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Author Francesco Fedele

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Clinical Features of LMNA-Related Cardiomyopathy in 18 Patients and Characterization of Two Novel Variants.

Valentina Ferradini, Joseph Cosma, Fabiana Romeo, Claudia De Masi, Michela Murdocca, Paola Spitalieri, Sara Mannucci, Giovanni Parlapiano, Francesca Di Lorenzo, Annamaria Martino, Francesco Fedele, Leonardo Calò, Giuseppe Novelli, Federica Sangiuolo, Ruggiero Mango,

Dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders characterized by ventricular dilation and depressed myocardial performance in the absence of hypertension, valvular, congenital, or ischemic heart disease. Mutations in LMNA gene, encoding for lamin A/C, account for 10% of familial DCM. LMNA-related cardiomyopathies are characterized by heterogeneous ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Sodium-glucose cotransporter 2 inhibitors and heart failure: the best timing for the right patient.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Bettina Costi, Danilo Angotti, Lucia Ilaria Birtolo, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially born as anti-diabetic drugs, have shown many beneficial effects on the cardiovascular system, in particular against heart failure (HF). HF is a complex and multifaceted disease that requires a comprehensive approach. It should not be considered as a simplistic cardiac disease, but a systemic ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, :]

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Prevalence and Clinical Implications of COVID-19 Myocarditis

Cristina Chimenti, Michele Magnocavallo, Federico Ballatore, Federico Bernardini, Maria Alfarano, Domenico Giovanni Della Rocca, Paolo Severino, Carlo Lavalle, Fedele Francesco, Andrea Frustaci,

Synopsis The clinical manifestations of COVID-19 are widely variable and may involve several districts. Although the clinical course is mostly characterized by respiratory involvement, up to 30% of hospitalized patients have evidence of myocardial injury due to acute coronary syndrome, cardiac arrhythmias, myocarditis, and cardiogenic shock. In particular, myocarditis is ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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ECG evaluation in 11 949 Italian teenagers: results of screening in secondary school.

Massimo Mancone, Viviana Maestrini, Antonio Fusto, Francesco Adamo, Paola Scarparo, Alessandra D'Ambrosi, Alessandra Cinque, Maria Chiara Gatto, Nicolò Salvi, Gianluca Agnes, Mariateresa Pucci, Lucia Ilaria Birtolo, Laura Marruncheddu, Igino Genuini, Claudio De Lazzari, Paolo Severino, Giuseppe Giunta, Carlo Lavalle, Danilo Alunni Fegatelli, Annarita Vestri, Francesco Fedele, ,

<h4>Background</h4>There is lack of evidence regarding the screening role of ECG for sudden cardiac death (SCD) prevention.<h4>Objective</h4>To evaluate the prevalence of ECG abnormalities among teenagers according to sport participation and competitive status.<h4>Methods</h4>Eleven thousand nine hundred and forty-nine Italian pupils from 179 secondary schools (13-19 years) were consecutively enrolled. ECG abnormalities were ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, :]

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Impact of COVID-19 Pandemic on Cardiac Electronic Device Management and Role of Remote Monitoring

Michele Magnocavallo, Giampaolo Vetta, Alessia Bernardini, Agostino Piro, Maria Chiara Mei, Martina Di Iorio, Marco Valerio Mariani, Domenico G. Della Rocca, Paolo Severino, Raffaele Quaglione, Giuseppe Giunta, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Francesco Fedele, Carlo Lavalle,

Synopsis During the Coronavirus Disease 2019 (COVID-19) worldwide pandemic, patients with cardiac implantable electronic device (CIED) refused scheduled follow-up visits due to the risk of infection. In this scenario, different telemedicine strategies have been implemented to ensure continuity of care to CIED patients. Patients can be monitored through dedicated apps, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Clinical Features of LMNA-Related Cardiomyopathy in 18 Patients and Characterization of Two Novel Variants

Valentina Ferradini, Joseph Cosma, Fabiana Romeo, Claudia De Masi, Michela Murdocca, Paola Spitalieri, Sara Mannucci, Giovanni Parlapiano, Francesca Di Lorenzo, Annamaria Martino, Francesco Fedele, Leonardo Calò, Giuseppe Novelli, Federica Sangiuolo, Ruggiero Mango,

Dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders characterized by ventricular dilation and depressed myocardial performance in the absence of hypertension, valvular, congenital, or ischemic heart disease. Mutations in LMNA gene, encoding for lamin A/C, account for 10% of familial DCM. LMNA-related cardiomyopathies are characterized by heterogeneous ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Michele Magnocavallo, Marco Valerio Mariani, Lucrezia Netti, Lucia Ilaria Birtolo, Paolo De Orchi, Cristina Chimenti, Viviana Maestrini, Fabio Miraldi, Carlo Lavalle, Viviana Caputo, Raffaele Palmirotta, Massimo Mancone, Francesco Fedele,

<b>Background:</b> IHD is determined by an inadequate coronary blood supply to the myocardium, and endothelial dysfunction may represent one of the main pathophysiological mechanisms involved. Genetic predisposition to endothelial dysfunction has been associated with IHD and its clinical manifestation. However, studies are often confounding and inconclusive for several reasons, such ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(9):]

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Effects of Metolazone Administration on Congestion, Diuretic Response and Renal Function in Patients with Advanced Heart Failure.

