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Author Francesco Bruni

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Author's reply to: Comments on the utilization of Mann-Whitney U test and Kaplan-Meier method.

Marcello Ceccaroni, Giovanni Roviglione, Simone Garzon, Francesco Bruni, Stefano Uccella,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e54]

Cited: 0 times

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Total laparoscopic vs. conventional open abdominal nerve-sparing radical hysterectomy: clinical, surgical, oncological and functional outcomes in 301 patients with cervical cancer.

Marcello Ceccaroni, Giovanni Roviglione, Mario Malzoni, Francesco Cosentino, Emanuela Spagnolo, Roberto Clarizia, Paolo Casadio, Renato Seracchioli, Fabio Ghezzi, Daniele Mautone, Francesco Bruni, Stefano Uccella,

<h4>Objective</h4>Total laparoscopic nerve-sparing radical hysterectomy (TL-NSRH) has been considered a promising approach, however, surgical, clinical, oncological and functional outcomes have not been systematically addressed. We present a large retrospective multi-center experience comparing TL-NSRH vs. open abdominal NSRH (OA-NSRH) for early and locally-advanced cervical cancer, with particular emphasis on post-surgical pelvic ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(1):e10]

Cited: 0 times

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Messenger RNA delivery to mitoribosomes - hints from a bacterial toxin.

Francesco Bruni, Yasmin Proctor-Kent, Robert N Lightowlers, Zofia M Chrzanowska-Lightowlers,

In mammalian mitochondria, messenger RNA is processed and matured from large primary transcripts in structures known as RNA granules. The identity of the factors and process transferring the matured mRNA to the mitoribosome for translation is unclear. Nascent mature transcripts are believed to associate initially with the small mitoribosomal subunit ... Read more >>

FEBS J (The FEBS journal)
[2021, 288(2):437-451]

Cited: 0 times

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Identification of a novel heterozygous guanosine monophosphate reductase (GMPR) variant in a patient with a late-onset disorder of mitochondrial DNA maintenance.

Ewen W Sommerville, Ilaria Dalla Rosa, Masha M Rosenberg, Francesco Bruni, Kyle Thompson, Mariana Rocha, Emma L Blakely, Langping He, Gavin Falkous, Andrew M Schaefer, Patrick Yu-Wai-Man, Patrick F Chinnery, Lizbeth Hedstrom, Antonella Spinazzola, Robert W Taylor, Gráinne S Gorman,

Autosomal dominant progressive external ophthalmoplegia (adPEO) is a late-onset, Mendelian mitochondrial disorder characterised by paresis of the extraocular muscles, ptosis, and skeletal-muscle restricted multiple mitochondrial DNA (mtDNA) deletions. Although dominantly inherited, pathogenic variants in POLG, TWNK and RRM2B are among the most common genetic defects of adPEO, identification of novel ... Read more >>

Clin Genet (Clinical genetics)
[2020, 97(2):276-286]

Cited: 1 time

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Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.

Lien Van Eyck, Francesco Bruni, Anne Ronan, Tracy A Briggs, Tony Roscioli, Gillian I Rice, Grace Vassallo, Mathieu P Rodero, Langping He, Robert W Taylor, John H Livingston, Zofia M A Chrzanowska-Lightowlers, Yanick J Crow,

BACKGROUND:A homozygous founder mutation in MTPAP/TENT6, encoding mitochondrial poly(A) polymerase (MTPAP), was first reported in six individuals of Old Order Amish descent demonstrating an early-onset, progressive spastic ataxia with optic atrophy and learning difficulties. MTPAP contributes to the regulation of mitochondrial gene expression through the polyadenylation of mitochondrially encoded mRNAs. ... Read more >>

Neuropediatrics (Neuropediatrics)
[2020, 51(3):178-184]

Cited: 2 times

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Sentinel Lymph Node Biopsy in the Treatment of Endometrial Cancer: Why We Fail? Results of a Prospective Multicenter Study on the Factors Associated with Failure of Node Mapping with Indocyanine Green.

