Full Text Journal Articles by
Author Francesco M Marincola

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Myeloid Cells Are Enriched in Tonsillar Crypts, Providing Insight into the Viral Tropism of Human Papillomavirus.

Austin K Mattox, Jessica Roelands, Talia M Saal, Yang Cheng, Darawan Rinchai, Wouter Hendrickx, Geoffrey D Young, Thomas J Diefenbach, Alan E Berger, William H Westra, Justin A Bishop, William C Faquin, Francesco M Marincola, Mikael J Pittet, Davide Bedognetti, Sara I Pai,

Viruses are the second leading cause of cancer worldwide, and human papillomavirus (HPV)-associated head and neck cancers are increasing in incidence in the United States. HPV preferentially infects the crypts of the tonsils rather than the surface epithelium. The present study sought to characterize the unique microenvironment within the crypts ... Read more >>

Am J Pathol (The American journal of pathology)
[2021, 191(10):1774-1786]

Cited: 0 times

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Network-based identification of key master regulators associated with an immune-silent cancer phenotype.

Raghvendra Mall, Mohamad Saad, Jessica Roelands, Darawan Rinchai, Khalid Kunji, Hossam Almeer, Wouter Hendrickx, Francesco M Marincola, Michele Ceccarelli, Davide Bedognetti,

A cancer immune phenotype characterized by an active T-helper 1 (Th1)/cytotoxic response is associated with responsiveness to immunotherapy and favorable prognosis across different tumors. However, in some cancers, such an intratumoral immune activation does not confer protection from progression or relapse. Defining mechanisms associated with immune evasion is imperative to ... Read more >>

Brief Bioinform (Briefings in bioinformatics)
[2021, :]

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Correction: A balance score between immune stimulatory and suppressive microenvironments identifies mediators of tumour immunity and predicts pan-cancer survival.

Tolga Turan, Sarah Kongpachith, Kyle Halliwill, Jessica Roelands, Wouter Hendrickx, Francesco M Marincola, Thomas J Hudson, Howard J Jacob, Davide Bedognetti, Josue Samayoa, Michele Ceccarelli,

Br J Cancer (British journal of cancer)
[2021, 124(7):1340]

Cited: 0 times

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Germline genetic contribution to the immune landscape of cancer.

Rosalyn W Sayaman, Mohamad Saad, Vésteinn Thorsson, Donglei Hu, Wouter Hendrickx, Jessica Roelands, Eduard Porta-Pardo, Younes Mokrab, Farshad Farshidfar, Tomas Kirchhoff, Randy F Sweis, Oliver F Bathe, Carolina Heimann, Michael J Campbell, Cynthia Stretch, Scott Huntsman, Rebecca E Graff, Najeeb Syed, Laszlo Radvanyi, Simon Shelley, Denise Wolf, Francesco M Marincola, Michele Ceccarelli, Jérôme Galon, Elad Ziv, Davide Bedognetti,

Understanding the contribution of the host's genetic background to cancer immunity may lead to improved stratification for immunotherapy and to the identification of novel therapeutic targets. We investigated the effect of common and rare germline variants on 139 well-defined immune traits in ∼9000 cancer patients enrolled in TCGA. High heritability ... Read more >>

Immunity (Immunity)
[2021, 54(2):367-386.e8]

Cited: 6 times

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Hypoxia and the phenomenon of immune exclusion.

Violena Pietrobon, Francesco M Marincola,

Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many types of cancer. However, the exclusion of lymphocytes from the tumor nest is a common phenomenon that limits the efficiency of immunotherapy in solid tumors. Despite several mechanisms proposed during ... Read more >>

J Transl Med (Journal of translational medicine)
[2021, 19(1):9]

Cited: 3 times

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A balance score between immune stimulatory and suppressive microenvironments identifies mediators of tumour immunity and predicts pan-cancer survival.

Tolga Turan, Sarah Kongpachith, Kyle Halliwill, Jessica Roelands, Wouter Hendrickx, Francesco M Marincola, Thomas J Hudson, Howard J Jacob, Davide Bedognetti, Josue Samayoa, Michele Ceccarelli,

<h4>Background</h4>The balance between immune-stimulatory and immune-suppressive mechanisms in the tumour microenvironment is associated with tumour rejection and can predict the efficacy of immune checkpoint-inhibition therapies.<h4>Methods</h4>We consider the observed differences between the transcriptional programmes associated with cancer types where the levels of immune infiltration predict a favourable prognosis versus those in ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 124(4):760-769]

Cited: 1 time

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No time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international study.