Alberto Palazzuoli, Gaetano Ruocco, Paolo Severino, Luigi Gennari, Filippo Pirrotta, Andrea Stefanini, Francesco Tramonte, Mauro Feola, Massimo Mancone, Francesco Fedele,

<h4>Background</h4>Advanced heart failure (HF) is a condition often requiring elevated doses of loop diuretics. Therefore, these patients often experience poor diuretic response. Both conditions have a detrimental impact on prognosis and hospitalization.<h4>Aims</h4>This retrospective, multicenter study evaluates the effect of the addition of oral metolazone on diuretic response (DR), clinical congestion, ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(18):]

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Reply to the Editor-High subthreshold pacing impedance from device-lead connection issues.

Carlo Pignalberi, Marco Valerio Mariani, Antonello Castro, Agostino Piro, Barbara Magris, Bruno Albano, Stefano Aquilani, Michele Magnocavallo, Furio Colivicchi, Francesco Fedele, Carlo Lavalle,

Heart Rhythm (Heart rhythm)
[2021, 18(12):2225-2226]

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Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up.

Viviana Maestrini, Lucia Ilaria Birtolo, Marco Francone, Gioacchino Galardo, Nicola Galea, Paolo Severino, Francesco Alessandri, Maria Chiara Colaiacomo, Giulia Cundari, Cristina Chimenti, Carlo Lavalle, Maria Ciardi, Paolo Palange, Alberto Deales, Gabriella d'Ettorre, Claudio M Mastroianni, Carlo Catalano, Franco Ruberto, Francesco Pugliese, Giulia d'Amati, Francesco Fedele, Massimo Mancone, ,

<h4>Background</h4>Cardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess: 1) CVD occurrence among hospitalized COVID-19 patients, 2) ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 339:235-242]

Cited: 3 times

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Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Francesca Fanisio, Lucia Ilaria Birtolo, Bettina Costi, Lucrezia Netti, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF patients. The association between HFpEF ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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Peripheral Arterial Stiffness in Acute Pulmonary Embolism and Pulmonary Hypertension at Short-Term Follow-Up.

Silvia Papa, Cristiano Miotti, Giovanna Manzi, Gianmarco Scoccia, Federico Luongo, Federica Toto, Claudia Malerba, Nadia Cedrone, Elena Sofia Canuti, Annalisa Caputo, Giulia Manguso, Serena Valentini, Susanna Sciomer, Francesco Ciciarello, Giulia Benedetti, Francesco Fedele, Carmine Dario Vizza, Roberto Badagliacca,

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe and under-recognized complication of acute pulmonary embolism (PE). Forty consecutive patients with acute PE (Group 1), predominantly female (22, 55%) with a mean age of 69 ± 15 years, were matched for demographic data with 40 healthy subjects (Group 2), 40 systemic ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(14):]

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T2-mapping increase is the prevalent imaging biomarker of myocardial involvement in active COVID-19: a Cardiovascular Magnetic Resonance study.

Nicola Galea, Livia Marchitelli, Giacomo Pambianchi, Federica Catapano, Giulia Cundari, Lucia Ilaria Birtolo, Viviana Maestrini, Massimo Mancone, Francesco Fedele, Carlo Catalano, Marco Francone,

<h4>Background</h4>Early detection of myocardial involvement can be relevant in coronavirus disease 2019 (COVID-19) patients to timely target symptomatic treatment and decrease the occurrence of the cardiac sequelae of the infection. The aim of the present study was to assess the clinical value of cardiovascular magnetic resonance (CMR) in characterizing myocardial ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2021, 23(1):68]

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How to perform a cardio-thoracic magnetic resonance imaging in COVID-19: comprehensive assessment of heart, pulmonary arteries, and lung parenchyma.