Manuel Maria Ianieri, Andrea Puppo, Antonia Novelli, Federica Campolo, Tommaso Staniscia, Giuseppe Di Martino, Elisa Piovano, Francesco Bruni, Giovanni Roviglione, Daniele Mautone, Marcello Ceccaroni,

<h4>Background</h4>The sentinel lymph node (SLN) mapping for endometrial cancer staging is gaining wide diffusion, but there is no definitive evidence on the factors associated with the failure of mapping.<h4>Objectives</h4>To analyze the factors associated with the possible failure of bilateral SLN mapping with indocyanine green (ICG).<h4>Methods</h4>A prospective observational study without control ... Read more >>

Gynecol Obstet Invest (Gynecologic and obstetric investigation)
[2019, 84(4):383-389]

Cited: 1 time

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Confirming TDP2 mutation in spinocerebellar ataxia autosomal recessive 23 (SCAR23).

Guido Zagnoli-Vieira, Francesco Bruni, Kyle Thompson, Langping He, Sarah Walker, Arjan P M de Brouwer, Robert W Taylor, Dmitriy Niyazov, Keith W Caldecott,

<h4>Objective</h4>To address the relationship between mutations in the DNA strand break repair protein tyrosyl DNA phosphodiesterase 2 (TDP2) and spinocerebellar ataxia autosomal recessive 23 (SCAR23) and to characterize the cellular phenotype of primary fibroblasts from this disease.<h4>Methods</h4>We have used exome sequencing, Sanger sequencing, gene editing and cell biology, biochemistry, and ... Read more >>

Neurol Genet (Neurology. Genetics)
[2018, 4(4):e262]

Cited: 7 times

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Clinical, biochemical, and genetic features associated with VARS2-related mitochondrial disease.

Francesco Bruni, Ivano Di Meo, Emanuele Bellacchio, Bryn D Webb, Robert McFarland, Zofia M A Chrzanowska-Lightowlers, Langping He, Ewa Skorupa, Isabella Moroni, Anna Ardissone, Anna Walczak, Henna Tyynismaa, Pirjo Isohanni, Hanna Mandel, Holger Prokisch, Tobias Haack, Penelope E Bonnen, Bertini Enrico, Ewa Pronicka, Daniele Ghezzi, Robert W Taylor, Daria Diodato,

In recent years, an increasing number of mitochondrial disorders have been associated with mutations in mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs), which are key enzymes of mitochondrial protein synthesis. Bi-allelic functional variants in VARS2, encoding the mitochondrial valyl tRNA-synthetase, were first reported in a patient with psychomotor delay and epilepsia partialis continua ... Read more >>

Hum Mutat (Human mutation)
[2018, 39(4):563-578]

Cited: 8 times

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Laparoscopy for primary cytoreduction with multivisceral resections in advanced ovarian cancer: prospective validation. "The times they are a-changin"?

Marcello Ceccaroni, Giovanni Roviglione, Francesco Bruni, Roberto Clarizia, Giacomo Ruffo, Matteo Salgarello, Michele Peiretti, Stefano Uccella,

BACKGROUND:Primary cytoreduction is the mainstay of treatment for advanced ovarian cancer (AOC). We developed and prospectively evaluated an algorithm to investigate the possible role of laparoscopic primary cytoreduction (LPC) in carefully selected patients, with AOC. METHODS:From June 2007 to July 2015, all patients with stage III-IV ovarian cancer and clinical ... Read more >>

Surg Endosc (Surgical endoscopy)
[2018, 32(4):2026-2037]

Cited: 4 times

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Human mitochondrial nucleases.