Paolo A Ascierto, Francesco M Marincola, Bernard A Fox, Jérôme Galon,

The multicenter international Society for Immunotherapy of Cancer (SITC) study of the consensus Immunoscore demonstrated the prediction of survival and response to chemotherapy in 763 Stage III colon cancer (CC) patients. Similar Immunoscore groups were found in elderly patients, and densities of immune cells and intratumoral T-cell repertoire were not ... Read more >>

Oncoimmunology (Oncoimmunology)
[2020, 9(1):1826132]

Cited: 1 time

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Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.

Bernhard Mlecnik, Carlo Bifulco, Gabriela Bindea, Florence Marliot, Alessandro Lugli, J Jack Lee, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Y Wang, Prashant Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia K Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Daniela Bruni, Anastasia Lanzi, Carine El Sissy, Nacilla Haicheur, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Muşină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Kyogo Itoh, Prabhu S Patel, Hemangini H Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Bernard A Fox, Franck Pagès, Jérôme Galon,

<h4>Purpose</h4>The purpose of this study was to evaluate the prognostic value of Immunoscore in patients with stage III colon cancer (CC) and to analyze its association with the effect of chemotherapy on time to recurrence (TTR).<h4>Methods</h4>An international study led by the Society for Immunotherapy of Cancer evaluated the predefined consensus ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(31):3638-3651]

Cited: 16 times

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Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated.

Muna Al Hashmi, Konduru S Sastry, Lee Silcock, Lotfi Chouchane, Valentina Mattei, Nicola James, Rebecca Mathew, Davide Bedognetti, Valeria De Giorgi, Daniela Murtas, Wei Liu, Aouatef Chouchane, Ramzi Temanni, Barbara Seliger, Ena Wang, Francesco M Marincola, Sara Tomei,

<h4>Background</h4>Most mutations in melanoma affect one critical amino acid on BRAF gene, resulting in the V600E substitution. Patient management is often based on the use of specific inhibitors targeting this mutation.<h4>Methods</h4>DNA and RNA mutation status was assessed in 15 melanoma cell lines by Sanger sequencing and RNA-seq. We tested the ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):192]

Cited: 1 time

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Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19.

Paolo Antonio Ascierto, Bernard A Fox, Walter J Urba, Ana Carrizosa Anderson, Michael B Atkins, Ernest C Borden, Julie R Brahmer, Lisa H Butterfield, Alessandra Cesano, Daniel C Chen, Tanja D de Gruijl, Robert O Dillman, Charles G Drake, Leisha A Emens, Thomas F Gajewski, James L Gulley, F Jr Stephen Hodi, Patrick Hwu, David Kaufman, Howard L Kaufman, Michael T Lotze, Douglas G McNeel, Kim M Margolin, Francesco M Marincola, Michael J Mastrangelo, Marcela V Maus, David R Parkinson, Pedro J Romero, Paul M Sondel, Stefani Spranger, Mario Sznol, George J Weiner, Jon M Wigginton, Jeffrey S Weber,

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(1):]

Cited: 26 times

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Oncogenic states dictate the prognostic and predictive connotations of intratumoral immune response.

Jessica Roelands, Wouter Hendrickx, Gabriele Zoppoli, Raghvendra Mall, Mohamad Saad, Kyle Halliwill, Giuseppe Curigliano, Darawan Rinchai, Julie Decock, Lucia G Delogu, Tolga Turan, Josue Samayoa, Lotfi Chouchane, Alberto Ballestrero, Ena Wang, Pascal Finetti, Francois Bertucci, Lance D Miller, Jerome Galon, Francesco M Marincola, Peter J K Kuppen, Michele Ceccarelli, Davide Bedognetti,

<h4>Background</h4>An immune active cancer phenotype typified by a T helper 1 (Th-1) immune response has been associated with increased responsiveness to immunotherapy and favorable prognosis in some but not all cancer types. The reason of this differential prognostic connotation remains unknown.<h4>Methods</h4>To explore the contextual prognostic value of cancer immune phenotypes, ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(1):]