Nicola Galea, Federica Catapano, Livia Marchitelli, Giulia Cundari, Viviana Maestrini, Valeria Panebianco, Massimo Mancone, Francesco Fedele, Carlo Catalano, Marco Francone,

We proposed a combined cardiothoracic-MRI (CaTh-MRI) protocol for the comprehensive assessment of cardiovascular structures, lung parenchyma, and pulmonary arterial tree, in COVID-19 patients with progressive worsening of clinical conditions and/or suspicion of acute-onset myocardial inflammation. A 25-minutes fast protocol was also conceived for unstable or uncooperative patients by restricting the ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal. Cardiovascular Imaging)
[2021, 22(7):728-731]

Cited: 7 times

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The Peritoneal Neovagina after Davydov's Laparoscopic Procedure in Mayer-Rokitansky-Küster-Hauser Syndrome: Morphology and Ultrastructure Investigation of the New Epithelium.

Massimo Origoni, Francesco Fedele, Marta Parma, Simona Di Fatta, Valentino Bergamini, Massimo Candiani, Luigi Fedele,

<h4>Study objective</h4>To investigate the clinical appearance and morphologic and ultrastructural aspects of the mucosa of the peritoneal neovagina after laparoscopic Davydov neovaginoplasty in patients with Mayer-Rokitansky-Küster-Hauser syndrome.<h4>Design</h4>The study group was a prospective, observational, experimental cohort of cases treated in the same institution between 2015 and 2019. Patients were followed up ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2021, 28(10):1795-1799]

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Updated antithrombotic strategies to reduce the burden of cardiovascular recurrences in patients with chronic coronary syndrome.

Giuseppe Patti, Francesco Fattirolli, Leonardo De Luca, Giulia Renda, Rossella Marcucci, Guido Parodi, Gian Piero Perna, Felicita Andreotti, Chiara Ghiglieno, Francesco Fedele, Niccolò Marchionni,

Despite recent achievements in secondary cardiovascular prevention, the risk of further events in patients with chronic coronary syndromes (CCS) remains elevated. Highest risk is seen in patients with recurrent events, comorbidities or multisite atherosclerosis. Optimising antithrombotic strategies in this setting may significantly improve outcomes. The higher the baseline risk, the ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 140:111783]

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Prognostic role of pre- and post-interventional myocardial injury in patients undergoing transcatheter aortic valve implantation.

Domenico Filomena, Sara Monosilio, Sara Cimino, Viviana Maestrini, Federico Luongo, Matteo Neccia, Nicolò Salvi, Riccardo Colantonio, Massimo Mancone, Gennaro Sardella, Francesco Fedele, Luciano Agati,

<h4>Background</h4>Chronic pre-procedural and acute post-procedural myocardial injury are frequently observed in patients with aortic stenosis undergoing trans-catheter aortic valve implantation (TAVI). The aim of our study was to investigate the prognostic role of high sensitivity cardiac troponins (hs-cTns) elevation before and after TAVI.<h4>Methods</h4>106 patients with severe aortic stenosis who underwent ... Read more >>

Minerva Cardiol Angiol (Minerva cardiology and angiology)
[2021, :]

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False-positive bone scintigraphy denoting transthyretin amyloid in elderly hypertrophic cardiomyopathy.

Cristina Chimenti, Maria Alfarano, Viviana Maestrini, Nicola Galea, Giuseppe De Vincentis, Romina Verardo, Francesco Fedele, Andrea Frustaci,

A positive nuclear scintigraphy with hydroxy bisphosphonate bone tracer (99mTc-HPD) is believed to have high sensitivity (>99%) and specificity (91%) for the diagnosis of transthyretin amyloid cardiomyopathy. We report the case of an 85-year-old man with increased thickness of ventricular walls and a positive bone scintigraphy, who was unexpectedly found ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(4):3387-3391]

Cited: 1 time

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HEART FAILURE HOSPITALIZATION RATE REDUCTION DURING COVID-19 PANDEMIC

Andrea D’Amato, Paolo Severino, Andrea Saglietto, Fabrizio D’Ascenzo, Claudia Marini, Marco Schiavone, Nicolò Ghionzoli, Filippo Pirrotta, Francesca Troiano, Margherita Cannillo, Marco Mennuni, Andrea Rognoni, Francesco Rametta, Alessandro Galluzzo, Gianluca Agnes, Fabio Infusino, Mariateresa Pucci, Carlo Lavalle, Luca Cacciotti, Paul Mather, Walter Grosso Marra, Fabrizio Ugo, Giovanni Forleo, Maurizio Viecca, Nuccia Morici, Giuseppe Patti, Gaetano Maria De Ferrari, Alberto Palazzuoli, Massimo Mancone, Francesco Fedele,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(18):791-791]

Cited: 0 times

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Return towards normality in admissions for myocardial infarction after the lockdown removal for COVID-19 outbreak in Italy.

