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Francesco Santoro, Ivan J Núñez-Gil, Natale Daniele Brunetti,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1183-e1184]

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Complete Genome Sequence of Streptococcus pneumoniae Strain Rx1, a Hex Mismatch Repair-Deficient Standard Transformation Recipient.

Anna Maria Cuppone, Lorenzo Colombini, Valeria Fox, David Pinzauti, Francesco Santoro, Gianni Pozzi, Francesco Iannelli,

The complete genome sequence of Streptococcus pneumoniae strain Rx1, a Hex mismatch repair-deficient standard transformation recipient, was obtained by combining Nanopore and Illumina sequencing technologies. The genome consists of a 2.03-Mb circular chromosome, with 2,054 open reading frames and a GC content of 39.72%. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2021, 10(41):e0079921]

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Antiplatelet therapy and outcome in COVID-19: the Health Outcome Predictive Evaluation Registry.

Francesco Santoro, Ivan Javier Nuñez-Gil, Enrica Vitale, Maria C Viana-Llamas, Begoña Reche-Martinez, Rodolfo Romero-Pareja, Gisela Feltez Guzman, Inmaculada Fernandez Rozas, Aitor Uribarri, Víctor Manuel Becerra-Muñoz, Emilio Alfonso-Rodriguez, Marcos Garcia-Aguado, Jia Huang, María Elizabeth Ortega-Armas, Juan F Garcia Prieto, Eva Maria Corral Rubio, Fabrizio Ugo, Matteo Bianco, Alba Mulet, Sergio Raposeiras-Roubin, Jorge Luis Jativa Mendez, Carolina Espejo Paeres, Adrián Rodríguez Albarrán, Francisco Marín, Federico Guerra, Ibrahim Akin, Bernardo Cortese, Harish Ramakrishna, Carlos Macaya, Antonio Fernandez-Ortiz, Natale Daniele Brunetti,

<h4>Background</h4>Standard therapy for COVID-19 is continuously evolving. Autopsy studies showed high prevalence of platelet-fibrin-rich microthrombi in several organs. The aim of the study was therefore to evaluate the safety and efficacy of antiplatelet therapy (APT) in hospitalised patients with COVID-19 and its impact on survival.<h4>Methods</h4>7824 consecutive patients with COVID-19 were ... Read more >>

Heart (Heart (British Cardiac Society))
[2021, :]

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Impact of interproximal composite restorations on periodontal tissue health: Clinical and cytokine profiles from a pre-post quasi-experimental study.

Discepoli Nicola, Marruganti Crystal, Santoro Francesco, Mirra Raffaele, Fabio Fiorino, Medaglini Donata, Pozzi Gianni, Ferrari Marco, Grandini Simone,

<h4>Background</h4>The aim of this study is to clinically and molecularly evaluate the effect of an interproximal iuxta/subgingival direct composite restoration on periodontal tissue healing.<h4>Methods</h4>Individuals in need of a posterior iuxta/subgingival interproximal restoration were consecutively enrolled. After enrollment, a test (site with tooth decay) and a control site (intact contralateral tooth) ... Read more >>

J Periodontol (Journal of periodontology)
[2021, :]

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A Mating Procedure for Genetic Transfer of Integrative and Conjugative Elements (ICEs) of Streptococci and Enterococci.

Francesco Iannelli, Francesco Santoro, Valeria Fox, Gianni Pozzi,

DNA sequencing of whole bacterial genomes has revealed that the entire set of mobile genes (mobilome) represents as much as 25% of the bacterial genome. Despite the huge availability of sequence data, the functional analysis of the mobile genetic elements (MGEs) is rarely reported. Therefore, established laboratory protocols are needed ... Read more >>

Methods Protoc (Methods and protocols)
[2021, 4(3):]

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Complete Genome Sequence of Lactobacillus crispatus Type Strain ATCC 33820.

Lucia Teodori, Lorenzo Colombini, Anna Maria Cuppone, Elisa Lazzeri, David Pinzauti, Francesco Santoro, Francesco Iannelli, Gianni Pozzi,

The complete genome sequence of Lactobacillus crispatus type strain ATCC 33820 was obtained by combining Nanopore and Illumina sequencing technologies. The genome consists of a 2.2-Mb circular chromosome with 2,194 open reading frames and an average GC content of 37.0%. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2021, 10(32):e0063421]

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Prognostic role of neoplastic markers in Takotsubo syndrome.

