara Lonati, Alexandre De la Taille, Benoit Peyronnet, Ekaterina Laukhtina, Benjamin Pradere, Andrea Mari, Wojciech Krajewski, Mario Alvarez-Maestro, Eiji Kikuchi, Keisuke Shigeta, Piotr Chlosta, Francesco Montorsi, Alberto Briganti, Giuseppe Simone, Paola I Ornaghi, Maria Angela Cerruto, Alessandro Antonelli, Kazumasa Matsumoto, Pierre I Karakiewicz, Livio Mordasini, Agostino Mattei, Shahrokh F Shariat, Marco Moschini,

<h4>Background</h4>Radical nephroureterectomy (RNU) with the concomitant excision of the distal ureter and bladder cuff is the current standard of care for the treatment of muscle invasive and/or high-risk upper tract urothelial carcinoma (UTUC). In small uncontrolled studies, laparoscopic RNU has been suggested to be associated with better perioperative outcomes compared ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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Neoadjuvant chemotherapy plus radical cystectomy versus radical cystectomy alone in clinical T2 bladder cancer without hydronephrosis.

Francesco Soria, Peter C Black, Adrian S Fairey, Michael S Cookson, Evan Y Yu, Wassim Kassouf, Marc A Dall'Era, Srikala S Sridhar, John S McGrath, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Siamak Daneshmand, Jeff M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Philippe E Spiess, Shahrokh F Shariat, Paolo Gontero,

<h4>Objectives</h4>To assess the efficacy of neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) in a retrospective multicentre cohort of patients with cT2N0M0 bladder cancer (BCa) without preoperative hydronephrosis.<h4>Patients and methods</h4>This was a propensity-based analysis of 619 patients. Of these, 316 were treated with NAC followed by RC and 303 with upfront ... Read more >>

BJU Int (BJU international)
[2021, 128(1):79-87]

Cited: 2 times

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