Andrea Rognoni, Fabrizio D'Ascenzo, Martina Solli, Marco G Mennuni, Vincenzo Galiffa, Roberta Rosso, Chiara Cavallino, Fabrizio Ugo, Ovidio De Filippo, Andrea Borin, Italo Porto, Francesco Fedele, Massimo Mancone, Gennaro Sardella, Daniela Trabattoni, Umberto Barbero, Cinzia Moncalvo, Roberto Verardi, Gianni Casella, Claudio Montalto, Sergio Leonardi, Danila Azzolina, Gaetano Maria De Ferrari, Giuseppe Patti,

<h4>Background</h4>Investigations demonstrated a decrease of admissions for myocardial infarction (MI) during the CoronaVirus Disease-19 (COVID-19) outbreak. No study has evaluated the time required to reverse this downward curve of MI admissions.<h4>Methods</h4>This is a retrospective analysis on patients (N = 2415) admitted to the Emergency Departments for acute MI in nine ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 332:235-237]

Cited: 1 time

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Sporadic high pacing and shock impedance on remote monitoring in hybrid implantable cardioverter-defibrillator systems: Clinical impact and management.

Carlo Pignalberi, Marco Valerio Mariani, Antonello Castro, Agostino Piro, Barbara Magris, Bruno Albano, Stefano Aquilani, Michele Magnocavallo, Furio Colivicchi, Francesco Fedele, Carlo Lavalle,

<h4>Background</h4>Sporadic high impedance values without other anomalies detected by remote monitoring of hybrid cardiac implantable electronic device systems have been described recently. The clinical significance and related hazard of this phenomenon are not fully understood.<h4>Objective</h4>The purpose of this study was to describe the prevalence, management, and outcomes associated with hybrid ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(8):1292-1300]

Cited: 0 times

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Effect of combined renin angiotensin aldosterone inhibitors and diuretic treatment among patients hospitalized with SARS-CoV-2 Infection COVID-19

Alberto Palazzuoli, Kristen Tecson, Marco Vicenzi, Fabrizio D’Ascenzo, Gaetano Maria De Ferrari, Silvia Monticone, Gioel Secco, Guido Tavazzi, Giovanni Forleo, Paolo Severino, Francesco Fedele, Francesco De Rosa, Peter McCullough,

<h4>Background: </h4> Antecedent use of renin angiotensin aldosterone inhibitors (RAASi) appears crucial to prevent clinical deterioration and protect against cardiovascular and/or thrombotic complications of Coronavirus Disease (COVID-19), for indicated patients. Doubts have been raised about continuing treatment throughout infection, and nothing is known regarding its effect with concomitant medications. Hence, ... Read more >>

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Electrocardiographic Criteria for Differentiating Left from Right Idiopathic Outflow Tract Ventricular Arrhythmias.

Marco V Mariani, Agostino Piro, Domenico G Della Rocca, Giovanni B Forleo, Naga Venkata Pothineni, Jorge Romero, Luigi Di Biase, Francesco Fedele, Carlo Lavalle,

Idiopathic ventricular arrhythmias are ventricular tachycardias or premature ventricular contractions presumably not related to myocardial scar or disorders of ion channels. Of the ventricular arrhythmias (VAs) without underlying structural heart disease, those arising from the ventricular outflow tracts (OTs) are the most common. The right ventricular outflow tract (RVOT) is ... Read more >>

Arrhythm Electrophysiol Rev (Arrhythmia & electrophysiology review)
[2021, 10(1):10-16]

Cited: 0 times

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Levosimendan in Europe and China: An Appraisal of Evidence and Context.

Xiangqing Kong, Xinqun Hu, Baotong Hua, Francesco Fedele, Dimitrios Farmakis, Piero Pollesello,

The calcium sensitiser levosimendan (SIMDAX; Orion Pharma) has been in clinical use for the management of acute heart failure and a range of related syndromes in many countries around the world for two decades. More recently, levosimendan has become available in China. The authors have examined the profile of levosimendan ... Read more >>

Eur Cardiol (European cardiology)
[2021, 16:e42]

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The evolving role of echocardiography in the assessment of patent foramen ovale in patients with left-side thromboembolism.

Domenico Filomena, Sara Cimino, Viviana Maestrini, Sara Monosilio, Lucia Ilaria Birtolo, Edoardo Vicenzini, Massimo Mancone, Francesco Fedele, Luciano Agati,

Patent foramen ovale (PFO) is the most common congenital cardiac abnormality found approximately in 25% of the adult population The pathophysiological role of paradoxical embolization through the PFO in ischemic stroke is well established. "Self-expanding double disk" and, more recently, suture-based "deviceless" systems are used for PFO closure in the ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2021, 38(4):657-675]

Cited: 1 time

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