Francesco Santoro, Tecla Zimotti, Adriana Mallardi, Alessandra Leopizzi, Enrica Vitale, Nicola Tarantino, Armando Ferraretti, Antonio Giovanni Solimando, Vito Racanelli, Massimo Iacoviello, Michele Cannone, Matteo Di Biase, Natale Daniele Brunetti,

Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and long-term follow-up in subjects with TTS. Ninety consecutive subjects ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):16548]

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Impact of COVID-19 Pandemic on the Italian Humanitarian Congenital Cardiac Surgery Activity: What No One Tells You.

Alessandro Giamberti, Federica Caldaroni, Alessandro Varrica, Carlo Pace Napoleone, Stefano Maria Marianeschi, Nicola Uricchio, Vittorio Vanini, Francesco Santoro, Giovanni Battista Luciani, Giovanni Stellin, Gaetano Gargiulo, Bruno Murzi, Sergio Filippelli, Guido Oppido, Salvatore Agati, Lorenzo Galletti, Alessandro Frigiola,

More than 4 millions of children with congenital heart disease (CHD) are waiting for cardiac surgery around the world. Few of these patients are treated only thanks to the support of many non-governmental organizations (NGOs). Starting in December 2019, the so-called coronavirus disease 2019 (COVID-19) has rapidly become a worldwide ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:705029]

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Effect of SAcubitril/Valsartan on left vEntricular ejection fraction and on the potential indication for Implantable Cardioverter Defibrillator in primary prevention: the SAVE-ICD study.

Federico Guerra, Ernesto Ammendola, Matteo Ziacchi, Vittorio Aspromonte, Pier Luigi Pellegrino, Giuseppe Del Giorno, Gabriele Dell'Era, Lorenzo Pimpini, Francesco Santoro, Roberto Floris, Giulia Stronati, Gerardo Nigro, Pasquale Paolisso, Alessandro Guido, Giampiero Maglia, Natale Daniele Brunetti, Angelo Carbone, Miriam Gravellone, Roberto Antonicelli, Michele Cannone, Michele Accogli, Antonio Dello Russo, Pietro Palmisano,

<h4>Purpose</h4>Sacubitril/valsartan has been associated with a positive reverse left ventricular remodelling in patients with heart failure with reduced ejection fraction (HFrEF). These patients may also benefit from an ICD implant. We aimed to assess EF improvement after 6 months of treatment with sacubitril/valsartan, evaluating when ICD as primary prevention was no ... Read more >>

Eur J Clin Pharmacol (European journal of clinical pharmacology)
[2021, :]

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Anticoagulation Therapy in Patients With Coronavirus Disease 2019: Results From a Multicenter International Prospective Registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019 [HOPE-COVID19]).

Francesco Santoro, Ivan J Núñez-Gil, María C Viana-Llamas, Charbel Maroun Eid, Rodolfo Romero, Inmaculada Fernández Rozas, Alvaro Aparisi, Victor Manuel Becerra-Muñoz, Marcos García Aguado, Jia Huang, Ludovica Maltese, Enrico Cerrato, Emilio Alfonso-Rodriguez, Alex Fernando Castro Mejía, Francisco Marin, Sergio Raposeiras Roubin, Martino Pepe, Victor H Moreno Munguia, Gisela Feltes, Jesus Varas Navas, Bernardo Cortese, Luis Buzón, Cristoph Liebetrau, Raquel Ramos-Martinez, Antonio Fernandez-Ortiz, Vicente Estrada, Natale Daniele Brunetti,

<h4>Objectives</h4>No standard therapy, including anticoagulation regimens, is currently recommended for coronavirus disease 2019. Aim of this study was to evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival.<h4>Design</h4>Multicenter international prospective registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019).<h4>Setting</h4>Hospitalized patients with coronavirus ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(6):e624-e633]

Cited: 3 times

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Incidence and Clinical Impact of Right Ventricular Involvement (Biventricular Ballooning) in Takotsubo Syndrome: Results From the GEIST Registry.

