Full Text Journal Articles by
Author Francesca Saretta

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Hypersensitivity Reactions to Monoclonal Antibodies in Children.

Francesca Mori, Francesca Saretta, Annamaria Bianchi, Giuseppe Crisafulli, Silvia Caimmi, Lucia Liotti, Paolo Bottau, Fabrizio Franceschini, Claudia Paglialunga, Giampaolo Ricci, Angelica Santoro, Carlo Caffarelli,

Biologic drugs are widely used in pediatric medicine. Monoclonal antibodies (mAbs) in particular are a therapeutic option for rheumatic, autoinflammatory and oncologic diseases. Adverse drug reactions and hypersensitivity reactions (HSR) to mAbs may occur in children. Clinical presentation of HSRs to mAbs can be classified according to phenotypes in infusion-related ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(5):]

Cited: 0 times

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Diagnostic testing for penicillin allergy: A survey of practices and cost perceptions.

Bernardo Sousa-Pinto, Kimberly G Blumenthal, Eric Macy, Sevim Bavbek, Mirjana Stanić Benić, Magna Alves-Correia, Adile Berna Dursun, Elina Jerschow, Bárbara Kong-Cardoso, Peter Kopač, Sébastien Lefèvre, Carla Lombardo, Paolo Marraccini, Luis Moral, Allison Eaddy Norton, Cristina Petrişor, Iwona Poziomkowska-Gęsicka, Frederico S Regateiro, Natacha Santos, Francesca Saretta, Mirjana Turkalj, Jelena Veličković, Stefan Wöhrl, Mehtap Yazicioglu, Mihaela Zidarn, Mariana Pereira, Eva Rebelo-Gomes, Ana Margarida Pereira, Luís Delgado, João Almeida Fonseca,

Allergy (Allergy)
[2020, 75(2):436-441]

Cited: 2 times

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Drug-induced anaphylaxis in children.

Fabio Cardinale, Doriana Amato, Maria Felicia Mastrototaro, Carlo Caffarelli, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Silvia Caimmi, Paolo Bottau, Francesca Saretta, Francesca Mori, Roberto Bernardini,

Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing  from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbidities in children.  Antibiotics and non-steroidal ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):30-35]

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Drug reaction with eosinophilia and systemic symptoms (DRESS) in children.

Francesca Mori, Carlo Caffarelli, Silvia Caimmi, Paolo Bottau, Lucia Liotti, Fabrizio Franceschini, Fabio Cardinale, Roberto Bernardini, Giuseppe Crisafulli, Francesca Saretta, Elio Novembre,

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe reaction to drugs. Incidence of DRESS in children is not well known and the mortality rate seems to be lower than 10%. Anticonvulsants are the main drugs involved both in adults and in children. The treatment of choice is ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):66-79]

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Mechanisms of hypersensitivity reactions induced by drugs.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Francesca Mori, Carlo Caffarelli,

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):44-51]

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Chronic urticaria and drug hypersensitivity in children.

Carlo Mastrorilli, Roberto Bernardini, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Francesca Mori, Fabio Cardinale, Francesca Saretta, Giovanni Simeone, Marcello Bergamini, Carlo Caffarelli,

The cause of chronic urticaria remains often elusive. The association between chronic urticaria and intake of medications have been reported in children. However, the causative role of drugs has been rarely ascertained by onset of symptoms on drug provocation test. Chronic urticaria can be mediated by immunologic and nonimmunologic mechanisms. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):61-65]

Cited: 0 times

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Drug desensitization in allergic children.

Silvia Caimmi, Carlo Caffarelli, Francesca Saretta, Lucia Liotti, Giuseppe Crisafulli, Fabio Cardinale, Paolo Bottau, Francesca Mori, Fabrizio Franceschini, Roberto Bernardini, Gian Luigi Marseglia,

Drug allergy is an increasing problem worldwide, affecting all populations and races, children and adults, and for which diagnosis and treatment are not well standardized yet. Besides classical treatments, new drugs have been developed, especially for patients suffering from malignancies and chronic inflammatory diseases, that specifically target the cause of ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):20-29]

Cited: 0 times

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Prolonged Beta-Lactam Provocation Challenges in Children: Do Extended Protocols Offer Any Benefit?

Sigrid Payne DaVeiga, Francesca Saretta,

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2019, 7(1):270-271]

Cited: 0 times

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Mild cutaneous reactions to drugs.

