Full Text Journal Articles by
Author Francesco Petrella

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Electronic cigarettes, vaping-related lung injury and lung cancer: where do we stand?

Francesco Petrella,

Electronic cigarettes have been considered a promising alternative to nicotine replacement products to help heavy tobacco smokers quit smoking. They work thanks to a heating coil causing evaporation of the liquid rapidly followed by cooling, thus creating an aerosol, a completely different mechanism from the combustion of tobacco in traditional ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(4):293-296]

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Veno-venous extra-corporeal membrane oxygenation-assisted right tracheal-sleeve pneumonectomy.

Antonio Mazzella, Luca Bertolaccini, Francesco Petrella, Lorenzo Spaggiari,

Tracheal sleeve pneumonectomy for lung cancer is an old technique, and it is reserved for exceptional cases with tracheal carina involvement. Intra-operative airways management of this operation is incredibly complex, involving thoracic surgeons, anaesthesiologists and pulmonologists. We report a case of a 38-year-old male with no clinical history, referred to ... Read more >>

Interact Cardiovasc Thorac Surg (Interactive cardiovascular and thoracic surgery)
[2021, :]

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The promising pro-healing role of the association of mesoglycan and lactoferrin on skin lesions.

Raffaella Belvedere, Emanuela Pessolano, Nunzia Novizio, Alessandra Tosco, Daniela Eletto, Amalia Porta, Amelia Filippelli, Francesco Petrella, Antonello Petrella,

Skin wound repair represents an important topic for the therapeutic challenges. Many molecules are commonly used as active principles of topical devices to induce the correct tissue regeneration. Among these molecules, mesoglycan, a mixture of glycosaminoglycans, and the lactoferrin have recently aroused interest. Here, for the first time, we used ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2021, 163:105886]

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Prognostic Value of the Hemoglobin/Red Cell Distribution Width Ratio in Resected Lung Adenocarcinoma.

Francesco Petrella, Monica Casiraghi, Davide Radice, Andrea Cara, Gabriele Maffeis, Elena Prisciandaro, Stefania Rizzo, Lorenzo Spaggiari,

<h4>Background</h4>The ratio of hemoglobin to red cell distribution width (HRR) has been described as an effective prognostic factor in several types of cancer. The aim of this study was to investigate the prognostic role of preoperative HRR in resected-lung-adenocarcinoma patients.<h4>Methods</h4>We enrolled 342 consecutive patients. Age, sex, surgical resection, adjuvant treatments, ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(4):]

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Diagnosis and Treatment of Primary and Secondary Lung Cancers.

Francesco Petrella,

Primary and secondary lung cancers are the most common clinical conditions that thoracic surgeons have to deal with: primary lung cancer, in fact, is one of the most frequently diagnosed cancers and is the leading cause of cancer-related death worldwide [...]. ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(3):]

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The Impact of Multidisciplinary Team Meetings on Patient Management in Oncologic Thoracic Surgery: A Single-Center Experience.

Francesco Petrella, Davide Radice, Juliana Guarize, Gaia Piperno, Cristiano Rampinelli, Filippo de Marinis, Lorenzo Spaggiari,

<h4>Background</h4>the aim of this paper is to quantify multidisciplinary team meeting (MDT) impact on the decisional clinical pathway of thoracic cancer patients, assessing the modification rate of the initial out-patient evaluation.<h4>Methods</h4>the impact of MDT was classified as follows: confirmation: same conclusions as out-patient hypothesis; modification: change of out-patient hypothesis; implementation: ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(2):]

Cited: 1 time

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Prognostic Value of Red Blood Cell Distribution Width in Resected pN1 Lung Adenocarcinoma.

Francesco Petrella, Monica Casiraghi, Davide Radice, Elena Prisciandaro, Stefania Rizzo, Lorenzo Spaggiari,

<i>Background:</i> Red blood cell distribution width is a measure of the variation of erythrocyte volume and has recently been advocated as a prognostic tool in neoplastic and non-neoplastic diseases. We studied the prognostic role of preoperative red blood cell distribution width (RDW) in resected pN1 lung adenocarcinoma patients. <i>Methods:</i> Sixty-seven ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(12):]

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Surgery for small cell lung cancer: When and how.

Monica Casiraghi, Giulia Sedda, Ester Del Signore, Gaia Piperno, Patrick Maisonneuve, Francesco Petrella, Filippo de Marinis, Lorenzo Spaggiari,

<h4>Objective</h4>Since data from large retrospective observational studies and cancer registries became available, suggesting a benefit for patients undergoing surgery, the role of surgery in the treatment of small cell lung cancer (SCLC) needs to be reconsidered. The aim of this study was to evaluate outcomes and results of patients with ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2021, 152:71-77]

Cited: 2 times

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Paclitaxel Priming of TRAIL Expressing Mesenchymal Stromal Cells (MSCs-TRAIL) Increases Antitumor Efficacy of Their Secretome.