Ibrahim El-Battrawy, Francesco Santoro, Thomas Stiermaier, Christian Möller, Francesca Guastafierro, Giuseppina Novo, Salvatore Novo, Enrica Mariano, Francesco Romeo, Fabiana Romeo, Holger Thiele, Federico Guerra, Alessandro Capucci, Irene Giannini, Natale Daniele Brunetti, Ingo Eitel, Ibrahim Akin,

<h4>Background</h4>The short- and long-term prognosis of Takotsubo syndrome (TTS) presenting with right ventricular (RV) involvement remains poorly understood.<h4>Research question</h4>What is the incidence and clinical outcome of RV involvement in TTS?<h4>Study design and methods</h4>This study analyzed 839 consecutive patients with TTS (758 female subjects and 81 male subjects) in a multicenter ... Read more >>

Chest (Chest)
[2021, 160(4):1433-1441]

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Working as a team in airway surgery: History, present and perspectives.

Michele Torre, Roberto D'Agostino, Ivana Fiz, Oliviero Sacco, Pietro Salvati, Annalisa Gallizia, Francesca Rizzo, Mirta Della Rocca, Serena Arrigo, Antonella Palmieri, Nicola Stagnaro, Italo Borini, Francesco Santoro, Halkwat Nuri, Giuseppe Pomé, Maurizio Marasini, Vittorio Guerriero, Luca Pio, Federica Lena, Elisabetta Lampugnani, Franco Puncuh, Silvia Buratti, Stefano Pezzato, Andrea Wolfler, Annalisa Costa, Monica Faggiolo, Daniela Tronconi, Maria Annunziata Pinna, Daniela Cordeglio, Armanda Ferullo, Girolamo Mattioli, Andrea Moscatelli, Annalisa Oneto, Claudia Barbieri, Marzia Musso,

Teamwork is one of the most important trend in modern medicine. Airway team were created in many places to respond in a multidisciplinary and coordinated way to challenging clinical problems which were beyond the possibility of an individual management. In this chapter, we illustrate the historical steps leading to the ... Read more >>

Semin Pediatr Surg (Seminars in pediatric surgery)
[2021, 30(3):151051]

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Safety and Efficacy of Cryoballoon Ablation for the Treatment of Atrial Fibrillation in Diabetic Patients.

Abdin Amr, Heeger Christian-H, Yalin Kivanc, Santoro Francesco, Brunetti Natale Daniele, Fink Thomas, Liosis Spyridon, Brueggemann Ben, Keelani Ahmad, Phan Huong Lan, Sano Makoto, Sciacca Vanessa, Lyan Evgeny, A N Dong, Meyer-Saraei Roza, Ouyang Feifan, Kuck Karl-Heinz, Eitel Charlotte, Vogler Julia, Tilz Roland Richard,

<h4>Background</h4>Cryoballoon based catheter ablation (CB-CA) is an established therapy for treatment of symptomatic atrial fibrillation (AF). However, data about AF ablation using the CB in the diabetic population is sparse. The aim of this single center retrospective study is to evaluate the safety and efficacy of CB ablation in patients ... Read more >>

J Atr Fibrillation (Journal of atrial fibrillation)
[2020, 12(6):2285]

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[Atrial fibrillation in patients with COVID-19. Usefulness of the CHA2DS2-VASc score: an analysis of the international HOPE COVID-19 registry].

Aitor Uribarri, Iván J Núñez-Gil, Álvaro Aparisi, Ramón Arroyo-Espliguero, Charbel Maroun Eid, Rodolfo Romero, Víctor M Becerra-Muñoz, Gisela Feltes, María Molina, Marcos García-Aguado, Enrico Cerrato, Thamar Capel-Astrua, Emilio Alfonso-Rodríguez, Alex F Castro-Mejía, Sergio Raposeiras-Roubín, Carolina Espejo, Nerea Pérez-Solé, Alfredo Bardají, Francisco Marín, Óscar Fabregat-Andrés, Fabrizio D'ascenzo, Francesco Santoro, Ibrahim Akin, Vicente Estrada, Antonio Fernández-Ortiz, Carlos Macaya, ,

<h4>Introduction and objectives</h4>Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Atrial fibrillation (AF) is common in acute situations, where it is associated with more complications and higher mortality.<h4>Methods</h4>Analysis of the international HOPE registry (NCT04334291). The objective was to assess the prognostic information of AF in ... Read more >>

Rev Esp Cardiol (Revista espanola de cardiologia)
[2021, 74(7):608-615]

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Genome Sequences of 10 SARS-CoV-2 Viral Strains Obtained by Nanopore Sequencing of Nasopharyngeal Swabs in Malta.