Francesco Bruni, Robert N Lightowlers, Zofia M Chrzanowska-Lightowlers,

Mitochondria are cytosolic organelles that have many essential roles including ATP production via oxidative phosphorylation, apoptosis, iron-sulfur cluster biogenesis, heme and steroid synthesis, calcium homeostasis, and regulation of cellular redox state. One of the unique features of these organelles is the presence of an extrachromosomal mitochondrial genome (mtDNA), together with ... Read more >>

FEBS J (The FEBS journal)
[2017, 284(12):1767-1777]

Cited: 8 times

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Near-infrared roll-off-free electroluminescence from highly stable diketopyrrolopyrrole light emitting diodes.

Mauro Sassi, Nunzio Buccheri, Myles Rooney, Chiara Botta, Francesco Bruni, Umberto Giovanella, Sergio Brovelli, Luca Beverina,

Organic light emitting diodes (OLEDs) operating in the near-infrared spectral region are gaining growing relevance for emerging photonic technologies, such as lab-on-chip platforms for medical diagnostics, flexible self-medicated pads for photodynamic therapy, night vision and plastic-based telecommunications. The achievement of efficient near-infrared electroluminescence from solution-processed OLEDs is, however, an open ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:34096]

Cited: 9 times

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Primary Vaginal Adenosarcoma With Sarcomatous Overgrowth Arising in Recurrent Endometriosis: Feasibility of Laparoscopic Treatment and Review of the Literature.

Giovanni Pontrelli, Mauro Cozzolino, Anna Stepniewska, Francesco Bruni, Anna Pesci, Marcello Ceccaroni,

We report a case of a primary vaginal adenosarcoma with sarcomatous overgrowth in a postmenopausal 58-year-old woman with recurrent endometriosis. In the past 5 years she underwent several biopsies of a polypoid lesion on the vaginal cuff, and the last histologic examination of the biopsy showed an adenosarcoma with "sarcomatous overgrowth" ... Read more >>

J Minim Invasive Gynecol (Journal of minimally invasive gynecology)
[2016, 23(5):833-838]

Cited: 8 times

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Laparoscopic vs. open treatment of endometrial cancer in the elderly and very elderly: An age-stratified multicenter study on 1606 women.

Stefano Uccella, Matteo Bonzini, Stefano Palomba, Francesco Fanfani, Mario Malzoni, Marcello Ceccaroni, Renato Seracchioli, Annamaria Ferrero, Roberto Berretta, Enrico Vizza, Davide Sturla, Giovanni Roviglione, Giorgia Monterossi, Paolo Casadio, Eugenio Volpi, Daniele Mautone, Giacomo Corrado, Francesco Bruni, Giovanni Scambia, Fabio Ghezzi,

<h4>Unlabelled</h4>Objective To investigate in depth the effect of increasing age on the peri-operative outcomes of laparoscopic treatment for endometrial cancer, compared to open surgery, with stratification of patients according to the different definitions of elderly age used in the literature.<h4>Methods</h4>Data of consecutive patients who underwent surgery for endometrial cancer staging ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2016, 141(2):211-217]

Cited: 14 times

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The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism.

Arnaud Besse, Ping Wu, Francesco Bruni, Taraka Donti, Brett H Graham, William J Craigen, Robert McFarland, Paolo Moretti, Seema Lalani, Kenneth L Scott, Robert W Taylor, Penelope E Bonnen,

ABAT is a key enzyme responsible for catabolism of principal inhibitory neurotransmitter γ-aminobutyric acid (GABA). We report an essential role for ABAT in a seemingly unrelated pathway, mitochondrial nucleoside salvage, and demonstrate that mutations in this enzyme cause an autosomal recessive neurometabolic disorder and mtDNA depletion syndrome (MDS). We describe a ... Read more >>

Cell Metab (Cell metabolism)
[2015, 21(3):417-427]

Cited: 51 times

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Radical improvement of signs and symptoms in systemic lupus erythematosus when treated with hemodiafiltration with endogenous reinfusion dialysis.