Giuseppe Crisafulli, Fabrizio Franceschini, Silvia Caimmi, Paolo Bottau, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Fabio Cardinale, Francesca Mori, Carlo Caffarelli,

Adverse reactions to drugs are not frequent in childhood. Cutaneous reactions are the most frequent in this age group. Mild cutaneous reactions are immediate or delayed adverse reactions that do not seriously compromise the clinical condition of children. The patients usually early improve and recover the state of health. Although ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):36-43]

Cited: 0 times

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Management of the child with allergy to non-antibiotic drugs.

Roberto Bernardini, Fabio Cardinale, Francesca Mori, Francesca Saretta, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Carlo Caffarelli,

Non-steroidal anti-inflammatory drugs, perioperative drugs, radio contrast media and chemotherapeutics drugs are, after the non-antibiotic drugs, the drugs most commonly responsible for allergic reactions in children. Management is different depending on the drug involved. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):5-10]

Cited: 0 times

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Pediatric drug hypersensitivity: which diagnostic tests?

Francesca Saretta, Francesca Mori, Fabio Cardinale, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Carlo Caffarelli,

Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled.  Only a few published studies evaluated sensitivity and specificity ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):94-107]

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Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

Lucia Liotti, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Fabio Cardinale, Francesca Saretta, Francesca Mori, Giuseppe Crisafulli, Fabrizio Franceschini, Carlo Caffarelli,

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be considered a late-onset allergic reaction, can cause serious long-term sequelae. SJS/TEN are considered a spectrum of life-threatening adverse drug reactions. They have the same clinical manifestations and the only difference is in the extent of epidermal detachment. These conditions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):52-60]

Cited: 1 time

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A practical management of children with antibiotic allergy.

Elisabetta Calamelli, Carlo Caffarelli, Fabrizio Franceschini, Francesca Saretta, Fabio Cardinale, Roberto Bernardini, Lucia Liotti, Francesca Mori, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau,

About 10% of the parents reported that their children are allergic to one drug and the betalactam antibiotics are the most frequently suspected. Even if most of the adverse events following antibiotic prescriptions to children are considered allergic, after a full allergy work-up only a few of the suspected reactions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):11-19]

Cited: 0 times

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 9 times

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Evaluating children with suspected allergic reactions to vaccines for infectious diseases.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Guido Pellegrini, Diego Peroni, Francesca Saretta, Carla Mastrorilli, Carlo Caffarelli,

BACKGROUND:Vaccines often contain potentially allergenic material in addition to pathogen-specific immunogens that may induce allergic reactions. Parents and physicians often suspect that adverse reactions to vaccines are allergic in etiology. The concern that some of the substances contained in vaccines may trigger an anaphylactic reaction may lead to a low ... Read more >>

Allergy Asthma Proc (Allergy and asthma proceedings)
[2018, 39(3):177-183]

Cited: 4 times

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The utility of the basophil activation test in the diagnosis of immediate amoxicillin or amoxicillin-clavulanate hypersensitivity in children and adults.

Simona Barni, Francesca Mori, Claudia Valleriani, Giusi Mangone, Sergio Testi, Francesca Saretta, Lucrezia Sarti, Neri Pucci, Maurizio de Martino, Chiara Azzari, Elio Novembre,

The basophil activation test (BAT), has been proposed as a possible assay for the diagnosis of immediate-type allergy to beta-lactams (BLs). The aim of this study was to assess the utility of BAT in the diagnosis of amoxicillin (AMX) or AMX-clavulanate (AMX-C) IgE-mediated hypersensitivity in children and adults.Eighteen children and ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2017, 43(1):42]

Cited: 2 times

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Case Report: Revaluation of a previously diagnosed hazelnut allergy with component resolved diagnosis (CRD).

Francesca Saretta, Roberto Perini, Elio Tonutti, Daniela Visentini,

Clin Transl Allergy (Clinical and translational allergy)
[2014, 4(Suppl 2):P39-P39]

Cited: 0 times

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Invariant natural killer T cells in children with eosinophilic esophagitis.

S Jyonouchi, C L Smith, F Saretta, V Abraham, K R Ruymann, P Modayur-Chandramouleeswaran, M-L Wang, J M Spergel, A Cianferoni,

Eosinophilic esophagitis (EoE) is an atopic disease characterized by eosinophilic inflammation in which dietary antigens (in particular, milk) play a major role. EoE is most likely a mixed IgE and non-IgE food-mediated reaction in which overexpression of Th2 cytokines, particularly IL-13, play a major role; however, the cells responsible for ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2014, 44(1):58-68]

Cited: 47 times

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