Manuele Biazzo, Silvia Madeddu, Elfath Elnifro, Tessabella Sultana, Josie Muscat, Christian A Scerri, Francesco Santoro, David Pinzauti,

The genome sequences of 10 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains from Sliema, Malta, were obtained by Nanopore sequencing using the amplicon sequencing approach developed by the Artic Network. The assembled genomes were analyzed with Pangolin software and assigned to the B.1 lineage, which is widely circulating in ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2021, 10(4):]

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Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine.

Francesco Santoro, Alessia Donato, Simone Lucchesi, Sara Sorgi, Alice Gerlini, Marielle C Haks, Tom H M Ottenhoff, Patricia Gonzalez-Dias, Vsv-Ebovac Consortium, Vsv-Eboplus Consortium, Helder I Nakaya, Angela Huttner, Claire-Anne Siegrist, Donata Medaglini, Gianni Pozzi,

Ebolavirus Disease (EVD) is a severe haemorrhagic fever that occurs in epidemic outbreaks, with a high fatality rate and no specific therapies available. rVSVΔG-ZEBOV-GP (Ervebo<sup>®</sup>), a live-attenuated recombinant vesicular stomatitis virus vector expressing the glycoprotein G of Zaire Ebolavirus, is the first vaccine approved for prevention of EVD. Both innate ... Read more >>

Vaccines (Basel) (Vaccines)
[2021, 9(2):]

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Atrial fibrillation in patients with COVID-19. Usefulness of the CHA2DS2-VASc score: an analysis of the international HOPE COVID-19 registry.

Aitor Uribarri, Iván J Núñez-Gil, Álvaro Aparisi, Ramón Arroyo-Espliguero, Charbel Maroun Eid, Rodolfo Romero, Víctor M Becerra-Muñoz, Gisela Feltes, María Molina, Marcos García-Aguado, Enrico Cerrato, Thamar Capel-Astrua, Emilio Alfonso-Rodríguez, Alex F Castro-Mejía, Sergio Raposeiras-Roubín, Carolina Espejo, Nerea Pérez-Solé, Alfredo Bardají, Francisco Marín, Óscar Fabregat-Andrés, Fabrizio D'ascenzo, Francesco Santoro, Ibrahim Akin, Vicente Estrada, Antonio Fernández-Ortiz, Carlos Macaya, ,

<h4>Introduction and objectives</h4>Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2. Atrial fibrillation (AF) is common in acute situations, where it is associated with more complications and higher mortality.<h4>Methods</h4>Analysis of the international HOPE registry (NCT04334291). The objective was to assess the prognostic information of AF in ... Read more >>

Rev Esp Cardiol (Engl Ed) (Revista espanola de cardiologia (English ed.))
[2021, 74(7):608-615]

Cited: 1 time

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Current Knowledge and Future Challenges in Takotsubo Syndrome: Part 2-Treatment and Prognosis.

Francesco Santoro, Adriana Mallardi, Alessandra Leopizzi, Enrica Vitale, Elias Rawish, Thomas Stiermaier, Ingo Eitel, Natale D Brunetti,

Takotsubo syndrome (TTS) represents a form of acute heart failure featured by reversible left ventricular systolic dysfunction. The management during the acute phase is mainly performed with supportive pharmacological (diuretics, ACE-inhibitors/angiotensin-receptor blockers (ARBs), anticoagulants, antiarrhythmics, non-catecholamine inotropics (levosimendan), and non-pharmacological (mechanical circulatory and respiratory support) therapy, due to the wide ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(3):]

Cited: 4 times

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Causes of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: Findings from the SYNCOPACED registry.

Pietro Palmisano, Gabriele Dell'Era, Pier Luigi Pellegrino, Ernesto Ammendola, Matteo Ziacchi, Federico Guerra, Vittorio Aspromonte, Mattia Laffi, Lorenzo Pimpini, Francesco Santoro, Enrico Boggio, Alessandro Guido, Giuseppe Patti, Natale Daniele Brunetti, Gerardo Nigro, Mauro Biffi, Antonio Dello Russo, Germano Gaggioli, Michele Accogli, ,

<h4>Background</h4>Few studies have examined the causes of syncope/collapse recurrences in patients with a previously implanted pacemaker for bradyarrhythmic syncope.<h4>Objective</h4>The purpose of this study was to assess the causes of syncope/collapse recurrences after pacemaker implantation for bradyarrhythmic syncope in a large patient population.<h4>Methods</h4>The SYNCOpal recurrences in patients treated with permanent PACing ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(5):770-777]

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Distribution of injectates in the thoracic paravertebral space of the dog and cat: A cadaveric study.