Francesco Giuseppe Solano, Elisa Bellei, Aurora Cuoghi, Marialuisa Caiazzo, Francesco Bruni,

Lupus nephritis is one of the most serious complications of systemic lupus erythematosus (SLE). In the kidney, immune complexes and autoantibodies activate mesangial cells that secrete cytokines that can further amplify inflammatory processes. We present the case of a 42-year-old woman with lupus nephritis accompanied by periods of exacerbation of ... Read more >>

Case Rep Nephrol Dial (Case reports in nephrology and dialysis)
[2015, 5(1):106-112]

Cited: 2 times

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Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA.

John W Yarham, Tek N Lamichhane, Angela Pyle, Sandy Mattijssen, Enrico Baruffini, Francesco Bruni, Claudia Donnini, Alex Vassilev, Langping He, Emma L Blakely, Helen Griffin, Mauro Santibanez-Koref, Laurence A Bindoff, Ileana Ferrero, Patrick F Chinnery, Robert McFarland, Richard J Maraia, Robert W Taylor,

Identifying the genetic basis for mitochondrial diseases is technically challenging given the size of the mitochondrial proteome and the heterogeneity of disease presentations. Using next-generation exome sequencing, we identified in a patient with severe combined mitochondrial respiratory chain defects and corresponding perturbation in mitochondrial protein synthesis, a homozygous p.Arg323Gln mutation ... Read more >>

PLoS Genet (PLoS genetics)
[2014, 10(6):e1004424]

Cited: 52 times

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Total laparoscopic hysterectomy of very enlarged uterus (3030 g): case report and review of the literature.

Marcello Ceccaroni, Giovanni Roviglione, Anna Pesci, Sara Quintana, Francesco Bruni, Roberto Clarizia,

Fibromatosis is the most frequent benign uterine pathology of fertile women, rarely causing anomalous enlargement of the uterus. Traditionally the surgical treatment has been abdominal hysterectomy. However, development of minimally invasive techniques has led to major safeness of the laparoscopic route. We report a case of total laparoscopic hysterectomy performed ... Read more >>

Wideochir Inne Tech Maloinwazyjne (Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques)
[2014, 9(2):302-307]

Cited: 3 times

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Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1.

Miguel A Fernández-Moreno, Rosana Hernández, Cristina Adán, Marina Roberti, Francesco Bruni, Paola Loguercio Polosa, Palmiro Cantatore, Yuichi Matsushima, Laurie S Kaguni, Rafael Garesse,

DREF [DRE (DNA replication-related element)-binding factor] controls the transcription of numerous genes in Drosophila, many involved in nuclear DNA (nDNA) replication and cell proliferation, three in mitochondrial DNA (mtDNA) replication and two in mtDNA transcription termination. In this work, we have analysed the involvement of DREF in the expression of ... Read more >>

Biochim Biophys Acta (Biochimica et biophysica acta)
[2013, 1829(10):1136-1146]

Cited: 1 time

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REXO2 is an oligoribonuclease active in human mitochondria.

Francesco Bruni, Pasqua Gramegna, Jorge M A Oliveira, Robert N Lightowlers, Zofia M A Chrzanowska-Lightowlers,

The Escherichia coli oligoribonuclease, ORN, has a 3' to 5' exonuclease activity specific for small oligomers that is essential for cell viability. The human homologue, REXO2, has hitherto been incompletely characterized, with only its in vitro ability to degrade small single-stranded RNA and DNA fragments documented. Here we show that ... Read more >>

PLoS One (PloS one)
[2013, 8(5):e64670]

Cited: 26 times

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The mystery of mitochondrial RNases.

Francesco Bruni, Pasqua Gramegna, Robert N Lightowlers, Zofia M A Chrzanowska-Lightowlers,

The central dogma states that DNA is transcribed to generate RNA and that the mRNA components are then translated to generate proteins; a simple statement that completely belies the complexities of gene expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to ... Read more >>

Biochem Soc Trans (Biochemical Society transactions)
[2012, 40(4):865-869]

Cited: 8 times

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Laparoscopic surgical treatment of diaphragmatic endometriosis: a 7-year single-institution retrospective review.