Valentina Coccè, Arianna Bonomi, Loredana Cavicchini, Francesca Sisto, Aldo Giannì, Giampietro Farronato, Giulio Alessandri, Francesco Petrella, Valeria Sordi, Eugenio Parati, Gianpietro Bondiolotti, Francesca Paino, Augusto Pessina,

<h4>Background</h4>Adipose tissue derived MSCs engineered with the tumor necrosis factor-related apoptosis-inducing ligand protein (MSCs-TRAIL) have a significant anticancer activity. MSCs, without any genetic modifications, exposed to high doses of chemotherapeutic agents are able to uptake the drug and release it in amount affecting tumor proliferation. The purpose of this study ... Read more >>

Curr Cancer Drug Targets (Current cancer drug targets)
[2020, :]

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Results of Surgical Resection of Locally Advanced Pulmonary Neuroendocrine Tumors.

Lara Girelli, Monica Casiraghi, Alberto Sandri, Francesco Petrella, Domenico Galetta, Roberto Gasparri, Patrick Maisonneuve, Nicola Fazio, Lorenzo Spaggiari,

<h4>Background</h4>Pulmonary neuroendocrine tumors include well-differentiated and poorly differentiated histology for which cell type has proved to be a determinant of survival in many studies. In patients diagnosed with bronchial carcinoid and large cell neuroendocrine carcinoma (LCNEC), surgery is the treatment of choice even in the case of locally advanced disease ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, :]

Cited: 1 time

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Outcomes and Safety Analysis in Superior Vena Cava Resection for Extended Thymic Epithelial Tumors.

Luca Bertolaccini, Elena Prisciandaro, Domenico Galetta, Monica Casiraghi, Juliana Guarize, Francesco Petrella, Giulia Sedda, Giorgio Lo Iacono, Daniela Brambilla, Lorenzo Spaggiari,

<h4>Background</h4>In stage III to IVa thymic epithelial tumors (TETs), infiltration of the superior vena cava (SVC) is not rare. The extent of SVC resection depends on the width of the area of neoplastic invasion. Our article aims to evaluate the safety and long-term outcomes of extended thymectomy for TETs with ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2020, :]

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The Role of Surgery in Lung Cancer Treatment.

Francesco Petrella,

&nbsp;[...]. ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(10):]

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Preliminary Results of Extracorporeal Membrane Oxygenation Assisted Tracheal Sleeve Pneumonectomy for Cancer.

Lorenzo Spaggiari, Giulia Sedda, Francesco Petrella, Marco Venturino, Fabiana Rossi, Juliana Guarize, Domenico Galetta, Monica Casiraghi, Giorgio Lo Iacono, Luca Bertolaccini, Francesco Alamanni,

<h4>Objective</h4>Tracheal sleeve pneumonectomy is a challenge in lung cancer management and in achieving long-term oncological results. In November 2018, we started a prospective study on the role of extracorporeal membrane oxygenation (ECMO) in tracheal sleeve pneumonectomy. We aim to present our preliminary results.<h4>Methods</h4>From November 2018 to November 2019, six patients ... Read more >>

Thorac Cardiovasc Surg (The Thoracic and cardiovascular surgeon)
[2021, 69(3):240-245]

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Recent developments and advances in secondary prevention of lung cancer.

Stefania Rizzo, Filippo Del Grande, Luciano Wannesson, Patrizia Froesch, Giuliana Giannetto, Francesco Petrella,

Lung cancer prevention may include primary prevention strategies, such as corrections of working conditions and life style - primarily smoking cessation - as well as secondary prevention strategies, aiming at early detection that allows better survival rates and limited resections. This review summarizes recent developments and advances in secondary prevention, ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2020, 29(4):321-328]

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Treatment of Chylothorax after Lung Resection: Indications, Timing, and Outcomes.

Francesco Petrella, Monica Casiraghi, Davide Radice, Luca Bertolaccini, Lorenzo Spaggiari,

<h4>Background</h4>Chylothorax following pulmonary resection and lymphadenectomy for cancer is a potential severe complication in thoracic surgery. In the present study, we investigated the efficacy of the nonsurgical approach as well as the need for reoperation after conservative approach failure.<h4>Methods</h4>Chylothorax was diagnosed when chylous leakage from the chest drainage was observed ... Read more >>

Thorac Cardiovasc Surg (The Thoracic and cardiovascular surgeon)
[2020, 68(6):520-524]

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Association of a CT-Based Clinical and Radiomics Score of Non-Small Cell Lung Cancer (NSCLC) with Lymph Node Status and Overall Survival.