Cited: 15 times

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Aitziber Buqué Martinez, Timothy A Chan, George Coukos, Sandra Demaria, Eric Deutsch, Dobrin Draganov, Richard L Edelson, Silvia C Formenti, Jitka Fucikova, Lucia Gabriele, Udo S Gaipl, Sofia R Gameiro, Abhishek D Garg, Encouse Golden, Jian Han, Kevin J Harrington, Akseli Hemminki, James W Hodge, Dewan Md Sakib Hossain, Tim Illidge, Michael Karin, Howard L Kaufman, Oliver Kepp, Guido Kroemer, Juan Jose Lasarte, Sherene Loi, Michael T Lotze, Gwenola Manic, Taha Merghoub, Alan A Melcher, Karen L Mossman, Felipe Prosper, Øystein Rekdal, Maria Rescigno, Chiara Riganti, Antonella Sistigu, Mark J Smyth, Radek Spisek, John Stagg, Bryan E Strauss, Daolin Tang, Kazuki Tatsuno, Stefaan W van Gool, Peter Vandenabeele, Takahiro Yamazaki, Dmitriy Zamarin, Laurence Zitvogel, Alessandra Cesano, Francesco M Marincola,

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(1):]

Cited: 96 times

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The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier.

Sara I Pai, Alessandra Cesano, Francesco M Marincola,

Checkpoint inhibitor therapy (CIT) has revolutionized cancer treatment but it has also reached a standstill when an absent dialog between cancer and immune cells makes it irrelevant. This occurs with high prevalence in the context of "immune silent" and, even perhaps, "immune-excluded" tumors. The latter are characterized by T cells restricted ... Read more >>

Cancer Treat Res (Cancer treatment and research)
[2020, 180:173-195]

Cited: 8 times

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Status of Immune Oncology: Challenges and Opportunities.

Alessandra Cesano, Francesco M Marincola, Magdalena Thurin,

This volume is intended to review the methods used to identify biomarkers predictive of cancer responsiveness to immunotherapy. The successful development of clinically actionable biomarkers depends upon three features: (a) their biological role with respect to malignant transformation and tumor progression; (b) the ability to detect them with robust, reliable, ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2020, 2055:3-21]

Cited: 1 time

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The Biology of Immune-Active Cancers and Their Regulatory Mechanisms.

Davide Bedognetti, Alessandra Cesano, Francesco M Marincola, Ena Wang,

The development of cancer results from the evolutionary balance between the proliferating aptitude of cancer cells and the response of the host's tissues. Some cancers are characterized by genetic instability dependent upon impaired DNA repair mechanisms that lead to the chaotic disruption of multiple cellular functions often in excess of ... Read more >>

Cancer Treat Res (Cancer treatment and research)
[2020, 180:149-172]

Cited: 0 times

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Melanoma: Prognostic Factors and Factors Predictive of Response to Therapy.

Martina Strudel, Lucia Festino, Vito Vanella, Massimiliano Beretta, Francesco M Marincola, Paolo A Ascierto,

BACKGROUND:A better understanding of prognostic factors and biomarkers that predict response to treatment is required in order to further improve survival rates in patients with melanoma. Prognostic Factors: The most important histopathological factors prognostic of worse outcomes in melanoma are sentinel lymph node involvement, increased tumor thickness, ulceration and higher ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2020, 27(17):2792-2813]

Cited: 4 times

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Functional Genome Profiling to Understand Cancer Immune Responsiveness.

Ena Wang, Davide Bedognetti, Francesco M Marincola,

It has been almost two decades since we first proposed the use of minimally invasive serial biopsies to dissect the biology underlining cancer immune responsiveness (CIR) by looking for predictors of response, understanding mechanisms of action (MOA) of therapeutics and documenting strategies adopted by tumor cells to escape immune recognition. ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2020, 2055:231-244]

Cited: 0 times

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A novel method for efficient generation of antigen-specific effector T-cells using dendritic cells transduced with recombinant adeno-associated virus and p38 kinase blockade.

Leonardo Mirandola, Maurizio Chiriva-Internati, Robert Bresalier, Lucia Piccotti, Fabio Grizzi, Francesco M Marincola,

BACKGROUND:The inefficacy of standard therapeutic strategies for ovarian cancer is reflected by the enduring poor prognosis of this malignancy. Due to the potential for exquisite specificity, sensitivity and long-term memory, immunotherapy offers an alternative modality for durable control of the disease, provided appropriate antigens can be identified and presented in ... Read more >>

J Transl Med (Journal of translational medicine)
[2019, 17(1):424]

Cited: 2 times

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Editorial: Lymphocyte Functional Crosstalk and Regulation.

Raghvendra M Srivastava, Francesco M Marincola, Anil Shanker,

Front Immunol (Frontiers in immunology)
[2019, 10:2916]

Cited: 0 times

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Peripheral Circulating CD45RA-FOXP3hi T Regulatory (TReg) II Cells Provide a Window into the Activity of Intratumoral TReg Cells.