Marcello Ceccaroni, Giovanni Roviglione, Pierluigi Giampaolino, Roberto Clarizia, Francesco Bruni, Giacomo Ruffo, Tito Silvio Patrelli, Giuseppe De Placido, Luca Minelli,

<h4>Background</h4>Diaphragmatic endometriosis is a rare condition that may cause invalidating epigastric or thoracic pain and catamenial pneumothorax. During the past decades, laparoscopy has been proposed as an optimal tool for diagnosis and surgical eradication of the disease.<h4>Methods</h4>We present a retrospective series of consecutive patients affected by diaphragmatic endometriosis, treated by ... Read more >>

Surg Endosc (Surgical endoscopy)
[2013, 27(2):625-632]

Cited: 15 times

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D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria.

Francesco Bruni, Caterina Manzari, Mariacristina Filice, Paola Loguercio Polosa, Matilde Colella, Claudia Carmone, Elena Hambardjieva, Miguel Garcia-Diaz, Palmiro Cantatore, Marina Roberti,

The MTERF protein family comprises members from Metazoans and plants. All the Metazoan MTERF proteins characterized to date, including the mitochondrial transcription termination factors, play a key role in mitochondrial gene expression. In this study we report the characterization of Drosophila MTERF5 (D-MTERF5), a mitochondrial protein existing only in insects, ... Read more >>

Mitochondrion (Mitochondrion)
[2012, 12(5):492-499]

Cited: 10 times

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Nerve-sparing laparoscopic eradication of deep endometriosis with segmental rectal and parametrial resection: the Negrar method. A single-center, prospective, clinical trial.

Marcello Ceccaroni, Roberto Clarizia, Francesco Bruni, Elisabetta D'Urso, Maria Lucia Gagliardi, Giovanni Roviglione, Luca Minelli, Giacomo Ruffo,

<h4>Background</h4>The weight of surgical radicality, together with a lack of anatomical theoretical basis for surgery and inappropriate practical skills, can lead to serious impairments to bladder, rectal, and sexual functions after laparoscopic excision of deep infiltrating endometriosis. Although the "classical" laparoscopic technique for endometriosis excision involving segmental bowel resection has ... Read more >>

Surg Endosc (Surgical endoscopy)
[2012, 26(7):2029-2045]

Cited: 38 times

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Pelvic dysfunctions and quality of life after nerve-sparing radical hysterectomy: a multicenter comparative study.

Marcello Ceccaroni, Giovanni Roviglione, Emanuela Spagnolo, Paolo Casadio, Roberto Clarizia, Michele Peiretti, Francesco Bruni, Inge Peters, Giovanni Aletti,

<h4>Aim</h4>To analyze pelvic dysfunctions, quality of life, and survival after nerve-sparing radical hysterectomy (NSRH) compared to classical radical hysterectomy (RH) for cervical cancer.<h4>Patients and methods</h4>All cervical cancer patients undergoing a RH or a NSRH were evaluated for pelvic dysfunctions and filled in a quality-of-life questionnaire.<h4>Results</h4>A total of 56 women were ... Read more >>

Anticancer Res (Anticancer research)
[2012, 32(2):581-588]

Cited: 31 times

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Pericardial, pleural and diaphragmatic endometriosis in association with pelvic peritoneal and bowel endometriosis: a case report and review of the literature.

Marcello Ceccaroni, Giovanni Roviglione, Piergiorgio Rosenberg, Anna Pesci, Roberto Clarizia, Francesco Bruni, Claudio Zardini, Giacomo Ruffo, Angelo Placci, Stefano Crippa, Luca Minelli,

Diaphragmatic endometriosis is a rare entity, often asymptomatic, which has been described only in small series. It is almost always associated with severe pelvic involvement. The most plausible theory about this condition is based on retrograde menstruation and subsequent transportation of viable cells in peritoneal fluid from the pelvis up ... Read more >>

Wideochir Inne Tech Maloinwazyjne (Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques)
[2012, 7(2):122-131]

Cited: 3 times

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