Francesca Botta, Sara Raimondi, Lisa Rinaldi, Federica Bellerba, Federica Corso, Vincenzo Bagnardi, Daniela Origgi, Rocco Minelli, Giovanna Pitoni, Francesco Petrella, Lorenzo Spaggiari, Alessio G Morganti, Filippo Del Grande, Massimo Bellomi, Stefania Rizzo,

BACKGROUND:To evaluate whether a model based on radiomic and clinical features may be associated with lymph node (LN) status and overall survival (OS) in lung cancer (LC) patients; to evaluate whether CT reconstruction algorithms may influence the model performance. METHODS:patients operated on for LC with a pathological stage up to ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(6):]

Cited: 1 time

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Lung cancer surgery in oligometastatic patients: outcome and survival.

Monica Casiraghi, Luca Bertolaccini, Giulia Sedda, Francesco Petrella, Domenico Galetta, Juliana Guarize, Patrick Maisonneuve, Filippo De Marinis, Lorenzo Spaggiari,

OBJECTIVES:A few studies have already demonstrated survival benefits for local treatment in solitary metastatic non-small-cell lung cancer (NSCLC). The aim of this study is to retrospectively investigate the role of surgery in patients with oligometastatic (OM) NSCLC. METHODS:Between January 1998 and December 2018, 57 patients with OM stage IV NSCLC ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2020, 57(6):1173-1180]

Cited: 3 times

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Case Report: Microfragmented Adipose Tissue Drug Delivery in Canine Mesothelioma: A Case Report on Safety, Feasibility, and Clinical Findings.

Offer Zeira, Erica Ghezzi, Letizia Pettinari, Valentina Re, Davide M Lupi, Silvia L Benali, Simone Borgonovo, Giulio Alessandri, Francesco Petrella, Rita Paroni, Michele Dei Cas, Carlo Tremolada, Valentina Coccè, Augusto Pessina,

Mesothelioma is a rare lethal tumor of dogs and humans involving cavities of the body. Dogs are considered a model for new drugs and therapeutic methods since they present spontaneous diseases similar to humans. Microfragmented adipose tissue (MFAT) uploaded by paclitaxel (PTX) is a drug delivery medium providing slow release ... Read more >>

Front Vet Sci (Frontiers in veterinary science)
[2020, 7:585427]

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MRI-guided segmental sternectomy for impalpable intraosseous lesion.

Francesco Petrella, Monica Casiraghi, Niccolò Filippi, Riccardo Orlandi, Andrea Alliata, Giorgio Lo Iacono, Luigi Funicelli, Stefania Rizzo, Lorenzo Spaggiari,

J Thorac Dis (Journal of thoracic disease)
[2020, 12(1):42-44]

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Radioisotope-guided localization and resection of non-palpable focal lesion of the rib.

Francesco Petrella, Giorgio Lo Iacono, Monica Casiraghi, Lorenzo Gherzi, Elena Prisciandaro, Cristiano Rampinelli, Marzia Colandrea, Chiara Maria Grana, Lorenzo Spaggiari,

J Thorac Dis (Journal of thoracic disease)
[2020, 12(1):36-38]

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Surgery of the chest wall: indications, timing and technical aspects.

Francesco Petrella, Lorenzo Spaggiari,

J Thorac Dis (Journal of thoracic disease)
[2020, 12(1):1-2]

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Chest wall resection and reconstruction by composite prosthesis for locally recurrent breast carcinoma.

Francesco Petrella, Giorgio Lo Iacono, Monica Casiraghi, Lorenzo Gherzi, Elena Prisciandaro, Cristina Garusi, Lorenzo Spaggiari,

J Thorac Dis (Journal of thoracic disease)
[2020, 12(1):39-41]

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Mesoglycan induces the secretion of microvesicles by keratinocytes able to activate human fibroblasts and endothelial cells: A novel mechanism in skin wound healing.

Raffaella Belvedere, Emanuela Pessolano, Amalia Porta, Alessandra Tosco, Luca Parente, Francesco Petrella, Mauro Perretti, Antonello Petrella,

Mesoglycan is a fibrinolytic compound but recently promising pro-healing effects in skin wound repair have been reported. Previously, we have showed that mesoglycan activates human keratinocytes, fibroblasts and endothelial cells and induces the secretion of microvesicles (EVs), particularly exosomes, from keratinocytes. These EVs may contribute to wound healing since they ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2020, 869:172894]

Cited: 3 times

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Erratum to: Surgical Treatment of Bilateral Lung Cancers: Long-Term Outcomes and Prognostic Factors.

Francesco Petrella, Samuele Frassoni, Vincenzo Bagnardi, Monica Casiraghi, Daniela Brambilla, Cristina Diotti, Lorenzo Spaggiari,

Thorac Cardiovasc Surg (The Thoracic and cardiovascular surgeon)
[2019, :]

Cited: 0 times

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Prolonged air leak after pulmonary lobectomy.

Francesco Petrella, Lorenzo Spaggiari,

J Thorac Dis (Journal of thoracic disease)
[2019, 11(Suppl 15):S1976-S1978]

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