Francesco Santoro, Paolo Franci, Annamaria Grandis, Simond Valgimigli,

<h4>Background</h4>Thoracic paravertebral block (TPVB) entails injecting a local anesthetic inside the thoracic paravertebral space (TPVS). Loss of resistance to air injection (air-LOR) was the first technique described in humans to locate the TPVS. To date, no study has investigated the spread of any substance after injection into the TPVS using ... Read more >>

Open Vet J (Open veterinary journal)
[2021, 11(1):27-35]

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Stroke and left atrial thrombi after cryoballoon ablation of atrial fibrillation: incidence and predictors. Results from a long-term follow-up.

Francesco Santoro, Natale Daniele Brunetti, Andreas Rillig, Bruno Reissmann, Christine Lemeš, Tilman Maurer, Thomas Fink, Naotaka Hashiguchi, Alessandra Leopizzi, Adriana Mallardi, Shibu Mathew, Feifan Ouyang, Karl-Heinz Kuck, Roland R Tilz, Andreas Metzner, Christian H Heeger,

Stroke after catheter ablation (CA) of atrial fibrillation (AF) is a potential complication with long term consequences. Aim of this study was to determine incidence and potential predictors of stroke and left atrial appendage (LAA) thrombi after AF ablation with cryo-energy. Two hundred nine consecutive patients with symptomatic drug refractory ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(1):74-80]

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Risk of syncopal recurrences in patients treated with permanent pacing for bradyarrhythmic syncope: role of correlation between symptoms and electrocardiogram findings.

Pietro Palmisano, Pier Luigi Pellegrino, Ernesto Ammendola, Matteo Ziacchi, Federico Guerra, Vittorio Aspromonte, Mattia Laffi, Lorenzo Pimpini, Francesco Santoro, Enrico Boggio, Alessandro Guido, Giuseppe Patti, Natale Daniele Brunetti, Gerardo Nigro, Mauro Biffi, Antonio Dello Russo, Germano Gaggioli, Michele Accogli, Gabriele Dell'Era,

<h4>Aims</h4>To evaluate the risk of syncopal recurrences after pacemaker implantation in a population of patients with syncope of suspected bradyarrhythmic aetiology.<h4>Methods and results</h4>Prospective, multicentre, observational registry enrolling 1364 consecutive patients undergoing pacemaker implantation for syncope of bradyarrhythmic aetiology (proven or presumed). Before pacemaker implantation, all patients underwent a cardiac work-up ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2020, 22(11):1729-1736]

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QTc interval prolongation and life-threatening arrhythmias during hospitalization in patients with COVID-19. Results from a multi-center prospective registry.

Francesco Santoro, Francesco Monitillo, Pasquale Raimondo, Agostino Lopizzo, Gaetano Brindicci, Michele Gilio, Francesco Musaico, Michele Mazzola, Domenico Vestito, Rossella Di Benedetto, Mohammad Abumayyaleh, Ibrahim El-Battrawy, Carmen Rita Santoro, Luigi Flavio Massimiliano Di Martino, Ibrahim Akin, Giulio De Stefano, Rosario Fiorilli, Michele Cannone, Annalisa Saracino, Salvatore Angarano, Sergio Carbonara, Salvatore Grasso, Luigi Di Biase, Natale Daniele Brunetti,

<h4>Background</h4>Prolonged QTc interval and life-threatening arrhythmias (LTA) are potential drug induced complications previously reported with antimalarial, antivirals and antibiotics.<h4>Objectives</h4>To evaluate prevalence and predictors of QTc interval prolongation and incidence of LTA during hospitalization for COVID-19 among patients with normal admission QTc.<h4>Methods</h4>110 consecutive patients were enrolled in a multicenter international registry. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 4 times

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COMPASS vs PEGASUS approach in a comparative budget impact analysis.

Natale Daniele Brunetti, Luisa De Gennaro, Michele Correale, Riccardo Ieva, Francesco Santoro,

Eur J Intern Med (European journal of internal medicine)
[2021, 83:102-104]

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Author Correction: Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination.

David Pejoski, Casimir de Rham, Paola Martinez-Murillo, Francesco Santoro, Floriane Auderset, Donata Medaglini, Gianni Pozzi, Maria Vono, Paul-Henri Lambert, Angela Huttner, Mariëlle C Haks, Tom H M Ottenhoff, Jean Villard, Claire-Anne Siegrist, , , ,

NPJ Vaccines (NPJ vaccines)
[2020, 5(1):93]

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