Sara I Pai, Francesco M Marincola,

The immune landscape of cancer determines its responsiveness to immunotherapy. Tumors infiltrated with CD8<sup>+</sup> T cells (immune-active tumors) are more likely to respond to immunomodulatory agents. However, immune activation often is counterbalanced by strong immunosuppressive mechanisms that are necessary to maintain homeostasis but consequentially can facilitate the survival of cancer cells ... Read more >>

Trends Cancer (Trends in cancer)
[2020, 6(1):3-6]

Cited: 1 time

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Single-Voxel 1 H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD+ ) in humans at 7T using a 32-channel volume coil.

Puneet Bagga, Hari Hariharan, Neil E Wilson, Joanne C Beer, Russell T Shinohara, Mark A Elliott, Joseph A Baur, Francesco M Marincola, Walter R Witschey, Mohammad Haris, John A Detre, Ravinder Reddy,

<h4>Purpose</h4>Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD<sup>+</sup> ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a <sup>1</sup> H MRS pulse sequence for the in vivo, localized <sup>1</sup> H MRS detection of NAD<sup>+</sup> from the human brain.<h4>Methods</h4>Studies were carried ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2020, 83(3):806-814]

Cited: 1 time

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Sugar alcohol provides imaging contrast in cancer detection.

Puneet Bagga, Neil Wilson, Laurie Rich, Francesco M Marincola, Mitchell D Schnall, Hari Hariharan, Mohammad Haris, Ravinder Reddy,

Clinical imaging is widely used to detect, characterize and stage cancers in addition to monitoring the therapeutic progress. Magnetic resonance imaging (MRI) aided by contrast agents utilizes the differential relaxivity property of water to distinguish between tumorous and normal tissue. Here, we describe an MRI contrast method for the detection ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):11092]

Cited: 3 times

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Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th-1 December 1st, 2018, Naples, Italy).

Paolo A Ascierto, Sanjiv S Agarwala, Gerardo Botti, Alfredo Budillon, Michael A Davies, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Silvia Formenti, Thomas F Gajewski, Claus Garbe, Omid Hamid, Roger S Lo, Jason J Luke, Oliver Michielin, Giuseppe Palmieri, Laurence Zitvogel, Francesco M Marincola, Giuseppe Masucci, Corrado Caracò, Magdalena Thurin, Igor Puzanov,

Diagnosis of melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges in melanoma. Recent studies have shown that immune checkpoint blockade that represents a forefront in cancer therapy, provide responses but they are not ... Read more >>

J Transl Med (Journal of translational medicine)
[2019, 17(1):234]

Cited: 6 times

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Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod.

Mariya Rozenblit, Wouter Hendrickx, Adriana Heguy, Luis Chiriboga, Cynthia Loomis, Karina Ray, Farbod Darvishian, Mikala Egeblad, Sandra Demaria, Francesco M Marincola, Davide Bedognetti, Sylvia Adams,

Imiquimod is a topical toll-like-receptor-7 agonist currently used for treating basal cell carcinoma. Recently, imiquimod has demonstrated tumor regression in melanoma and breast cancer skin metastases. However, the molecular perturbations induced by imiquimod in breast cancer metastases have not been previously characterized. Here, we describe transcriptomic profiles associated with responsiveness ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):8572]

Cited: 9 times

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Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.

Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M Coussens, Daniel D De Carvalho, David G DeNardo, Jérôme Galon, Howard L Kaufman, Tomas Kirchhoff, Michael T Lotze, Jason J Luke, Andy J Minn, Katerina Politi, Leonard D Shultz, Richard Simon, Vésteinn Thórsson, Joanne B Weidhaas, Maria Libera Ascierto, Paolo Antonio Ascierto, James M Barnes, Valentin Barsan, Praveen K Bommareddy, Adrian Bot, Sarah E Church, Gennaro Ciliberto, Andrea De Maria, Dobrin Draganov, Winson S Ho, Heather M McGee, Anne Monette, Joseph F Murphy, Paola Nisticò, Wungki Park, Maulik Patel, Michael Quigley, Laszlo Radvanyi, Harry Raftopoulos, Nils-Petter Rudqvist, Alexandra Snyder, Randy F Sweis, Sara Valpione, Roberta Zappasodi, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Alessandra Cesano, Francesco M Marincola, ,

Following publication of the original article [1], the author reported that an author name, Roberta Zappasodi, was missed in the authorship list. ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2019, 7(1):167]

Cited: 1 time

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